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  1. Article ; Online: IFN-γ and CD38 in AML: a T-cell engagement made in heaven?

    Lamble, Adam J / Rau, Rachel E

    Blood

    2024  Volume 143, Issue 16, Page(s) 1556–1557

    MeSH term(s) Humans ; Leukemia, Myeloid, Acute ; T-Lymphocytes ; ADP-ribosyl Cyclase 1 ; Interferon-gamma
    Chemical Substances ADP-ribosyl Cyclase 1 (EC 3.2.2.6) ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023023786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Fusion and flow: refining risk prediction in

    Conneely, Shannon E / Rau, Rachel E

    Translational pediatrics

    2023  Volume 12, Issue 12, Page(s) 2099–2102

    Language English
    Publishing date 2023-11-30
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2901309-4
    ISSN 2224-4344 ; 2224-4344 ; 2224-4336
    ISSN (online) 2224-4344
    ISSN 2224-4344 ; 2224-4336
    DOI 10.21037/tp-23-436
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  3. Article ; Online: A viral cause of APL.

    Rau, Rachel E

    Blood

    2021  Volume 138, Issue 18, Page(s) 1653–1655

    MeSH term(s) Antibodies, Antiphospholipid ; Viral Proteins
    Chemical Substances Antibodies, Antiphospholipid ; Viral Proteins
    Language English
    Publishing date 2021-11-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021013630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: SIRPAssing other xenograft murine models?

    Rau, Rachel E

    Blood

    2020  Volume 135, Issue 19, Page(s) 1612–1614

    MeSH term(s) Animals ; Antigens, Differentiation ; Disease Models, Animal ; Hematopoietic Stem Cell Transplantation ; Heterografts ; Humans ; Mice ; Neoplasms ; Neoplastic Stem Cells ; Receptors, Immunologic ; Xenograft Model Antitumor Assays
    Chemical Substances Antigens, Differentiation ; Receptors, Immunologic ; SIRPA protein, human
    Language English
    Publishing date 2020-05-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020005554
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  5. Article: Current Use of Asparaginase in Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma.

    Maese, Luke / Rau, Rachel E

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 902117

    Abstract: Pediatric Acute Lymphoblastic Leukemia (ALL) cure rates have improved exponentially over the past five decades with now over 90% of children achieving long-term survival. A direct contributor to this remarkable feat is the development and expanded ... ...

    Abstract Pediatric Acute Lymphoblastic Leukemia (ALL) cure rates have improved exponentially over the past five decades with now over 90% of children achieving long-term survival. A direct contributor to this remarkable feat is the development and expanded understanding of combination chemotherapy. Asparaginase is the most recent addition to the ALL chemotherapy backbone and has now become a hallmark of therapy. It is generally accepted that the therapeutic effects of asparaginase is due to depletion of the essential amino acid asparagine, thus occupying a unique space within the therapeutic landscape of ALL. Pharmacokinetic and pharmacodynamic profiling have allowed a detailed and accessible insight into the biochemical effects of asparaginase resulting in regular clinical use of therapeutic drug monitoring (TDM). Asparaginase's derivation from bacteria, and in some cases conjugation with a polyethylene glycol (PEG) moiety, have contributed to a unique toxicity profile with hypersensitivity reactions being the most salient. Hypersensitivity, along with several other toxicities, has limited the use of asparaginase in some populations of ALL patients. Both TDM and toxicities have contributed to the variety of approaches to the incorporation of asparaginase into the treatment of ALL. Regardless of the approach to asparagine depletion, it has continually demonstrated to be among the most important components of ALL therapy. Despite regular use over the past 50 years, and its incorporation into the standard of care treatment for ALL, there remains much yet to be discovered and ample room for improvement within the utilization of asparaginase therapy.
    Language English
    Publishing date 2022-06-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.902117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: CMML/JMML PDXs: as easy as 1, 2, NSG-SGM3.

    Rau, Rachel E

    Blood

    2017  Volume 130, Issue 4, Page(s) 385–386

    MeSH term(s) Animals ; Disease Models, Animal ; Humans ; Leukemia, Myelomonocytic, Chronic ; Leukemia, Myelomonocytic, Juvenile
    Language English
    Publishing date 2017-07-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-06-789123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Corrigendum: Murine models of acute myeloid leukemia.

    Kurtz, Kristen J / Conneely, Shannon E / O'Keefe, Madeleine / Wohlan, Katharina / Rau, Rachel E

    Frontiers in oncology

    2023  Volume 12, Page(s) 1089874

    Abstract: This corrects the article DOI: 10.3389/fonc.2022.854973.]. ...

    Abstract [This corrects the article DOI: 10.3389/fonc.2022.854973.].
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1089874
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  8. Article ; Online: Beyond KIT in CBF-AML: chromatin and cohesin.

    Rau, Rachel E

    Blood

    2016  Volume 127, Issue 20, Page(s) 2370–2371

    MeSH term(s) Cell Cycle Proteins ; Chromatin ; Chromosomal Proteins, Non-Histone ; Core Binding Factors/genetics ; Leukemia, Myeloid, Acute ; Cohesins
    Chemical Substances Cell Cycle Proteins ; Chromatin ; Chromosomal Proteins, Non-Histone ; Core Binding Factors
    Language English
    Publishing date 2016-05-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2016-03-707083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Temporal trends of hysterectomy modality for premalignant gynecologic pathology in the United States, 2016-2019.

    Mann, Pavan K / Rau, Alesandra R / Mandelbaum, Rachel S / Roman, Lynda D / Matsuo, Koji

    Journal of surgical oncology

    2023  Volume 127, Issue 6, Page(s) 1079–1081

    MeSH term(s) Female ; United States ; Humans ; Hysterectomy ; Uterine Neoplasms/surgery ; Precancerous Conditions ; Retrospective Studies
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 82063-5
    ISSN 1096-9098 ; 0022-4790
    ISSN (online) 1096-9098
    ISSN 0022-4790
    DOI 10.1002/jso.27212
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  10. Article ; Online: The genomics of acute myeloid leukemia in children.

    Conneely, Shannon E / Rau, Rachel E

    Cancer metastasis reviews

    2020  Volume 39, Issue 1, Page(s) 189–209

    Abstract: Acute myeloid leukemia (AML) is a clinically, morphologically, and genetically heterogeneous disorder. Like many malignancies, the genomic landscape of pediatric AML has been mapped recently through sequencing of large cohorts of patients. Much has been ... ...

    Abstract Acute myeloid leukemia (AML) is a clinically, morphologically, and genetically heterogeneous disorder. Like many malignancies, the genomic landscape of pediatric AML has been mapped recently through sequencing of large cohorts of patients. Much has been learned about the biology of AML through studies of specific recurrent genetic lesions. Further, genetic lesions have been linked to specific clinical features, response to therapy, and outcome, leading to improvements in risk stratification. Lastly, targeted therapeutic approaches have been developed for the treatment of specific genetic lesions, some of which are already having a positive impact on outcomes. While the advances made based on the discoveries of sequencing studies are significant, much work is left. The biologic, clinical, and prognostic impact of a number of genetic lesions, including several seemingly unique to pediatric patients, remains undefined. While targeted approaches are being explored, for most, the efficacy and tolerability when incorporated into standard therapy is yet to be determined. Furthermore, the challenge of how to study small subpopulations with rare genetic lesions in an already rare disease will have to be considered. In all, while questions and challenges remain, precisely defining the genomic landscape of AML, holds great promise for ultimately leading to improved outcomes for affected patients.
    MeSH term(s) Child ; Genomics/methods ; Humans ; Leukemia, Myeloid, Acute/genetics ; Prognosis
    Language English
    Publishing date 2020-01-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 604857-2
    ISSN 1573-7233 ; 0167-7659
    ISSN (online) 1573-7233
    ISSN 0167-7659
    DOI 10.1007/s10555-020-09846-1
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