LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 29

Search options

  1. Article ; Online: Coinfection of syphilis and monkeypox in HIV positive man in Prague, Czech Republic.

    Bížová, Beatrice / Veselý, Dan / Trojánek, Milan / Rob, Filip

    Travel medicine and infectious disease

    2022  Volume 49, Page(s) 102368

    MeSH term(s) Coinfection ; Czech Republic/epidemiology ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Male ; Mpox (monkeypox) ; Syphilis/complications ; Syphilis/diagnosis ; Syphilis/epidemiology
    Language English
    Publishing date 2022-06-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2022.102368
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Epidemiology of dengue, chikungunya and Zika virus infections in travellers: A 16-year retrospective descriptive study at a tertiary care centre in Prague, Czech Republic.

    Trojánek, Milan / Grebenyuk, Vyacheslav / Manďáková, Zdenka / Sojková, Naděžda / Zelená, Hana / Roháčová, Hana / Stejskal, František

    PloS one

    2023  Volume 18, Issue 2, Page(s) e0281612

    Abstract: Introduction: This study aims to describe the epidemiological characteristics of imported cases of dengue (DEN), chikungunya (CHIK), and Zika virus (ZIKV) infections in Czech travellers.: Materials and methods: This single-centre descriptive study ... ...

    Abstract Introduction: This study aims to describe the epidemiological characteristics of imported cases of dengue (DEN), chikungunya (CHIK), and Zika virus (ZIKV) infections in Czech travellers.
    Materials and methods: This single-centre descriptive study has retrospectively analysed data of patients with laboratory confirmed DEN, CHIK, and ZIKV infections diagnosed at the Department of Infectious, Parasitic and Tropical Diseases of the University Hospital Bulovka in Prague, Czech Republic from 2004 to 2019.
    Results: The study included a total of 313 patients with DEN, 30 with CHIK, and 19 with ZIKV infections. Most patients travelled as tourists:263 (84.0%), 28 (93.3%), and 17 (89.5%), respectively (p = 0.337). The median duration of stay was 20 (IQR 14-27), 21 (IQR 14-29), and 15 days (IQR 14-43), respectively (p = 0.935). Peaks of imported DEN and ZIKV infections were noted in 2016, and in 2019 in the case of CHIK infection. Most cases of DEN and CHIKV infections were acquired in Southeast Asia:212 (67.7%) and 15 (50%), respectively, while ZIKV infection was most commonly imported from the Caribbean (11; 57,9%).
    Conclusions: Arbovirus infections represent an increasingly significant cause of illness in Czech travellers. Comprehensive knowledge of the specific epidemiological profile of these diseases is an essential prerequisite for good travel medicine practice.
    MeSH term(s) Humans ; Zika Virus Infection/epidemiology ; Chikungunya Fever/epidemiology ; Zika Virus ; Retrospective Studies ; Czech Republic ; Chikungunya virus ; Tertiary Care Centers ; Dengue/epidemiology
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0281612
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Epidemiology of dengue, chikungunya and Zika virus infections in travellers

    Milan Trojánek / Vyacheslav Grebenyuk / Zdenka Manďáková / Naděžda Sojková / Hana Zelená / Hana Roháčová / František Stejskal

    PLoS ONE, Vol 18, Iss

    A 16-year retrospective descriptive study at a tertiary care centre in Prague, Czech Republic

    2023  Volume 2

    Abstract: Introduction This study aims to describe the epidemiological characteristics of imported cases of dengue (DEN), chikungunya (CHIK), and Zika virus (ZIKV) infections in Czech travellers. Materials and methods This single-centre descriptive study has ... ...

    Abstract Introduction This study aims to describe the epidemiological characteristics of imported cases of dengue (DEN), chikungunya (CHIK), and Zika virus (ZIKV) infections in Czech travellers. Materials and methods This single-centre descriptive study has retrospectively analysed data of patients with laboratory confirmed DEN, CHIK, and ZIKV infections diagnosed at the Department of Infectious, Parasitic and Tropical Diseases of the University Hospital Bulovka in Prague, Czech Republic from 2004 to 2019. Results The study included a total of 313 patients with DEN, 30 with CHIK, and 19 with ZIKV infections. Most patients travelled as tourists:263 (84.0%), 28 (93.3%), and 17 (89.5%), respectively (p = 0.337). The median duration of stay was 20 (IQR 14–27), 21 (IQR 14–29), and 15 days (IQR 14–43), respectively (p = 0.935). Peaks of imported DEN and ZIKV infections were noted in 2016, and in 2019 in the case of CHIK infection. Most cases of DEN and CHIKV infections were acquired in Southeast Asia:212 (67.7%) and 15 (50%), respectively, while ZIKV infection was most commonly imported from the Caribbean (11; 57,9%). Conclusions Arbovirus infections represent an increasingly significant cause of illness in Czech travellers. Comprehensive knowledge of the specific epidemiological profile of these diseases is an essential prerequisite for good travel medicine practice.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  4. Article ; Online: Epidemiology of dengue, chikungunya and Zika virus infections in travellers

    Milan Trojánek / Vyacheslav Grebenyuk / Zdenka Manďáková / Naděžda Sojková / Hana Zelená / Hana Roháčová / František Stejskal

    PLoS ONE, Vol 18, Iss 2, p e

    A 16-year retrospective descriptive study at a tertiary care centre in Prague, Czech Republic.

    2023  Volume 0281612

    Abstract: Introduction This study aims to describe the epidemiological characteristics of imported cases of dengue (DEN), chikungunya (CHIK), and Zika virus (ZIKV) infections in Czech travellers. Materials and methods This single-centre descriptive study has ... ...

    Abstract Introduction This study aims to describe the epidemiological characteristics of imported cases of dengue (DEN), chikungunya (CHIK), and Zika virus (ZIKV) infections in Czech travellers. Materials and methods This single-centre descriptive study has retrospectively analysed data of patients with laboratory confirmed DEN, CHIK, and ZIKV infections diagnosed at the Department of Infectious, Parasitic and Tropical Diseases of the University Hospital Bulovka in Prague, Czech Republic from 2004 to 2019. Results The study included a total of 313 patients with DEN, 30 with CHIK, and 19 with ZIKV infections. Most patients travelled as tourists:263 (84.0%), 28 (93.3%), and 17 (89.5%), respectively (p = 0.337). The median duration of stay was 20 (IQR 14-27), 21 (IQR 14-29), and 15 days (IQR 14-43), respectively (p = 0.935). Peaks of imported DEN and ZIKV infections were noted in 2016, and in 2019 in the case of CHIK infection. Most cases of DEN and CHIKV infections were acquired in Southeast Asia:212 (67.7%) and 15 (50%), respectively, while ZIKV infection was most commonly imported from the Caribbean (11; 57,9%). Conclusions Arbovirus infections represent an increasingly significant cause of illness in Czech travellers. Comprehensive knowledge of the specific epidemiological profile of these diseases is an essential prerequisite for good travel medicine practice.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  5. Article ; Online: Artemether-lumefantrine, mefloquine and atovaquone-proguanil in the treatment of uncomplicated Plasmodium falciparum malaria in travellers: A retrospective comparative study of efficacy and treatment failures.

    Grebenyuk, Vyacheslav / Stejskal, František / Nohýnková, Eva / Zicklerová, Ivana / Richterová, Lenka / Roháčová, Hana / Rozsypal, Hanuš / Trojánek, Milan

    Travel medicine and infectious disease

    2023  Volume 52, Page(s) 102549

    Abstract: Background: The aim of this study was to evaluate the rates of parasitaemia clearance and the prevalence of treatment failure in patients with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (AL), mefloquine (MQ), and ... ...

    Abstract Background: The aim of this study was to evaluate the rates of parasitaemia clearance and the prevalence of treatment failure in patients with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (AL), mefloquine (MQ), and atovaquone-proguanil (AP).
    Method: The retrospective descriptive study included adult patients with uncomplicated P. falciparum malaria treated at the University Hospital Bulovka in Prague from 2006 to 2019. Parasitaemia clearance was estimated using a linear regression model.
    Results: The study included 72 patients with a median age of 33 years (IQR 27-45) and a male to female ratio of 3.2:1. Thirty-six patients (50.0%) were treated with AL, 27 (37.5%) with MQ and 9 (12.5%) with AP. The proportion of VFR and migrants was 22.2% with no significant differences among the three groups. The median time to the parasitaemia clearance was two days (IQR 2-3) in patients treated with AL versus four days in the MQ (IQR 3-4) and AP (IQR 3-4) groups, p < 0.001. The clearance rate constant was 3.3/hour (IQR 2.5-4.0) for AL, 1.6/hour (IQR 1.3-1.9) for MQ, and 1.9/hour (IQR 1.3-2.4) for AP, p < 0.001. Malaria recrudescence occurred in 5/36 (13.9%) patients treated with AL and in no patients treated with MQ or AP.
    Conclusions: The findings demonstrate the superior efficacy of AL compared to other oral antimalarials in early malaria treatment. However, we observed a higher rate of late treatment failure in patients treated with AL than previously reported. This issue warrants further investigation of possible dose adjustments, extended regimens, or alternative artemisinin-based combinations.
    MeSH term(s) Adult ; Male ; Female ; Humans ; Middle Aged ; Antimalarials/adverse effects ; Mefloquine/therapeutic use ; Mefloquine/adverse effects ; Artemether, Lumefantrine Drug Combination/therapeutic use ; Retrospective Studies ; Artemether/therapeutic use ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/epidemiology ; Drug Combinations ; Malaria/drug therapy ; Treatment Failure ; Plasmodium falciparum ; Ethanolamines/therapeutic use
    Chemical Substances Antimalarials ; atovaquone, proguanil drug combination ; Mefloquine (TML814419R) ; Artemether, Lumefantrine Drug Combination ; Artemether (C7D6T3H22J) ; Drug Combinations ; Ethanolamines
    Language English
    Publishing date 2023-02-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2023.102549
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: [The first case of scrub typhus diagnosed in a Czech traveler].

    Trojánek, Milan / Grebenyuk, Vyacheslav / Lhoťan, Jakub / Sojková, Naděžda / Richterová, Lenka / Roháčová, Hana / Stejskal, František

    Klinicka mikrobiologie a infekcni lekarstvi

    2021  Volume 26, Issue 3, Page(s) 99–105

    Abstract: This case report describes the first case of imported scrub typhus in a Czech traveler. The infection was diagnosed in a 38-year-old male traveler returning from a one-week business/tourist trip to Laos who presented with fever, chills, joint and muscle ... ...

    Abstract This case report describes the first case of imported scrub typhus in a Czech traveler. The infection was diagnosed in a 38-year-old male traveler returning from a one-week business/tourist trip to Laos who presented with fever, chills, joint and muscle pain, localized inguinal lymphadenopathy, rash and a typical eschar. Although laboratory findings included elevation of CRP, hepatic aminotransferases and lactate dehydrogenase, complete blood count revealed only borderline leukocytosis with mild thrombocytopenia. The diagnosis of scrub typhus was made by serological detection of specific antibodies. The patient was treated with a 200 mg daily dose of oral doxycycline for 20 days. His clinical course was uncomplicated. The case underpins the need for a broader differential diagnosis in patients with travel-related health problems, especially those presenting with fever and rash, including less common or neglected tropical diseases.
    MeSH term(s) Adult ; Czech Republic ; Doxycycline/therapeutic use ; Humans ; Male ; Scrub Typhus/diagnosis ; Scrub Typhus/drug therapy ; Travel ; Travel-Related Illness
    Chemical Substances Doxycycline (N12000U13O)
    Language Czech
    Publishing date 2021-01-06
    Publishing country Czech Republic
    Document type Case Reports ; Journal Article
    ZDB-ID 2214815-2
    ISSN 1211-264X
    ISSN 1211-264X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Epidemiology and clinical features of imported malaria: a 14-year retrospective single-centre descriptive study in Prague, Czech Republic.

    Trojánek, Milan / Grebenyuk, Vyacheslav / Richterová, Lenka / Zicklerová, Ivana / Nohýnková, Eva / Manďáková, Zdenka / Kantor, Jakub / Roháčová, Hana / Stejskal, František

    Malaria journal

    2022  Volume 21, Issue 1, Page(s) 257

    Abstract: Background: Malaria represents one of the most important imported tropical infectious diseases in European travellers. The objective of the study was to identify changes in the epidemiological features of imported malaria and to analyse the clinical ... ...

    Abstract Background: Malaria represents one of the most important imported tropical infectious diseases in European travellers. The objective of the study was to identify changes in the epidemiological features of imported malaria and to analyse the clinical findings and outcomes of imported malaria.
    Methods: This single-centre descriptive study retrospectively analysed the medical records of all imported malaria cases in travellers treated at the Department of Infectious Diseases of University Hospital Bulovka in Prague from 2006 to 2019.
    Results: The study included 203 patients with a median age of 37 years (IQR 30-48) and a male to female ratio of 3.72:1. Plasmodium falciparum was the predominant species (149/203), and its proportion significantly increased from 35/60 cases (58.3%) in 2006-2011 to 69/80 (86.3%) in 2016-2019 (p < 0.001). In contrast, the incidence of Plasmodium vivax malaria decreased from 19/60 cases (31.7%) in 2006-2011 to 5/80 (6.3%) in 2016-2019 (p < 0.001). Malaria was imported from sub-Saharan Africa in 161/203 cases (79.3%). The proportion of travellers from Southeast and South Asia decreased from 16/60 (26.7%) and 6/60 (10.0%) in 2006-2011 to 2/80 (2.5%) and no cases (0.0%) in 2016-2019, respectively (p < 0.001 and p = 0.006). Tourism was the most common reason for travel (82/203), however, the proportion of non-tourists significantly increased over time from 29/60 (48.3%) in 2006-2011 to 55/80 (68.8%) in 2016-2019, p = 0.015. Severe malaria developed in 32/203 (15.8%) patients who were significantly older (p = 0.013) and whose treatment was delayed (p < 0.001). Two lethal outcomes were observed during the study period.
    Conclusions: This study demonstrated a significant increase in P. falciparum malaria, which frequently resulted in severe disease, especially in older patients and those with delayed treatment initiation. The rising proportion of imported malaria in non-tourists, including business travellers and those visiting friends and relatives, is another characteristic finding analogous to the trends observed in Western European and North American centres. The described changes in the aetiology and epidemiology of imported malaria may serve to optimize pre-travel consultation practices and improve post-travel diagnostics and medical care.
    MeSH term(s) Adult ; Aged ; Antimalarials/therapeutic use ; Czech Republic ; Female ; Humans ; Malaria/epidemiology ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/epidemiology ; Malaria, Vivax/epidemiology ; Male ; Middle Aged ; Retrospective Studies ; Travel
    Chemical Substances Antimalarials
    Language English
    Publishing date 2022-09-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091229-8
    ISSN 1475-2875 ; 1475-2875
    ISSN (online) 1475-2875
    ISSN 1475-2875
    DOI 10.1186/s12936-022-04282-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: A case of amoebic colitis with Crohn-like endoscopic and histopathological features.

    Fabián, Ondřej / Trojánek, Milan / Richterová, Lenka / Stejskal, František / Dundrová, Kamila / Roznetinská, Markéta / Zámečník, Josef

    Ceskoslovenska patologie

    2020  Volume 56, Issue 2, Page(s) 95–98

    Abstract: Amoebic colitis represents a common parasitic infection in developing countries. In western world, it is encountered only sporadically. The clinical presentation is usually non-specific, non-invasive laboratory tests are often false negative and ... ...

    Title translation Případ amébové kolitidy s endoskopickými i histopatologickými rysy Crohnovy choroby.
    Abstract Amoebic colitis represents a common parasitic infection in developing countries. In western world, it is encountered only sporadically. The clinical presentation is usually non-specific, non-invasive laboratory tests are often false negative and endoscopic and histopathological appearance may mimic other illnesses, especially Crohns disease. The disease therefore harbours a huge risk of misdiagnosing and a proper diagnosis is usually challenging. We present a case of an amoebic colitis with Crohn-like features and negative parasitological testing in a 53-years-old woman, in which the final diagnosis was established on the basis of its histopathological examination.
    MeSH term(s) Crohn Disease/complications ; Crohn Disease/diagnosis ; Crohn Disease/pathology ; Diagnosis, Differential ; Dysentery, Amebic/complications ; Dysentery, Amebic/diagnosis ; Dysentery, Amebic/pathology ; Female ; Humans ; Middle Aged
    Language English
    Publishing date 2020-06-05
    Publishing country Czech Republic
    Document type Case Reports ; Journal Article
    ZDB-ID 138273-1
    ISSN 1210-7875 ; 0009-0611 ; 0371-1854
    ISSN 1210-7875 ; 0009-0611 ; 0371-1854
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Commonly available but highly effective protection against SARS-CoV-2 during gastrointestinal endoscopies.

    Keil, Radan / Hlava, Štěpán / Stanovský, Petr / Ždímal, Vladimír / Šťovíček, Jan / Trojánek, Milan / Drábek, Jiří / Frýbová, Barbora / Petráček, Vojtěch / Wasserbauer, Martin

    PloS one

    2021  Volume 16, Issue 7, Page(s) e0254979

    Abstract: Background and aims: SARS-CoV-2 is a worldwide serious health problem. The aim of this study was to demonstrate the number of potentially infectious particles present during endoscopic procedures and find effective tools to eliminate the risks of SARS- ... ...

    Abstract Background and aims: SARS-CoV-2 is a worldwide serious health problem. The aim of this study was to demonstrate the number of potentially infectious particles present during endoscopic procedures and find effective tools to eliminate the risks of SARS-CoV-2 infection while performing them.
    Methods: An experimental model which focused on aerosol problematics was made in a specialized laboratory. This model simulated conditions present during endoscopic procedures and monitored the formation of potentially infectious fluid particles from the patient's body, which pass through the endoscope and are then released into the environment. For this reason, we designed and tested a prototype of a protective cover for the endoscope's control body to prevent the release and spread of these fluid particles from its working channel. We performed measurements with and without the protective cover of the endoscope's control body.
    Results: It was found that liquid coming through the working channel of the endoscope with forceps or other instruments inside generates droplets with a diameter in the range of 0.1-1.1 mm and an initial velocity of up to 0.9 m/s. The average number of particles per measurement per whole measured area without a protective cover on the endoscope control body was 51.1; with this protective cover on, the measurement was 0.0, p<0.0001.
    Conclusions: Our measurements proved that fluid particles are released from the working channel of an endoscope when forceps are inserted. A special protective cover for the endoscope control body, made out of breathable material (surgical cap) and designed by our team, was found to eliminate this release of potentially infectious fluid particles.
    MeSH term(s) COVID-19/prevention & control ; COVID-19/transmission ; Endoscopy, Gastrointestinal ; Humans ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Protective Clothing ; SARS-CoV-2
    Language English
    Publishing date 2021-07-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0254979
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Neurotoxic side effects of acyclovir: two case reports.

    Paluch, Zoltan / Trojánek, Milan / Velíšková, Zuzana / Mlíchová, Jana / Chrbolka, Pavel / Gregorová, Jana / Marques, Emanuel / Kalatova, Dagmar / Pícha, Dušan

    Neuro endocrinology letters

    2021  Volume 42, Issue 6, Page(s) 375–382

    Abstract: Acyclovir is an antiviral drug frequently used in clinical practice. It is indicated for the treatment of infections caused by herpes simplex virus and varicella zoster virus. The drug has a good safety profile; however, severe side effects may rarely ... ...

    Abstract Acyclovir is an antiviral drug frequently used in clinical practice. It is indicated for the treatment of infections caused by herpes simplex virus and varicella zoster virus. The drug has a good safety profile; however, severe side effects may rarely occur during therapy. These include renal failure as a major risk factor for neurotoxic side effects potentially developing within 24-48 hours of therapy initiation. The paper presents the cases of two patients developing neurotoxic side effects while treated for herpes zoster. The aim of the authors is to highlight the potential for developing neurotoxic side effects in high-risk groups such as the elderly, patients with impaired renal function or multiple comorbidities on polypharmacy, or those using nephrotoxic drugs. Acyclovir use could lead to renal impairment and an increase in its plasma and CNS concentrations with severe neuropsychiatric side effects. The neurotoxic side effects are reversible after therapy withdrawal. Thus, in patients developing mental impairment or showing other neurological symptoms during acyclovir therapy, the patient should be promptly assessed for potential drug neurotoxicity, their therapy should be discontinued and drug elimination with forced diuresis or hemodialysis considered. Early recognition of acyclovir neurotoxic side effects can significantly improve a patient's prognosis.
    MeSH term(s) Acyclovir/adverse effects ; Aged ; Antiviral Agents/adverse effects ; Herpes Zoster/chemically induced ; Herpes Zoster/diagnosis ; Herpes Zoster/drug therapy ; Herpesvirus 3, Human ; Humans ; Mental Disorders
    Chemical Substances Antiviral Agents ; Acyclovir (X4HES1O11F)
    Language English
    Publishing date 2021-10-29
    Publishing country Sweden
    Document type Case Reports ; Journal Article
    ZDB-ID 135951-4
    ISSN 2354-4716 ; 0172-780X
    ISSN (online) 2354-4716
    ISSN 0172-780X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top