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Article ; Online: Technomyrmex montaseri sp. n., a new ant species of the T. gibbosus-group from Oman (Hymenoptera, Formicidae) with a key to the Technomyrmex species of the Arabian Peninsula.

Sharaf, Mostafa R / Collingwood, Cedric A / Aldawood, Abdulrahman S

2011 , Issue 108, Page(s) 11–19

Abstract: Technomyrmex montaserisp. n. is described and illustrated from Oman based on the worker caste ...

Abstract	Technomyrmex montaserisp. n. is described and illustrated from Oman based on the worker caste collected in Bani Sur. It belongs to the Technomyrmex gibbosus-group, with closest resemblance to Technomyrmex vexatus (Santschi, 1919) and Technomyrmex gibbosus W. M. Wheeler, 1906. A key to the Arabian Technomyrmex is given.
Language	English
Publishing date	2011-06-17
Publishing country	Bulgaria
Document type	Journal Article
ZDB-ID	2445640-8
ISSN	1313-2970 ; 1313-2989
ISSN (online)	1313-2970
ISSN	1313-2989
DOI	10.3897/zookeys.108.930
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Article ; Online: Technomyrmex montaseri sp. n., a new ant species of the T. gibbosus-group from Oman (Hymenoptera, Formicidae) with a key to the Technomyrmex species of the Arabian Peninsula

Mostafa Sharaf / Cedric Collingwood / Abdulrahman Aldawood

ZooKeys, Vol 108, Iss 0, Pp 11-

2011 Volume 19

Abstract: Technomyrmex montaseri sp. n. is described and illustrated from Oman based on the worker caste ... collected in Bani Sur. It belongs to the Technomyrmex gibbosus-group, with closest resemblance to T. vexatus ... Santschi, 1919) and T. gibbosus W. M. Wheeler, 1906. A key to the Arabian Technomyrmex is given. ...

Abstract	Technomyrmex montaseri sp. n. is described and illustrated from Oman based on the worker caste collected in Bani Sur. It belongs to the Technomyrmex gibbosus-group, with closest resemblance to T. vexatus (Santschi, 1919) and T. gibbosus W. M. Wheeler, 1906. A key to the Arabian Technomyrmex is given.
Keywords	Technomyrmex ; Palaearctic ; Middle East ; Alpha taxonomy ; Arabia ; Key ; Zoology ; QL1-991
Language	English
Publishing date	2011-06-01T00:00:00Z
Publisher	Pensoft Publishers
Document type	Article ; Online
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Article ; Online: Systemic Pharmacokinetics, Safety, and Preliminary Efficacy of Topical AhR Agonist Tapinarof: Results of a Phase 1 Study.

Bissonnette, Robert / Vasist, Lakshmi S / Bullman, Jonathan N / Collingwood, Therese / Chen, Geng / Maeda-Chubachi, Tomoko

Clinical pharmacology in drug development

2018 Volume 7, Issue 5, Page(s) 524–531

Abstract: ... Median T ...

Abstract	Tapinarof cream is a novel topical nonsteroidal agent that represents a unique class of anti-inflammatory molecules targeting the aryl hydrocarbon receptor. Study 201851 was an open-label, 2-cohort sequential study that assessed the systemic pharmacokinetics, safety, and efficacy of tapinarof in adults with moderate to severe atopic dermatitis. A total of 11 participants were enrolled: 5 received 2% cream, and 6 received 1% cream. Tapinarof was systemically absorbed, and measurable amounts were detected in both cohorts. Generally, plasma exposure was greater with the 2% cream and decreased from day 1 to day 21. Median T
MeSH term(s)	Administration, Topical ; Adult ; Dermatitis, Atopic/drug therapy ; Dose-Response Relationship, Drug ; Female ; Humans ; Male ; Middle Aged ; Resorcinols/administration & dosage ; Resorcinols/adverse effects ; Resorcinols/pharmacokinetics ; Stilbenes/administration & dosage ; Stilbenes/adverse effects ; Stilbenes/pharmacokinetics ; Treatment Outcome ; Young Adult
Chemical Substances	Resorcinols ; Stilbenes ; tapinarof (84HW7D0V04)
Language	English
Publishing date	2018-02-01
Publishing country	United States
Document type	Clinical Trial, Phase I ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649010-9
ISSN	2160-7648 ; 2160-763X
ISSN (online)	2160-7648
ISSN	2160-763X
DOI	10.1002/cpdd.439
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Article ; Online: School readiness of children at high risk of cerebral palsy r

Boyd, Roslyn N / Novak, Iona / Morgan, Catherine / Bora, Samudragupta / Sakzewski, Leanne / Ware, Robert S / Comans, Tracy / Fahey, Michael Collingwood / Whittingham, Koa / Trost, Stewart / Pannek, Kerstin / Pagnozzi, Alex / Mcintyre, Sarah / Badawi, Nadia / Smithers Sheedy, Hayley / Palmer, Kirsten Rebecca / Burgess, Andrea / Keramat, Afroz / Bell, Kristie /

Hines, Ashleigh / Benfer, Katherine / Gascoigne-Pees, Laura / Leishman, Shaneen / Oftedal, Stina

BMJ open

2023 Volume 13, Issue 2, Page(s) e068675

Abstract: ... n=425) recruited to four randomised trials of neuroprotectants (n=1), early neurorehabilitation (n=2 ... or early parenting support (n=1) will be re-recruited to one overarching follow-up study at age 4-6 ... compared with a historical control group of children (n=245) who were diagnosed with CP in their second ...

Abstract	Introduction: School readiness includes cognitive, socio-emotional, language and physical growth and development domains which share strong associations with life-course opportunities. Children with cerebral palsy (CP) are at increased risk of poor school readiness compared with their typically developing peers. Recently, earlier diagnosis of CP has allowed interventions to commence sooner, harnessing neuroplasticity. First, we hypothesise that early referral to intervention for children at-risk of CP will lead to improved school readiness at 4-6 years relative to placebo or care as usual. Second, we hypothesise that receipt of early diagnosis and early intervention will lead to cost-savings in the form of reduced healthcare utilisation. Methods and analysis: Infants identified as at-risk of CP ≤6 months corrected age (n=425) recruited to four randomised trials of neuroprotectants (n=1), early neurorehabilitation (n=2) or early parenting support (n=1) will be re-recruited to one overarching follow-up study at age 4-6 years 3 months. A comprehensive battery of standardised assessments and questionnaires will be administered to assess all domains of school readiness and associated risk factors. Participants will be compared with a historical control group of children (n=245) who were diagnosed with CP in their second year of life. Mixed-effects regression models will be used to compare school readiness outcomes between those referred for early intervention versus placebo/care-as-usual. We will also compare health-resource use associated with early diagnosis and intervention versus later diagnosis and intervention. Ethics and dissemination: The Children's Health Queensland Hospital and Health Service, The University of Queensland, University of Sydney, Monash University and Curtin University Human Research Ethics Committees have approved this study. Informed consent will be sought from the parent or legal guardian of every child invited to participate. Results will be disseminated in peer-reviewed journals, scientific conferences and professional organisations, and to people with lived experience of CP and their families. Trial registration number: ACTRN12621001253897.
MeSH term(s)	Infant ; Humans ; Child ; Child, Preschool ; Neuroprotection ; Cerebral Palsy ; Follow-Up Studies ; Hospitals, Pediatric ; Schools ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-02-27
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-068675
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Article ; Online: Synchrotron XRF imaging of Alzheimer's disease basal ganglia reveals linear dependence of high-field magnetic resonance microscopy on tissue iron concentration.

Finnegan, Mary E / Visanji, Naomi P / Romero-Canelon, Isolda / House, Emily / Rajan, Surya / Mosselmans, J Frederick W / Hazrati, Lili-Naz / Dobson, Jon / Collingwood, Joanna F

Journal of neuroscience methods

2019 Volume 319, Page(s) 28–39

Abstract: ... 7 T.: New method: Magnetic resonance microscopy at 9.4 T is used to calculate parametric images ... of chemically-unfixed post-mortem tissue from Alzheimer's cases (n = 3) and healthy controls (n = 2). Iron-rich ... of chemical elements on clinical imaging parameters.: Conclusion: The results at 9.4 T are in excellent quantitative ...

Abstract	Background: Chemical imaging of the human brain has great potential for diagnostic and monitoring purposes. The heterogeneity of human brain iron distribution, and alterations to this distribution in Alzheimer's disease, indicate iron as a potential endogenous marker. The influence of iron on certain magnetic resonance imaging (MRI) parameters increases with magnetic field, but is under-explored in human brain tissues above 7 T. New method: Magnetic resonance microscopy at 9.4 T is used to calculate parametric images of chemically-unfixed post-mortem tissue from Alzheimer's cases (n = 3) and healthy controls (n = 2). Iron-rich regions including caudate nucleus, putamen, globus pallidus and substantia nigra are analysed prior to imaging of total iron distribution with synchrotron X-ray fluorescence mapping. Iron fluorescence calibration is achieved with adjacent tissue blocks, analysed by inductively coupled plasma mass spectrometry or graphite furnace atomic absorption spectroscopy. Results: Correlated MR images and fluorescence maps indicate linear dependence of R Comparison with existing methods: This method permits simultaneous non-destructive imaging of most bioavailable elements. Iron is the focus of the present study as it offers strong scope for clinical evaluation; the approach may be used more widely to evaluate the impact of chemical elements on clinical imaging parameters. Conclusion: The results at 9.4 T are in excellent quantitative agreement with predictions from experiments performed at lower magnetic fields.
MeSH term(s)	Aged ; Aged, 80 and over ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/metabolism ; Basal Ganglia/chemistry ; Female ; Humans ; Image Processing, Computer-Assisted ; Iron/analysis ; Magnetic Resonance Imaging/methods ; Male ; Optical Imaging/instrumentation ; Optical Imaging/methods ; Synchrotrons
Chemical Substances	Iron (E1UOL152H7)
Language	English
Publishing date	2019-03-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	282721-9
ISSN	1872-678X ; 0165-0270
ISSN (online)	1872-678X
ISSN	0165-0270
DOI	10.1016/j.jneumeth.2019.03.002
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Article ; Online: Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells.

Nature medicine

2021 Volume 27, Issue 4, Page(s) 677–687

Abstract: β-Thalassemia pathology is due not only to loss of β-globin (HBB), but also to erythrotoxic accumulation and aggregation of the β-globin-binding partner, α-globin (HBA1/2). Here we describe a Cas9/AAV6-mediated genome editing strategy that can replace ... ...

Abstract	β-Thalassemia pathology is due not only to loss of β-globin (HBB), but also to erythrotoxic accumulation and aggregation of the β-globin-binding partner, α-globin (HBA1/2). Here we describe a Cas9/AAV6-mediated genome editing strategy that can replace the entire HBA1 gene with a full-length HBB transgene in β-thalassemia-derived hematopoietic stem and progenitor cells (HSPCs), which is sufficient to normalize β-globin:α-globin messenger RNA and protein ratios and restore functional adult hemoglobin tetramers in patient-derived red blood cells. Edited HSPCs were capable of long-term and bilineage hematopoietic reconstitution in mice, establishing proof of concept for replacement of HBA1 with HBB as a novel therapeutic strategy for curing β-thalassemia.
MeSH term(s)	Anemia, Sickle Cell/pathology ; Animals ; Antigens, CD34/metabolism ; Dependovirus/genetics ; Erythrocytes/metabolism ; Gene Editing ; Genes, Reporter ; Genetic Loci ; Genetic Therapy ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/metabolism ; Hemoglobins/metabolism ; Humans ; Mice ; Promoter Regions, Genetic/genetics ; alpha-Globins/genetics ; beta-Globins/genetics ; beta-Thalassemia/genetics ; beta-Thalassemia/therapy
Chemical Substances	Antigens, CD34 ; Hemoglobins ; alpha-Globins ; beta-Globins
Language	English
Publishing date	2021-03-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-021-01284-y
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Article ; Online: Identification of preexisting adaptive immunity to Cas9 proteins in humans.

Nature medicine

2019 Volume 25, Issue 2, Page(s) 249–254

Abstract: The CRISPR-Cas9 system is a powerful tool for genome editing, which allows the precise modification of specific DNA sequences. Many efforts are underway to use the CRISPR-Cas9 system to therapeutically correct human genetic ... ...

Abstract	The CRISPR-Cas9 system is a powerful tool for genome editing, which allows the precise modification of specific DNA sequences. Many efforts are underway to use the CRISPR-Cas9 system to therapeutically correct human genetic diseases
MeSH term(s)	Adaptive Immunity ; Adult ; CRISPR-Associated Protein 9/metabolism ; Cell Separation ; Female ; Humans ; Immunity, Humoral ; Male ; T-Lymphocytes/immunology
Chemical Substances	CRISPR-Associated Protein 9 (EC 3.1.-)
Language	English
Publishing date	2019-01-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-018-0326-x
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Article ; Online: AsCas12a ultra nuclease facilitates the rapid generation of therapeutic cell medicines.

Zhang, Liyang / Zuris, John A / Viswanathan, Ramya / Edelstein, Jasmine N / Turk, Rolf / Thommandru, Bernice / Rube, H Tomas / Glenn, Steve E / Collingwood, Michael A / Bode, Nicole M / Beaudoin, Sarah F / Lele, Swarali / Scott, Sean N / Wasko, Kevin M / Sexton, Steven / Borges, Christopher M / Schubert, Mollie S / Kurgan, Gavin L / McNeill, Matthew S /

Fernandez, Cecilia A / Myer, Vic E / Morgan, Richard A / Behlke, Mark A / Vakulskas, Christopher A

Nature communications

2021 Volume 12, Issue 1, Page(s) 3908

Abstract: ... T cells, and NK cells. We show that AsCas12a Ultra maintains high on-target specificity thereby mitigating ... We achieved simultaneous targeting of three clinically relevant genes in T cells at >90% efficiency and ...

Abstract	Though AsCas12a fills a crucial gap in the current genome editing toolbox, it exhibits relatively poor editing efficiency, restricting its overall utility. Here we isolate an engineered variant, "AsCas12a Ultra", that increased editing efficiency to nearly 100% at all sites examined in HSPCs, iPSCs, T cells, and NK cells. We show that AsCas12a Ultra maintains high on-target specificity thereby mitigating the risk for off-target editing and making it ideal for complex therapeutic genome editing applications. We achieved simultaneous targeting of three clinically relevant genes in T cells at >90% efficiency and demonstrated transgene knock-in efficiencies of up to 60%. We demonstrate site-specific knock-in of a CAR in NK cells, which afforded enhanced anti-tumor NK cell recognition, potentially enabling the next generation of allogeneic cell-based therapies in oncology. AsCas12a Ultra is an advanced CRISPR nuclease with significant advantages in basic research and in the production of gene edited cell medicines.
MeSH term(s)	Acidaminococcus/enzymology ; Acidaminococcus/genetics ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; CRISPR-Associated Proteins/genetics ; CRISPR-Associated Proteins/metabolism ; CRISPR-Cas Systems ; Cells, Cultured ; Endonucleases/genetics ; Endonucleases/metabolism ; Gene Editing/methods ; HEK293 Cells ; Hematopoietic Stem Cells/metabolism ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Jurkat Cells ; Killer Cells, Natural/metabolism ; Reproducibility of Results ; T-Lymphocytes/metabolism
Chemical Substances	Bacterial Proteins ; CRISPR-Associated Proteins ; Endonucleases (EC 3.1.-)
Language	English
Publishing date	2021-06-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-24017-8
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Article: Nuclear receptors: coactivators, corepressors and chromatin remodeling in the control of transcription.

Collingwood, T N / Urnov, F D / Wolffe, A P

Journal of molecular endocrinology

1999 Volume 23, Issue 3, Page(s) 255–275

Abstract: A contemporary view of hormone action at the transcriptional level requires knowledge of the transcription factors including the hormone receptor that may bind to promoters or enhancers, together with the chromosomal context within which these regulatory ...

Abstract	A contemporary view of hormone action at the transcriptional level requires knowledge of the transcription factors including the hormone receptor that may bind to promoters or enhancers, together with the chromosomal context within which these regulatory proteins function. Nuclear receptors provide the best examples of transcriptional control through the targeted recruitment of large protein complexes that modify chromosomal components and reversibly stabilize or destabilize chromatin. Ligand-dependent recruitment of transcriptional coactivators destabilizes chromatin by mechanisms including histone acetylation and contacts with the basal transcriptional machinery. In contrast, the recruitment of corepressors in the absence of ligand or in the presence of hormone antagonists serves to stabilize chromatin by the targeting of histone deacetylases. Both activation and repression require the action of other chromatin remodeling engines of the switch 2/sucrose non-fermentable 2 (SWI2/SNF2) class. Here we summarize this information and integrate hormone action into a chromatin context.
MeSH term(s)	Animals ; Chromatin/chemistry ; Chromatin/genetics ; Chromatin/metabolism ; Gene Expression Regulation/genetics ; Histone Deacetylases/metabolism ; Humans ; Mammary Tumor Virus, Mouse/genetics ; Promoter Regions, Genetic/genetics ; Receptors, Cytoplasmic and Nuclear/metabolism ; Receptors, Glucocorticoid/metabolism ; Receptors, Thyroid Hormone/metabolism ; Repressor Proteins/metabolism ; Trans-Activators/metabolism ; Transcription, Genetic/genetics
Chemical Substances	Chromatin ; Receptors, Cytoplasmic and Nuclear ; Receptors, Glucocorticoid ; Receptors, Thyroid Hormone ; Repressor Proteins ; Trans-Activators ; Histone Deacetylases (EC 3.5.1.98)
Language	English
Publishing date	1999-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	645012-x
ISSN	1479-6813 ; 0952-5041
ISSN (online)	1479-6813
ISSN	0952-5041
DOI	10.1677/jme.0.0230255
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Article ; Online: ENaC-mediated effects assessed by MRI in a rat model of hypertonic saline-induced lung hydration.

Blé, F-X / Cannet, C / Collingwood, S / Danahay, H / Beckmann, N

British journal of pharmacology

2010 Volume 160, Issue 4, Page(s) 1008–1015

Abstract: ... approach: Lung images from spontaneously breathing rats were acquired following intra-tracheal (i.t ... given i.t. prior to saline. Volumes of fluid signals were quantified on the images.: Key results ...

Abstract	Background and purpose: The epithelial sodium channel (ENaC) regulates airway mucosal hydration and mucus clearance. The lack of such regulation in cystic fibrosis patients leads to desiccation of the airway lumen, resulting in mucostasis that establishes the environment for infections. Osmotic agents and negative ENaC regulators can be used to restore mucosal hydration. We aimed to assess whether: (i) osmotically driven fluid flux into the rat lung could be quantified in vivo by magnetic resonance imaging (MRI); and (ii) the MRI signals could be modulated through the regulation of ENaC function. Experimental approach: Lung images from spontaneously breathing rats were acquired following intra-tracheal (i.t.) administration of physiological or hypertonic saline (HS). Compounds known to modulate the ENaC function were given i.t. prior to saline. Volumes of fluid signals were quantified on the images. Key results: A tonicity-dependent increase in lung fluid was demonstrated following HS administration. Pretreatment with the ENaC blockers, amiloride or 552-02, resulted in an enhancement of HS-induced lung fluid signals, which were detectable for up to 4 h, consistent with a role for ENaC in fluid clearance. Aprotinin, a serine protease inhibitor that attenuates ENaC function, likewise enhanced the HS-induced increase in lung fluid signal, while alpha(1)-anti-trypsin was without significant effect. Conclusions and implications: Proton MRI provides a non-invasive technique for studying modulators of lung fluid hydration in rat lung in vivo. The pharmacological sensitivity of MRI-detected fluid signals is consistent with ENaC-mediated fluid reabsorption after HS. This target-related readout may be used to characterize new ENaC modulators.
MeSH term(s)	Administration, Inhalation ; Amiloride/administration & dosage ; Amiloride/pharmacology ; Amiloride/therapeutic use ; Animals ; Aprotinin/administration & dosage ; Aprotinin/pharmacology ; Aprotinin/therapeutic use ; Body Water ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/physiopathology ; Cystic Fibrosis/therapy ; Dose-Response Relationship, Drug ; Epithelial Sodium Channel Blockers ; Epithelial Sodium Channels/physiology ; Extravascular Lung Water/physiology ; Fluid Shifts/drug effects ; Fluid Shifts/physiology ; Guanidines/administration & dosage ; Guanidines/pharmacology ; Guanidines/therapeutic use ; Lung/chemistry ; Lung/pathology ; Lung/physiology ; Magnetic Resonance Imaging/methods ; Male ; Mucociliary Clearance/drug effects ; Mucociliary Clearance/physiology ; Protease Inhibitors/administration & dosage ; Protease Inhibitors/pharmacology ; Protease Inhibitors/therapeutic use ; Pyrazines/administration & dosage ; Pyrazines/pharmacology ; Pyrazines/therapeutic use ; Rats ; Rats, Inbred BN ; Respiratory Mucosa/drug effects ; Respiratory Mucosa/physiology ; Saline Solution, Hypertonic/administration & dosage ; Sodium Channel Blockers/administration & dosage ; Sodium Channel Blockers/pharmacology ; Sodium Channel Blockers/therapeutic use ; Time Factors ; alpha 1-Antitrypsin/administration & dosage ; alpha 1-Antitrypsin/pharmacology
Chemical Substances	Epithelial Sodium Channel Blockers ; Epithelial Sodium Channels ; Guanidines ; N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-(4-(4-(2,3-dihydroxypropoxy)phenyl)butyl)guanidine ; Protease Inhibitors ; Pyrazines ; Saline Solution, Hypertonic ; Sodium Channel Blockers ; alpha 1-Antitrypsin ; Amiloride (7DZO8EB0Z3) ; Aprotinin (9087-70-1)
Language	English
Publishing date	2010-08-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/j.1476-5381.2010.00747.x
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