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Article ; Online: Validierung des deutschsprachigen Menière’s Disease Patient-Oriented Symptom Severity Index.

Plath, Michaela / Sand, Matthias / Appel, Maximilian / Euteneuer, Sara / Praetorius, Mark / Baumann, Ingo / Zaoui, Karim

Laryngo- rhino- otologie

2023 Volume 102, Issue 11, Page(s) 856–866

Abstract: ... quality of life (HRQoL) of patients with Menière's disease (MD).: Objectives: Validity and reliability ... Menière's disease. HRQoL was assessed using the German translation of the MD POSI, the Vertigo Symptom Score ... VSS) and the Short Form (SF-36). Reliability was measured by Cronbach's α and test-retesting after 12 ...

Title translation	Validity of the German Menière's Disease Patient-Oriented Symptom Severity Index.
Abstract	Background: The MD POSI is a disease-specific questionnaire to determine the health-related quality of life (HRQoL) of patients with Menière's disease (MD). Objectives: Validity and reliability of the German translation of the MD POSI. Material and methods: Prospective data analysis of a patient group with vertigo (n = 162), which was treated in the otorhinolaryngology of a University Hospital from 2005-2019. A clinical selection was made according to the new Bárány classification in a "definite" and "probable" Menière's disease. HRQoL was assessed using the German translation of the MD POSI, the Vertigo Symptom Score (VSS) and the Short Form (SF-36). Reliability was measured by Cronbach's α and test-retesting after 12 months and again 2 weeks later. Content and agreement validity were examined. Results: Cronbach α values greater than 0.9 indicated good internal consistency. There was no statistically significant difference from baseline to 12 months, except for the subscore "during the attack". There were significant positive correlations between the VSS overall/VER/AA and the overall index of the MD POSI and negative significant correlations with the SF-36 domains physical functioning, physical role functioning, social functioning, emotional role functioning, mental well-being. There were low SRM (standardized response mean) values below 0.5. Conclusions: The German translation of the MD POSI is a valid and reliable instrument to evaluate the impact of MD on patients' disease-specific quality of life.
MeSH term(s)	Humans ; Meniere Disease/diagnosis ; Meniere Disease/therapy ; Prospective Studies ; Quality of Life/psychology ; Reproducibility of Results ; Vertigo/diagnosis ; Dizziness ; Surveys and Questionnaires
Language	German
Publishing date	2023-04-18
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	96005-6
ISSN	1438-8685 ; 0340-1588 ; 0935-8943
ISSN (online)	1438-8685
ISSN	0340-1588 ; 0935-8943
DOI	10.1055/a-2047-3806
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Article ; Online: A retrospective study for association between post-transfusion hemoglobin S level and pre-transfusion hemoglobin S level at the next scheduled transfusion.

Wu, Ding Wen / Jacobson, Jessica / Lifshitz, Mark / Li, Yanhua / Lyu, Chen / Friedmann, Rachel / Walsh, Ronald / Himchak, Evan / Mohandas, Kala / Karim, Sadiqa / Marks, Etan / Himchak, Sang Hwa / Hilbert, Timothy

Journal of clinical apheresis

2023 Volume 38, Issue 5, Page(s) 529–539

Abstract: ... such as stroke. These treatment procedures are performed with a target hemoglobin S (HbS) of ≤30%, or a goal ...

Abstract	Background: Patients with sickle cell disease (SCD) frequently undergo prophylactic red blood cell (RBC) exchange transfusion and simple transfusion (RCE/T) to prevent complications of disease, such as stroke. These treatment procedures are performed with a target hemoglobin S (HbS) of ≤30%, or a goal of maintaining an HbS level of <30% immediately prior to the next transfusion. However, there is a lack of evidence-based instructions for how to perform RCE/T in a way that will result in an HbS value <30% between treatments. Principal objective: To determine whether targets for post-treatment HbS (post-HbS) or post-treatment HCT (post-HCT) can help to maintain an HbS <30% or <40% between treatments. Materials and methods: We performed a retrospective study of patients with SCD treated with RCE/T at Montefiore Medical Center from June 2014 to June 2016. The analysis included patients of all ages, and data including 3 documented parameters for each RCE/T event: post-HbS, post-HCT, and follow-up HbS (F/u-HbS), which is the pre-treatment HbS prior to the next RCE/T. Generalized linear mixed model was used for estimating the association between post-HbS or post-HCT levels and F/u-HbS <30%. Results: Based on our results, targeting post-HbS ≤10% was associated with higher odds of having events of F/u-HbS <30% between monthly treatments. Targeting post-HbS ≤15% was associated with higher odds of events of F/u-HbS < 40%. As compared to post-HCT ≤30%, a post-HCT >30%-36% did not contribute to more F/u-HbS <30% or HbS <40% events. Conclusions: For patients with SCD undergoing regular RCE/T for stroke prevention, a post-HbS ≤10% can be used as a goal to help maintain an HbS <30% for 1 month, and a post-HbS ≤15% allowed patients to maintain HbS <40%.
Language	English
Publishing date	2023-05-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	604912-6
ISSN	1098-1101 ; 0733-2459
ISSN (online)	1098-1101
ISSN	0733-2459
DOI	10.1002/jca.22056
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Article ; Online: Unlocking the potential of novel RTS, S/AS01, and R21/Matrix-M™ malaria vaccines in African nations.

Oduoye, Malik Olatunde / Haider, Muhammad Usman / Marsool, Mohammed Dheyaa Marsool / Kareem, Mayowa Odunayo / Adedayo, Adenike Ebunoluwa / Abdulkarim, Abdulkarim Surajo / Adegoke, Abdullahi Adeyemi / Kaushik, Ikshwaki / Irfan, Hamza / Yusuf, Hassan Abdullahi / Shah, Hussain Haider / Karim, Karim Arif

Health science reports

2024 Volume 7, Issue 1, Page(s) e1797

Abstract: ... Strategies," and "Public Health.": Results: The recently approved RTS, S/AS01, and R21/Matrix-M™ ...

Abstract	Introduction: Mass malaria vaccination, rather than vaccinating only children below age 5, has been proven to have the potential to reduce morbidity and mortality among those vaccinated, both young and old. Addressing vaccine scepticism and misinformation is crucial in African nations to build public trust in malaria prevention. Therefore, including a wider range of demographics in vaccine trials is necessary for equitable representation and achieving herd immunity against malaria. Aim: This present article aims to identify some of the obstacles that impede malaria vaccination usage and acceptability in African Nations in combating malaria in the region as it continues to pose a significant global public health problem. Methodology: A literature search was done on the Malaria vaccine between 2000 and 2023. Past and present articles/studies on this topic were consulted on PubMed, Google Scholar, Scopus and Web of Science using the following keywords; "Malaria," "Vaccines," "African Nations," "Obstacles, Strategies," and "Public Health." Results: The recently approved RTS, S/AS01, and R21/Matrix-M™ Malaria vaccines have the potential to prevent numerous deaths and cases of Malaria in Africa. These vaccines Malaria vaccines are cost-effective in African areas with moderate to high plasmodium falciparum and can be delivered through routine immunization. Conclusion: To combat malaria effectively in African Nations, African leaders need to set up a comprehensive approach that involves; prevention, healthcare access, implementation research strategies towards adoption and acceptance of malaria vaccines in Africa as well as community engagement with the religious leaders, the market women, community heads, schools, as well as students' union towards the willingness and acceptability of the malaria vaccines among the African populations.
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ISSN	2398-8835
ISSN (online)	2398-8835
DOI	10.1002/hsr2.1797
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Article ; Online: Pancreatic ductal adenocarcinoma: exploring clinicopathological trends and racial disparities in a comprehensive U.S. population-based study.

Yasinzai, Abdul Qahar Khan / Tareen, Bisma / Tracy, Katharine / Jamil, Nimra / Khan, Marjan / Ullah, Hafeez / Raza, Muhammad / Khan, Amin Ullah / Arif, Dauod / Waheed, Abdul / Sidhwa, Feroze / Misra, Subhasis / Karki, Nabin Raj / Karim, Nagla Abdel / Cavalcante, Ludimila / Ullah, Asad

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2024

Abstract: Introduction: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy about 50% of PDAC are metastatic at presentation. In this study, we evaluated PDAC demographics, annual trend analysis, racial disparities, survival rate, and the ... ...

Abstract	Introduction: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy about 50% of PDAC are metastatic at presentation. In this study, we evaluated PDAC demographics, annual trend analysis, racial disparities, survival rate, and the role of different treatment modalities in localized and metastatic disease. Methods: A total of 144,824 cases of PDAC were obtained from the SEER database from 2000 to 2018. Results: The median age was 69 years, with a slightly higher incidence in males (52%) and 80% of all cases were white. Among cases with available data, 43% were grade III tumors and 57% were metastatic. The most common site of metastasis was the liver (15.7%). The annual incidence has increased steadily from 2000 to 2018. The overall observed (OS) 5-year survival rate was 4.4% (95% CI 4.3-4.6%), and 5 years cause-specific survival (CSS) was 5% (95% CI 5.1-5.4%). The 5-year survival with multimodal therapy (chemotherapy, surgery, and radiation) was 22% (95% CI 20.5-22.8%). 5-year CSS for the blacks was lower at 4.7% (95% CI 4.2-5.1%) compared to the whites at 5.3% (95% CI 5.1-5.4%). Multivariate analysis found male gender and black race associated with worse prognosis. Kaplan-Meier survival analysis found multimodal therapy to have the best outcomes in all three stages. Conclusion: PDAC is an aggressive malignancy with male gender and black race are associated with a poor prognosis. Surgery with chemoradiation was associated with the best overall survival. With steadily increasing rates of PDAC, improved treatment modalities are paramount to improving survival in these patients.
Language	English
Publishing date	2024-04-14
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-024-03484-7
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Article ; Online: Maritime dimension of Modi’s foreign policy

Asia Karim / Manzoor Ahmad Naazer / Amna Mahmood / Saiqa Bukhari

Liberal Arts and Social Sciences International Journal, Vol 7, Iss 1, Pp 202-

Indo-Gulf maritime cooperation and its implications for Pakistan

2023 Volume 220

Abstract: ... The study aims to uncover the maritime dimension of PM Modi’s foreign policy, the strategic significance ... interaction between India and Gulf states is seriously challenging Pakistan’s historical standing in the area ... cooperation for Pakistan's foreign and defence policies. For probing the issue, a qualitative research method ...

Abstract	Owing to its geostrategic significance, the Indian Ocean is central to global maritime competition. Aimed at establishing its dominance over the Indian Ocean, India is an important player in this global power struggle. The current paper focuses on a crucial sub-region of the Indian Ocean, i.e., the Persian Gulf. Indian maritime security strategy (2015) mentioned the region as central to its interests. The study aims to uncover the maritime dimension of PM Modi’s foreign policy, the strategic significance of the Persian Gulf region for India, and the enhanced maritime Indo-Gulf interaction since Modi took office in 2014. A significant focus of the research is to analyse the possible implications of enriched Indo-Gulf maritime cooperation for Pakistan's foreign and defence policies. For probing the issue, a qualitative research method has been utilised. Primary sources included official documents and reports by the Ministry of External Affairs and the Ministry of Defence of the Indian government. Books, newspapers, and research articles were consulted as secondary data. The Paper concludes that the gradual increase in the maritime interaction between India and Gulf states is seriously challenging Pakistan’s historical standing in the area. Pakistan needs to pursue a proactive strategy for securing its interests.
Keywords	india ; indian ocean ; persian gulf ; gulf states ; maritime competition ; sea born trade ; seaports ; energy security ; sea lanes of communication ; Social Sciences ; H ; Political science ; J
Subject code	320 ; 950
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	IDEA PUBLISHERS
Document type	Article ; Online
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Article: Capacity building for pediatric neuro-oncology in Pakistan- a project by my child matters program of Foundation S.

Mushtaq, Naureen / Qureshi, Bilal Mazhar / Javed, Gohar / Sheikh, Nabeel Ashfaque / Bakhshi, Saqib Kamran / Laghari, Altaf Ali / Enam, Syed Ather / Anwar, Shayan Sirat Maheen / Hilal, Kiran / Kabir, Arsalan / Ahmad, Alia / Goraya, Amber / Mistry, Anum Salman / Rashid, Aqeela / Maaz, Ata Ur Rehman / Munawar, Muhammad Atif / Khan, Atiq Ahmed / Bashir, Farrah / Hashmi, Hina /

Frontiers in oncology

2024 Volume 14, Page(s) 1325167

Abstract: ... oncology (PNO) care, supported by a My Child Matters/Foundation S grant.: Methods: We aimed to establish ... Foundation S grant, showcases the success of capacity building in pediatric neuro-oncology in low-middle ... development. Notably, Pakistan's first pediatric neuro-oncology fellowship program was launched, producing two ...

Abstract	Introduction: Initiated in June 2019, this collaborative effort involved 15 public and private sector hospitals in Pakistan. The primary objective was to enhance the capacity for pediatric neuro-oncology (PNO) care, supported by a My Child Matters/Foundation S grant. Methods: We aimed to establish and operate Multidisciplinary Tumor Boards (MTBs) on a national scale, covering 76% of the population (185.7 million people). In response to the COVID-19 pandemic, MTBs transitioned to videoconferencing. Fifteen hospitals with essential infrastructure participated, holding monthly sessions addressing diagnostic and treatment challenges. Patient cases were anonymized for confidentiality. Educational initiatives, originally planned as in-person events, shifted to a virtual format, enabling continued implementation and collaboration despite pandemic constraints. Results: A total of 124 meetings were conducted, addressing 545 cases. To augment knowledge, awareness, and expertise, over 40 longitudinal lectures were organized for healthcare professionals engaged in PNO care. Additionally, two symposia with international collaborators and keynote speakers were also held to raise national awareness. The project achieved significant milestones, including the development of standardized national treatment protocols for low-grade glioma, medulloblastoma, and high-grade glioma. Further protocols are currently under development. Notably, Pakistan's first pediatric neuro-oncology fellowship program was launched, producing two graduates and increasing the number of trained pediatric neuro-oncologists in the country to three. Discussion: The initiative exemplifies the potential for capacity building in PNO within low-middle income countries. Success is attributed to intra-national twinning programs, emphasizing collaborative efforts. Efforts are underway to establish a national case registry for PNO, ensuring a comprehensive and organized approach to monitoring and managing cases. This collaborative initiative, supported by the My Child Matters/Foundation S grant, showcases the success of capacity building in pediatric neuro-oncology in low-middle income countries. The establishment of treatment protocols, fellowship programs, and regional tumor boards highlights the potential for sustainable improvements in PNO care.
Language	English
Publishing date	2024-02-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1325167
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Article: Pharm.D.s and M.D.s in the Transplant World - Friends, Foes, Competitors or All are in Evolution?

Mohamed, Mahmoud M / Fulop, Tibor / Soliman, Karim Magdy

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

2021 Volume 32, Issue 1, Page(s) 1–8

Abstract: ... From a unique perspective, this overview aimed to discuss the emerging role of Pharm. D.s and ... long-lasting renal transplant. From the renal transplant recipient's side ...

Abstract	Mutual trust, efforts, and commitment between patients and providers are essential for a successful, long-lasting renal transplant. From the renal transplant recipient's side, non-adherence to the medication has gained recognition as a predominant cause of late antibody-mediated rejection. Since the early 1970s, pharmacists have been involved in the care of transplant recipients and the incorporation of transplant pharmacists has improved the outcomes in solid organ transplantation. Such involvement of clinical pharmacists extends beyond improving graft outcomes: various studies demonstrated benefits in the care of diabetes, hypertension, and hyperlipidemia, with commensurate reduction of cardiovascular risk. From a unique perspective, this overview aimed to discuss the emerging role of Pharm. D.s and clinical pharmacists in general as it relates to team care, education of patients and healthcare providers and the sometimes conflicting relationship between physicians and pharmacists. Additional clinically relevant studies from culturally diverse settings are needed to explore the responsibilities of clinical team members to ensure optimized teamwork efforts without overlapping and duplication of efforts.
MeSH term(s)	Clinical Medicine ; Humans ; Interprofessional Relations ; Kidney Transplantation ; Patient Care Team ; Pharmacology, Clinical ; Treatment Outcome
Language	English
Publishing date	2021-06-18
Publishing country	Saudi Arabia
Document type	Editorial
ZDB-ID	1379955-1
ISSN	1319-2442
ISSN	1319-2442
DOI	10.4103/1319-2442.318510
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Article ; Online: Gene-Based Therapeutics for Parkinson’s Disease

Karim E. Shalaby / Omar M. A. El-Agnaf

Biomedicines, Vol 10, Iss 8, p

2022 Volume 1790

Abstract: Parkinson’s disease (PD) is a complex multifactorial disorder that is not yet fully surmised, and ... of gene therapy for PD. Gene therapy’s variety of potential in interfering with PD’s pathology ...

Abstract	Parkinson’s disease (PD) is a complex multifactorial disorder that is not yet fully surmised, and it is only when such a disease is tackled on multiple levels simultaneously that we should expect to see fruitful results. Gene therapy is a modern medical practice that theoretically and, so far, practically, has demonstrated its capability in joining the battle against PD and other complex disorders on most if not all fronts. This review discusses how gene therapy can efficiently replace current forms of therapy such as drugs, personalized medicine or invasive surgery. Furthermore, we discuss the importance of enhancing delivery techniques to increase the level of transduction and control of gene expression or tissue specificity. Importantly, the results of current trials establish the safety, efficacy and applicability of gene therapy for PD. Gene therapy’s variety of potential in interfering with PD’s pathology by improving basal ganglial circuitry, enhancing dopamine synthesis, delivering neuroprotection or preventing neurodegeneration may one day achieve symptomatic benefit, disease modification and eradication.
Keywords	neurodegeneration ; Parkinson’s disease ; gene therapy ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Mechanisms of ACL injuries in men’s football

Raouf Rekik / Roald Bahr / Flavio Cruz / Paul Read / Rod Whiteley / Pieter D’hooghe / Montassar Tabben / Karim Chamari

Biology of Sport, Vol 40, Iss 2, Pp 575-

A systematic video analysis over six seasons in the Qatari professional league

2022 Volume 586

Abstract: To assess the mechanisms of ACL injury in male professional football players in Qatar across multiple seasons using systematic video analysis. 15 ACL injuries occurred in competition among the professional football teams that participated in an injury ... ...

Abstract	To assess the mechanisms of ACL injury in male professional football players in Qatar across multiple seasons using systematic video analysis. 15 ACL injuries occurred in competition among the professional football teams that participated in an injury Surveillance Programme during 6 seasons (2013/2014 to 2018/2019). High-definition broadcast videos of these injuries were analyzed (49 views; 34 slow motion) by five analysts who independently described the injury mechanisms (situation, behavior, biomechanical characteristics) using validated observational tools. A knee valgus mechanism was observed in two-thirds of the cases (1 with direct contact to the knee, 3 with indirect contact (other body parts) and 6 with no contact). No visible valgus was reported in 2 of the direct knee contact injuries, while 3 cases of non-contact and indirect contact injuries were unclear. We observed 4 main categories of injury situation among those (n = 12) classified as non-contact/indirect contact (multiple combinations were possible): pressing (n = 6), tackling or being tackled (n = 4), blocking (n = 3) and screening (n = 2). Direct contact injuries (n = 3) were suffered by 2 players during tackling and 1 whilst being tackled. Contact injuries represented only 20% of ACL injuries occurring during competition in Qatari professional soccer players. Independent of the playing situation, knee valgus was frequently observed (10/15 cases). Pressing was the most common situation (6/15 cases) leading to injury. Landing after heading was not reported in any of these ACL injuries.
Keywords	soccer ; knee ligament ; risk factors ; etiology ; middle east ; prevention ; Sports medicine ; RC1200-1245 ; Biology (General) ; QH301-705.5
Subject code	796
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	Termedia Publishing House
Document type	Article ; Online
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Article ; Online: Bioaccumulation and sources of metal(loid)s in fish species from a subtropical river in Bangladesh: a public health concern.

Ali, Mir Mohammad / Kubra, Khadijatul / Alam, Edris / Mondol, Anwar Hossain / Akhtar, Shahrina / Islam, Md Saiful / Karim, Ehsanul / Ahmed, A S Shafiuddin / Siddique, Md Abu Bakar / Malafaia, Guilherme / Rahman, Md Zillur / Rahman, Md Mostafizur / Islam, Abu Reza Md Towfiqul

Environmental science and pollution research international

2023 Volume 31, Issue 2, Page(s) 2343–2359

Abstract: Toxic metals and freshwater fish's metalloid contamination are significant environmental concerns ... According to multivariate statistical findings, the research area's potential sources of metal(loid) were ... not at any increased risk of developing cancer. The children's group was more vulnerable ...

Abstract	Toxic metals and freshwater fish's metalloid contamination are significant environmental concerns for overall public health. However, the bioaccumulation and sources of metal(loids) in freshwater fishes from Bangladesh still remain unknown. Thus, the As, Pb, Cd, and Cr concentrations in various freshwater fish species from the Rupsha River basin were measured, including Tenualosa ilisha, Gudusia chapra, Otolithoides pama, Setipinna phasa, Mystus vittatus, Glossogobius giuris, and Pseudeutropius atherinoides. An atomic absorption spectrophotometer was used to determine metal concentrations. The mean concentrations of metal(loids) in the fish muscle (mg/kg) were found to be As (1.53) > Pb (1.25) > Cr (0.51) > Cd (0.39) in summer and As (1.72) > Pb (1.51) > Cr (0.65) > Cd (0.49) in winter. The analyzed fish species had considerably different metal(loid) concentrations with seasonal variation, and the distribution of the metals (loids) was consistent with the normal distribution. The demersal species, M. vittatus, displayed the highest bio-accumulative value over the summer. However, in both seasons, none of the species were bio-accumulative. According to multivariate statistical findings, the research area's potential sources of metal(loid) were anthropogenic activities linked to geogenic processes. Estimated daily intake, target hazard quotient (THQ), and carcinogenic risk (CR) were used to assess the influence of the risk on human health. The consumers' THQs values were < 1, indicating that there were no non-carcinogenic concerns for local consumers. Both categories of customers had CRs that fell below the permissible range of 1E - 6 to 1E - 4, meaning they were not at any increased risk of developing cancer. The children's group was more vulnerable to both carcinogenic and non-carcinogenic hazards. Therefore, the entry of metal(loids) must be regulated, and appropriate laws must be used by policymakers.
MeSH term(s)	Animals ; Child ; Humans ; Metals, Heavy/analysis ; Rivers ; Cadmium ; Bioaccumulation ; Public Health ; Bangladesh ; Lead ; Fishes ; Environmental Monitoring ; Catfishes ; Water Pollutants, Chemical/analysis ; Risk Assessment
Chemical Substances	Metals, Heavy ; Cadmium (00BH33GNGH) ; Lead (2P299V784P) ; Water Pollutants, Chemical
Language	English
Publishing date	2023-12-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-31324-8
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