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  1. Article ; Online: Cellular plasticity: A mechanism for homeostasis in the kidney.

    Assmus, Adrienne M / Mullins, John J / Brown, Cara M / Mullins, Linda J

    Acta physiologica (Oxford, England)

    2020  Volume 229, Issue 1, Page(s) e13447

    Abstract: Cellular plasticity is a topical subject with interest spanning a wide range of fields from developmental biology to regenerative medicine. Even the nomenclature is a subject of debate, and the underlying mechanisms are still under investigation. On top ... ...

    Abstract Cellular plasticity is a topical subject with interest spanning a wide range of fields from developmental biology to regenerative medicine. Even the nomenclature is a subject of debate, and the underlying mechanisms are still under investigation. On top of injury repair, cell plasticity is a constant physiological process in adult organisms and tissues, in response to homeostatic challenges. In this review we discuss two examples of plasticity for the maintenance of homeostasis in the renal system-namely the renin-producing juxtaglomerular cells (JG cells) and cortical collecting duct (CCD) cells. JG cells show plasticity through recruitment mechanisms, answering the demand for an increase in renin production. In the CCD, cells appear to have the ability to transdifferentiate between principal and intercalated cells to help maintain the highly regulated solute transport levels of that segment. These two cases highlight the complexity of plasticity processes and the role they can play in the kidney.
    MeSH term(s) Animals ; Cell Plasticity ; Homeostasis ; Humans ; Kidney/cytology ; Kidney/metabolism ; Renin/metabolism
    Chemical Substances Renin (EC 3.4.23.15)
    Language English
    Publishing date 2020-02-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13447
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  2. Article ; Online: Loss of Adam10 Disrupts Ion Transport in Immortalized Kidney Collecting Duct Cells.

    Assmus, Adrienne / Mullins, Linda / Ward, Mairi / Dobie, Ross / Hunter, Robert / Henderson, Neil C / Mullins, John J

    Function (Oxford, England)

    2021  Volume 2, Issue 4, Page(s) zqab024

    Abstract: The kidney cortical collecting duct (CCD) comprises principal cells (PCs), intercalated cells (IC), and the recently discovered intermediate cell type. Kidney pathology in a mouse model of the syndrome of apparent aldosterone excess revealed plasticity ... ...

    Abstract The kidney cortical collecting duct (CCD) comprises principal cells (PCs), intercalated cells (IC), and the recently discovered intermediate cell type. Kidney pathology in a mouse model of the syndrome of apparent aldosterone excess revealed plasticity of the CCD, with altered PC:intermediate cell:IC ratio. The self-immortalized mouse CCD cell line, mCCD
    MeSH term(s) Animals ; Mice ; ADAM10 Protein/genetics ; Aldosterone/metabolism ; Amyloid Precursor Protein Secretases/genetics ; Cell Line ; Ion Transport/physiology ; Kidney Tubules, Collecting/metabolism ; Membrane Proteins/genetics
    Chemical Substances ADAM10 Protein (EC 3.4.24.81) ; Adam10 protein, mouse (EC 3.4.24.81) ; Aldosterone (4964P6T9RB) ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; Membrane Proteins
    Language English
    Publishing date 2021-05-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2633-8823
    ISSN (online) 2633-8823
    DOI 10.1093/function/zqab024
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  3. Article ; Online: Research Synthesis, HIV Prevention Response, and Public Health: CDC's HIV/AIDS Prevention Research Synthesis Project.

    Koenig, Linda J / Lyles, Cynthia M / Higa, Darrel / Mullins, Mary M / Sipe, Theresa A

    Public health reports (Washington, D.C. : 1974)

    2021  Volume 137, Issue 1, Page(s) 32–47

    Abstract: Objective: Research synthesis, through qualitative or quantitative systematic reviews, allows for integrating results of primary research to improve public health. We examined more than 2 decades of work in HIV prevention by the Centers for Disease ... ...

    Abstract Objective: Research synthesis, through qualitative or quantitative systematic reviews, allows for integrating results of primary research to improve public health. We examined more than 2 decades of work in HIV prevention by the Centers for Disease Control and Prevention's (CDC's) HIV/AIDS Prevention Research Synthesis (PRS) Project. We describe the context and contributions of research synthesis, including systematic reviews and meta-analyses, through the experience of the PRS Project.
    Methods: We reviewed PRS Project publications and products and summarized PRS contributions from 1996 to July 2020 in 4 areas: synthesis of interventions and epidemiologic studies, synthesis methods, prevention programs, and prevention policy.
    Results: PRS Project publications summarized risk behaviors and effects of prevention interventions (eg, changing one's perception of risk, teaching condom negotiation skills) across populations at risk for HIV infection and intervention approaches (eg, one-on-one or group meetings) as the HIV/AIDS epidemic and science evolved. We used the PRS Project cumulative database and intervention efficacy reviews to contribute to prevention programs and policies through identification of evidence-based interventions and development of program guidance. Subject matter experts and scientific evidence informed PRS Project products and contributions, which were implemented through strategic programmatic partnerships.
    Conclusions: The contributions of the PRS Project to HIV prevention and public health efforts in the United States can be credited to CDC's long-standing support of the project and its context within a federal prevention agency, where HIV programs and policies were developed and implemented. The effect of the PRS Project was likely facilitated by opportunities to directly influence program and policy because of connections with other research translation activities and program and policy decision making within CDC.
    MeSH term(s) Acquired Immunodeficiency Syndrome/prevention & control ; Centers for Disease Control and Prevention, U.S. ; Epidemiologic Studies ; HIV Infections/prevention & control ; Humans ; Policy ; Primary Prevention/organization & administration ; Public Health ; Research/organization & administration ; Research Design ; United States
    Language English
    Publishing date 2021-02-26
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Systematic Review
    ZDB-ID 120953-x
    ISSN 1468-2877 ; 0033-3549
    ISSN (online) 1468-2877
    ISSN 0033-3549
    DOI 10.1177/0033354920988871
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  4. Article ; Online: Transdermal Measurement of Glomerular Filtration Rate in Preclinical Research.

    Mullins, Thomas P / Schock-Kusch, Daniel / Gallo, Linda A

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2664, Page(s) 309–315

    Abstract: The measurement of glomerular filtration rate (GFR) is essential to understanding renal physiology, including the monitoring of disease progression and treatment effectiveness. Transdermal measurement of glomerular filtration rate (tGFR) using a ... ...

    Abstract The measurement of glomerular filtration rate (GFR) is essential to understanding renal physiology, including the monitoring of disease progression and treatment effectiveness. Transdermal measurement of glomerular filtration rate (tGFR) using a miniaturized fluorescence monitor in combination with a fluorescent exogenous GFR tracer has become a common technique to measure GFR in the preclinical setting, especially in rodent models. It allows for close to real-time measurement of GFR in conscious unrestrained animals and overcomes several limitations of other GFR measures. Its widespread use is reflected by published research articles and conference abstracts from different research fields, including in the assessment of new and existing kidney therapeutics, evaluation of nephrotoxicity, screening of novel chemical or medical agents, and fundamental understanding of kidney function.
    MeSH term(s) Animals ; Glomerular Filtration Rate/physiology ; Kidney/physiology ; Kidney Function Tests/methods ; Administration, Cutaneous ; Coloring Agents
    Chemical Substances Coloring Agents
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3179-9_19
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  5. Article ; Online: Why Aren't Sexual Orientation and Gender Identity Being Measured and What Role Do Cancer Researchers Play?

    Mullins, Megan A / Matthews, Phoenix A / Plascak, Jesse J / Hastert, Theresa A / Ko, Linda K / Gray, Marquita S / Molina, Yamilé

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

    2020  Volume 29, Issue 9, Page(s) 1837–1839

    MeSH term(s) Female ; Gender Identity ; Humans ; Male ; Neoplasms/epidemiology ; Research ; Sexual Behavior/statistics & numerical data
    Language English
    Publishing date 2020-07-10
    Publishing country United States
    Document type Journal Article ; Technical Report
    ZDB-ID 1153420-5
    ISSN 1538-7755 ; 1055-9965
    ISSN (online) 1538-7755
    ISSN 1055-9965
    DOI 10.1158/1055-9965.EPI-20-0540
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    Zs.A 3693: Show issues Location:
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  6. Article ; Online: scRNA Transcription Profile of Adult Zebrafish Podocytes Using a Novel Reporter Strain.

    Brown, Cara / Mullins, Linda J / Wesencraft, Katrina / McConnell, Gail / Beltran, Mariana / Henderson, Neil C / Conway, Bryan / Hoffmann, Scott / Rider, Sebastian / Mullins, John J

    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

    2021  Volume 55, Issue S4, Page(s) 35–47

    Abstract: Background/aims: The role of podocytes is well conserved across species from drosophila to teleosts, and mammals. Identifying the molecular markers that actively maintain the integrity of the podocyte will enable a greater understanding of the changes ... ...

    Abstract Background/aims: The role of podocytes is well conserved across species from drosophila to teleosts, and mammals. Identifying the molecular markers that actively maintain the integrity of the podocyte will enable a greater understanding of the changes that lead to damage.
    Methods: We generated transgenic zebrafish, expressing fluorescent reporters driven by the podocin promoter, for the visualization and isolation of podocytes. We have conducted single cell RNA sequencing (scRNA-seq) on isolated podocytes from a zebrafish reporter line.
    Results: We demonstrated that the LifeAct-TagRFP-T fluorescent reporter faithfully replicated podocin expression in vivo. We were also able to show spontaneous GCaMP6s fluorescence using light sheet (single plane illumination) microscopy. We identified many podocyte transcripts, encoding proteins related to calcium-binding and actin filament assembly, in common with those expressed in human and mouse mature podocytes.
    Conclusion: We describe the establishment of novel transgenic zebrafish and their use to identify and isolate podocyte cells for the preparation of a scRNA-seq library from normal podocytes. The scRNA-seq data identifies distinct populations of cells and potential gene switching between clusters. These data provide a foundation for future comparative studies and for exploiting the zebrafish as a model for kidney development, disease, injury and repair.
    MeSH term(s) Animals ; Animals, Genetically Modified/genetics ; Gene Expression Profiling ; Podocytes/metabolism ; RNA, Small Cytoplasmic/genetics ; Transcriptome ; Zebrafish/genetics
    Chemical Substances RNA, Small Cytoplasmic
    Language English
    Publishing date 2021-05-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1067572-3
    ISSN 1421-9778 ; 1015-8987
    ISSN (online) 1421-9778
    ISSN 1015-8987
    DOI 10.33594/000000366
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  7. Article ; Online: Investigating the RAS can be a fishy business: interdisciplinary opportunities using Zebrafish.

    Hoffmann, Scott / Mullins, Linda / Buckley, Charlotte / Rider, Sebastien / Mullins, John

    Clinical science (London, England : 1979)

    2018  Volume 132, Issue 23, Page(s) 2469–2481

    Abstract: The renin-angiotensin system (RAS) is highly conserved, and components of the RAS are present in all vertebrates to some degree. Although the RAS has been studied since the discovery of renin, its biological role continues to broaden with the ... ...

    Abstract The renin-angiotensin system (RAS) is highly conserved, and components of the RAS are present in all vertebrates to some degree. Although the RAS has been studied since the discovery of renin, its biological role continues to broaden with the identification and characterization of new peptides. The evolutionarily distant zebrafish is a remarkable model for studying the kidney due to its genetic tractability and accessibility for
    MeSH term(s) Angiotensin Receptor Antagonists/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Animals, Genetically Modified ; Gene Expression Regulation, Developmental ; Kidney Diseases/chemically induced ; Kidney Diseases/genetics ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Pronephros/drug effects ; Pronephros/metabolism ; Pronephros/pathology ; Renin-Angiotensin System/drug effects ; Renin-Angiotensin System/genetics ; Signal Transduction ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish/metabolism ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Luminescent Proteins ; Zebrafish Proteins
    Language English
    Publishing date 2018-12-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20180721
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  8. Article ; Online: Abnormal neonatal sodium handling in skin precedes hypertension in the SAME rat.

    Mullins, Linda / Ivy, Jessica / Ward, Mairi / Tenstad, Olav / Wiig, Helge / Kitada, Kento / Manning, Jon / Rakova, Natalia / Muller, Dominik / Mullins, John

    Pflugers Archiv : European journal of physiology

    2021  Volume 473, Issue 6, Page(s) 897–910

    Abstract: We discovered high ... ...

    Abstract We discovered high Na
    MeSH term(s) 11-beta-Hydroxysteroid Dehydrogenase Type 2/genetics ; 11-beta-Hydroxysteroid Dehydrogenase Type 2/metabolism ; Animals ; Blood Pressure ; Kidney/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mineralocorticoid Excess Syndrome, Apparent/genetics ; Mineralocorticoid Excess Syndrome, Apparent/metabolism ; Mineralocorticoid Excess Syndrome, Apparent/physiopathology ; Rats ; Rats, Inbred F344 ; Rats, Sprague-Dawley ; Skin/metabolism ; Sodium/metabolism
    Chemical Substances Sodium (9NEZ333N27) ; 11-beta-Hydroxysteroid Dehydrogenase Type 2 (EC 1.1.1.146)
    Language English
    Publishing date 2021-05-24
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-021-02582-7
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  9. Article: Not so Dangerous After All? Venom Composition and Potency of the Pholcid (Daddy Long-Leg) Spider

    Zobel-Thropp, Pamela A / Mullins, Jennifer / Kristensen, Charles / Kronmiller, Brent A / David, Cynthia L / Breci, Linda A / Binford, Greta J

    Frontiers in ecology and evolution

    2019  Volume 7

    Abstract: Pholcid spiders (Araneae: Pholcidae), officially "cellar spiders" but popularly known as "daddy long-legs," are renown for the potential of deadly toxic venom, even though venom composition and potency has never formally been studied. Here we detail the ... ...

    Abstract Pholcid spiders (Araneae: Pholcidae), officially "cellar spiders" but popularly known as "daddy long-legs," are renown for the potential of deadly toxic venom, even though venom composition and potency has never formally been studied. Here we detail the venom composition of male
    Language English
    Publishing date 2019-07-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2745634-1
    ISSN 2296-701X
    ISSN 2296-701X
    DOI 10.3389/fevo.2019.00256
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  10. Article ; Online: Noise Exposure on Mixed Grain and Livestock Farms in Western Australia.

    Mead-Hunter, Ryan / Selvey, Linda A / Rumchev, Krassi B / Netto, Kevin J / Mullins, Benjamin J

    Annals of work exposures and health

    2018  Volume 63, Issue 3, Page(s) 305–315

    Abstract: Noise presents an ongoing occupational health and safety issue, which despite numerous studies still presents a significant risk in agriculture with high exposures prevalent. In this study, we measured noise exposures associated with significant ... ...

    Abstract Noise presents an ongoing occupational health and safety issue, which despite numerous studies still presents a significant risk in agriculture with high exposures prevalent. In this study, we measured noise exposures associated with significant activities on 42 mixed grain and livestock farms in Western Australia. Employing a mixture of personal noise measurements using dosimeters, noise measurements using sound level meters, and a validated survey, we identified that 32% of farm workers were exposed to noise levels above the LAeq,8h 85 dB(A) limit, before considering extended shifts. We also noted that extended shift lengths, of up to 16 h in some cases, were possible. In addition, we found that 37% of workers were exposed to noise peak of 140 dB(C) or greater. It was further noted that hearing protection is not typically worn for the duration of an activity and is only for a small number of tasks. However we did find some evidence that farmers had begun to implement some form of noise management practice, usually in the form of buying quieter equipment or separating noisy tasks from quiet tasks. Improved education for farmer and farm workers in terms of the risks posed by noise, identifying noisy tasks, is recommended, as well as a programme to encourage better and consistent use of hearing protection.
    MeSH term(s) Agriculture ; Farms ; Humans ; Noise, Occupational ; Occupational Exposure/analysis ; Occupational Health ; Western Australia
    Language English
    Publishing date 2018-12-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2885096-8
    ISSN 2398-7316 ; 2398-7308
    ISSN (online) 2398-7316
    ISSN 2398-7308
    DOI 10.1093/annweh/wxy105
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