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  1. Article: NARSAD Artworks.

    Michaels, Aranda

    Journal of psychosocial nursing and mental health services

    2024  Volume 62, Issue 4, Page(s) 56

    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 225817-1
    ISSN 1938-2413 ; 0279-3695
    ISSN (online) 1938-2413
    ISSN 0279-3695
    DOI 10.3928/02793695-20240307-02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1216: Show issues Location:
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  2. Article ; Online: MicroRNAs and thyroid hormone action.

    Aranda, Ana

    Molecular and cellular endocrinology

    2021  Volume 525, Page(s) 111175

    Abstract: MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally repress gene expression by binding generally to the 3'-untranslated regions of their target mRNAs. miRNAs regulate a large fraction of the genome, playing a key role in most ... ...

    Abstract MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally repress gene expression by binding generally to the 3'-untranslated regions of their target mRNAs. miRNAs regulate a large fraction of the genome, playing a key role in most physiological and pathological processes. The thyroid hormones (T4 and T3) are major regulators of development, metabolism and cell growth. The thyroid hormones (THs) are synthetized in the thyroid gland and enter the cells through transporter proteins. In the cells, T4 and T3 are metabolized by deiodinase enzymes and bind to nuclear receptors (TRs), which have a higher affinity by T3. TRs act as hormone dependent transcription factors by binding to thyroid hormone response elements (TREs) in the target genes and recruiting transcriptional coregulators. There is increasing evidence that a variety of miRNAs target deiodinases and the receptor, thus regulating TH signaling is different tissues. In turn, the THs have been shown to modulate the expression of specific miRNAs and their mRNA targets in different cell types and organs. In many cases, the existence of TREs in the regulatory regions of these miRNAs has been identified, and the hormone bound receptors transcriptionally regulate expression of these molecules. Changes in the levels of miRNAs have been demonstrated to mediate some of the important actions of the THs in processes such as muscle and heart function, lipid liver metabolism or skin physiology. In addition, miRNA regulation is involved in the effects of TRs on cell proliferation and cancer.
    MeSH term(s) Animals ; Gene Expression Regulation ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Models, Biological ; Signal Transduction ; Thyroid Hormones/metabolism
    Chemical Substances MicroRNAs ; Thyroid Hormones
    Language English
    Publishing date 2021-01-27
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 187438-x
    ISSN 1872-8057 ; 0303-7207
    ISSN (online) 1872-8057
    ISSN 0303-7207
    DOI 10.1016/j.mce.2021.111175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: NARSAD Artworks.

    Michaels, Aranda

    Journal of psychosocial nursing and mental health services

    2023  Volume 61, Issue 12, Page(s) 56

    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 225817-1
    ISSN 1938-2413 ; 0279-3695
    ISSN (online) 1938-2413
    ISSN 0279-3695
    DOI 10.3928/02793695-20231024-01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Computational Pipeline for the Detection of Plant RNA Viruses Using High-Throughput Sequencing.

    Donaire, Livia / Aranda, Miguel A

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2724, Page(s) 1–20

    Abstract: In this chapter, we describe a computational pipeline for the in silico detection of plant viruses by high-throughput sequencing (HTS) from total RNA samples. The pipeline is designed for the analysis of short reads generated using an Illumina platform ... ...

    Abstract In this chapter, we describe a computational pipeline for the in silico detection of plant viruses by high-throughput sequencing (HTS) from total RNA samples. The pipeline is designed for the analysis of short reads generated using an Illumina platform and free-available software tools. First, we provide advice for high-quality total RNA purification, library preparation, and sequencing. The bioinformatics pipeline begins with the raw reads obtained from the sequencing machine and performs some curation steps to obtain long contigs. Contigs are blasted against a local database of reference nucleotide viral sequences to identify the viruses in the samples. Then, the search is refined by applying specific filters. We also provide the code to re-map the short reads against the viruses found to get information on sequencing depth and read coverage for each virus. No previous bioinformatics background is required, but basic knowledge of the Unix command line and R language is recommended.
    MeSH term(s) RNA, Plant ; RNA Viruses/genetics ; Plant Viruses/genetics ; High-Throughput Nucleotide Sequencing ; Computational Biology
    Chemical Substances RNA, Plant
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3485-1_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Fluorescently labelled pepino mosaic virus strains share infected tissues and colocalize in cellular aggregates reminiscent of viral replication complexes.

    Alcaide, Cristina / Aranda, Miguel A

    Virus research

    2023  Volume 329, Page(s) 199100

    Abstract: Mixed infections of pepino mosaic virus (PepMV) isolates from the EU and CH2 strains are frequent in tomato crops. An asymmetric antagonistic relationship has been described between these strains, making their in planta interaction worthy of study. The ... ...

    Abstract Mixed infections of pepino mosaic virus (PepMV) isolates from the EU and CH2 strains are frequent in tomato crops. An asymmetric antagonistic relationship has been described between these strains, making their in planta interaction worthy of study. The aim of this work was to verify if PepMV isolates labelled with fluorescent proteins recapitulate the interactions described for wild type isolates and, if so, to determine the proportion of cells infected with each isolate in single and mixed infected plants. Infectious clones were prepared for PepMV-CH2-GFP and -EU-TagRFP, and also for their reciprocal combination, PepMV-CH2-TagRFP and -EU-GFP, and used to inoculate Nicotiana benthamiana plants. The accumulation of viral RNA followed trends that differed from wild type viruses, with the PepMV-EU-GFP and -CH2-TagRFP pair reproducing more closely the wild type interaction. Protoplasts were isolated from leaves that were systemically infected with PepMV-EU-GFP, -CH2-TagRFP, or both, and flow cytometry was used to determine the proportion of cells infected with each tagged isolate. A significant proportion (16.6%) of cells were found to be infected with both, without strong evidence of virus exclusion in coinfections, as could have been expected for related viruses; in fact, cellular structures reminiscent of viral replication complexes were found to be labelled with both fluorescent reporters.
    MeSH term(s) Solanum lycopersicum ; Potexvirus/genetics ; Nicotiana ; Virus Replication ; Plant Diseases
    Language English
    Publishing date 2023-03-23
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2023.199100
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  6. Article ; Online: Early human selection of crops' wild progenitors explains the acquisitive physiology of modern cultivars.

    Gómez-Fernández, Alicia / Aranda, Ismael / Milla, Rubén

    Nature plants

    2024  Volume 10, Issue 1, Page(s) 25–36

    Abstract: Crops have resource-acquisitive leaf traits, which are usually attributed to the process of domestication. However, early choices of wild plants amenable for domestication may also have played a key role in the evolution of crops' physiological traits. ... ...

    Abstract Crops have resource-acquisitive leaf traits, which are usually attributed to the process of domestication. However, early choices of wild plants amenable for domestication may also have played a key role in the evolution of crops' physiological traits. Here we compiled data on 1,034 annual herbs to place the ecophysiological traits of 69 crops' wild progenitors in the context of global botanical variation, and we conducted a common-garden experiment to measure the effects of domestication on crop ecophysiology. Our study found that crops' wild progenitors already had high leaf nitrogen, photosynthesis, conductance and transpiration and soft leaves. After domestication, ecophysiological traits varied little and in idiosyncratic ways. Crops did not surpass the trait boundaries of wild species. Overall, the resource-acquisitive strategy of crops is largely due to the inheritance from their wild progenitors rather than to further breeding improvements. Our study concurs with recent literature highlighting constraints of crop breeding for faster ecophysiological traits.
    MeSH term(s) Humans ; Plant Breeding ; Crops, Agricultural/physiology ; Phenotype ; Photosynthesis ; Domestication
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2055-0278
    ISSN (online) 2055-0278
    DOI 10.1038/s41477-023-01588-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Antibiotics or Appendectomy for Vulnerable Populations.

    Talan, David A / Machado-Aranda, David / Saltzman, Darin

    JAMA surgery

    2024  Volume 159, Issue 3, Page(s) 349

    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Appendectomy ; Vulnerable Populations ; Treatment Outcome ; Appendicitis/surgery
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2023.6251
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  8. Article: NARSAD Artworks.

    Michaels, Aranda

    Journal of psychosocial nursing and mental health services

    2021  Volume 59, Issue 7, Page(s) 48

    Language English
    Publishing date 2021-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 225817-1
    ISSN 1938-2413 ; 0279-3695
    ISSN (online) 1938-2413
    ISSN 0279-3695
    DOI 10.3928/02793695-20210611-01
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  9. Article ; Online: Neuropsychiatric symptoms and caregiver relationship quality for older Mexican Americans.

    Cantu, Phillip A / Aranda, María P

    Aging & mental health

    2022  Volume 27, Issue 5, Page(s) 896–903

    Abstract: Objectives: Caregivers play a key role in supporting older Mexican Americans, who are less likely to enter nursing facilities than other racial/ethnic groups in the US. However, there is little research on how Neuropsychiatric symptoms (NPS) affect ... ...

    Abstract Objectives: Caregivers play a key role in supporting older Mexican Americans, who are less likely to enter nursing facilities than other racial/ethnic groups in the US. However, there is little research on how Neuropsychiatric symptoms (NPS) affect relationship quality between caregivers and care recipients.
    Method: Using data from the 2015 wave of the Hispanic Established Populations for Epidemiologic Studies of the Elderly (H-EPESE) (
    Results: Hyperactivity symptoms were associated with appreciation, arguing, and nerves. Psychosis symptoms were associated with arguing and nerves. Spousal caregivers were more likely to report arguing and nerves and less likely to report feeling appreciated. Enjoyment assessments were not associated with NPS.
    Conclusion: Relationship quality is related to behavioral changes in late life. Mexican American caregivers negatively evaluate their relationships, not in response to care tasks per se, but when the older person exhibits behavioral problems. The relationship between NPS and negative relationship assessments may be due to unanticipated behavior changes in late life and stigma around psychiatric symptomatology.
    MeSH term(s) Humans ; Aged ; Aged, 80 and over ; Mexican Americans/psychology ; Caregivers/psychology ; Mental Disorders/epidemiology ; Hispanic or Latino ; Logistic Models
    Language English
    Publishing date 2022-03-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1474804-6
    ISSN 1364-6915 ; 1360-7863
    ISSN (online) 1364-6915
    ISSN 1360-7863
    DOI 10.1080/13607863.2022.2048358
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  10. Article ; Online: Cultivating university students' critical sense of belonging through community-responsive scholar-activism.

    Deeb-Sossa, Natalia / Manzo, Rosa / Aranda, Alfonso / Kelty, Jacklyn Skye

    Collaborations (Coral Gables, Fla.)

    2024  Volume 7, Issue 1

    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ISSN 2638-4396
    ISSN (online) 2638-4396
    DOI 10.33596/coll.125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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