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Book ; Online: Functional Nanomaterials for Healthcare

Terracciano, Monica / Rea, Ilaria / Borbone, Nicola / Tramontano, Chiara

2023

Keywords	Technology: general issues ; Biotechnology ; mitochondrial targeting ; gold nanoparticles ; cancer chemotherapy ; drug delivery ; betulinic acid ; laminin receptor ; zinc oxide nanoparticles ; organic surface deposit ; cytotoxicity assay ; photocatalytic activity ; ROS generation ; toxicity mechanism ; MDA-MB-231 ; HT-29 ; ebselen ; cerium ; ERK1/2 ; STAT-6 ; IL-4 ; STAT-1 ; antimicrobial activity ; carbon nanotubes ; human SP-D ; cancer cells ; apoptosis ; immunotherapy ; Alhydrogel® ; silica nanoparticles ; Bet v 1 ; BM4 ; SiO2 ; allergen ; structural integrity ; alum ; nanoparticles ; antimicrobial resistance ; bacteria ; resistance mechanism ; hyaluronic acid ; adipic acid dihydrazide ; silver nanoparticles ; polymer molecular weight ; antimicrobial ; SARS-CoV-2 ; protein nanoparticles ; vaccines ; nanovaccine ; nanomedicine ; protein-based nanotechnology ; graphene oxide ; biopolymer blends ; biomineralization ; ectopic bone formation ; osteoinduction ; ex vivo analysis ; nanotechnology ; cosmetic ; chitosan ; essential oils ; preservative agents ; metal-organic framework ; cardiovascular diseases ; graphene ; G+ ; PLA ; Grafylon ; scaffold ; neuronal differentiation ; stem cells ; 3D printing ; regenerative medicine ; Curcumin ; Paclitaxel ; triple-negative breast cancer cell lines (4T1 and MDA MB 231) ; metastasis ; capsaicin ; human ; pruritogens ; desensitization ; itch ; polymers ; compartments ; biomedical ; mesoporous silica nanoparticles ; MSN ; porous materials ; functionalisation ; NMR ; HR-MAS NMR ; surface ; COVID-19 ; cationic surfactants ; virucidal activity ; quaternary ammonium compounds ; disinfectants ; nanoprophylaxis ; viral inhibition ; human papillomavirus ; HPV ; pseudovirus ; viral infection inhibition ; nanocomplex formation ; photodynamic therapy ; photosensitizer ; upconversion nanoparticles ; graphene quantum dots ; reactive oxygen species ; green synthesis ; carbon nanomaterials ; biomass ; sustainability ; nanomaterials ; machine learning ; antioxidant ; biopolymers ; therapeutic substances ; incorporation ; biocompatibility ; healthcare ; biomedical applications ; surface characterization ; quantum yield ; label-free detection ; zinc oxide nanostructure ; surface functionalization ; mesoporous polydopamine ; ferric ions ; doxorubicin (DOX) ; hyaluronic acid target modification
Language	English
Size	1 electronic resource (482 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030645650
ISBN	9783036591025 ; 3036591028
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Summary of the Current Status of DNA Vaccination for Alzheimer Disease.

Vicidomini, Caterina / Borbone, Nicola / Roviello, Valentina / Roviello, Giovanni N / Oliviero, Giorgia

Vaccines

2023 Volume 11, Issue 11

Abstract: Alzheimer disease (AD) is one of the most common and disabling neuropathies in the ever-growing aged population around the world, that especially affects Western countries. We are in urgent need of finding an effective therapy but also a valid ... ...

Abstract	Alzheimer disease (AD) is one of the most common and disabling neuropathies in the ever-growing aged population around the world, that especially affects Western countries. We are in urgent need of finding an effective therapy but also a valid prophylactic means of preventing AD. There is a growing attention currently paid to DNA vaccination, a technology particularly used during the COVID-19 era, which can be used also to potentially prevent or modify the course of neurological diseases, including AD. This paper aims to discuss the main features and hurdles encountered in the immunization and therapy against AD using DNA vaccine technology. Ultimately, this work aims to effectively promote the efforts in research for the development of safe and effective DNA and RNA vaccines for AD.
Language	English
Publishing date	2023-11-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11111706
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nucleoside Analogs and Nucleoside Precursors as Drugs in the Fight against SARS-CoV-2 and Other Coronaviruses.

Borbone, Nicola / Piccialli, Gennaro / Roviello, Giovanni Nicola / Oliviero, Giorgia

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 4

Abstract: Coronaviruses (CoVs) are positive-sense RNA enveloped viruses, members of the family Coronaviridae, that cause infections in a broad range of mammals including humans. Several CoV species lead to mild upper respiratory infections typically associated ... ...

Abstract	Coronaviruses (CoVs) are positive-sense RNA enveloped viruses, members of the family Coronaviridae, that cause infections in a broad range of mammals including humans. Several CoV species lead to mild upper respiratory infections typically associated with common colds. However, three human CoV (HCoV) species: Severe Acute Respiratory Syndrome (SARS)-CoV-1, Middle East Respiratory Syndrome (MERS)-CoV, and SARS-CoV-2, are responsible for severe respiratory diseases at the origin of two recent epidemics (SARS and MERS), and of the current COronaVIrus Disease 19 (COVID-19), respectively. The easily transmissible SARS-CoV-2, emerging at the end of 2019 in China, spread rapidly worldwide, leading the World Health Organization (WHO) to declare COVID-19 a pandemic. While the world waits for mass vaccination, there is an urgent need for effective drugs as short-term weapons to combat the SARS-CoV-2 infection. In this context, the drug repurposing approach is a strategy able to guarantee positive results rapidly. In this regard, it is well known that several nucleoside-mimicking analogs and nucleoside precursors may inhibit the growth of viruses providing effective therapies for several viral diseases, including HCoV infections. Therefore, this review will focus on synthetic nucleosides and nucleoside precursors active against different HCoV species, paying great attention to SARS-CoV-2. This work covers progress made in anti-CoV therapy with nucleoside derivatives and provides insight into their main mechanisms of action.
MeSH term(s)	Animals ; Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; COVID-19/epidemiology ; COVID-19/metabolism ; Drug Repositioning ; Humans ; Nucleosides/chemistry ; Nucleosides/therapeutic use ; Severe acute respiratory syndrome-related coronavirus/metabolism ; SARS-CoV-2/metabolism ; Severe Acute Respiratory Syndrome/drug therapy ; Severe Acute Respiratory Syndrome/epidemiology ; Severe Acute Respiratory Syndrome/metabolism ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; Nucleosides
Language	English
Publishing date	2021-02-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26040986
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nucleoside Analogs and Nucleoside Precursors as Drugs in the Fight against SARS-CoV-2 and Other Coronaviruses

Nicola Borbone / Gennaro Piccialli / Giovanni Nicola Roviello / Giorgia Oliviero

Molecules, Vol 26, Iss 4, p

2021 Volume 986

Abstract	Coronaviruses (CoVs) are positive-sense RNA enveloped viruses, members of the family Coronaviridae, that cause infections in a broad range of mammals including humans. Several CoV species lead to mild upper respiratory infections typically associated with common colds. However, three human CoV (HCoV) species: Severe Acute Respiratory Syndrome (SARS)-CoV-1, Middle East Respiratory Syndrome (MERS)-CoV, and SARS-CoV-2, are responsible for severe respiratory diseases at the origin of two recent epidemics (SARS and MERS), and of the current COronaVIrus Disease 19 (COVID-19), respectively. The easily transmissible SARS-CoV-2, emerging at the end of 2019 in China, spread rapidly worldwide, leading the World Health Organization (WHO) to declare COVID-19 a pandemic. While the world waits for mass vaccination, there is an urgent need for effective drugs as short-term weapons to combat the SARS-CoV-2 infection. In this context, the drug repurposing approach is a strategy able to guarantee positive results rapidly. In this regard, it is well known that several nucleoside-mimicking analogs and nucleoside precursors may inhibit the growth of viruses providing effective therapies for several viral diseases, including HCoV infections. Therefore, this review will focus on synthetic nucleosides and nucleoside precursors active against different HCoV species, paying great attention to SARS-CoV-2. This work covers progress made in anti-CoV therapy with nucleoside derivatives and provides insight into their main mechanisms of action.
Keywords	coronavirus ; SARS-CoV-1 ; SARS-CoV-2 ; MERS-CoV ; nucleoside drugs ; remdesivir ; Organic chemistry ; QD241-441
Subject code	572
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Exploring the Relationship between G-Quadruplex Nucleic Acids and Plants: From Plant G-Quadruplex Function to Phytochemical G4 Ligands with Pharmaceutic Potential.

Falanga, Andrea P / Terracciano, Monica / Oliviero, Giorgia / Roviello, Giovanni N / Borbone, Nicola

Pharmaceutics

2022 Volume 14, Issue 11

Abstract: G-quadruplex (G4) oligonucleotides are higher-order DNA and RNA secondary structures of enormous relevance due to their implication in several biological processes and pathological states in different organisms. Strategies aiming at modulating human G4 ... ...

Abstract	G-quadruplex (G4) oligonucleotides are higher-order DNA and RNA secondary structures of enormous relevance due to their implication in several biological processes and pathological states in different organisms. Strategies aiming at modulating human G4 structures and their interrelated functions are first-line approaches in modern research aiming at finding new potential anticancer treatments or G4-based aptamers for various biomedical and biotechnological applications. Plants offer a cornucopia of phytocompounds that, in many cases, are effective in binding and modulating the thermal stability of G4s and, on the other hand, contain almost unexplored G4 motifs in their genome that could inspire new biotechnological strategies. Herein, we describe some G4 structures found in plants, summarizing the existing knowledge of their functions and biological role. Moreover, we review some of the most promising G4 ligands isolated from vegetal sources and report on the known relationships between such phytochemicals and G4-mediated biological processes that make them potential leads in the pharmaceutical sector.
Language	English
Publishing date	2022-11-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14112377
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: 3D Chitosan-Gallic Acid Complexes: Assessment of the Chemical and Biological Properties.

Marzano, Maria / Borbone, Nicola / Amato, Felice / Oliviero, Giorgia / Fucile, Pierpaolo / Russo, Teresa / Sannino, Filomena

Gels (Basel, Switzerland)

2022 Volume 8, Issue 2

Abstract: Three-dimensional chitosan-gallic acid complexes were proposed and prepared for the first time by a simple adsorption process of gallic acid (GA) on three-dimensional chitosan structures (3D chitosan). Highly porous 3D devices facilitate a high GA load, ... ...

Abstract	Three-dimensional chitosan-gallic acid complexes were proposed and prepared for the first time by a simple adsorption process of gallic acid (GA) on three-dimensional chitosan structures (3D chitosan). Highly porous 3D devices facilitate a high GA load, up to 2015 mmol/kg at pH 4.0. The preservation of the redox state of GA released from 3D chitosan was confirmed by spectroscopic analyses. The antioxidant activity of 3D chitosan-GA complexes was assessed using the DPPH radical scavenging assay and was found to be dramatically higher than that of free chitosan. The mechanical property of 3D chitosan-GA complexes was also evaluated using a compression test. Finally, 3D chitosan-GA complexes showed a significant antimicrobial capacity against
Language	English
Publishing date	2022-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2813982-3
ISSN	2310-2861 ; 2310-2861
ISSN (online)	2310-2861
ISSN	2310-2861
DOI	10.3390/gels8020124
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nucleic Acids as Biotools at the Interface between Chemistry and Nanomedicine in the COVID-19 Era.

Borbone, Nicola / Piccialli, Ilaria / Falanga, Andrea Patrizia / Piccialli, Vincenzo / Roviello, Giovanni N / Oliviero, Giorgia

International journal of molecular sciences

2022 Volume 23, Issue 8

Abstract: The recent development of mRNA vaccines against the SARS-CoV-2 infection has turned the spotlight on the potential of nucleic acids as innovative prophylactic agents and as diagnostic and therapeutic tools. Until now, their use has been severely limited ... ...

Abstract	The recent development of mRNA vaccines against the SARS-CoV-2 infection has turned the spotlight on the potential of nucleic acids as innovative prophylactic agents and as diagnostic and therapeutic tools. Until now, their use has been severely limited by their reduced half-life in the biological environment and the difficulties related to their transport to target cells. These limiting aspects can now be overcome by resorting to chemical modifications in the drug and using appropriate nanocarriers, respectively. Oligonucleotides can interact with complementary sequences of nucleic acid targets, forming stable complexes and determining their loss of function. An alternative strategy uses nucleic acid aptamers that, like the antibodies, bind to specific proteins to modulate their activity. In this review, the authors will examine the recent literature on nucleic acids-based strategies in the COVID-19 era, focusing the attention on their applications for the prophylaxis of COVID-19, but also on antisense- and aptamer-based strategies directed to the diagnosis and therapy of the coronavirus pandemic.
MeSH term(s)	COVID-19 ; Humans ; Nanomedicine ; Nucleic Acids/therapeutic use ; Oligonucleotides/chemistry ; Oligonucleotides/therapeutic use ; SARS-CoV-2
Chemical Substances	Nucleic Acids ; Oligonucleotides
Language	English
Publishing date	2022-04-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23084359
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: State of art in the chemistry of nucleoside-based Pt(II) complexes.

D'Errico, Stefano / Falanga, Andrea Patrizia / Greco, Francesca / Piccialli, Gennaro / Oliviero, Giorgia / Borbone, Nicola

Bioorganic chemistry

2022 Volume 131, Page(s) 106325

Abstract: After the fortuitous discovery of the anticancer properties of cisplatin, many Pt(II) complexes have been synthesized, to obtain less toxic leads which could overcome the resistance phenomena. Given the importance of nucleosides and nucleotides as ... ...

Abstract	After the fortuitous discovery of the anticancer properties of cisplatin, many Pt(II) complexes have been synthesized, to obtain less toxic leads which could overcome the resistance phenomena. Given the importance of nucleosides and nucleotides as antimetabolites, studying their coordinating properties towards Pt(II) ions is challenging for bioorganic and medicinal chemistry. This review aims to describe the results achieved so far in the aforementioned field, paying particular attention to the synthetic aspects, the chemical-physical characterization, and the biological activities of the nucleoside-based Pt(II) complexes.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Cisplatin/chemistry ; Coordination Complexes/pharmacology ; Nucleosides/pharmacology ; Nucleotides ; Platinum Compounds/chemistry ; Platinum Compounds/pharmacology
Chemical Substances	Antineoplastic Agents ; Cisplatin (Q20Q21Q62J) ; Coordination Complexes ; Nucleosides ; Nucleotides ; Platinum Compounds
Language	English
Publishing date	2022-12-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2022.106325
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ultrashort Cationic Peptide Fmoc-FFK as Hydrogel Building Block for Potential Biomedical Applications.

Gallo, Enrico / Diaferia, Carlo / Giordano, Sabrina / Rosa, Elisabetta / Carrese, Barbara / Piccialli, Gennaro / Borbone, Nicola / Morelli, Giancarlo / Oliviero, Giorgia / Accardo, Antonella

Gels (Basel, Switzerland)

2023 Volume 10, Issue 1

Abstract: Fmoc-diphenylalanine (Fmoc-FF) is a low-molecular-weight peptide hydrogelator. This simple all-aromatic peptide can generate self-supporting hydrogel materials, which have been proposed as novel materials for diagnostic and pharmaceutical applications. ... ...

Abstract	Fmoc-diphenylalanine (Fmoc-FF) is a low-molecular-weight peptide hydrogelator. This simple all-aromatic peptide can generate self-supporting hydrogel materials, which have been proposed as novel materials for diagnostic and pharmaceutical applications. Our knowledge of the molecular determinants of Fmoc-FF aggregation is used as a guide to design new peptide-based gelators, with features for the development of improved tools. Here, we enlarge the plethora of Fmoc-FF-based hydrogelated matrices by studying the properties of the Fmoc-FFK tripeptide, alone or in combination with Fmoc-FF. For multicomponent matrices, the relative weight ratios between Fmoc-FFK and Fmoc-FF (specifically, 1/1, 1/5, 1/10, and 1/20
Language	English
Publishing date	2023-12-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2813982-3
ISSN	2310-2861 ; 2310-2861
ISSN (online)	2310-2861
ISSN	2310-2861
DOI	10.3390/gels10010012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cytosine-rich oligonucleotides incorporating a non-nucleotide loop: A further step towards the obtainment of physiologically stable i-motif DNA.

Greco, Francesca / Marzano, Maria / Falanga, Andrea Patrizia / Terracciano, Monica / Piccialli, Gennaro / Roviello, Giovanni Nicola / D'Errico, Stefano / Borbone, Nicola / Oliviero, Giorgia

International journal of biological macromolecules

2022 Volume 219, Page(s) 626–636

Abstract: i-Motifs, also known as i-tetraplexes, are secondary structures of DNA occurring in cytosine-rich oligonucleotides (CROs) that recall increasing interest in the scientific community for their relevance in various biological processes and DNA ... ...

Abstract	i-Motifs, also known as i-tetraplexes, are secondary structures of DNA occurring in cytosine-rich oligonucleotides (CROs) that recall increasing interest in the scientific community for their relevance in various biological processes and DNA nanotechnology. This study reports the design of new structurally modified CROs, named Double-Ended-Linker-CROs (DEL-CROs), capable of forming stable i-motif structures. Here, two C-rich strands having sequences d(AC
MeSH term(s)	Acrylamides ; Circular Dichroism ; Cytosine/chemistry ; DNA/chemistry ; Hydrogen-Ion Concentration ; Nucleic Acid Conformation ; Oligonucleotides/chemistry
Chemical Substances	Acrylamides ; Oligonucleotides ; Cytosine (8J337D1HZY) ; DNA (9007-49-2)
Language	English
Publishing date	2022-08-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.08.016
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