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  1. Article: Deuterium Metabolic Imaging-Rediscovery of a Spectroscopic Tool.

    Polvoy, Ilona / Qin, Hecong / Flavell, Robert R / Gordon, Jeremy / Viswanath, Pavithra / Sriram, Renuka / Ohliger, Michael A / Wilson, David M

    Metabolites

    2021  Volume 11, Issue 9

    Abstract: The growing demand for metabolism-specific imaging techniques has rekindled interest in Deuterium ( ...

    Abstract The growing demand for metabolism-specific imaging techniques has rekindled interest in Deuterium (
    Language English
    Publishing date 2021-08-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo11090570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nuclear Imaging of Bacterial Infection: The State of the Art and Future Directions.

    Polvoy, Ilona / Flavell, Robert R / Rosenberg, Oren S / Ohliger, Michael A / Wilson, David M

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2020  Volume 61, Issue 12, Page(s) 1708–1716

    Abstract: Increased mortality rates from infectious diseases is a growing public health concern. Successful management of acute bacterial infections requires early diagnosis and treatment, which are not always easy to achieve. Structural imaging techniques such as ...

    Abstract Increased mortality rates from infectious diseases is a growing public health concern. Successful management of acute bacterial infections requires early diagnosis and treatment, which are not always easy to achieve. Structural imaging techniques such as CT and MRI are often applied to this problem. However, these methods generally rely on secondary inflammatory changes and are frequently not specific to infection. The use of nuclear medicine techniques can add crucial complementary information, allowing visualization of infectious pathophysiology beyond morphologic imaging. This review will discuss the current structural and functional imaging techniques used for the diagnosis of bacterial infection and their roles in different clinical scenarios. We will also present several new radiotracers in development, with an emphasis on probes targeting bacteria-specific metabolism. As highlighted by the current coronavirus disease 2019 epidemic, caused by the novel severe acute respiratory syndrome coronavirus 2, similar thinking may apply in imaging viral pathogens; for this case, prominent effects on host proteins, most notably angiotensin-converting enzyme 2, might also provide worthwhile imaging targets.
    MeSH term(s) Animals ; Bacterial Infections/diagnostic imaging ; Bacterial Infections/drug therapy ; Diagnostic Imaging/methods ; Humans ; Nuclear Medicine/methods
    Keywords covid19
    Language English
    Publishing date 2020-08-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.120.244939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 114: Show issues Location:
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    Zs.MO 328: Show issues

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  3. Article: Nuclear imaging of bacterial infection- state of the art and future directions

    Polvoy, Ilona / Flavell, Robert R / Ohliger, Michael / Rosenberg, Oren / Wilson, David M

    J. nucl. med

    Abstract: Increased mortality rates from infectious diseases is a growing public health concern. Successful management of acute bacterial infections requires early diagnosis and treatment, which are not always easy to achieve. Structural imaging techniques such as ...

    Abstract Increased mortality rates from infectious diseases is a growing public health concern. Successful management of acute bacterial infections requires early diagnosis and treatment, which are not always easy to achieve. Structural imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI) are often applied to this problem. However, these methods generally rely on secondary inflammatory changes and are frequently not specific to infection. The use of nuclear medicine (NM) techniques can add crucial complementary information, allowing visualization of infectious pathophysiology beyond morphologic imaging. This review will discuss the current structural and functional imaging techniques used for the diagnosis of bacterial infection and their roles in different clinical scenarios. We will also present several new radiotracers in development, with an emphasis on probes targeting bacteria-specific metabolism. As highlighted by the current COVID-19 epidemic, caused by the novel coronavirus SARS-CoV-2, similar thinking may apply in imaging viral pathogens; for this case prominent effects on host proteins most notably ACE2 might also provide worthwhile imaging targets.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #696487
    Database COVID19

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  4. Article ; Online: Imaging joint infections using D-methyl-

    Polvoy, Ilona / Seo, Youngho / Parker, Matthew / Stewart, Megan / Siddiqua, Khadija / Manacsa, Harrison S / Ravanfar, Vahid / Blecha, Joseph / Hope, Thomas A / Vanbrocklin, Henry / Flavell, Robert R / Barry, Jeffrey / Hansen, Erik / Villanueva-Meyer, Javier E / Engel, Joanne / Rosenberg, Oren S / Wilson, David M / Ohliger, Michael A

    European journal of nuclear medicine and molecular imaging

    2022  Volume 49, Issue 11, Page(s) 3761–3771

    Abstract: Purpose: Non-invasive imaging is a key clinical tool for detection and treatment monitoring of infections. Existing clinical imaging techniques are frequently unable to distinguish infection from tumors or sterile inflammation. This challenge is well- ... ...

    Abstract Purpose: Non-invasive imaging is a key clinical tool for detection and treatment monitoring of infections. Existing clinical imaging techniques are frequently unable to distinguish infection from tumors or sterile inflammation. This challenge is well-illustrated by prosthetic joint infections that often complicate joint replacements. D-methyl-
    Methods: 614.5 ± 100.2 MBq of D-
    Results: D-
    Conclusion: D-
    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Methionine ; Positron-Emission Tomography/methods ; Radiometry ; Tissue Distribution
    Chemical Substances Methionine (AE28F7PNPL)
    Language English
    Publishing date 2022-06-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-022-05858-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1227: Show issues Location:
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  5. Article ; Online: Evaluating the Performance of Pathogen-Targeted Positron Emission Tomography Radiotracers in a Rat Model of Vertebral Discitis-Osteomyelitis.

    Parker, Matthew F L / López-Álvarez, Marina / Alanizi, Aryn A / Luu, Justin M / Polvoy, Ilona / Sorlin, Alexandre M / Qin, Hecong / Lee, Sanghee / Rabbitt, Sarah J / Pichardo-González, Priamo A / Ordonez, Alvaro A / Blecha, Joseph / Rosenberg, Oren S / Flavell, Robert R / Engel, Joanne / Jain, Sanjay K / Ohliger, Michael A / Wilson, David M

    The Journal of infectious diseases

    2023  Volume 228, Issue Suppl 4, Page(s) S281–S290

    Abstract: Background: Vertebral discitis-osteomyelitis (VDO) is a devastating infection of the spine that is challenging to distinguish from noninfectious mimics using computed tomography and magnetic resonance imaging. We and others have developed novel ... ...

    Abstract Background: Vertebral discitis-osteomyelitis (VDO) is a devastating infection of the spine that is challenging to distinguish from noninfectious mimics using computed tomography and magnetic resonance imaging. We and others have developed novel metabolism-targeted positron emission tomography (PET) radiotracers for detecting living Staphylococcus aureus and other bacteria in vivo, but their head-to-head performance in a well-validated VDO animal model has not been reported.
    Methods: We compared the performance of several PET radiotracers in a rat model of VDO. [11C]PABA and [18F]FDS were assessed for their ability to distinguish S aureus, the most common non-tuberculous pathogen VDO, from Escherichia coli.
    Results: In the rat S aureus VDO model, [11C]PABA could detect as few as 103 bacteria and exhibited the highest signal-to-background ratio, with a 20-fold increased signal in VDO compared to uninfected tissues. In a proof-of-concept experiment, detection of bacterial infection and discrimination between S aureus and E coli was possible using a combination of [11C]PABA and [18F]FDS.
    Conclusions: Our work reveals that several bacteria-targeted PET radiotracers had sufficient signal to background in a rat model of S aureus VDO to be potentially clinically useful. [11C]PABA was the most promising tracer investigated and warrants further investigation in human VDO.
    MeSH term(s) Humans ; Rats ; Animals ; Discitis/diagnostic imaging ; 4-Aminobenzoic Acid ; Escherichia coli ; Positron-Emission Tomography/methods ; Staphylococcal Infections/diagnostic imaging ; Osteomyelitis/microbiology ; Bacteria ; Staphylococcus aureus ; Radiopharmaceuticals
    Chemical Substances Carbon-11 ; 4-Aminobenzoic Acid (TL2TJE8QTX) ; Radiopharmaceuticals
    Language English
    Publishing date 2023-10-03
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.50: Show issues Location:
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    Zs.MO 445: Show issues

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