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  1. Book ; Online: Shuo Wen Jie Zi

    Wang, Yuxuan / Wang, Jianghui / Zhao, Dongyan / Zheng, Zilong

    Rethinking Dictionaries and Glyphs for Chinese Language Pre-training

    2023  

    Abstract: We introduce CDBERT, a new learning paradigm that enhances the semantics understanding ability of the Chinese PLMs with dictionary knowledge and structure of Chinese characters. We name the two core modules of CDBERT as Shuowen and Jiezi, where Shuowen ... ...

    Abstract We introduce CDBERT, a new learning paradigm that enhances the semantics understanding ability of the Chinese PLMs with dictionary knowledge and structure of Chinese characters. We name the two core modules of CDBERT as Shuowen and Jiezi, where Shuowen refers to the process of retrieving the most appropriate meaning from Chinese dictionaries and Jiezi refers to the process of enhancing characters' glyph representations with structure understanding. To facilitate dictionary understanding, we propose three pre-training tasks, i.e., Masked Entry Modeling, Contrastive Learning for Synonym and Antonym, and Example Learning. We evaluate our method on both modern Chinese understanding benchmark CLUE and ancient Chinese benchmark CCLUE. Moreover, we propose a new polysemy discrimination task PolyMRC based on the collected dictionary of ancient Chinese. Our paradigm demonstrates consistent improvements on previous Chinese PLMs across all tasks. Moreover, our approach yields significant boosting on few-shot setting of ancient Chinese understanding.

    Comment: To appear at ACL 2023 Findings
    Keywords Computer Science - Computation and Language
    Subject code 401
    Publishing date 2023-05-30
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Huang-Lian-Jie-Du decoction alleviates depressive-like behaviors in dextran sulfate sodium-induced colitis mice via Trem2/Dap12 pathway.

    Zheng, Jia-Yi / Li, Xiao-Xiao / Lin, Wei-Yao / Su, Shan / Wu, Hai-Cui / Hu, Rui-Dan / Pan, Hua-Feng / Ye, Jiang-Hong / Cai, Ye-Feng / Zhang, Shi-Jie

    Journal of ethnopharmacology

    2023  Volume 315, Page(s) 116658

    Abstract: Ethnopharmacological relevance: Huang-Lian-Jie-Du decoction (HLJD), a traditional Chinese medicine ...

    Abstract Ethnopharmacological relevance: Huang-Lian-Jie-Du decoction (HLJD), a traditional Chinese medicine prescription, has been implicated as effective in treating colitis, depression and inflammation-related diseases. Whether HLJD decoction could ameliorate colitis-induced depression was still unknown and the underlying mechanism was needed to be clarified.
    Aim of the study: Our study aimed to explore the effect and the underlying mechanism of HLJD treatment on colitis-induced depression and the involvement of the inflammatory factors and microglial-activated related genes.
    Materials and methods: The chronic colitis model was established by treating male mice with 1% dextran sulfate sodium (DSS) for 8 weeks. One week after DSS-treated, HLJD decoction was administered orally with 2 and 4 g/kg daily for 7 weeks. Behavior tests (Open field/Elevated plus maze/Novel object recognition) and TUNEL staining were then assessed. The expression of inflammatory-related genes and microglial dysregulation were measured by RT-PCR and the expression of Trem2, Danp12 and Iba1 were assessed by immunofluorescence methods.
    Results: Depressive-like behaviors were observed in mice treated with DSS, which suffered colitis. Compared to normal control (NC-V) mice, the density of TUNEL + cells in the habenula (Hb), hippocampus (HIP), and cortex were significantly higher in colitis (DSS-V) mice, especially in Hb. Compared to NC-V and several brain regions, the expression levels of the Il-1β, Il-10 and Dap12 mRNA were significantly increased in the lateral habenula (LHb) of colitis mice. Moreover, the expression of Trem2, Dap12 and Iba1 were increased in LHb of DSS-V mice. HLJD treatment could alleviate depressive-like behaviors, reduce the density of TUNEL + cells in Hb and the expression of Il-6, Il-10 and Dap12 mRNA in LHb of DSS-V mice. The overexpression of Trem2, Dap12 and Iba1 in LHb of DSS-V mice were reversed after HLJD treatment.
    Conclusion: These results reveal LHb is an important brain region during the process of colitis-induced depression. HLJD treatment could alleviates depressive-like behaviors in colitis mice via inhibiting the Trem2/Dap12 pathway in microglia of LHb, which would contribute to the precise treatment. It provides a potential mechanistic explanation for the effectiveness of HLJD treatment in colitis patients with depression.
    MeSH term(s) Male ; Animals ; Mice ; Interleukin-10/metabolism ; Dextran Sulfate ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/metabolism ; Drugs, Chinese Herbal/adverse effects ; Mice, Inbred C57BL ; Disease Models, Animal ; Colitis, Ulcerative/drug therapy ; Colon ; Membrane Glycoproteins/metabolism ; Receptors, Immunologic/metabolism
    Chemical Substances oren gedoku to ; Interleukin-10 (130068-27-8) ; Dextran Sulfate (9042-14-2) ; Drugs, Chinese Herbal ; Trem2 protein, mouse ; Membrane Glycoproteins ; Receptors, Immunologic
    Language English
    Publishing date 2023-05-30
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Effects of Jie Yu Wan on Generalized Anxiety Disorder: A Randomized Clinical Trial.

    Li, Xue / Zheng, Sisi / Feng, Sitong / Ma, Rui / Jia, Yuan / Zhao, Anquan / Wei, Dan / Guo, Hua / Duan, Na / Ding, Ying / Chen, Jindong / Zhu, Hong / Jia, Hongxiao

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 9951693

    Abstract: Objective: To systematically assess the clinical efficacy of the : Methods: A multicenter, prospective, double-blind, double-dummy, randomized controlled trial (RCT) was conducted at four hospitals in China. A total of one hundred thirty-three ... ...

    Abstract Objective: To systematically assess the clinical efficacy of the
    Methods: A multicenter, prospective, double-blind, double-dummy, randomized controlled trial (RCT) was conducted at four hospitals in China. A total of one hundred thirty-three patients with GAD were enrolled from 2017 to 2019. This study aimed to evaluate the effects of a Traditional Chinese Medicine (TCM) JYW formula on GAD at eight weeks, with the use of Buspirone as the comparator. A stepwise dosing protocol was used (JYW: high dose 24 g/day, low dose 12 g/day; Buspirone: high dose 30 mg/day, low dose 15 mg/day) and the dose was adjusted depending on whether the treatment response of Hamilton Anxiety Scale (HAMA) score was less than or equal to 25% after one week. The primary outcome was a change in total score on the HAMA. The secondary outcomes included the Hamilton Depression Scale (HAMD), Clinical Global Impression (CGI) scale, and TCM Syndrome Scale. Adverse events were recorded using the Treatment Emergent Symptom Scale (TESS). Assessments were conducted at the baseline and 1, 2, 4, and 8 weeks.
    Results: A total of one hundred thirty-three participants were randomly assigned to the JYW group (
    Conclusions: The conclusion of this study supports that JYW and Buspirone can effectively alleviate the anxiety symptoms of GAD patients, which are both effective and safe for treatment of mild to moderate GAD. Besides, high-dose JYW or Buspirone are more effective than low-dose, which is of great importance in assisting clinical medication choice.
    Language English
    Publishing date 2022-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/9951693
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of Jie Yu Wan on Generalized Anxiety Disorder

    Xue Li / Sisi Zheng / Sitong Feng / Rui Ma / Yuan Jia / Anquan Zhao / Dan Wei / Hua Guo / Na Duan / Ying Ding / Jindong Chen / Hong Zhu / Hongxiao Jia

    Evidence-Based Complementary and Alternative Medicine, Vol

    A Randomized Clinical Trial

    2022  Volume 2022

    Abstract: Objective. To systematically assess the clinical efficacy of the Jie Yu Wan (JYW) formula ...

    Abstract Objective. To systematically assess the clinical efficacy of the Jie Yu Wan (JYW) formula in treating generalized anxiety disorder (GAD). Methods. A multicenter, prospective, double-blind, double-dummy, randomized controlled trial (RCT) was conducted at four hospitals in China. A total of one hundred thirty-three patients with GAD were enrolled from 2017 to 2019. This study aimed to evaluate the effects of a Traditional Chinese Medicine (TCM) JYW formula on GAD at eight weeks, with the use of Buspirone as the comparator. A stepwise dosing protocol was used (JYW: high dose 24 g/day, low dose 12 g/day; Buspirone: high dose 30 mg/day, low dose 15 mg/day) and the dose was adjusted depending on whether the treatment response of Hamilton Anxiety Scale (HAMA) score was less than or equal to 25% after one week. The primary outcome was a change in total score on the HAMA. The secondary outcomes included the Hamilton Depression Scale (HAMD), Clinical Global Impression (CGI) scale, and TCM Syndrome Scale. Adverse events were recorded using the Treatment Emergent Symptom Scale (TESS). Assessments were conducted at the baseline and 1, 2, 4, and 8 weeks. Results. A total of one hundred thirty-three participants were randomly assigned to the JYW group (n = 66) and the Buspirone group (n = 67). One hundred twenty-one patients (91%) completed at least one follow-up session. There were no significant differences between the two groups in terms of gender, age, disease course, HAMA, HAMD, CGI, and TCM Syndrome Scale scores at baseline (all P>0.05). Repeated-measures analysis of variance revealed statistically significant time effects for the HAMA (P=0.002), HAMD (P = 0.018), and CGI (P=0.001) in both groups. Sensitivity analyses supported the credibility of the main results (P>0.05). The group effect was not significant for the HAMA (P=0.43), HAMD (P=0.27), CGI (P=0.37), and TCM Syndrome Scale (P=0.86). Furthermore, there were no significant interaction effects between time and group in terms of the HAMA (P=0.47), HAMD ...
    Keywords Other systems of medicine ; RZ201-999
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Xue-Jie-San prevents the early development of colitis-associated intestinal fibrosis by blocking Notch1 and FGL1 signaling pathways.

    Gao, Ying / Lu, Li-Juan / Zhang, Zhao-Zheng / Yang, Xiao / Du, Jun / Wen, Ke / Huang, Hua / Wang, Xiao-Peng / Sun, Xue-Liang

    Journal of ethnopharmacology

    2023  Volume 315, Page(s) 116678

    Abstract: Ethnopharmacological relevance: Xue-Jie-San (XJS), as a traditional Chinese herb prescription, has ...

    Abstract Ethnopharmacological relevance: Xue-Jie-San (XJS), as a traditional Chinese herb prescription, has satisfactory effects on improving clinical symptoms and facilitating the healing of intestinal ulcers in patients with Crohn's disease (CD). This motivates the application of XJS on CD-associated complications.
    Aim of the study: Intestinal fibrosis is a debilitating complication of CD. Currently, there is no effective medication available for preventing or reversing CD-related intestinal fibrosis. This study aimed to assess the efficacy and underlying mechanisms of XJS in the treatment of colitis-associated intestinal fibrosis.
    Materials and methods: A rat model of CD-related intestinal fibrosis was induced by 2,4,6-trinitrobenzene sulfonic acid administration and treated with XJS. The pathological changes of intestinal fibrosis were evaluated using Masson staining. Collagen deposition and epithelial-to-mesenchymal transition (EMT) were verified by immunohistochemical staining and Western blot analysis. Endothelial-to-mesenchymal transition (EndoMT) was assessed with immunofluorescence and immunohistochemical staining as well as Western blot analysis. Transmission electron microscopy was utilized to observe autophagosomes. The levels of autophagy-related proteins were detected via immunofluorescence staining and Western blot. Finally, the mTOR/ULK1 signaling pathway regulated by Notch1 or FGL1 was analyzed by Western blot.
    Results: The results found that XJS ameliorated intestinal fibrosis through reducing the deposition of collagens such as Collagen 1 and Collagen 3. XJS inhibited the EMT process by increasing E-cadherin levels and decreasing the expressions of N-cadherin, Vimentin and Snail, which played a crucial role in collagen secretion and intestinal fibrosis. In addition, XJS also repressed the EndoMT process as reflected by the upregulation of CD31 and VE-cadherin levels and the downregulation of FSP1 and α-SMA expressions. Autophagy was activated following XJS treatment via suppression of the mTOR/ULK1 signaling pathway. Furthermore, XJS acted as an inhibitor of Notch1 and FGL1 signals, both of which regulated the mTOR signaling.
    Conclusions: Our findings validated that XJS prevented the early development of CD-related intestinal fibrosis by blocking the Notch1 and FGL1 signaling pathways to activate autophagy and thereby inhibit EMT and EndoMT.
    MeSH term(s) Rats ; Animals ; Intestines/pathology ; Colitis/chemically induced ; Colitis/complications ; Colitis/drug therapy ; Fibrosis ; Signal Transduction ; TOR Serine-Threonine Kinases ; Epithelial-Mesenchymal Transition ; Receptor, Notch1
    Chemical Substances TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Notch1 protein, rat ; Receptor, Notch1
    Language English
    Publishing date 2023-05-30
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Real-World Study on Chai-Shi-Jie-Du Granules for the Treatment of Dengue Fever and the Possible Mechanisms Based on Network Pharmacology.

    Yang, Huiqin / Ma, Dehong / Li, Qin / Zhou, Wen / Chen, Hongyi / Shan, Xiyun / Zheng, Haipeng / Luo, Chun / Ou, Zhiyue / Xu, Jielan / Wang, Changtai / Zhao, Lingzhai / Su, Rui / Chen, Yuehong / Liu, Qingquan / Tan, Xinghua / Lin, Luping / Jiang, Tao / Zhang, Fuchun

    Evidence-based complementary and alternative medicine : eCAM

    2023  Volume 2023, Page(s) 9942842

    Abstract: ... for dengue fever. This real-world study aimed to evaluate the effects of Chai-Shi-Jie-Du (CSJD) granules ...

    Abstract Objectives: Traditional Chinese medicine (TCM) is a widely used method for treating dengue fever in China. TCM improves the symptoms of patients with dengue, but there is no standard TCM prescription for dengue fever. This real-world study aimed to evaluate the effects of Chai-Shi-Jie-Du (CSJD) granules for the treatment of dengue fever and the underlying mechanisms.
    Methods: We implemented a multicenter real-world study, an
    Results: 137 pairs of patients were successfully matched according to age, sex, and the time from onset to presentation. The time to defervescence (1.7 days vs. 2.5 days,
    Conclusions: CSJD granules exhibit high potential for the treatment of dengue fever, and the therapeutic mechanisms involved could be related to regulating immunity, moderating the oxidative stress response, and the response to lipopolysaccharide.
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2023/9942842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Neuroprotective effects of Jie-du-huo-xue decoction on microglia pyroptosis after cerebral ischemia and reperfusion--From the perspective of glial-vascular unit.

    Zhou, Chang / Li, Jin-Xia / Zheng, Cai-Xing / Zhou, Xiao-Qing / Chen, Cong / Qiu, Shi-Wei / Liu, Wang-Hua / Li, Hua

    Journal of ethnopharmacology

    2023  Volume 318, Issue Pt B, Page(s) 116990

    Abstract: ... of life. Jie-Du-Huo-Xue decoction (JDHXD) is a classical and well-known Chinese formula for stroke ...

    Abstract Ethnopharmacological relevance: Ischemic stroke poses a serious risk to public health and quality of life. Jie-Du-Huo-Xue decoction (JDHXD) is a classical and well-known Chinese formula for stroke treatment, but the pharmacological mechanism is still unclear.
    Aim of the study: This study aims to investigate the mechanism underlying microglial pyroptosis and polarization, as well as the potential efficacy of JDHXD against cerebral ischemia-reperfusion injury (CIRI).
    Materials and methods: Models of CIRI were established by the middle cerebral artery occlusion/reperfusion (MCAO/R) method in rats. In the first stage, 36 SD rats were randomly divided into sham group, I/R group, JDHXD-L group (5.36 g/kg/day), JDHXD-M group (10.71 g/kg/day), JDHXD-H group (21.42 g/kg/day), and positive drug edaravone group. The effectiveness of JDHXD on CIRI was confirmed by neurological function testing and cerebral infarct measuring. The best dose (JDXHD-M) was subsequently chosen to perform the tests that followed. In the second stage, 36 SD rats were randomly divided into the sham group, the I/R group, and the JDHXD-M group. Detection of nerve damage using Nissl staining, proteins of pyroptosis, Iba-1, and NeuN expressions were detected by western blotting, and proteins of microglial pyroptosis and M1/M2 phenotypic polarization were detected by immunofluorescence.
    Results: In rats after CIRI, JDHXD significantly reduced neurological impairment and cerebral infarction. In addition, JDHXD facilitated the M1-to-M2 transition of microglia in order to minimize neuroinflammation and improve anti-inflammatory repair. In addition, JDXHD inhibited microglial pyroptosis by blocking the cleavage of caspase-1 P10 and gasdermin D, hence reducing neuronal damage and enhancing neuronal survival following reperfusion. Interestingly, JDHXD also demonstrated a protective effect on the glial-vascular unit (GVU).
    Conclusions: Our investigation demonstrated that JDHXD exerted a GVU-protective effect on CIRI rats by decreasing neuroinflammation-associated microglial pyroptosis, suppressing microglial M1 activation, and promoting microglial M2 activation.
    MeSH term(s) Rats ; Animals ; Microglia ; Pyroptosis ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Neuroprotective Agents/metabolism ; Neuroinflammatory Diseases ; Quality of Life ; Rats, Sprague-Dawley ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Infarction, Middle Cerebral Artery/drug therapy ; Infarction, Middle Cerebral Artery/metabolism ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Reperfusion
    Chemical Substances Neuroprotective Agents
    Language English
    Publishing date 2023-08-01
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116990
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Zhuang Gu Guan Jie Wan

    Bin Liu / Danping Fan / Wen Sun / Kang Zheng / Guoming Pang / Xiaojuan He / Cheng Xiao / Cheng Lu

    Evidence-Based Complementary and Alternative Medicine, Vol

    Reasonable Application Can Alleviate the Liver Injury for Osteoarthritis Treatment

    2018  Volume 2018

    Abstract: ... Chinese patent medicine, Zhuang Gu Guan Jie Wan (ZGGJW) has been brought into focus recently ...

    Abstract The potential toxicity of herbal drugs, particularly drug-induced liver injury (DILI), has received extensive attention as the use of Chinese herbal medicine has rapidly increased globally. As a classic Chinese patent medicine, Zhuang Gu Guan Jie Wan (ZGGJW) has been brought into focus recently because of its satisfactory therapeutic effects on osteoarthritis (OA) as well as its unanticipated side effects. This study aimed to decipher the puzzling phenomenon of liver injury developing in response to ZGGJW that varies by the subtype of OA. Normal, anterior cruciate ligament transaction (ACLT) and partial medial meniscectomy (MMx) induced OA and ovariectomy combined with ACLT and partial MMx induced rat models were used and treated orally with ZGGJW or distilled water for 30 days. The results from histopathology, biochemistry, and immunohistochemistry showed that ZGGJW induced liver injury, increased the level of malondialdehyde (MDA), and decreased the levels of total antioxidation capability (T-AOC), superoxide dismutase (SOD), interleukin-22 (IL-22), and signal transducer and activator of transcription factor 3 (STAT3) in the liver of normal rats, while liver injury was alleviated and showed different tendencies in the above markers for ACLT and partial MMx induction rats and ovariectomy combined with ACLT and partial MMx induction rats after ZGGJW treatment. In the OA disease states, hepatic injury induced by ZGGJW could be associated with an impairment in antioxidant capacity and the high levels of IL-22 and STAT3 after ZGGJW treatment may be responsible for the slight hepatic injury of ZGGJW based on the subtype of OA. This study provides a novel approach to better understanding of the risks and limitations when using potentially toxic Chinese patent medicine in clinical applications.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 610
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis using omics analysis.

    Pan, Hudan / Zheng, Yanfang / Liu, Zhongqiu / Yuan, Zhongwen / Ren, Rutong / Zhou, Hua / Xie, Ying / Liu, Liang

    Frontiers of medicine

    2019  Volume 13, Issue 5, Page(s) 564–574

    Abstract: ... are complex and remain unclear. Guan-Jie-Kang (GJK), a prescription modified from "Wu Tou Decoction ...

    Abstract Traditional Chinese medicine (TCM) formulas have attracted increasing attention worldwide in the past few years for treating complex disease including rheumatoid arthritis. However, their mechanisms are complex and remain unclear. Guan-Jie-Kang (GJK), a prescription modified from "Wu Tou Decoction," was found to significantly relieve arthritis symptoms in rats with adjuvant-induced arthritis after 30-day treatment, especially in the 24 g/kg/day group. By analyzing 1749 targets related to 358 compounds in the five herbs of GJK, we identified the possible anti-arthritis pathways of GJK, including the calcium signaling and metabolic pathways. Bone damage levels were assessed by micro-computed tomography, and greater bone protective effect was observed with GJK treatment than with methotrexate. Receptor activator of nuclear factor κB ligand (RANKL)-RANK signaling, which is related to calcium signaling, was significantly regulated by GJK. Moreover, a target metabolomics assay of serum was conducted; 17 metabolic biomarkers showed significant correlations with treatment. An integrated pathway analysis revealed that pyruvate metabolism, purine metabolism, and glycolysis metabolism were significantly associated with the effects of GJK in arthritis treatment. Thus, this study establishes a new omics analytical method integrated with bioinformatics analysis for elucidating the multi-pathway mechanisms of TCM.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Arthritis, Experimental/blood ; Arthritis, Experimental/drug therapy ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/drug therapy ; Biomarkers/blood ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Male ; Metabolomics ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; X-Ray Microtomography
    Chemical Substances Anti-Inflammatory Agents ; Biomarkers ; Drugs, Chinese Herbal ; wu-tou
    Language English
    Publishing date 2019-05-14
    Publishing country China
    Document type Journal Article
    ZDB-ID 2617113-2
    ISSN 2095-0225 ; 2095-0217
    ISSN (online) 2095-0225
    ISSN 2095-0217
    DOI 10.1007/s11684-018-0676-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Multimodal Magnetic Resonance Imaging and Therapeutic Intervention With Yi-nao-jie-yu Decoction in a Rat Model of Post-stroke Depression.

    Zhao, Zijun / Zhang, Wen / Zhang, Yuan / Zhao, Yun / Zheng, Chunxiang / Tian, Huiling / Lei, Jianfeng / Liu, Yan / Zhao, Ruizhen / Tang, Qisheng

    Frontiers in psychiatry

    2020  Volume 11, Page(s) 557423

    Abstract: ... for investigating neurophysiological changes associated with PSD. Yi-nao-jie-yu decoction (YNJYD) is a Chinese ...

    Abstract Post-stroke depression (PSD) is the most common neuropsychiatric complication after a stroke, though its neuropathological characteristics have not been fully elucidated. Comprehensive and non-invasive magnetic resonance (MR) assessment techniques are urgently needed for current research, as diffusion tensor imaging (DTI), arterial spin labeling (ASL), and magnetic resonance spectroscopy (MRS) can allow for a comprehensive assessment of neuropathological changes in the brain. These techniques can provide information about microscopic tissue integrity, cerebral perfusion, and cerebral metabolism, and can serve as powerful tools for investigating neurophysiological changes associated with PSD. Yi-nao-jie-yu decoction (YNJYD) is a Chinese herbal formulation based on the theory of traditional Chinese medicine, with demonstrated clinical efficacy in the treatment of PSD. The aim of this study was to use these MR techniques to evaluate changes in PSD and YNJYD-treated rats. This is the first experimental study in animals to investigate neuropathological changes associated with PSD using a combination of multiple MR techniques, including DTI, ASL, and MRS. In addition, we investigated the effect of YNJYD in a rat model of PSD by assessing changes in brain tissue microstructure, brain metabolism, and cerebral perfusion. First, depressive-like behaviors of PSD rats were assessed by the open field test (OFT), sucrose preference test (SPT), and Morris water maze (MWM) test, and then the integrity of the rats' microstructure was assessed by DTI, the levels of regional cerebral perfusion were assessed by ASL, and changes in the relative concentrations of brain metabolites were determined by MRS. The results showed that OFT and SPT scores were significantly reduced in PSD rats, as was performance in the MWM; these PSD-associated changes were attenuated in rats administered YNJYD, with improved depressive-like behaviors evidenced by increased OFT and SPT scores and improved performance in the MWM task. Furthermore, we found that PSD rats had lower perfusion levels in the prefrontal cortex (PFC) and hippocampus (HP), microstructural damage, and abnormal changes in the concentrations of brain metabolites; YNJYD exerted therapeutic effects on PSD rats by improving microcirculation in the PFC and HP, regulating glutamatergic systems and membrane phospholipid metabolism, and repairing microstructural damage.
    Language English
    Publishing date 2020-11-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2020.557423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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