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Article ; Online: Radical Activation of N-H and O-H Bonds at Bismuth(II).

Yang, Xiuxiu / Reijerse, Edward J / Bhattacharyya, Kalishankar / Leutzsch, Markus / Kochius, Markus / Nöthling, Nils / Busch, Julia / Schnegg, Alexander / Auer, Alexander A / Cornella, Josep

Journal of the American Chemical Society

2022 Volume 144, Issue 36, Page(s) 16535–16544

Abstract: The development of unconventional strategies for the activation of ammonia ( ... ...

Abstract	The development of unconventional strategies for the activation of ammonia (NH
MeSH term(s)	Amines ; Ammonia/chemistry ; Bismuth/chemistry ; Water/chemistry
Chemical Substances	Amines ; Water (059QF0KO0R) ; Ammonia (7664-41-7) ; Bismuth (U015TT5I8H)
Language	English
Publishing date	2022-09-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.2c05882
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Article: Radical Activation of N–H and O–H Bonds at Bismuth(II)

Yang, Xiuxiu / Reijerse, Edward J. / Bhattacharyya, Kalishankar / Leutzsch, Markus / Kochius, Markus / Nöthling, Nils / Busch, Julia / Schnegg, Alexander / Auer, Alexander A. / Cornella, Josep

Journal of the American Chemical Society. 2022 Sept. 02, v. 144, no. 36

2022

Abstract: ... II) engages with various amines and alcohols and exerts an unprecedented effect onto the X–H bond ... leading to low BDFEX–H. As a result, radical activation of various N–H and O–H bonds─including ammonia and ... with the triad of H⁺, H–, and H• sources, thus providing alternative pathways for main group chemistry. ...

Abstract	The development of unconventional strategies for the activation of ammonia (NH₃) and water (H₂O) is of capital importance for the advancement of sustainable chemical strategies. Herein we provide the synthesis and characterization of a radical equilibrium complex based on bismuth featuring an extremely weak Bi–O bond, which permits the in situ generation of reactive Bi(II) species. The ensuing organobismuth(II) engages with various amines and alcohols and exerts an unprecedented effect onto the X–H bond, leading to low BDFEX–H. As a result, radical activation of various N–H and O–H bonds─including ammonia and water─occurs in seconds at room temperature, delivering well-defined Bi(III)-amido and -alkoxy complexes. Moreover, we demonstrate that the resulting Bi(III)–N complexes engage in a unique reactivity pattern with the triad of H⁺, H–, and H• sources, thus providing alternative pathways for main group chemistry.
Keywords	ambient temperature ; ammonia ; bismuth ; capital ; chemistry
Language	English
Dates of publication	2022-0902
Size	p. 16535-16544.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.2c05882
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Whole-Cell Biocatalysts for Stereoselective C-H Amination Reactions.

Both, Peter / Busch, Hanna / Kelly, Paul P / Mutti, Francesco G / Turner, Nicholas J / Flitsch, Sabine L

Angewandte Chemie (International ed. in English)

2016 Volume 55, Issue 4, Page(s) 1511–1513

Abstract: ... attractive strategies is the stereoselective installation of a chiral amine through C-H amination, which is ... example of the successful de novo design of a single whole-cell biocatalyst for formal stereoselective C-H ...

Abstract	Enantiomerically pure chiral amines are ubiquitous chemical building blocks in bioactive pharmaceutical products and their synthesis from simple starting materials is of great interest. One of the most attractive strategies is the stereoselective installation of a chiral amine through C-H amination, which is a challenging chemical transformation. Herein we report the application of a multienzyme cascade, generated in a single bacterial whole-cell system, which is able to catalyze stereoselective benzylic aminations with ee values of 97.5%. The cascade uses four heterologously expressed recombinant enzymes with cofactors provided by the host cell and isopropyl amine added as the amine donor. The cascade presents the first example of the successful de novo design of a single whole-cell biocatalyst for formal stereoselective C-H amination.
MeSH term(s)	Amination ; Biocatalysis ; Biotransformation ; Carbon/chemistry ; Chromatography, Gas ; Escherichia coli/metabolism ; Hydrogen/chemistry ; Stereoisomerism
Chemical Substances	Carbon (7440-44-0) ; Hydrogen (7YNJ3PO35Z)
Language	English
Publishing date	2016-01-22
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.201510028
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: 3rd International Cancer Immunotherapy Conference. Immuntherapie als Teil von Kombinationsbehandlungen. Im Gespräch mit Prof. Dr. med. Dirk H. Busch

Busch, Dirk H.

Im Focus Onkologie

2017 Volume 20, Issue 10, Page(s) 54

Language	German
Document type	Article
ZDB-ID	2044841-7
ISSN	1435-7402
Database	Current Contents Medicine

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Article ; Online: Moss-Produced, Glycosylation-Optimized Human Factor H for Therapeutic Application in Complement Disorders.

Michelfelder, Stefan / Parsons, Juliana / Bohlender, Lennard L / Hoernstein, Sebastian N W / Niederkrüger, Holger / Busch, Andreas / Krieghoff, Nicola / Koch, Jonas / Fode, Benjamin / Schaaf, Andreas / Frischmuth, Thomas / Pohl, Martin / Zipfel, Peter F / Reski, Ralf / Decker, Eva L / Häffner, Karsten

Journal of the American Society of Nephrology : JASN

2016 Volume 28, Issue 5, Page(s) 1462–1474

Abstract: ... The majority of the mutations found in patients with these diseases affect the glycoprotein complement factor H ... desirable. Substitution with biologically active factor H could potentially treat a variety of diseases ... that involve increased alternative pathway activation, but no therapeutic factor H is commercially available ...

Abstract	Genetic defects in complement regulatory proteins can lead to severe renal diseases, including atypical hemolytic uremic syndrome and C3 glomerulopathies, and age-related macular degeneration. The majority of the mutations found in patients with these diseases affect the glycoprotein complement factor H, the main regulator of the alternative pathway of complement activation. Therapeutic options are limited, and novel treatments, specifically those targeting alternative pathway activation, are highly desirable. Substitution with biologically active factor H could potentially treat a variety of diseases that involve increased alternative pathway activation, but no therapeutic factor H is commercially available. We recently reported the expression of full-length recombinant factor H in moss (
MeSH term(s)	Animals ; Atypical Hemolytic Uremic Syndrome/drug therapy ; Bryopsida/metabolism ; Complement Factor H/biosynthesis ; Complement Factor H/metabolism ; Complement Factor H/therapeutic use ; Complement System Proteins ; Glycosylation ; Humans ; Immune System Diseases/drug therapy ; Mice
Chemical Substances	CFH protein, human ; Complement Factor H (80295-65-4) ; Complement System Proteins (9007-36-7)
Language	English
Publishing date	2016-12-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.2015070745
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Ultralong-Chain-Spaced Crystalline Poly(H-phosphonate)s and Poly(phenylphosphonate)s

Busch, Hanna / Mecking Stefan / Schiebel Eva / Sickinger Annika

Macromolecules. 2017 Oct. 24, v. 50, no. 20

2017

Abstract: Aliphatic poly(H-phosphonate)s were obtained by polyesterification of dimethyl H-phosphonate ... with dimethyl H-phosphonate yield the corresponding polyphosphoesters (PPE19H, PPE23H, and PPE48H ... yields the selectively functionalized poly(H-phosphonate)s PPE19Ph, PPE23Ph, and PPE48Ph. DSC analysis ...

Abstract	Aliphatic poly(H-phosphonate)s were obtained by polyesterification of dimethyl H-phosphonate with bio-based long-chain diols. Nonadecane-1,19-diol, tricosane-1,23-diol, and octatetracontane-1,48-diol with dimethyl H-phosphonate yield the corresponding polyphosphoesters (PPE19H, PPE23H, and PPE48H) with molecular weights (Mn) up to 4.3 × 104 g mol–1. Postfunctionalization of these polymers via Hirao cross-coupling yields the selectively functionalized poly(H-phosphonate)s PPE19Ph, PPE23Ph, and PPE48Ph. DSC analysis revealed significantly enhanced crystallinities and melting points (up to Tm = 110 °C) with increasing methylene sequence lengths. Hydrolytic degradation of polymer powder of poly-(H-phosphonate) occurred up to 95% in 2 days. The degradation rates decreased with increasing methylene sequence length. After postfunctionalization, degradation occurred only to a minimal extent over 3 months in basic and in acidic media.
Keywords	cross-coupling reactions ; esterification ; glycols ; melting point ; molecular weight ; polymers
Language	English
Dates of publication	2017-1024
Size	p. 7901-7910.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1491942-4
ISSN	1520-5835 ; 0024-9297
ISSN (online)	1520-5835
ISSN	0024-9297
DOI	10.1021%2Facs.macromol.7b01368
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Coherence during scattering of fast H atoms from a LiF(001) surface.

Lienemann, J / Schüller, A / Blauth, D / Seifert, J / Wethekam, S / Busch, M / Maass, K / Winter, H

Physical review letters

2011 Volume 106, Issue 6, Page(s) 67602

Abstract: ... dimensional angular distributions for scattered projectiles with their energy loss. For keV H atoms ...

Abstract	The coherence for diffraction effects during grazing scattering of fast hydrogen and helium atoms from a LiF(001) surface with energies up to some keV is investigated via the coincident detection of two-dimensional angular distributions for scattered projectiles with their energy loss. For keV H atoms, we identify electronic excitations of the target surface as the dominant mechanism for decoherence, whereas for He atoms this contribution is small. The suppression of electronic excitations owing to the band gap of insulators plays an essential role for preserving quantum coherence and thus for the application of fast atom diffraction as a surface analytical tool.
Language	English
Publishing date	2011-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.106.067602
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Article ; Online: Helicobacter pylori FliD protein is a highly sensitive and specific marker for serologic diagnosis of H. pylori infection.

Khalifeh Gholi, Mohammad / Kalali, Behnam / Formichella, Luca / Göttner, Gereon / Shamsipour, Fereshteh / Zarnani, Amir Hassan / Hosseini, Mostafa / Busch, Dirk H / Shirazi, Mohammad Hasan / Gerhard, Markus

International journal of medical microbiology : IJMM

2013 Volume 303, Issue 8, Page(s) 618–623

Abstract: Screening for H. pylori in large populations continues to be a challenging task, since available ... to significant numbers of false positive and false negative results. Various H. pylori proteins associated ... defined markers that are recognized in all H. pylori infected patients and that do not show cross ...

Abstract	Screening for H. pylori in large populations continues to be a challenging task, since available tests have limited sensitivity and specificity, which, in population-based approaches, leads to significant numbers of false positive and false negative results. Various H. pylori proteins associated with virulence are highly immunogenic and therefore candidates to detect the infection. There are currently no defined markers that are recognized in all H. pylori infected patients and that do not show cross-reactivity with other bacterial proteins. We identified the H. pylori "hook-associated protein 2 homologue", FliD (UniProtKB/Swiss-Prot: P96786.4) as a novel marker of infection for serological analysis. The H. pylori FliD protein is an essential element in the assembly of the functional flagella. However, this virulence factor has not yet been tested as a diagnostic marker in serology. For this purpose FliD was recombinantly expressed in E. coli, purified by affinity chromatography and gel filtration and used to coat ELISA plates or immobilized on nitrocellulose stripes. To evaluate its antigenicity we screened a defined panel of patient sera. The recombinant H. pylori FliD protein reacted with a high percentage of human sera. Among 318 samples reported positive by histology, 310 (97.4%) were tested positive by FliD Line assay, and 165 out of 170 samples were tested positive by ELISA (97%). We could also reconfirm 297 out of 300 (99%) negative sera by Line assay and 73 from 76 (96%) by ELISA. Taken together, application of FliD in serological diagnosis of H. pylori infection presents a high specificity of up to 99% and a sensitivity of up to 97%. This makes especially the FliD ELISA a simple, cost effective and highly efficient tool to detect H. pylori infection in developing countries where prevalence is high and other screening methods are either not available or are unaffordable.
MeSH term(s)	Antibodies, Bacterial/blood ; Bacterial Proteins/genetics ; Bacterial Proteins/immunology ; Enzyme-Linked Immunosorbent Assay/methods ; Escherichia coli/genetics ; Female ; Helicobacter Infections/diagnosis ; Helicobacter pylori/immunology ; Helicobacter pylori/isolation & purification ; Humans ; Male ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Sensitivity and Specificity ; Serologic Tests/methods
Chemical Substances	Antibodies, Bacterial ; Bacterial Proteins ; Recombinant Proteins ; FlaD protein, Bacteria (147757-14-0)
Language	English
Publishing date	2013-12
Publishing country	Germany
Document type	Evaluation Studies ; Journal Article
ZDB-ID	2006518-8
ISSN	1618-0607 ; 1438-4221
ISSN (online)	1618-0607
ISSN	1438-4221
DOI	10.1016/j.ijmm.2013.08.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: The Utopian Vision of H.G. Wells

Busch, Justin E. A

2009

Abstract: This book examines and develops the evolutionary utopian ideas of H.G. Wells. It begins ...

Abstract	This book examines and develops the evolutionary utopian ideas of H.G. Wells. It begins with a detailed consideration of the types of individuals who could create and live in ideal societies, as well as the social, aesthetic and intellectual aspects of utopian life in Wells's books. It then discusses the role of the state and how Wells's utopian thought requires a permanent commitment to expanding freedom. The final chapter covers death and how utopian thought can profoundly reshape the reader's understanding of his or her own position relative to current and future societies
Language	English
Size	Online-Ressource (213 p)
Publisher	McFarland & Company, Inc., Publishers
Publishing place	Jefferson
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9780786446056 ; 0786446056
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book: Teilvorhaben: Fh-IWM-H und Fh-CSP

Busch, Michael

Title variant	Developing lightweight plastic photovoltaic modules with integrated functions. Subproject: Fh-IWM-H and Fh-CSP
Institution	Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung, Fraunhofer-Institut fuer Werkstoffmechanik, Aussenstelle Halle, Walter-Huelse-Str. 1, 06120, Halle (Saale), DE
Keywords	Thermoplast ; Polymer ; Pruefverfahren ; Zuverlaessigkeit ; Photovoltaik ; Kunststoff ; Leichtbau ; Solartechnik ; Energietechnik ; Faser ; Verbundwerkstoff ; Produktionstechnik ; Aluminium ; Werkstoffkunde ; Materialpruefung ; Haltbarkeit
Document type	Book
Remark	project start: 08/01/2008 project end: 07/31/2011 grant ID: 03X3024A
Database	Environmental research database (UFORDAT) of the German Federal Environment Agency (UBA)

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