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Article: Interventions for Students with Problem Behaviors: A Workshop Incorporating Applied Behavior Analysis for Japanese Teachers.

Inoue, Masahiko / Kishimoto, Tomohiro / Fukuzaki, Toshiki

2021 Volume 64, Issue 1, Page(s) 98–106

Abstract: Background: We conducted a workshop-style program based on applied behavior analysis (ABA) for Japanese teachers in charge of children with developmental disabilities who had behavioral problems. Additionally, we investigated whether making and ... ...

Abstract	Background: We conducted a workshop-style program based on applied behavior analysis (ABA) for Japanese teachers in charge of children with developmental disabilities who had behavioral problems. Additionally, we investigated whether making and implementing behavioral intervention plans (BIPs) for participants, improved students' behavioral problems, and the mental health of participants. Methods: The participants were 18 Japanese elementary and kindergarten teachers in charge of students with behavioral problems. The workshop comprised eight two-hour sessions of lectures and group discussions related to ABA. Achievement level was evaluated for the development and implementation of the BIP and improvement of behavioral problems. In addition, we analyzed changes in the 30-item General Health Questionnaire (GHQ-30) scores pre- and post-workshop to assess participants' mental health. Fifteen teachers who participated in more than half of the sessions were analyzed. Results: All 15 teachers analyzed were able to perform appropriate functional behavioral assessment (FBA) and make a BIP, and 12 showed improvement in the targeted problem behaviors. Many target behaviors had avoidance functions and many antecedent strategies were behavior contracts. Adaptive behaviors incompatible with problem behaviors were selected as alternative behaviors to problem behaviors. Also, there was no aversive control over the outcome strategy. The average score for "social activity disorder" and "anxiety / caprice" in GHQ30 showed a statistically significant improvement in pre- and post-workshop. Conclusion: It was found that appropriate FAB and BIP could be created using "the strategy sheet," in workshops based on the ABA. It was also suggested that the workshop program may in turn improve teachers' mental health. Further study is needed on the effectiveness of the workshop program using intergroup comparison designs for more subjects.
Language	English
Publishing date	2021-01-25
Publishing country	Japan
Document type	Journal Article
ZDB-ID	840719-8
ISSN	1346-8049 ; 0513-5710
ISSN (online)	1346-8049
ISSN	0513-5710
DOI	10.33160/yam.2021.02.013
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Article ; Online: Improvement of IgG4-related Disease with a Supplemental Steroid.

Hashimoto, Hirotsugu / Kurata, Atsushi / Kuroda, Masahiko / Kishimoto, Masahiko

Internal medicine (Tokyo, Japan)

2015 Volume 54, Issue 22, Page(s) 2949–2950

Language	English
Publishing date	2015
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.54.4561
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Article ; Online: Retrograde transgastric jejunostomy for nutritional management and aspiration prevention in cases with severe malignant esophageal strictures.

Yamashita, Takeshi / Otsuka, Koji / Goto, Satoru / Ariyoshi, Tomotake / Motegi, Kentaro / Kohmoto, Masahiro / Saito, Akira / Sato, Yoshihito / Kishimoto, Yutaka / Murakami, Masahiko

DEN open

2023 Volume 4, Issue 1, Page(s) e321

Abstract: Locally advanced esophageal cancer often presents with dysphagia and can be complicated by aspiration pneumonia. Therefore, nutritional management is important to prevent pneumonia. Enteral nutrition via gastrostomies is common in esophageal cancer ... ...

Abstract	Locally advanced esophageal cancer often presents with dysphagia and can be complicated by aspiration pneumonia. Therefore, nutritional management is important to prevent pneumonia. Enteral nutrition via gastrostomies is common in esophageal cancer patients. Here, we describe the efficacy of nutritional management using a gastrojejunostomy tube retrogradely inserted in the esophagus through gastrostomy to simultaneously drain accumulated fluid on the proximal side of a malignant stricture. We performed this procedure for two cases with severe malignant strictures using two types of endoscope insertion. A 57-year-old male patient (Case 1) underwent a retrograde insertion of a gastrojejunostomy tube for severe esophageal malignant stricture with severe nausea and salivary reflux. After a narrow endoscope was inserted through the gastrostomy fistula, a gastrojejunostomy tube was inserted alongside a guidewire allowing the patient to undergo definitive chemoradiotherapy without symptoms. An 82-year-old male patient (Case 2) was scheduled for a minimally invasive esophagectomy following neoadjuvant chemotherapy after gastrostomy. However, the patient developed aspiration pneumonia due to salivary reflux; before surgery, a narrow nasal endoscope was inserted and passed through the strictures. The percutaneous endoscopic transgastric jejunostomy catheter was retrogradely inserted alongside the guidewire. In patients with malignant strictures and salivary reflux, retrograde insertion of gastrojejunostomy tubes can simultaneously provide enteral nutrition and saliva drainage.
Language	English
Publishing date	2023-11-20
Publishing country	Australia
Document type	Case Reports
ISSN	2692-4609
ISSN (online)	2692-4609
DOI	10.1002/deo2.321
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Article ; Online: Histology of the tricuspid valve annulus and right atrioventricular muscle distance.

Yamane, Kokoro / Takahashi, Yosuke / Fujii, Hiromichi / Morisaki, Akimasa / Sakon, Yoshito / Kishimoto, Noriaki / Kawase, Takumi / Ohsawa, Masahiko / Shibata, Toshihiko

Interactive cardiovascular and thoracic surgery

2022 Volume 35, Issue 2

Abstract: Objectives: Histologically, the mitral valve annulus comprises a collection of collagen fibres. However, the existence of collagen fibres in the tricuspid valve annulus has not been elucidated. Our goal was to clarify the histology of the tricuspid ... ...

Abstract	Objectives: Histologically, the mitral valve annulus comprises a collection of collagen fibres. However, the existence of collagen fibres in the tricuspid valve annulus has not been elucidated. Our goal was to clarify the histology of the tricuspid annulus. Methods: Fifty human hearts without heart disease that were autopsied at Osaka City University Hospital between January 2009 and December 2017 were examined. The tricuspid valve was sectioned at 12 sites around the annulus, and the atrioventricular junction distance was measured. Results: None of the tricuspid valve annulus samples had a continuous aggregation of collagen fibres that could be called an annulus. The interventricular space between the right atria and ventricles was composed of adipose tissue only on the anterosuperior and inferior sides, and no adipose tissue was found on the septal side. Comparing the atrioventricular muscle distance of the anterosuperior and inferior sides, the distance at the inferior side was statistically significantly larger than that of the anterosuperior side in 47 cases (P < 0.0001). Conclusions: There was no continuous circumferential aggregation of collagen fibres in the right atrioventricular junction. The distance between the right atrial and ventricular myocardium was greater at the inferior side than that at the anterosuperior side, which might lead to more inferior annular dilation versus anterosuperior dilation. These anatomical features will be fundamental for future discussions of the suturing method used in prosthetic ring annuloplasty for tricuspid regurgitation.
MeSH term(s)	Collagen ; Humans ; Mitral Valve/surgery ; Muscles ; Tricuspid Valve/surgery ; Tricuspid Valve Insufficiency/surgery
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2022-07-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2095298-3
ISSN	1569-9285 ; 1569-9293
ISSN (online)	1569-9285
ISSN	1569-9293
DOI	10.1093/icvts/ivac175
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Article: Different community assembly of ground beetles and spiders in subalpine forests and alpine scoria deserts of a young volcano, Mt. Fuji

Ohwaki, Atsushi / Tanikawa, Akio / Kishimoto, Toshio / Maeda, Saki / Kitahara, Masahiko

Ecological research. 2021 Sept., v. 36, no. 5

2021

Abstract: While the colonization processes of arthropods in new volcanoes have attracted our attention, the arthropod assembly process in sites where vegetation reaches climax forests after the Holocene catastrophic eruption is unknown. In this study, ground ... ...

Abstract	While the colonization processes of arthropods in new volcanoes have attracted our attention, the arthropod assembly process in sites where vegetation reaches climax forests after the Holocene catastrophic eruption is unknown. In this study, ground beetles and spiders were investigated using pitfall traps in 12 sites from the subalpine and alpine areas of Mt. Fuji, which were shaped about 2300 years ago and where undisturbed subalpine climax forests and alpine deserts are formed. We examined how elevation, canopy and forest floor vegetation affected turnover and nestedness structure of these assemblages. The alpine desert and subalpine forest comprised different species for both beetles and spiders. The species from the alpine desert seemed to have high dispersal ability. In the subalpine forest, the beetle assemblage found at higher elevations was a subset of those at lower elevations. This nested structure was generated by the expansion of flightless species from montane forests to subalpine forests. Species tolerance to harsh weather conditions may decide the upper elevational limit. The spider assemblage was affected by forest floor vegetation, where species turnover was observed between different floor types. Subalpine spiders included both species expanding from the montane area and those probably colonizing from distant subalpine areas by ballooning. These results suggest that the assembly process differed between alpine and subalpine areas, and also between different taxa particularly in subalpine forests. Examining the genetic relationship between Mt. Fuji populations and possible source populations in other mountains will elucidate the detailed community assembly process in Mt. Fuji.
Keywords	canopy ; forest litter ; genetic relationships ; nestedness ; research ; spiders ; weather
Language	English
Dates of publication	2021-09
Size	p. 866-881.
Publishing place	John Wiley & Sons, Inc.
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	233459-8
ISSN	1440-1703 ; 0912-3814
ISSN (online)	1440-1703
ISSN	0912-3814
DOI	10.1111/1440-1703.12250
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Article ; Online: Which symptoms negatively affect the oral health-related quality of life in patients with osteonecrosis of the jaw?

Sato, Takumi / Kusumoto, Junya / Takeda, Daisuke / Kishimoto, Megumi / Kashin, Masahiko / Furudoi, Shungo / Akashi, Masaya

Oral surgery, oral medicine, oral pathology and oral radiology

2020 Volume 130, Issue 2, Page(s) 175–180

Abstract: Objectives: One of the treatment goals for osteonecrotic lesions of the jaw, such as medication-related osteonecrosis of the jaw (MRONJ) or osteoradionecrosis (ORN), is restoration of quality of life (QOL). This study aimed to identify symptoms that ... ...

Abstract	Objectives: One of the treatment goals for osteonecrotic lesions of the jaw, such as medication-related osteonecrosis of the jaw (MRONJ) or osteoradionecrosis (ORN), is restoration of quality of life (QOL). This study aimed to identify symptoms that negatively affect QOL in patients with unhealed MRONJ or ORN. Study design: This cross-sectional study included patients who were previously diagnosed with MRONJ or ORN and who underwent treatment at the Kobe University Hospital between June 2015 and February 2016. Patient QOL was measured by using the Oral Health Impact Profile (OHIP-14). The predictor variable was disease status (stage and healing). The outcome variable was OHIP-14. One-way analysis of variance and Tukey's test were performed. Results: The study included 74 patients (37 men and 37 women; mean age 70 years). Although there was no significant difference between the OHIP-14 scores of unhealed MRONJ and ORN (stages 1-3) and those of healed ones, the "worsened sense of taste" resulted in significant differences among stages in patients with unhealed MRONJ (P = .027) and the "painful mouth aching" in patients with unhealed ORN (P = .041). Conclusions: Worsened sense of taste and pain negatively affected QOL in patients with unhealed MRONJ and ORN.
MeSH term(s)	Aged ; Bisphosphonate-Associated Osteonecrosis of the Jaw ; Bone Density Conservation Agents ; Cross-Sectional Studies ; Female ; Humans ; Male ; Oral Health ; Osteoradionecrosis ; Quality of Life
Chemical Substances	Bone Density Conservation Agents
Language	English
Publishing date	2020-05-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2650843-6
ISSN	2212-4411 ; 2212-4403
ISSN (online)	2212-4411
ISSN	2212-4403
DOI	10.1016/j.oooo.2020.03.051
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Article ; Online: Functional maintenance of calcium store by ShcB adaptor protein in cerebellar Purkinje cells.

Kakizawa, Sho / Kishimoto, Yasushi / Yamamoto, Shinichiro / Onga, Kazuko / Yasuda, Kunihiko / Miyamoto, Yoshiaki / Watanabe, Masahiko / Sakai, Ryuichi / Mori, Nozomu

Scientific reports

2020 Volume 10, Issue 1, Page(s) 14475

Abstract: Intracellular ... ...

Abstract	Intracellular Ca
MeSH term(s)	Animals ; Calcium/metabolism ; Calcium Signaling/genetics ; Cerebellum/metabolism ; Cerebellum/pathology ; Endoplasmic Reticulum/genetics ; Humans ; Long-Term Synaptic Depression/genetics ; Mice ; Mice, Knockout ; Motor Disorders/genetics ; Motor Disorders/physiopathology ; Neuronal Plasticity/genetics ; Purkinje Cells/metabolism ; Purkinje Cells/pathology ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics ; Src Homology 2 Domain-Containing, Transforming Protein 2/genetics ; Synapses/genetics
Chemical Substances	Src Homology 2 Domain-Containing, Transforming Protein 2 ; Sarcoplasmic Reticulum Calcium-Transporting ATPases (EC 3.6.3.8) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-09-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-71414-y
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Article: Severe Complications after General Anesthesia versus Sedation during Pediatric Diagnostic Cardiac Catheterization for Ventricular Septal Defect.

Ogawa, Yuki / Yamana, Hayato / Noda, Tatsuya / Kishimoto, Miwa / Yoshihara, Shingo / Kanaoka, Koshiro / Matsui, Hiroki / Fushimi, Kiyohide / Yasunaga, Hideo / Kawaguchi, Masahiko / Imamura, Tomoaki

Journal of clinical medicine

2022 Volume 11, Issue 17

Abstract: Pediatric cardiac catheterization requires unconsciousness and immobilization through general anesthesia or sedation. This study aimed to compare the occurrence of severe complications in pediatric diagnostic cardiac catheterization for ventricular ... ...

Abstract	Pediatric cardiac catheterization requires unconsciousness and immobilization through general anesthesia or sedation. This study aimed to compare the occurrence of severe complications in pediatric diagnostic cardiac catheterization for ventricular septal defect between general anesthesia and sedation performed under similar institutional environments. Using the Japanese Diagnosis Procedure Combination database, we retrospectively identified pediatric patients (aged <2 years) who underwent diagnostic cardiac catheterization for ventricular septal defect between July 2010 and March 2019. The composite outcome was the occurrence of severe complications, including catecholamine use and intensive care unit admission, within seven days after catheterization. Overlap weighting based on propensity scores was used to adjust for patient- and hospital-level confounding factors. We identified 3159 patients from 87 hospitals, including 930 under general anesthesia and 2229 under sedation. The patient- and hospital-level baseline characteristics differed between the groups. After adjustment, the proportion of patients with severe complications was significantly higher in the general anesthesia group than in the sedation group (2.4% vs. 0.6%; risk difference, 1.8% [95% confidence interval, 0.93−2.6%]). Severe complications occurred more frequently in the general anesthesia group than in the sedation group. Further research on anesthetic methods is necessary to assess the safety and accuracy of pediatric diagnostic cardiac catheterization.
Language	English
Publishing date	2022-08-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11175165
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Article: Identification of source populations for reintroduction in extinct populations based on genome-wide SNPs and mtDNA sequence: a case study of the endangered subalpine grassland butterfly Aporia hippia (Lepidoptera; Pieridae) in Japan

Nakahama, Naoyuki / Hanaoka, Toshimichi / Itoh, Tateo / Kishimoto, Toshio / Ohwaki, Atsushi / Matsuo, Ayumi / Kitahara, Masahiko / Usami, Shin-ichi / Suyama, Yoshihisa / Suka, Takeshi

Journal of insect conservation. 2022 Feb., v. 26, no. 1

2022

Abstract: The use of genetically closely related populations as reintroduction sources is crucial in restoration programmes for endangered species because genetically distant populations may cause genetic disturbances. Aporia hippia (Lepidoptera; Pieridae) is an ... ...

Abstract	The use of genetically closely related populations as reintroduction sources is crucial in restoration programmes for endangered species because genetically distant populations may cause genetic disturbances. Aporia hippia (Lepidoptera; Pieridae) is an endangered subalpine grassland butterfly in Japan and its distribution area is restricted to the Asama, Yatsugatake and Akaishi Mountains in central Honshu Island. In the Yatsugatake Mountains, its population is probably already extinct, and reintroduction from the other sites is now under consideration. Here, we estimated the genetic diversity and spatial genetic structure of A. hippia in Japan to identify candidate source populations for reintroduction in extinct populations via multiplexed inter-simple sequence repeat genotyping by sequencing (MIG-seq) and mitochondrial DNA sequencing methods. The MIG-seq method indicated the presence of very few genetic differences among the populations. The mitochondrial DNA sequencing method identified two haplotypes: haplotype A in the Asama, Yatsugatake and northern Akaishi Mountains, and haplotype B in the central and southern Akaishi Mountains. The two haplotypes exhibited only a one base pair substitution between them.Implications for insect conservation: Based on these results, we suggest the existence of two conservation units: the first group consisting of populations in the Asama, Yatsugatake, and northern Akaishi Mountains, and the second group consisting of those in the central and southern Akaishi Mountains. According to this genetic proximity, however, all populations of A. hippia in Japan can also be defined as one conservation unit group, given the risk of inbreeding depression or difficulty of adaptation in different environments.
Keywords	Aporia ; Japan ; butterflies ; case studies ; endangered species ; genetic distance ; genetic structure ; genetic variation ; grasslands ; haplotypes ; microsatellite repeats ; mitochondrial DNA ; risk
Language	English
Dates of publication	2022-02
Size	p. 121-130.
Publishing place	Springer International Publishing
Document type	Article
ZDB-ID	1395198-1
ISSN	1572-9753 ; 1366-638X
ISSN (online)	1572-9753
ISSN	1366-638X
DOI	10.1007/s10841-022-00369-4
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Article ; Online: Nintedanib plus chemotherapy for nonsmall cell lung cancer with idiopathic pulmonary fibrosis: a randomised phase 3 trial.

Otsubo, Kohei / Kishimoto, Junji / Ando, Masahiko / Kenmotsu, Hirotsugu / Minegishi, Yuji / Horinouchi, Hidehito / Kato, Terufumi / Ichihara, Eiki / Kondo, Masashi / Atagi, Shinji / Tamiya, Motohiro / Ikeda, Satoshi / Harada, Toshiyuki / Takemoto, Shinnosuke / Hayashi, Hidetoshi / Nakatomi, Keita / Kimura, Yuichiro / Kondoh, Yasuhiro / Kusumoto, Masahiko /

Ichikado, Kazuya / Yamamoto, Nobuyuki / Nakagawa, Kazuhiko / Nakanishi, Yoichi / Okamoto, Isamu

The European respiratory journal

2022 Volume 60, Issue 6

Abstract: Background: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease implicated as an independent risk factor for lung cancer. However, optimal treatment for advanced lung cancer with IPF remains to be established. We performed a randomised phase 3 ... ...

Abstract	Background: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease implicated as an independent risk factor for lung cancer. However, optimal treatment for advanced lung cancer with IPF remains to be established. We performed a randomised phase 3 trial (J-SONIC) to assess the efficacy and safety of nintedanib plus chemotherapy (experimental arm) compared with chemotherapy alone (standard-of-care arm) for advanced nonsmall cell lung cancer (NSCLC) with IPF. Methods: Chemotherapy-naïve advanced NSCLC patients with IPF were allocated to receive carboplatin (area under the curve of 6 on day 1) plus nanoparticle albumin-bound paclitaxel (nab-paclitaxel) (100 mg·m Results: Between May 2017 and February 2020, 243 patients were enrolled. Median EFS was 14.6 months in the nintedanib plus chemotherapy group and 11.8 months in the chemotherapy group (hazard ratio (HR) 0.89, 90% CI 0.67-1.17; p=0.24), whereas median progression-free survival was 6.2 and 5.5 months, respectively (HR 0.68, 95% CI 0.50-0.92). Overall survival was improved by nintedanib in patients with nonsquamous histology (HR 0.61, 95% CI 0.40-0.93) and in those at GAP (gender-age-physiology) stage I (HR 0.61, 95% CI 0.38-0.98). Seven (2.9%) out of 240 patients experienced acute exacerbation during study treatment. Conclusions: The primary end-point of the study was not met. However, carboplatin plus nab-paclitaxel was found to be effective and tolerable in advanced NSCLC patients with IPF. Moreover, nintedanib in combination with such chemotherapy improved overall survival in patients with nonsquamous histology.
MeSH term(s)	Humans ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Carboplatin ; Carcinoma, Non-Small-Cell Lung/complications ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Idiopathic Pulmonary Fibrosis/complications ; Idiopathic Pulmonary Fibrosis/drug therapy ; Lung Neoplasms/complications ; Lung Neoplasms/drug therapy ; Paclitaxel ; Male ; Female
Chemical Substances	Carboplatin (BG3F62OND5) ; nintedanib (G6HRD2P839) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2022-12-15
Publishing country	England
Document type	Clinical Trial, Phase III ; Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.00380-2022
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