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Article ; Online: L-theanine attenuates H

Li, Zhongqing / Huang, Zhiqing / Jia, Gang / Zhao, Hua / Liu, Guangmang / Chen, Xiaoling

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2024 Volume 186, Page(s) 114561

Abstract: This study investigated the protective effects of L-theanine on hydrogen peroxide (H ...

Abstract	This study investigated the protective effects of L-theanine on hydrogen peroxide (H
MeSH term(s)	Humans ; Hydrogen Peroxide/toxicity ; NF-kappa B/metabolism ; MAP Kinase Signaling System ; Intestinal Diseases ; Apoptosis ; p38 Mitogen-Activated Protein Kinases/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism ; Inflammation ; Epithelial Cells/metabolism ; Glutamates
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; NF-kappa B ; theanine (8021PR16QO) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Glutamates
Language	English
Publishing date	2024-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2024.114561
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Article ; Online: Enzymatic acylation improves the stability and bioactivity of lutein: Protective effects of acylated lutein derivatives on L-O2 cells upon H

Tan, Xinjia / Li, Haimei / Huang, Wenjing / Ma, Wenwen / Lu, Yuyun / Yan, Rian

Food chemistry

2023 Volume 410, Page(s) 135393

Abstract: The instability of lutein has limited its wide application especially in the food industry. In this study, enzymatic acylation of lutein with divinyl adipate was investigated. Three new acylated lutein derivatives, lutein-3-O-adipate (compound 1), lutein- ...

Abstract	The instability of lutein has limited its wide application especially in the food industry. In this study, enzymatic acylation of lutein with divinyl adipate was investigated. Three new acylated lutein derivatives, lutein-3-O-adipate (compound 1), lutein-3'-O-adipate (compound 2) and lutein-di-adipate (compound 3), were identified and their stabilities and bioactivates were evaluated. Notably, compounds 1-3 showed better thermal, light stability and stronger scavenging capacity to ABTS radical cation (ABTS
MeSH term(s)	Hydrogen Peroxide/toxicity ; Lutein/pharmacology ; Oxidative Stress ; Antioxidants/pharmacology ; Acylation
Chemical Substances	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid (28752-68-3) ; Hydrogen Peroxide (BBX060AN9V) ; Lutein (X72A60C9MT) ; Antioxidants
Language	English
Publishing date	2023-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2023.135393
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Article ; Online: Bistrochelides H-L: Biscembranoids from the south China sea soft coral Sarcophyton serenei.

Yan, Xia / Liu, Jing / Huang, Jian / Wang, Yiji / Leng, Xue / Li, Te / Ouyang, Han / Yan, Xiaojun / He, Shan

Phytochemistry

2022 Volume 204, Page(s) 113438

Abstract: Five undescribed biscembranoids, bistrochelides H-L, along with four known biscembranoids ...

Abstract	Five undescribed biscembranoids, bistrochelides H-L, along with four known biscembranoids, glaucumolides A-B and bistrochelides A-B, were isolated from the soft coral Sarcophyton serenei collected off the Xisha Island in the South China Sea. The structures of these compounds were elucidated by HRESIMS (high-resolution electrospray ionization mass spectroscopy) spectrometry, NMR (nuclear magnetic resonance) spectroscopy, X-ray diffraction analysis, electronic circular dichroism (ECD), and the comparison of their spectroscopic data with those reported in the literature. In bioassay, some compounds showed a strong inhibitory effect on osteoclast precursor cells at the concentration of 10 μM. Additionally, all compounds exhibited weakly antimicrobial activity against Vibrio harveyi.
Language	English
Publishing date	2022-09-23
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2022.113438
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Article ; Online: Barn-Raising on the Digital Frontier: The L.A.U.N.C.H. Collaborative.

Journal of Appalachian health

2020 Volume 2, Issue 1, Page(s) 6–20

Abstract: A meta-analysis of oncology papers from around the world revealed that cancer patients who lived more than 50 miles away from hospital centers routinely presented with more advanced stages of disease at diagnosis, exhibited lower adherence to prescribed ... ...

Abstract	A meta-analysis of oncology papers from around the world revealed that cancer patients who lived more than 50 miles away from hospital centers routinely presented with more advanced stages of disease at diagnosis, exhibited lower adherence to prescribed treatments, presented with poorer diagnoses, and reported a lower quality of life than patients who lived nearer to care facilities. Connected health approaches-or the use of broadband and telecommunications technologies to evaluate, diagnose, and monitor patients beyond the clinic-are becoming an indispensable tool in medicine to overcome the obstacle of distance.
Language	English
Publishing date	2020-01-26
Publishing country	United States
Document type	Journal Article
ISSN	2641-7804
ISSN (online)	2641-7804
DOI	10.13023/jah.0201.02
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Article ; Online: Protective Effects of L-3-n-Butylphthalide Against H

Wang, Shan / Huang, Longjian / Zhang, Yong / Peng, Yuchen / Wang, Xiaoliang / Peng, Ying

Neuroscience

2018 Volume 393, Page(s) 164–174

Abstract: ... the neuroprotective effect of L-NBP in NSCs against H ... It has been reported that oxidative stress could result in damage to the developing brain. L-3-n ... butylphthalide (L-NBP) could inhibit neuronal cell apoptosis and has neurogenesis effect in different animal and ...

Abstract	It has been reported that oxidative stress could result in damage to the developing brain. L-3-n-butylphthalide (L-NBP) could inhibit neuronal cell apoptosis and has neurogenesis effect in different animal and cellular models. However, whether L-NBP could protect the process of neurogenesis in neural stem cells (NSCs) against oxidative stress injury is still unclear. Here, in the present study, we evaluated the neuroprotective effect of L-NBP in NSCs against H
MeSH term(s)	Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Animals ; Apoptosis/drug effects ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Differentiation/drug effects ; Hydrogen Peroxide/pharmacology ; Neural Stem Cells/drug effects ; Neural Stem Cells/metabolism ; Neurogenesis/drug effects ; Neurons/metabolism ; Neuroprotective Agents/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats, Sprague-Dawley ; Signal Transduction/drug effects
Chemical Substances	Ascl1 protein, rat ; Basic Helix-Loop-Helix Transcription Factors ; Neuroprotective Agents ; Hydrogen Peroxide (BBX060AN9V) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2018-10-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2018.10.003
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Article ; Online: Neolignans from Red Raspberry ( Rubus idaeus L.) Exhibit Enantioselective Neuroprotective Effects against H

Zhou, Le / Yao, Guo-Dong / Lu, Li-Wei / Song, Xiao-Yu / Lin, Bin / Wang, Xiao-Bo / Huang, Xiao-Xiao / Song, Shao-Jiang

Journal of agricultural and food chemistry

2018 Volume 66, Issue 43, Page(s) 11390–11397

Abstract: ... enantioselective protective effects against H ...

Abstract	Red raspberry has been well-known for its nutritional purpose. Although this fruit has been reported for its potent antioxidant activity and health-promoting properties, systematic studies responsible for the bioactive constituents were still insufficient. In the current study, three pairs of dihydrobenzofuran-type enantiomeric neolignans (1a/1b-3a/3b), including two new compounds (1b and 2a), were isolated from the fruit of Rubus idaeus. The structures of these enantiomers were determined through spectroscopic methods and quantum mechanical calculations. Biologically, enantiomers 2a and 2b exhibited significant enantioselective protective effects against H
MeSH term(s)	Apoptosis ; Cell Line, Tumor ; Fruit/chemistry ; Humans ; Hydrogen Peroxide ; Lignans/isolation & purification ; Lignans/pharmacology ; Membrane Potential, Mitochondrial ; Mitochondria/drug effects ; Molecular Structure ; Neuroprotective Agents/isolation & purification ; Neuroprotective Agents/pharmacology ; Oxidative Stress ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Reactive Oxygen Species/metabolism ; Rubus/chemistry
Chemical Substances	Lignans ; Neuroprotective Agents ; Phytochemicals ; Reactive Oxygen Species ; rasidasin I ; rasidasin II ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2018-10-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.8b03725
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Article ; Online: Targeted chromatin profiling reveals novel enhancers in Ig H and Ig L chain Loci.

Predeus, Alexander V / Gopalakrishnan, Suhasni / Huang, Yue / Tang, Jun / Feeney, Ann J / Oltz, Eugene M / Artyomov, Maxim N

Journal of immunology (Baltimore, Md. : 1950)

2013 Volume 192, Issue 3, Page(s) 1064–1070

Abstract: The assembly and expression of mouse Ag receptor genes are controlled by a collection of cis-acting regulatory elements, including transcriptional promoters and enhancers. Although many powerful enhancers have been identified for Ig (Ig) and TCR (Tcr) ... ...

Abstract	The assembly and expression of mouse Ag receptor genes are controlled by a collection of cis-acting regulatory elements, including transcriptional promoters and enhancers. Although many powerful enhancers have been identified for Ig (Ig) and TCR (Tcr) loci, it remained unclear whether additional regulatory elements remain undiscovered. In this study, we use chromatin profiling of pro-B cells to define 38 epigenetic states in mouse Ag receptor loci, each of which reflects a distinct regulatory potential. One of these chromatin states corresponds to known transcriptional enhancers and identifies a new set of candidate elements in all three Ig loci. Four of the candidates were subjected to functional assays, and all four exhibit enhancer activity in B but not in T lineage cells. The new regulatory elements identified by focused chromatin profiling most likely have important functions in the creation, refinement, and expression of Ig repertoires.
MeSH term(s)	Acetylation ; Animals ; B-Lymphocytes/metabolism ; Cell Lineage ; Chromatin/genetics ; Chromatin Immunoprecipitation ; Computational Biology ; DNA-Binding Proteins/deficiency ; Enhancer Elements, Genetic ; Epigenesis, Genetic ; Gene Expression Regulation ; Genes, Immunoglobulin ; Histones/metabolism ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Light Chains/genetics ; Lymphopoiesis ; Methylation ; Mice ; Mice, Inbred C57BL ; Pre-B Cell Receptors/genetics ; Protein Processing, Post-Translational ; Receptors, Antigen, B-Cell/genetics ; Transcription Factors/metabolism
Chemical Substances	Chromatin ; DNA-Binding Proteins ; Histones ; Immunoglobulin Heavy Chains ; Immunoglobulin Light Chains ; Pre-B Cell Receptors ; Rag2 protein, mouse ; Receptors, Antigen, B-Cell ; Transcription Factors
Language	English
Publishing date	2013-12-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1302800
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Article: Transcriptomic analysis reveals vacuolar Na+ (K+)/H+ antiporter gene contributing to growth, development, and defense in switchgrass (Panicum virgatum L.)

Huang, Yanhua / Xin Cui / Huifang Cen / Kehua Wang / Yunwei Zhang

BMC plant biology. 2018 Dec., v. 18, no. 1

2018

Abstract: ... underlying their actions in switchgrass (Panicum virgatum L.), we analyzed transcriptomic changes between ... BACKGROUND: Intracellular Na⁺ (K⁺)/H⁺ antiporters (NHXs) have pivotal functions in regulating ...

Abstract	BACKGROUND: Intracellular Na⁺ (K⁺)/H⁺ antiporters (NHXs) have pivotal functions in regulating plant growth, development, and resistance to a range of stresses. To gain insight into the molecular events underlying their actions in switchgrass (Panicum virgatum L.), we analyzed transcriptomic changes between PvNHX1-overexpression transgenic lines and wild-type (WT) plants using RNA sequencing (RNA-seq) technology. RESULTS: The comparison of transcriptomic data from the WT and transgenic plants revealed a large number of differentially expressed genes (DEGs) in the latter. Gene ontology (GO) and KEGG pathway analyses showed that these DEGs were associated with a wide range of functions, and participated in many biological processes. For example, we found that PvNHX1 had an important role in plant growth through its regulation of photosynthetic activity and cell expansion. In addition, PvNHX1 regulated K⁺ homeostasis, cell expansion and pollen development, indicating that it has unique and specific roles in flower development. We also found that transgenic switchgrass exhibited a higher level of transcription of defense-related genes, especially those involved in disease resistance. CONCLUSION: We showed that PvNHX1 had an important role in plant growth and development through its regulation of photosynthetic activity, cell expansion, K⁺ homeostasis, and pollen development. Additionally, PvNHX1 overexpression activated a complex signal transduction network in response to various biotic and abiotic stresses. In relation to plant growth, development, and defense responses, PvNHX1 also had a vital regulatory role in the formation of a series of plant hormones and transcription factors (TFs). The reliability of the RNA-seq data was confirmed by quantitative real-time PCR. Our data provide a valuable foundation for further research into the molecular mechanisms and physiological roles of NHXs in plants.
Keywords	Panicum virgatum ; abiotic stress ; antiporters ; disease resistance ; flowering ; gene ontology ; genes ; homeostasis ; pathogenesis-related proteins ; photosynthesis ; plant growth ; plant hormones ; pollen ; potassium ; quantitative polymerase chain reaction ; sequence analysis ; signal transduction ; sodium ; transcription factors ; transcriptomics ; transgenic plants ; vacuoles
Language	English
Dates of publication	2018-12
Size	p. 57.
Publishing place	BioMed Central
Document type	Article
ISSN	1471-2229
DOI	10.1186/s12870-018-1278-5
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Quantification and purification of mangiferin from Chinese Mango (Mangifera indica L.) cultivars and its protective effect on human umbilical vein endothelial cells under H(2)O(2)-induced stress.

Luo, Fenglei / Lv, Qiang / Zhao, Yuqin / Hu, Guibing / Huang, Guodi / Zhang, Jiukai / Sun, Chongde / Li, Xian / Chen, Kunsong

International journal of molecular sciences

2012 Volume 13, Issue 9, Page(s) 11260–11274

Abstract: ... in fruit peel, pulp, and seed kernel was carried out in 11 Chinese mango (Mangifera indica L.) cultivars ... scavenging capacities and ferric reducing ability of plasma (FRAP) than by l-ascorbic acid (Vc) or Trolox ... H(2)O(2)-induced stress. Cells treated with mangiferin resulted in significant enhanced ...

Abstract	Mangiferin is a natural xanthonoid with various biological activities. Quantification of mangiferin in fruit peel, pulp, and seed kernel was carried out in 11 Chinese mango (Mangifera indica L.) cultivars. The highest mangiferin content was found in the peel of Lvpimang (LPM) fruit (7.49 mg/g DW). Efficient purification of mangiferin from mango fruit peel was then established for the first time by combination of macroporous HPD100 resin chromatography with optimized high-speed counter-current chromatography (HSCCC). Purified mangiferin was identified by both HPLC and LC-MS, and it showed higher DPPH(•) free-radical scavenging capacities and ferric reducing ability of plasma (FRAP) than by l-ascorbic acid (Vc) or Trolox. In addition, it showed significant protective effects on human umbilical vein endothelial cells (HUVEC) under H(2)O(2)-induced stress. Cells treated with mangiferin resulted in significant enhanced cell survival under of H(2)O(2) stress. Therefore, mangiferin from mango fruit provides a promising perspective for the prevention of oxidative stress-associated diseases.
MeSH term(s)	China ; Chromatography, High Pressure Liquid ; Free Radical Scavengers/chemistry ; Free Radical Scavengers/metabolism ; Fruit/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Hydrogen Peroxide/toxicity ; Mangifera/chemistry ; Mangifera/metabolism ; Oxidative Stress/drug effects ; Plant Extracts/chemistry ; Plant Extracts/metabolism ; Xanthones/metabolism
Chemical Substances	Free Radical Scavengers ; Plant Extracts ; Xanthones ; mangiferin (1M84LD0UMD) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2012-09-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms130911260
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Article ; Online: Re : He B, Yan L, Guo H, et al. The difference in superior adjacent segment pathology after lumbar posterolateral fusion by using 2 different pedicle screw insertion techniques in 9-year minimum follow-up. Spine (Phila Pa 1976) 2014;39:1093-8.

Gu, Su-xi / Ma, Yuanzheng / Chen, Xing / Cai, Xiao-jun / Cui, Xu / Bao, Da / Huang, Feng-shan / Luo, Zhan-peng / Li, Da-wei / Luo, Xiao-bo / Li, Li-tao

Spine

2014 Volume 39, Issue 24, Page(s) E1493

MeSH term(s)	Female ; Humans ; Lumbar Vertebrae/surgery ; Male ; Pedicle Screws ; Spinal Fusion/methods ; Spondylolisthesis/surgery
Language	English
Publishing date	2014-11-15
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	752024-4
ISSN	1528-1159 ; 0362-2436
ISSN (online)	1528-1159
ISSN	0362-2436
DOI	10.1097/BRS.0000000000000618
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