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Article ; Online: Author Correction: DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer.

Zhivagui, Maria / Hoda, Areebah / Valenzuela, Noelia / Yeh, Yi-Yu / Dai, Jason / He, Yudou / Nandi, Shuvro P / Otlu, Burcak / Van Houten, Bennett / Alexandrov, Ludmil B

Nature communications

2023 Volume 14, Issue 1, Page(s) 1424

Language	English
Publishing date	2023-03-14
Publishing country	England
Document type	Published Erratum
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-37245-x
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Article ; Online: Cardiovascular Events Among Survivors of Sepsis Hospitalization: A Retrospective Cohort Analysis.

Jentzer, Jacob C / Lawler, Patrick R / Van Houten, Holly K / Yao, Xiaoxi / Kashani, Kianoush B / Dunlay, Shannon M

Journal of the American Heart Association

2023 Volume 12, Issue 3, Page(s) e027813

Abstract: Background Sepsis is associated with an elevated risk of late cardiovascular events among hospital survivors. Methods and Results We included OptumLabs Data Warehouse patients from 2009 to 2019 who survived a medical/nonsurgical hospitalization lasting ... ...

Abstract	Background Sepsis is associated with an elevated risk of late cardiovascular events among hospital survivors. Methods and Results We included OptumLabs Data Warehouse patients from 2009 to 2019 who survived a medical/nonsurgical hospitalization lasting at least 2 nights. The association between sepsis during hospitalization, based on explicit and implicit discharge
MeSH term(s)	Humans ; Retrospective Studies ; Aftercare ; Risk Factors ; Patient Discharge ; Cohort Studies ; Sepsis/complications ; Hospitalization ; Heart Failure/epidemiology ; Heart Failure/therapy ; Heart Failure/complications ; Survivors ; Proportional Hazards Models
Language	English
Publishing date	2023-02-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.122.027813
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Article ; Online: Characterizing the Myoarchitecture of the Supraspinatus and Infraspinatus Muscles With MRI Using Diffusion Tensor Imaging.

Tous, Cyril / Jodoin, Alexandre / Pontré, Beau / Grabs, Detlev / Begon, Mikael / Bureau, Nathalie J / Van Houten, Elijah

Journal of magnetic resonance imaging : JMRI

2023 Volume 59, Issue 3, Page(s) 851–862

Abstract: ... gradient encoding directions, b-values of 500 and 800 s/mm: Assessment: Each voxel was binned ...

Abstract	Background: The societal cost of shoulder disabilities in our aging society keeps rising. Providing biomarkers of early changes in the microstructure of rotator cuff (RC) muscles might improve surgical planning. Elevation angle (E1A) and pennation angle (PA) assessed by ultrasound change with RC tears. Furthermore, ultrasounds lack repeatability. Purpose: To propose a repeatable framework to quantify the myocyte angulation in RC muscles. Study type: Prospective. Subjects: Six asymptomatic healthy volunteers (1 female aged 30 years; 5 males, mean age 35 years, range 25-49 years), who underwent three repositioned scanning sessions (10 minutes apart) of the right infraspinatus muscle (ISPM) and supraspinatus muscle (SSPM). Field strength/sequence: 3-T, T1-weighted and diffusion tensor imaging (DTI; 12 gradient encoding directions, b-values of 500 and 800 s/mm Assessment: Each voxel was binned in percentage of depth defined by the shortest distance in the antero-posterior direction (manual delineation), i.e. the radial axis. A second order polynomial fit for PA across the muscle depth was used, while E1A described a sigmoid across depth: Statistical tests: Repeatability was assessed with the nonparametric Wilcoxon's rank-sum test for paired comparisons across repeated scans in each volunteer for each anatomical muscle region and across repeated measures of the radial axis. A P-value <0.05 was considered statistically significant. Results: In the ISPM, E1A was constantly negative, became helicoidal, then mainly positive across the antero-posterior depth, respective at the caudal, central and cranial regions. In the SSPM, posterior myocytes ran more parallel to the intramuscular tendon ( Data conclusion: ElA and PA in the proposed framework of the ISPM and SSPM are repeatable with DTI. Variations of myocyte angulation in the ISPM and SSPM can be quantified across volunteers. Evidence level: 2 TECHNICAL EFFICACY: Stage 2.
MeSH term(s)	Male ; Humans ; Female ; Adult ; Middle Aged ; Rotator Cuff/surgery ; Diffusion Tensor Imaging ; Prospective Studies ; Shoulder ; Rotator Cuff Injuries/surgery ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.28840
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Article ; Online: Large Variety of Medical Specialties Involved in Management of Pediatric Minor Traumatic Head Injury in the Netherlands.

Niele, Nicky / Willemars, Lonneke / van Houten, Marlies / Plötz, Frans B

Global pediatric health

2019 Volume 6, Page(s) 2333794X19846117

Language	English
Publishing date	2019-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2785531-4
ISSN	2333-794X ; 2333-794X
ISSN (online)	2333-794X
ISSN	2333-794X
DOI	10.1177/2333794X19846117
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Article ; Online: Editors' Note.

Jeggo, Penny / Van Houten, Bennett

DNA repair

2023 Volume 122, Page(s) 103447

Language	English
Publishing date	2023-01-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2071608-4
ISSN	1568-7856 ; 1568-7864
ISSN (online)	1568-7856
ISSN	1568-7864
DOI	10.1016/j.dnarep.2023.103447
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Article ; Online: Minimizing Measurement-Induced Errors in Viscoelastic MR Elastography.

Kurtz, Samuel / Wattrisse, Bertrand / Van Houten, Elijah E W

IEEE transactions on medical imaging

2024 Volume 43, Issue 3, Page(s) 1138–1148

Abstract: The inverse problem that underlies Magnetic Resonance Elastography (MRE) is sensitive to the measurement data and the quality of the results of this tissue elasticity imaging process can be influenced both directly and indirectly by measurement noise. In ...

Abstract	The inverse problem that underlies Magnetic Resonance Elastography (MRE) is sensitive to the measurement data and the quality of the results of this tissue elasticity imaging process can be influenced both directly and indirectly by measurement noise. In this work, we apply a coupled adjoint field formulation of the viscoelastic constitutive parameter identification problem, where the indirect influence of noise through applied boundary conditions is avoided. A well-posed formulation of the coupled field problem is obtained through conditions applied to the adjoint field, relieving the computed displacement field from kinematic errors on the boundary. The theoretical framework for this formulation via a nearly incompressible, parallel subdomain-decomposition approach is presented, along with verification and a detailed exploration of the performance of the methods via a numerical simulation study. In addition, the advantages of this novel approach are demonstrated in-vivo in the human brain, showing the ability of the method to obtain viable tissue property maps in difficult configurations, enhancing the accuracy of the method.
MeSH term(s)	Humans ; Elasticity Imaging Techniques/methods ; Phantoms, Imaging ; Computer Simulation ; Brain/diagnostic imaging ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	622531-7
ISSN	1558-254X ; 0278-0062
ISSN (online)	1558-254X
ISSN	0278-0062
DOI	10.1109/TMI.2023.3329293
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Article ; Online: Clinical-based phenotypes in children with pediatric post-COVID-19 condition.

Noij, Lieke C E / Blankestijn, Jelle M / Lap, Coen R / van Houten, Marlies A / Biesbroek, Giske / der Zee, Anke-Hilse Maitland-van / Abdel-Aziz, Mahmoud I / van Goudoever, Johannes B / Alsem, Mattijs W / Brackel, Caroline L H / Oostrom, Kim J / Hashimoto, Simone / Terheggen-Lagro, Suzanne W J

World journal of pediatrics : WJP

2024

Abstract: Background: Pediatric post coronavirus disease 2019 (COVID-19) condition (PPCC) is a heterogeneous syndrome, which can significantly affect the daily lives of children. This study aimed to identify clinically meaningful phenotypes in children with PPCC, ...

Abstract	Background: Pediatric post coronavirus disease 2019 (COVID-19) condition (PPCC) is a heterogeneous syndrome, which can significantly affect the daily lives of children. This study aimed to identify clinically meaningful phenotypes in children with PPCC, to better characterize and treat this condition. Methods: Participants were children with physician-diagnosed PPCC, referred to the academic hospital Amsterdam UMC in the Netherlands between November 2021 and March 2023. Demographic factors and information on post-COVID symptoms, comorbidities, and impact on daily life were collected. Clinical clusters were identified using an unsupervised and unbiased approach for mixed data types. Results: Analysis of 111 patients (aged 3-18 years) revealed three distinct clusters within PPCC. Cluster 1 (n = 62, median age = 15 years) predominantly consisted of girls (74.2%). These patients suffered relatively more from exercise intolerance, dyspnea, and smell disorders. Cluster 2 (n = 33, median age = 13 years) contained patients with an even gender distribution (51.5% girls). They suffered from relatively more sleep problems, memory loss, gastrointestinal symptoms, and arthralgia. Cluster 3 (n = 16, median age = 11 years) had a higher proportion of boys (75.0%), suffered relatively more from fever, had significantly fewer symptoms (median age of 5 years compared to 8 and 10 years for clusters 1 and 2 respectively), and experienced a lower impact on daily life. Conclusions: This study identified three distinct clinical PPCC phenotypes, with variations in sex, age, symptom patterns, and impact on daily life. These findings highlight the need for further research to understand the potentially diverse underlying mechanisms contributing to post-COVID symptoms in children.
Language	English
Publishing date	2024-04-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2236681-7
ISSN	1867-0687 ; 1708-8569
ISSN (online)	1867-0687
ISSN	1708-8569
DOI	10.1007/s12519-024-00805-2
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Article ; Online: DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer.

Zhivagui, Maria / Hoda, Areebah / Valenzuela, Noelia / Yeh, Yi-Yu / Dai, Jason / He, Yudou / Nandi, Shuvro P / Otlu, Burcak / Van Houten, Bennett / Alexandrov, Ludmil B

Nature communications

2023 Volume 14, Issue 1, Page(s) 276

Abstract: Ultraviolet A light is commonly emitted by UV-nail polish dryers with recent reports suggesting that long-term use may increase the risk for developing skin cancer. However, no experimental evaluation has been conducted to reveal the effect of radiation ... ...

Abstract	Ultraviolet A light is commonly emitted by UV-nail polish dryers with recent reports suggesting that long-term use may increase the risk for developing skin cancer. However, no experimental evaluation has been conducted to reveal the effect of radiation emitted by UV-nail polish dryers on mammalian cells. Here, we show that irradiation by a UV-nail polish dryer causes high levels of reactive oxygen species, consistent with 8-oxo-7,8-dihydroguanine damage and mitochondrial dysfunction. Analysis of somatic mutations reveals a dose-dependent increase of C:G>A:T substitutions in irradiated samples with mutagenic patterns similar to mutational signatures previously attributed to reactive oxygen species. In summary, this study demonstrates that radiation emitted by UV-nail polish dryers can both damage DNA and permanently engrave mutations on the genomes of primary mouse embryonic fibroblasts, human foreskin fibroblasts, and human epidermal keratinocytes.
MeSH term(s)	Animals ; Humans ; Mice ; DNA Damage ; Fibroblasts ; Keratinocytes/radiation effects ; Mammals ; Mutation/radiation effects ; Reactive Oxygen Species/metabolism ; Ultraviolet Rays/adverse effects ; Nails
Chemical Substances	Reactive Oxygen Species
Language	English
Publishing date	2023-01-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-35876-8
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Article ; Online: Limited effect of anatomical insert geometry on in vitro laxity in balanced anatomic posterior cruciate ligament retaining total knee arthroplasty.

van Houten, Albert H / Heesterbeek, Petra J C / Hannink, Gerjon / Labey, Luc / Wymenga, Ate B

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

2021 Volume 30, Issue 4, Page(s) 1273–1281

Abstract: Purpose: The present study assessed the effect of insert articular surface geometry (anatomical versus conventional insert design) on anteroposterior (AP) translation and varus-valgus (VV) laxity in balanced posterior cruciate ligament (PCL) retaining ... ...

Abstract	Purpose: The present study assessed the effect of insert articular surface geometry (anatomical versus conventional insert design) on anteroposterior (AP) translation and varus-valgus (VV) laxity in balanced posterior cruciate ligament (PCL) retaining total knee arthroplasty (TKA). Secondly, we evaluated if the AP translation and VV laxity in the reconstructed knee resembled the stability of the native knee. Methods: Nine fresh-frozen full-leg cadaver specimens were used in this study. After testing the native knee, anatomical components of a PCL-retaining implant were implanted. The knee joints were subjected to anteriorly and posteriorly directed forces (at 20° and 90° flexion) and varus-valgus stresses (at 20°, 45° and 90° flexion) in both non-weightbearing and weightbearing situations in a knee kinematics simulator. Measurements were performed in the native knee, TKA with anatomical insert geometry (3° built-in varus, medial concave, lateral convex), and TKA with symmetrical insert geometry. Results: In weightbearing conditions, anterior translations ranged between 2.6 and 3.9 mm at 20° flexion and were < 1 mm at 90° flexion. Posterior translation at 20° flexion was 2.7 mm for the native knee versus 4.0 mm (p = 0.047) and 7.0 mm (p = 0.02) for the symmetrical insert and the anatomical insert, respectively. Posterior translation at 90° flexion was < 1.1 mm and not significantly different between the native knee and insert types. In non-weightbearing conditions, the anterior translation at 20° flexion was 5.9 mm for the symmetrical and 4.6 mm for the anatomical insert (n.s.), compared with 3.0 mm for the native knee (p = 0.02). The anterior translation at 90° flexion was significantly higher for the reconstructed knees (anatomical insert 7.0 mm; symmetrical insert 9.2 mm), compared with 1.6 mm for the native knee (both p = 0.02). Varus-valgus laxity at different flexion angles was independent of insert geometry. A valgus force in weightbearing conditions led to significantly more medial laxity (1°-3° opening) in the native knee at 45° and 90° flexion compared with the reconstructed knee for all flexion angles. Conclusions: Insert geometry seems to have a limited effect with respect to AP translation and VV laxity, in the well-balanced PCL-retaining TKA with an anatomical femoral component. Secondly, AP translation and VV laxity in the reconstructed knee approximated the laxity of the native knee.
MeSH term(s)	Arthroplasty, Replacement, Knee/methods ; Biomechanical Phenomena ; Cadaver ; Humans ; Joint Instability/surgery ; Knee Joint/surgery ; Knee Prosthesis ; Posterior Cruciate Ligament/surgery ; Range of Motion, Articular
Language	English
Publishing date	2021-04-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1159064-6
ISSN	1433-7347 ; 0942-2056
ISSN (online)	1433-7347
ISSN	0942-2056
DOI	10.1007/s00167-021-06564-1
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Article: Group B

Nusman, Charlotte M / Snoek, Linde / van Leeuwen, Lisanne M / Dierikx, Thomas H / van der Weijden, Bo M / Achten, Niek B / Bijlsma, Merijn W / Visser, Douwe H / van Houten, Marlies A / Bekker, Vincent / de Meij, Tim G J / van Rossem, Ellen / Felderhof, Mariet / Plötz, Frans B

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 3

Abstract: ... perspective include Group B ...

Abstract	The difficulty in recognizing early-onset neonatal sepsis (EONS) in a timely manner due to non-specific symptoms and the limitations of diagnostic tests, combined with the risk of serious consequences if EONS is not treated in a timely manner, has resulted in a low threshold for starting empirical antibiotic treatment. New guideline strategies, such as the neonatal sepsis calculator, have been proven to reduce the antibiotic burden related to EONS, but lack sensitivity for detecting EONS. In this review, the potential of novel, targeted preventive and diagnostic methods for EONS is discussed from three different perspectives: maternal, umbilical cord and newborn perspectives. Promising strategies from the maternal perspective include Group B
Language	English
Publishing date	2023-03-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12030489
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