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  1. Book: Casarett and Doull's toxicology

    Klaassen, Curtis D. / Casarett, Louis J. / Doull, John

    the basic science of poisons

    2013  

    Title variant Toxicology
    Author's details ed. Curtis D. Klaassen
    Keywords Poisoning / physiopathology ; Toxicology / methods ; Poisons
    Language English
    Size XIII, 1454 S. : Ill., graph. Darst., Kt.
    Edition 8. ed.
    Publisher McGraw-Hill Education Medical
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Systemvoraussetzungen: Windows XP or higher; Mac OS v10.5 or higher ; Includes bibliographical references and index
    Accompanying material 1 DVD (12 cm)
    HBZ-ID HT017717003
    ISBN 978-0-07-176923-5 ; 0-07-176923-4 ; 978-0-07-176925-9 ; 0-07-176925-0 ; 978-0-07-176924-2 ; 0-07-176924-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2009 A 10970 order for loan Magazin
    2013 MO 236 <<[Begleitmaterial]>> order for loan Magazin

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  2. Article ; Online: The Life and Times of John Doull, PhD, MD (1922-2017).

    Klaassen, Curtis D

    Toxicological sciences : an official journal of the Society of Toxicology

    2018  Volume 162, Issue 1, Page(s) 5–11

    MeSH term(s) Biomedical Research/history ; History, 20th Century ; History, 21st Century ; Pharmacology/education ; Pharmacology/history ; Schools, Medical/history ; Toxicology/education ; Toxicology/history ; United States
    Language English
    Publishing date 2018-03-12
    Publishing country United States
    Document type Biography ; Editorial ; Historical Article ; Portrait
    ZDB-ID 1420885-4
    ISSN 1096-0929 ; 1096-6080
    ISSN (online) 1096-0929
    ISSN 1096-6080
    DOI 10.1093/toxsci/kfy009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Molecular Regulation of Bile Acid Homeostasis.

    Choudhuri, Supratim / Klaassen, Curtis D

    Drug metabolism and disposition: the biological fate of chemicals

    2021  Volume 50, Issue 4, Page(s) 425–455

    Abstract: Bile acids have been known for decades to aid in the digestion and absorption of dietary fats and fat-soluble vitamins in the intestine. The development of gene knockout mice models and transgenic humanized mouse models have helped us understand other ... ...

    Abstract Bile acids have been known for decades to aid in the digestion and absorption of dietary fats and fat-soluble vitamins in the intestine. The development of gene knockout mice models and transgenic humanized mouse models have helped us understand other functions of bile acids, such as their role in modulating fat, glucose, and energy metabolism, and in the molecular regulation of the synthesis, transport, and homeostasis of bile acids. The G-protein coupled receptor TGR5 regulates the bile acid induced alterations of intermediary metabolism, whereas the nuclear receptor FXR regulates bile acid synthesis and homeostasis. However, this review indicates that unidentified factors in addition to FXR must exist to aid in the regulation of bile acid synthesis and homeostasis. SIGNIFICANCE STATEMENT: This review captures the present understanding of bile acid synthesis, the role of bile acid transporters in the enterohepatic circulation of bile acids, the role of the nuclear receptor FXR on the regulation of bile acid synthesis and bile acid transporters, and the importance of bile acids in activating GPCR signaling via TGR5 to modify intermediary metabolism. This information is useful for developing drugs for the treatment of various hepatic and intestinal diseases, as well as the metabolic syndrome.
    MeSH term(s) Animals ; Bile Acids and Salts/metabolism ; Homeostasis/physiology ; Mice ; Receptors, Cytoplasmic and Nuclear ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction
    Chemical Substances Bile Acids and Salts ; Receptors, Cytoplasmic and Nuclear ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2021-10-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 186795-7
    ISSN 1521-009X ; 0090-9556
    ISSN (online) 1521-009X
    ISSN 0090-9556
    DOI 10.1124/dmd.121.000643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Elucidation of OATP1B1 and 1B3 transporter function using transgenic rodent models and commonly known single nucleotide polymorphisms.

    Choudhuri, Supratim / Klaassen, Curtis D

    Toxicology and applied pharmacology

    2020  Volume 399, Page(s) 115039

    Abstract: The clearance of many drugs from the blood into the liver, such as the statins, is dependent on the organic anion transporting polypeptides (OATPs). Patients with *5 and *15 polymorphisms of OATP1B1 remove less of the statin as it traverses the liver and ...

    Abstract The clearance of many drugs from the blood into the liver, such as the statins, is dependent on the organic anion transporting polypeptides (OATPs). Patients with *5 and *15 polymorphisms of OATP1B1 remove less of the statin as it traverses the liver and thus more reaches the rest of the body, including the skeletal muscle where it can cause myalgia, myopathy, and rhabdomyolysis. OATP1B1 polymorphisms also affect the pharmacokinetics of anticancer drugs (methotrexate, taxanes, and doxorubicin) and numerous anti-hypertensive drugs. In contrast to OATP1B1, OATP1B3 does not appear to have polymorphisms of known physiological and pharmacological significance, except for Rotor patients, who have both defective OATP1B1 and OATP1B3 transport function. OATP1B1 and OATP1B3 also play important roles in the hepatic uptake of many endogenous molecules, such as bile acids, bilirubin, and coproporphyrins. However, the transport of individual bile acids is not well understood. Complete deficiency of OATP1B1 and 1B3 function in Rotor syndrome disrupts the hepatic reuptake of conjugated bilirubin with a corresponding clinical presentation as mild hyperbilirubinemia. Interestingly, cholecystokinin is only transported into the liver by OATP1B3. Hepatotoxicants such as the mushroom toxin phalloidin and the cyanobacterias toxin microcystin-LR are transported by the OATP1Bs as they are not hepatotoxic in Oatp1b2 "knock-out" mice. In conclusion, the OATP1Bs are important in the hepatic uptake of endogenous chemicals, drugs, and toxicants. Because there are polymorphisms of OATP1B1, knowledge of the genotype/phenotype is of importance in diagnosing and treatment of patients.
    MeSH term(s) Animals ; Animals, Genetically Modified/genetics ; Humans ; Liver-Specific Organic Anion Transporter 1/genetics ; Polymorphism, Single Nucleotide/genetics ; Rodentia/genetics ; Solute Carrier Organic Anion Transporter Family Member 1B3/genetics
    Chemical Substances Liver-Specific Organic Anion Transporter 1 ; Solute Carrier Organic Anion Transporter Family Member 1B3
    Language English
    Publishing date 2020-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2020.115039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Casarett and Doull's toxicology

    Casarett, Louis J. / Doull, John / Klaassen, Curtis D.

    the basic science of poisons

    2008  

    Title variant Toxicology ; Casarett & Doull's toxicology
    Author's details ed. Curtis D. Klaassen
    Keywords Poisoning ; Poisons ; Toxikologie
    Subject Giftkunde ; Klinische Toxikologie
    Language English
    Size XV, 1309 S. : Ill., graph. Darst.
    Edition 7. ed.
    Publisher McGraw-Hill Med
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015268225
    ISBN 978-0-07-147051-3 ; 0-07-147051-4
    Database Catalogue ZB MED Medicine, Health

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    2006 A 6648 order for loan Magazin
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  6. Article ; Online: Distinct bile acid alterations in response to a single administration of PFOA and PFDA in mice.

    Yu, Xiaoxiao / Zhang, Youcai / Cogliati, Bruno / Klaassen, Curtis D / Kumar, Sanaya / Cheng, Xingguo / Bu, Pengli

    Toxicology

    2024  Volume 502, Page(s) 153719

    Abstract: Per- and polyfluoroalkyl substances (PFASs), a group of synthetic chemicals that were once widely used for industrial purposes and in consumer products, are widely found in the environment and in human blood due to their extraordinary resistance to ... ...

    Abstract Per- and polyfluoroalkyl substances (PFASs), a group of synthetic chemicals that were once widely used for industrial purposes and in consumer products, are widely found in the environment and in human blood due to their extraordinary resistance to degradation. Once inside the body, PFASs can activate nuclear receptors such as PPARα and CAR. The present study aimed to investigate the impact of perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) on liver structure and functions, as well as bile acid homeostasis in mice. A single administration of 0.1 mmole/kg of PFDA, not PFOA, elevated serum ALT and bilirubin levels and caused cholestasis in WT mice. PFDA increased total and various bile acid species in serum but decreased them in the liver. Furthermore, in mouse livers, PFDA, not PFOA, down-regulated mRNA expression of uptake transporters (Ntcp, Oatp1a1, 1a4, 1b2, and 2b1) but induced efflux transporters (Bcrp, Mdr2, and Mrp2-4). In addition, PFDA, not PFOA, decreased Cyp7a1, 7b1, 8b1, and 27a1 mRNA expression in mouse livers with concomitant hepatic accumulation of cholesterol. In contrast, in PPARα-null mice, PFDA did not increase serum ALT, bilirubin, or total bile acids, but produced prominent hepatosteatosis; and the observed PFDA-induced expression changes of transporters and Cyps in WT mice were largely attenuated or abolished. In CAR-null mice, the observed PFDA-induced bile acid alterations in WT mice were mostly sustained. These results indicate that, at the dose employed, PFDA has more negative effects than PFOA on liver function. PPARα appears to play a major role in mediating most of PFDA-induced effects, which were absent or attenuated in PPARα-null mice. Lack of PPARα, however, exacerbated hepatic steatosis. Our findings indicate separated roles of PPARα in mediating the adaptive responses to PFDA: protective against hepatosteatosis but exacerbating cholestasis.
    MeSH term(s) Humans ; Mice ; Animals ; Bile Acids and Salts/metabolism ; PPAR alpha/genetics ; PPAR alpha/metabolism ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Neoplasm Proteins ; Liver ; Fluorocarbons/metabolism ; Cholestasis ; Mice, Knockout ; Bilirubin/toxicity ; Bilirubin/metabolism ; RNA, Messenger/metabolism ; Caprylates ; Decanoic Acids
    Chemical Substances perfluorooctanoic acid (947VD76D3L) ; Bile Acids and Salts ; perfluorodecanoic acid (335-76-2) ; PPAR alpha ; ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Neoplasm Proteins ; Fluorocarbons ; Bilirubin (RFM9X3LJ49) ; RNA, Messenger ; Caprylates ; Decanoic Acids
    Language English
    Publishing date 2024-01-03
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 184557-3
    ISSN 1879-3185 ; 0300-483X
    ISSN (online) 1879-3185
    ISSN 0300-483X
    DOI 10.1016/j.tox.2023.153719
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  7. Article ; Online: Safety Assessment of

    Burnett, Christina L / Bergfeld, Wilma F / Belsito, Donald V / Hill, Ronald A / Klaassen, Curtis D / Liebler, Daniel C / Marks, James G / Shank, Ronald C / Slaga, Thomas J / Snyder, Paul W / Fiume, Monice / Heldreth, Bart

    International journal of toxicology

    2024  Volume 43, Issue 1_suppl, Page(s) 82S–95S

    Abstract: The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of ... ...

    Abstract The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 13
    MeSH term(s) Cosmetics/toxicity ; Consumer Product Safety
    Chemical Substances Cosmetics
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1379845-5
    ISSN 1092-874X ; 1091-5818
    ISSN (online) 1092-874X
    ISSN 1091-5818
    DOI 10.1177/10915818231224230
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  8. Article ; Online: Safety Assessment of Palm-Derived Ingredients as Used in Cosmetics.

    Johnson, Wilbur / Bergfeld, Wilma F / Belsito, Donald V / Klaassen, Curtis D / Liebler, Daniel C / Marks, James G / Peterson, Lisa A / Shank, Ronald C / Slaga, Thomas J / Snyder, Paul W / Fiume, Monice / Heldreth, Bart

    International journal of toxicology

    2024  , Page(s) 10915818241237797

    Abstract: The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 8 palm tree ( ...

    Abstract The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 8 palm tree (
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1379845-5
    ISSN 1092-874X ; 1091-5818
    ISSN (online) 1092-874X
    ISSN 1091-5818
    DOI 10.1177/10915818241237797
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  9. Article ; Online: Zinc Phenolsulfonate.

    Tucker, Regina / Bergfeld, Wilma F / Belsito, Donald V / Cohen, David E / Klaassen, Curtis D / Rettie, Alan / Ross, David / Slaga, Thomas J / Snyder, Paul W / Tilton, Susan / Fiume, Monice / Heldreth, Bart

    International journal of toxicology

    2024  , Page(s) 10915818241249416

    Abstract: The Expert Panel for Cosmetic Ingredient Safety reviewed newly available studies since their original assessment in 1986 and a previous re-review in 2004, along with updated information regarding product types and concentrations of use. Considering this ... ...

    Abstract The Expert Panel for Cosmetic Ingredient Safety reviewed newly available studies since their original assessment in 1986 and a previous re-review in 2004, along with updated information regarding product types and concentrations of use. Considering this information, the Panel confirmed that Zinc Phenolsulfonate is safe as a cosmetic ingredient in the present practices of use and concentration as described in this report.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1379845-5
    ISSN 1092-874X ; 1091-5818
    ISSN (online) 1092-874X
    ISSN 1091-5818
    DOI 10.1177/10915818241249416
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  10. Book: Casarett and Doull's toxicology

    Casarett, Louis J. / Klaassen, Curtis D.

    the basic science of poisons

    2001  

    Title variant Toxicology
    Author's details ed. Curtis D. Klaassen
    Keywords Poisoning ; Poisons ; Toxikologie
    Subject Giftkunde ; Klinische Toxikologie
    Language English
    Size XIX, 1236 S. : Ill., graph. Darst.
    Edition 6. ed.
    Publisher McGraw-Hill
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013170812
    ISBN 0-07-134721-6 ; 978-0-07-134721-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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