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Article ; Online: Isolated bone marrow candidiasis in an immunocompetent elderly.

Dubey, Deval B / Jain, Mili / Verma, Shailendra P / Agarwal, Preeti

Indian journal of pathology & microbiology

2024 Volume 67, Issue 1, Page(s) 149–150

MeSH term(s)	Humans ; Aged ; Bone Marrow ; Candidiasis/diagnosis
Language	English
Publishing date	2024-02-12
Publishing country	India
Document type	Journal Article
ZDB-ID	197621-7
ISSN	0974-5130 ; 0377-4929
ISSN (online)	0974-5130
ISSN	0377-4929
DOI	10.4103/ijpm.ijpm_918_21
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Article ; Online: Temperature-dependent aqueous OH kinetics of C 2 –C 10 linear and terpenoid alcohols and diols

B. Witkowski / P. Jain / B. Wileńska / T. Gierczak

Atmospheric Chemistry and Physics, Vol 24, Pp 663-

new rate coefficients, structure–activity relationship, and atmospheric lifetimes

2024 Volume 688

Abstract: Aliphatic alcohols (AAs), including terpenoic alcohols (TAs), are ubiquitous in the atmosphere due to their widespread emissions from natural and anthropogenic sources. Hydroxyl radical (OH) is the most important atmospheric oxidant in both aqueous and ... ...

Abstract	Aliphatic alcohols (AAs), including terpenoic alcohols (TAs), are ubiquitous in the atmosphere due to their widespread emissions from natural and anthropogenic sources. Hydroxyl radical (OH) is the most important atmospheric oxidant in both aqueous and gas phases. Consequently, the aqueous oxidation of the TAs by the OH inside clouds and fogs is a potential source of aqueous secondary organic aerosols ( aq SOAs). However, the kinetic data, necessary for estimating the timescales of such reactions, remain limited. Here, bimolecular rate coefficients ( k OH aq <svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="27pt" height="16pt" class="svg-formula" dspmath="mathimg" md5hash="9f9f16e16217a8d294acd471a22b5999"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="acp-24-663-2024-ie00001.svg" width="27pt" height="16pt" src="acp-24-663-2024-ie00001.png"/></svg:svg> ) for the aqueous oxidation of 29 C 2 –C 10 AAs by hydroxyl radicals (OH) were measured with the relative rate technique in the temperature range 278–328 K. The values of k OH aq <svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="27pt" height="16pt" class="svg-formula" dspmath="mathimg" md5hash="05d730519381fbb0231f432727f62899"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="acp-24-663-2024-ie00002.svg" width="27pt" height="16pt" src="acp-24-663-2024-ie00002.png"/></svg:svg> for the 15 AAs studied in this work were measured for the first time after validating the experimental approach. The k OH aq <svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="27pt" height="16pt" class="svg-formula" dspmath="mathimg" md5hash="3f1d1957d331842f50e14b71260018d9"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="acp-24-663-2024-ie00003.svg" width="27pt" height="16pt" src="acp-24-663-2024-ie00003.png"/></svg:svg> values measured for the C 2 –C 10 AAs at 298 K ranged from 1.80 × 10 9 to 6.5 × 10 9 M −1 s −1 . The values of activation parameters, activation energy ...
Keywords	Physics ; QC1-999 ; Chemistry ; QD1-999
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
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Article ; Online: Value realization: an unattained challenge for integrated practice units.

Jain, Pankaj / Jain, Bhav / Jain, Urvish / Palakodeti, Sandeep

The American journal of managed care

2022 Volume 28, Issue 6, Page(s) e198–e202

Abstract: Central to the Porter-Lee value agenda, integrated practice unit (IPU) pilots have multiplied over time, striving to fundamentally reorganize the delivery of care via multidisciplinary teams while improving outcome measurement and driving competitive ... ...

Abstract	Central to the Porter-Lee value agenda, integrated practice unit (IPU) pilots have multiplied over time, striving to fundamentally reorganize the delivery of care via multidisciplinary teams while improving outcome measurement and driving competitive volumes. As these pilots emerge to form bridges of coordinated care, critics continue to question the value proposition of these IPUs: Do they achieve the Quadruple Aim of modern health care by improving cost of care, health outcomes, patient experience, and provider experience? Noting that value realization has eluded IPU pilots globally over the past 15 years, the authors examine 6 critical challenges and propose recommendations to consistently deploy effective IPUs, leading to a win-win proposition for all key stakeholders.
MeSH term(s)	Delivery of Health Care ; Humans
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2035781-3
ISSN	1936-2692 ; 1088-0224 ; 1096-1860
ISSN (online)	1936-2692
ISSN	1088-0224 ; 1096-1860
DOI	10.37765/ajmc.2022.89157
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Article ; Online: Corporate Social Responsibility Framework: An Innovative Solution to Social Determinants of Health in the USA.

Jain, Pankaj / Jain, Bhav / Dee, Edward Christopher

Journal of racial and ethnic health disparities

2023 Volume 11, Issue 1, Page(s) 7–22

Abstract: Purpose: Expand firms' corporate social responsibility (CSR) framework to systematically address social determinants of health (SDOH) in their communities and improve firms' performance (FP). GAP: The U.S. healthcare system has struggled to improve ... ...

Abstract	Purpose: Expand firms' corporate social responsibility (CSR) framework to systematically address social determinants of health (SDOH) in their communities and improve firms' performance (FP). GAP: The U.S. healthcare system has struggled to improve population health outcomes while enhancing delivery performance. An oft-overlooked contributor to this deficit is SDOH inequities, accounting for 25-60% of deaths in the USA annually. Ironically, most healthcare firms do not view investment in SDOH, a neglected phenomenon, to develop sustainable healthy communities as their direct responsibility due to the "wrong pocket problem." Although extant literature theorizes the CSR construct, there is a paucity of research on SDOH integration with the CSR framework. Design: We integrate a quantitative and qualitative study with supplementary literature on CSR and SDOH using the grounded theory method by researching fourteen health plan firms across the USA. Findings: Research reveals early efforts undertaken by top-performing healthcare insurers to address SDOH and provides evidence that such measures can be integrated profitably under CSR as a competitive advantage. Originality: Contributes to CSR theory and practice by providing an empirical model and expanding its framework to address SDOH systematically. Key implications are as follows: (1) healthcare firms to link with unconventional partners, such as housing authorities, food banks, employment agencies, and schools; (2) the entire healthcare supply chain to collaborate with social enterprises and regulators to develop sustainable communities; (3) policymakers must incentivize firms to align social equity and corporate goals; and (4) long-term view on CSR, SDOH, and healthy living (HL) will in-turn eliminate social inequities while enhancing FP.
MeSH term(s)	Humans ; United States ; Social Determinants of Health ; Organizations ; Social Responsibility ; Schools ; Health Status
Language	English
Publishing date	2023-01-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2760524-3
ISSN	2196-8837 ; 2197-3792
ISSN (online)	2196-8837
ISSN	2197-3792
DOI	10.1007/s40615-022-01493-2
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Article: ANXIETY SYNDROMES IN ADOLESCENTS WITH OPERATIONAL RESPIRATORY CONDITIONS: A PROSPECTIVE STUDY.

Gupta, M / Jain, Sh / Chandani, P / Patel J, D / Asha, K / Kumar, B

Georgian medical news

2024 , Issue 345, Page(s) 166–171

Abstract: Aim - determining the prevalence of anxiety disorders and their effect on disease progression and quality of life in adults with organic illnesses and functional disorders of the respiratory system treated in a pulmonology environment. A total of 135 ... ...

Abstract	Aim - determining the prevalence of anxiety disorders and their effect on disease progression and quality of life in adults with organic illnesses and functional disorders of the respiratory system treated in a pulmonology environment. A total of 135 young adults between the ages of 13 and 17 were analyzed. There were a total of 46 adolescents diagnosed with somatoform respiratory disorders (SRD), 45 adolescents diagnosed with bronchial asthma (BA), and 44 adolescents diagnosed with pneumonia. The Spielberger-Khanin anxiety questionnaire and the Nijmegen hyperventilation syndrome (HVS) scale were used for the research and diagnosis, respectively. The quality of life was measured using the asthma quality of life questionnaire (AQLQ). In comparison to adults with asthma (33.2%) and pneumonia (32.3%), adults with SRD (34.5%). There were mild immediate associations between the Spielberger scale and the Nijmegen HVS questionnaire for both trait and state anxiety, and mild inverse correlations between the Spielberger scale and the AQLQ for both state and trait anxiety. Adolescents with anxiety had a higher prevalence of trauma, pain, and social issues than their non-anxious counterparts who were referred to psychiatry. In adolescents, 5.1% had severe trait anxiety, and 19.3% had severe condition anxiety. Adolescents with SRD were twice as likely to suffer from extreme state and trait anxiety as the general population. It is hypothesized that anxiety problems are at the root of HVS and contribute to adults' dissatisfaction with their quality of life due to lung ailments. Although certain adolescents with anxiety disorders were referred for anxiety, this data nevertheless lends credence to the idea that using standardized and structured instruments regularly might help increase accuracy and detection rates in the clinic, regardless of the reason for referral. Complete evaluations are essential for this patient population due to the intricacy of their symptoms.
MeSH term(s)	Young Adult ; Humans ; Adolescent ; Prospective Studies ; Quality of Life ; Anxiety/diagnosis ; Anxiety/epidemiology ; Anxiety Disorders/diagnosis ; Anxiety Disorders/epidemiology ; Asthma ; Hyperventilation/diagnosis ; Hyperventilation/epidemiology ; Syndrome ; Surveys and Questionnaires ; Pneumonia
Language	English
Publishing date	2024-01-26
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
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Article ; Online: Co-variate adjusted associations between serum concentrations of selected perfluoroalkyl substances and urinary concentrations of selected arsenic species.

Jain, Ram B

Environmental science and pollution research international

2022 Volume 30, Issue 12, Page(s) 34750–34759

Abstract: ... with all four arsenic variables but statistical significance was observed for IAS only (β = 0.33364, P = 0.04 ... Concentrations of PFDA were positively associated with UAS (β = 0.20688, P = 0.01), IAS (β = 0.23712, P = 0.02 ... and UAB (β = 0.26049, P = 0.02). Concentrations of PFUnDA were positively associated with UAS (β = 0 ...

Abstract	Data from National Health and Nutrition Examination Survey for 2011-2012 were used to estimate associations of the serum concentrations of perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS), perfluoroundecanoic acid (PFUnDA), and 2-(N-methyl-perfluorooctane sulfonamido) acetic acid (Me-PFOSA) with urinary concentrations of total arsenic (UAS), inorganic arsenic (IAS), arsenobetaine (UAB), and dimethyl arsinic acid (UDMA) among US adults aged > = 20 years. Concentrations of PFNA were positively associated with all four arsenic variables but statistical significance was observed for IAS only (β = 0.33364, P = 0.04). Concentrations of PFDA were positively associated with UAS (β = 0.20688, P = 0.01), IAS (β = 0.23712, P = 0.02), and UAB (β = 0.26049, P = 0.02). Concentrations of PFUnDA were positively associated with UAS (β = 0.49946, P < 0.01), IAS (β = 0.51782, P < 0.01), UAB (β = 0.62924, P < 0.01), and UDMA (β = 0.26375, P < 0.01). Concentrations of Me-PFOSA with PFAS were inversely associated with every PFAS but statistical significance was observed for UDMA only (β = - 0.05613, P = 0.03). PFOA, PFHxS, and PFOS were, in general, negatively associated with concentrations of all four arsenic variables but without reaching statistical significance. Positive associations of PFDA, PFNA, and PFUnDA with arsenic necessitate investigation about impact of the co-exposure of these PFAS with arsenic and their impact on health. Fluorinated carbon chain length > 8 as opposed to ≤ 8 may have a role in defining associations of PFAS with arsenic.
MeSH term(s)	Adult ; Humans ; Environmental Pollutants ; Arsenic ; Nutrition Surveys ; Fluorocarbons ; Alkanesulfonic Acids ; Alkanesulfonates
Chemical Substances	perfluoroundecanoic acid ; perfluorooctanesulfonamide (80AM718FML) ; perfluorooctane (6P60ZBK0QL) ; Environmental Pollutants ; Arsenic (N712M78A8G) ; Fluorocarbons ; perfluorooctanoic acid (947VD76D3L) ; perfluoro-n-nonanoic acid (375-95-1) ; perfluorooctane sulfonic acid (9H2MAI21CL) ; Alkanesulfonic Acids ; perfluorodecanoic acid (335-76-2) ; perflexane (FX3WJ41CMX) ; Alkanesulfonates
Language	English
Publishing date	2022-12-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-24745-4
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Article ; Online: Serum concentrations of perfluoro-1-heptane sulfonate (PFHpS) among US adults: variabilities across different stages of kidney function.

Jain, Ram B

Environmental science and pollution research international

2022 Volume 30, Issue 9, Page(s) 23184–23191

Abstract: ... p < 0.01). Concentrations of PFHpS across various stages of kidney function were located on inverted ...

Abstract	For the first time, data (N = 1311) from US National Health and Nutrition Examination Survey for 2017-2018 were analyzed for gender and racial/ethnic differences for perfluoro-1-heptane sulfonate (PFHpS) for US adults aged ≥ 20 years. In addition, variability in adjusted concentrations across various stages of glomerular filtration (GF) was also studied. While no racial/ethnic differences were observed, males had statistically significantly higher concentrations of PFHpS than females (0.30 vs. 0.19 ng/mL, p < 0.01). Concentrations of PFHpS across various stages of kidney function were located on inverted U-shaped curves with point of inflection located at GF-3A (45 ≤ eGFR < 60 mL/min/1.73 m
MeSH term(s)	Male ; Female ; Adult ; Humans ; Environmental Pollutants ; Nutrition Surveys ; Alkanesulfonic Acids ; Fluorocarbons ; Alkanesulfonates ; Kidney
Chemical Substances	Environmental Pollutants ; Alkanesulfonic Acids ; Fluorocarbons ; Alkanesulfonates
Language	English
Publishing date	2022-11-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-23881-1
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Article ; Online: Autofusion in early-onset scoliosis growing constructs: occurrence, risk factors, and impacts.

Menapace, Bryan / Jain, Viral / Sturm, Peter

Spine deformity

2024

Abstract: ... via odds ratios and Pearson regression correlates. Statistical significance was p ≤ 0.05 or ≥ 0.95 ... Grade IV, and 3.6% Grade V. Idiopathic EOS tended to have lower AF grades (p = 0.37). AF risk factors ... included GR age < 8 (10.4×, p = 0.01), any interval open procedures (6.3×, p = 0.05), and residual curve ...

Abstract	Purposes: Autofusion (AF) during growing rod (GR) instrumentation for early-onset scoliosis (EOS) has been reported, but AF incidence, causation, and clinical implications remain unknown. This article aims to (1) quantify frequency and severity of AF, (2) determine risk factors for AF, and (3) assess the influence of AF on final curve correction and spinal lengthening. Methods: EOS patients were prospectively enrolled (2016-2021). Patients underwent evaluation, GR implantation, lengthenings, and posterior spinal fusion (PSF). Cobb angle and spinal length measurements were collected. AF was assessed and graded, with grades I-II being low-grade and III-V being high-grade. Exposure analysis quantified risk factors' impact via odds ratios and Pearson regression correlates. Statistical significance was p ≤ 0.05 or ≥ 0.95. Results: 28 patients, with variable EOS diagnoses, were included. On average, GR were implanted at 8.54-year-old and lengthened over 4.66 years. 53.6% of patients received magnetically controlled GR (MCGR) and 46.4% traditional GR (TGR). The average construct bridged 13.4 levels. Over the lengthening period, for all indications, patients averaged 2.9 total open procedures. Curves corrected from 68.5º preoperatively to 35.3º after index GR to 35.6º after PSF. Spinal length increased from 30.0 cm preoperatively to 33.9 cm after index GR to 39.5 cm after PSF. AF grading was: 28.6% Grade I, 25.0% Grade II, 17.9% Grade III, 25.0% Grade IV, and 3.6% Grade V. Idiopathic EOS tended to have lower AF grades (p = 0.37). AF risk factors included GR age < 8 (10.4×, p = 0.01), any interval open procedures (6.3×, p = 0.05), and residual curve > 30º after index GR (13.7×, p = 0.02). Protective factors included preoperative spinal length of > 30.0 cm (0.11×, p = 0.01) and index MCGR (0.16×, p = 0.03). Maintenance of Cobb angles from index GR through PSF was relatively better in low-grade patients (p = 0.08). Spinal length gained was no different between low- and high-grade AF (p = 0.50). Conclusions: This largest-to-date evaluation found AF is nearly ubiquitous in GR constructs, but with variable severity. Both risk factors and protective factors coincide with AF. Ultimately, even in high-grade AF, curve correction was maintained, and spinal lengthening was achieved. Level of evidence: Level II-prospective cohort study.
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2717704-X
ISSN	2212-1358 ; 2212-134X ; 2212-1358
ISSN (online)	2212-1358 ; 2212-134X
ISSN	2212-1358
DOI	10.1007/s43390-024-00853-8
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Article ; Online: Peripheral gangrene secondary to vasculitis: A rare extra-articular manifestation of rheumatoid arthritis.

Indu, M B / Meena, D S / Jain, P / Sharma, B

Journal of postgraduate medicine

2022 Volume 68, Issue 3, Page(s) 182–183

MeSH term(s)	Arthritis, Rheumatoid ; Gangrene ; Humans ; Vasculitis
Language	English
Publishing date	2022-08-16
Publishing country	India
Document type	Case Reports
ZDB-ID	410691-x
ISSN	0972-2823 ; 0022-3859
ISSN (online)	0972-2823
ISSN	0022-3859
DOI	10.4103/jpgm.jpgm_1126_21
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Article ; Online: Emerging Lipid-based Carriers for Systematic Utilization in the Pharmaceutical and Biomedical Sciences: A Review.

N Kendre, Prakash / R Kayande, Dhiraj / P Pote, Ajinkya / B Kanthale, Sanagmeshwar / G Prajapati, Bhupendra / Kendre, Yuvraj / Jain, Shirish

Pharmaceutical nanotechnology

2024

Abstract: Emerging lipid-based carriers are revolutionizing drug delivery in the pharmaceutical and biomedical sciences. These innovative carriers harness the unique properties of lipids to improve the solubility, stability, and targeted delivery of therapeutic ... ...

Abstract	Emerging lipid-based carriers are revolutionizing drug delivery in the pharmaceutical and biomedical sciences. These innovative carriers harness the unique properties of lipids to improve the solubility, stability, and targeted delivery of therapeutic agents, ushering in a new era of precision medicine. Lipid- based carriers, such as liposomes, lipid nanoparticles, and solid lipid nanoparticles, offer several advantages. They can encapsulate both hydrophilic and hydrophobic drugs, enabling the delivery of a wide range of compounds. Additionally, lipids are biocompatible and biodegradable, minimizing the risk of toxicity. Their ability to mimic cell membranes allows for enhanced cellular uptake and controlled release, optimizing drug efficacy while minimizing side effects. Furthermore, lipid-based carriers are ideal for delivering drugs to specific sites within the body. By modifying the lipid composition, surface charge, and size, researchers can tailor these carriers to target tumours, inflamed tissues, or specific cells, improving therapeutic outcomes and reducing systemic toxicity. In summary, emerging lipid-based carriers are poised to transform pharmaceutical and biomedical sciences by addressing critical challenges in drug delivery. These carriers enhance drug stability, bioavailability, and targeted delivery, offering the potential to revolutionize the treatment of various diseases and improve patient outcomes. As research in this field continues to advance, we can expect even more sophisticated lipid-based carrier systems to emerge, further expanding the possibilities for precision medicine. This review focuses on the contribution of lipid carriers in the pharmaceutical and biomedical sciences.
Language	English
Publishing date	2024-01-25
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	2211-7393
ISSN (online)	2211-7393
DOI	10.2174/0122117385268268231204061938
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