LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU=Ye Keqiang
  2. AU="Huda, Walter"
  3. AU="Petrova, Polina E"
  4. AU="Pond, Gregory"
  5. AU=Krzewski Konrad
  6. AU="Feng, Yuquan"
  7. AU="Schmermund, Ben Niklas"
  8. AU="Soni, Payal D"
  9. AU="Romero-García, Carolina"
  10. AU="Petty, Lloyd"
  11. AU="James E. Posey"

Search results

Result 1 - 10 of total 324

Search options

  1. Article ; Online: A promising PET tracer candidate targeting α-synuclein inclusions.

    Xiang, Jie / Zhang, Zhentao / Ye, Keqiang

    Clinical and translational medicine

    2023  Volume 13, Issue 9, Page(s) e1408

    MeSH term(s) alpha-Synuclein ; Positron-Emission Tomography
    Chemical Substances alpha-Synuclein
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Letter
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1408
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: A promising PET tracer candidate targeting α‐synuclein inclusions

    Jie Xiang / Zhentao Zhang / Keqiang Ye

    Clinical and Translational Medicine, Vol 13, Iss 9, Pp n/a-n/a (2023)

    2023  

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Protocol for screening α-synuclein PET tracer candidates in vitro and ex vivo

    Jie Xiang / Yiyuan Xia / Shilin Luo / Zhentao Zhang / Keqiang Ye

    STAR Protocols, Vol 5, Iss 1, Pp 102788- (2024)

    1481  

    Abstract: Summary: Alpha-synuclein (α-Syn) positron emission tomography (PET) imaging is a valuable approach for diagnosing and monitoring synucleinopathies-related diseases, such as Parkinson disease. Here, we present a protocol for screening potential α-Syn PET ... ...

    Abstract Summary: Alpha-synuclein (α-Syn) positron emission tomography (PET) imaging is a valuable approach for diagnosing and monitoring synucleinopathies-related diseases, such as Parkinson disease. Here, we present a protocol for screening potential α-Syn PET tracers using in vitro and ex vivo approaches. We describe steps for employing recombinant pre-formed fibrils and conducting screening procedures on neuronal models, mouse models, and patients’ brain tissue sections to assess the specificity and selectivity of the candidate compounds.For complete details on the use and execution of this protocol, please refer to Xiang et al. (2023).1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
    Keywords Model Organisms ; Neuroscience ; Molecular/Chemical Probes ; Science (General) ; Q1-390
    Language English
    Publishing date 2024-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: C/EBPβ/AEP Signaling Drives Alzheimer's Disease Pathogenesis.

    Xiong, Jing / Zhang, Zhentao / Ye, Keqiang

    Neuroscience bulletin

    2023  Volume 39, Issue 7, Page(s) 1173–1185

    Abstract: Alzheimer's disease (AD) is the most common type of dementia. Almost two-thirds of patients with AD are female. The reason for the higher susceptibility to AD onset in women is unclear. However, hormone changes during the menopausal transition are known ... ...

    Abstract Alzheimer's disease (AD) is the most common type of dementia. Almost two-thirds of patients with AD are female. The reason for the higher susceptibility to AD onset in women is unclear. However, hormone changes during the menopausal transition are known to be associated with AD. Most recently, we reported that follicle-stimulating hormone (FSH) promotes AD pathology and enhances cognitive dysfunctions via activating the CCAAT-enhancer-binding protein (C/EBPβ)/asparagine endopeptidase (AEP) pathway. This review summarizes our current understanding of the crucial role of the C/EBPβ/AEP pathway in driving AD pathogenesis by cleaving multiple critical AD players, including APP and Tau, explaining the roles and the mechanisms of FSH in increasing the susceptibility to AD in postmenopausal females. The FSH-C/EBPβ/AEP pathway may serve as a novel therapeutic target for the treatment of AD.
    MeSH term(s) Female ; Humans ; Male ; Alzheimer Disease/pathology ; CCAAT-Enhancer-Binding Protein-beta/metabolism ; Cognitive Dysfunction/metabolism ; Signal Transduction ; Follicle Stimulating Hormone
    Chemical Substances CCAAT-Enhancer-Binding Protein-beta ; Follicle Stimulating Hormone (9002-68-0)
    Language English
    Publishing date 2023-02-03
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2419741-5
    ISSN 1995-8218 ; 1673-7067
    ISSN (online) 1995-8218
    ISSN 1673-7067
    DOI 10.1007/s12264-023-01025-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6734: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Protocol for screening α-synuclein PET tracer candidates in vitro and ex vivo.

    Xiang, Jie / Xia, Yiyuan / Luo, Shilin / Zhang, Zhentao / Ye, Keqiang

    STAR protocols

    2023  Volume 5, Issue 1, Page(s) 102788

    Abstract: Alpha-synuclein (α-Syn) positron emission tomography (PET) imaging is a valuable approach for diagnosing and monitoring synucleinopathies-related diseases, such as Parkinson disease. Here, we present a protocol for screening potential α-Syn PET tracers ... ...

    Abstract Alpha-synuclein (α-Syn) positron emission tomography (PET) imaging is a valuable approach for diagnosing and monitoring synucleinopathies-related diseases, such as Parkinson disease. Here, we present a protocol for screening potential α-Syn PET tracers using in vitro and ex vivo approaches. We describe steps for employing recombinant pre-formed fibrils and conducting screening procedures on neuronal models, mouse models, and patients' brain tissue sections to assess the specificity and selectivity of the candidate compounds. For complete details on the use and execution of this protocol, please refer to Xiang et al. (2023).
    MeSH term(s) Mice ; Animals ; Humans ; alpha-Synuclein ; Parkinson Disease/diagnostic imaging ; Positron-Emission Tomography
    Chemical Substances alpha-Synuclein
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102788
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Thy1-ApoE4/C/EBPβ double transgenic mice act as a sporadic model with Alzheimer's disease.

    Qian, Zhengjiang / Wang, ZhiHao / Li, Bowei / Meng, Xin / Kuang, Zhonghua / Li, Yanjiao / Yang, Yongfeng / Ye, Keqiang

    Molecular psychiatry

    2024  

    Abstract: Early onset familial Alzheimer's disease (FAD) with APP, PS1/2 (presenilins) mutation accounts for only a small portion of AD cases, and most are late-onset sporadic. However, majority of AD mouse models are developed to mimic the genetic cause of human ... ...

    Abstract Early onset familial Alzheimer's disease (FAD) with APP, PS1/2 (presenilins) mutation accounts for only a small portion of AD cases, and most are late-onset sporadic. However, majority of AD mouse models are developed to mimic the genetic cause of human AD by overexpressing mutated forms of human APP, PS1/2, and/or Tau protein, though there is no Tau mutation in AD, and no single mouse model recapitulates all aspects of AD pathology. Here, we report Thy1-ApoE4/C/EBPβ double transgenic mouse model that demonstrates key AD pathologies in an age-dependent manner in absence of any human APP or PS1/2 mutation. Using the clinical diagnosis criteria, we show that this mouse model exhibits tempo-spatial features in AD patient brains, including progressive cognitive decline associated with brain atrophy, which is accompanied with extensive neuronal degeneration. Remarkably, the mice display gradual Aβ aggregation and neurofibrillary tangles formation in the brain validated by Aβ PET and Tau PET. Moreover, the mice reveal widespread neuroinflammation as shown in AD brains. Hence, Thy1-ApoE4/C/EBPβ mouse model acts as a sporadic AD mouse model, reconstituting the major AD pathologies.
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-024-02565-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4812: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Author Correction: Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth.

    Qi, Qi / Liu, Xia / Li, Shiyong / Joshi, Harish C / Ye, Keqiang

    Acta pharmacologica Sinica

    2021  Volume 43, Issue 4, Page(s) 1100

    Language English
    Publishing date 2021-09-03
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1360774-1
    ISSN 1745-7254 ; 0253-9756 ; 1671-4083
    ISSN (online) 1745-7254
    ISSN 0253-9756 ; 1671-4083
    DOI 10.1038/s41401-021-00762-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1904: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: The development and application of advanced analytical methods in microplastics contamination detection: A critical review.

    Ye, Yongkai / Yu, Keqiang / Zhao, Yanru

    The Science of the total environment

    2021  Volume 818, Page(s) 151851

    Abstract: Microplastics have gradually become emerging environmental contaminants for their extensive distribution, small particle size, and harmful effects on organisms. Therefore, finding accurate, efficient, and rapid analytical methods for detecting ... ...

    Abstract Microplastics have gradually become emerging environmental contaminants for their extensive distribution, small particle size, and harmful effects on organisms. Therefore, finding accurate, efficient, and rapid analytical methods for detecting microplastics pollution has become an urgent problem. We reviewed the derivation, transport, and classification of microplastics and then highlighted the harmfulness of microplastics which would bring microplastics pollution to the environment and potential damage to organisms. Further, various analytical methods were classified into the thermal analytical method, spectral analytical approach, and other analytical methods based on detection principles. In addition, the application of each analytical method in sea and soil was concluded in detail, and the promising development prospect of each analytical method was discussed. In the end, the chemical analytical method was proposed to explore further in the direction of no sample preparation, nondestructive analysis, low detection limit and it is crucial to establish a unified detection and identification method for microplastics in different environments.
    MeSH term(s) Environmental Monitoring ; Environmental Pollution/analysis ; Microplastics ; Plastics/analysis ; Soil ; Water Pollutants, Chemical/analysis
    Chemical Substances Microplastics ; Plastics ; Soil ; Water Pollutants, Chemical
    Language English
    Publishing date 2021-11-22
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2021.151851
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: The development and application of advanced analytical methods in microplastics contamination detection: A critical review

    Ye, Yongkai / Yu, Keqiang / Zhao, Yanru

    Science of the total environment. 2021 Nov. 17,

    2021  

    Abstract: Microplastics have gradually become emerging environmental contaminants for their extensive distribution, small particle size, and harmful effects on organisms. Therefore, finding accurate, efficient, and rapid analytical methods for detecting ... ...

    Abstract Microplastics have gradually become emerging environmental contaminants for their extensive distribution, small particle size, and harmful effects on organisms. Therefore, finding accurate, efficient, and rapid analytical methods for detecting microplastics pollution has become an urgent problem. We reviewed the derivation, transport, and classification of microplastics and then highlighted the harmfulness of microplastics which would bring microplastics pollution to the environment and potential damage to organisms. Further, various analytical methods were classified into the thermal analytical method, spectral analytical approach, and other analytical methods based on detection principles. In addition, the application of each analytical method in sea and soil was concluded in detail, and the promising development prospect of each analytical method was discussed. In the end, the chemical analytical method was proposed to explore further in the direction of no sample preparation, nondestructive analysis, low detection limit and it is crucial to establish a unified detection and identification method for microplastics in different environments.
    Keywords analytical methods ; detection limit ; environment ; microplastics ; nondestructive methods ; particle size ; pollution ; soil
    Language English
    Dates of publication 2021-1117
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2021.151851
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 74/341: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease

    Seong Su Kang / Eun Hee Ahn / Keqiang Ye

    Experimental and Molecular Medicine, Vol 52, Iss 8, Pp 1275-

    2020  Volume 1287

    Abstract: ... to forming aggregates and thus facilitating disease progression. Keqiang Ye and co-workers at Emory ...

    Abstract Alzheimer’s disease: Enzyme’s role in disease progression The identification of an enzyme that plays a critical role in the progression of Alzheimer’s disease (AD) could lead to novel therapeutic interventions. In the earliest stage of AD, the build-up of Tau protein aggregates causes degeneration of a site in the brainstem. These abnormal Tau accumulations then spread to other parts of the brain. Recent research suggests that an enzyme called delta-secretase cleaves Tau and other key molecules, making Tau more prone to forming aggregates and thus facilitating disease progression. Keqiang Ye and co-workers at Emory University School of Medicine in Atlanta, USA, reviewed current understanding of the role of delta-secretase in AD pathology. Studies show that delta-secretase expression levels are high in aged mice and AD brains. Inhibiting delta-secretase could therefore limit neurodegeneration and alleviate cognitive deficits in patients.
    Keywords Medicine ; R ; Biochemistry ; QD415-436
    Subject code 572
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top