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  1. Article ; Online: Nutraceutical management of metabolic syndrome as a palliative and a therapeutic to coronavirus disease (COVID) crisis.

    Nna, Victor Udo / McGrowder, Donovan / Nwokocha, Chukwuemeka

    Archives of physiology and biochemistry

    2021  Volume 129, Issue 5, Page(s) 1123–1142

    Abstract: The global market for medicinal plants and herbs is on the increase due to their desirability, efficacy, and less adverse effects as complementary and alternative medications to the orthodox pharmaceuticals, perhaps due to their natural components and ... ...

    Abstract The global market for medicinal plants and herbs is on the increase due to their desirability, efficacy, and less adverse effects as complementary and alternative medications to the orthodox pharmaceuticals, perhaps due to their natural components and qualities. Metabolic syndromes are managed with changes in diet, exercise, lifestyle modifications and the use of pharmacological agents. Plants are now known to have potent antioxidant and cholinergic activities which are relevant to the management of several metabolic syndromes, which are unfortunately, co-morbidity factors in the coronavirus disease crisis. This review will focus on the biological activities of some plant products used as complementary and alternative medicines in the management of metabolic syndromes, and on their reported antiviral, antithrombotic, angiotensin-converting enzyme inhibitory properties, which are integral to their usage in the management of viral infections and may give an avenue for prophylactic and therapeutics especially in the absence of vaccines/formulated antiviral therapies.
    MeSH term(s) Metabolic Syndrome/drug therapy ; COVID-19 ; Plants, Medicinal ; Antiviral Agents/therapeutic use ; Dietary Supplements
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2021-03-26
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1238320-x
    ISSN 1744-4160 ; 1381-3455
    ISSN (online) 1744-4160
    ISSN 1381-3455
    DOI 10.1080/13813455.2021.1903041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Gongronema latifolium leaf extract protects against dexamethasone-induced myocardial cell injury via cardiac oxido-inflammatory molecules modulation.

    Okon, Idara Asuquo / Beshel, Justin Atiang / Nna, Victor Udo / Owu, Daniel Udofia

    Journal of food biochemistry

    2022  

    Abstract: The use of glucocorticoids in the treatment of inflammatory disorders can result in myocardial injury. This study was carried out to investigate the protective effects of ethanolic leaf extract of Gongronema latifolium (GL) in dexamethasone (DEX)-induced ...

    Abstract The use of glucocorticoids in the treatment of inflammatory disorders can result in myocardial injury. This study was carried out to investigate the protective effects of ethanolic leaf extract of Gongronema latifolium (GL) in dexamethasone (DEX)-induced myocardial injury. Wistar rats were assigned to 4 groups (n = 6) namely, control, GL, DEX, and DEX+GL groups. DEX (35 μg/kg body weight) was administered subcutaneously to induce myocardial injury, while GL leaf extract (200 mg/kg body weight) was administered orally. Both agents were administered to their respective groups for 14 days. DEX (p < .05) decreased nitric oxide and increased angiotensin-converting enzyme activity compared with the control. Serum superoxide dismutase activity and bilirubin level were decreased (p < .05), while malondialdehyde level was increased (p < .05) in the DEX group. Serum liver enzymes, inflammatory biomarkers (C-reactive protein and interleukin-6), and cardiac injury biomarkers (creatinine kinase, cardiac troponin-T, and lactate dehydrogenase) were significantly (p < .05) increased in the DEX group relative to the control. Administration of GL leaf extract attenuated these changes significantly. The study therefore suggests that GL is beneficial in the treatment of myocardial injury via the downregulation of high serum concentration of cardiac biomarkers, oxidative stress markers, and inflammatory biomarkers released as a result of the insult caused by glucocorticoid administration. PRACTICAL APPLICATIONS: In this study, we demonstrated that prolonged use of dexamethasone resulted in myocardial cell injury via increased production of reactive oxygen species, inflammatory biomarkers, and inhibition of nitric oxide, a potent vasodilator. The leaves extract of Gongronema latifolium elicits the anti-inflammatory and cardioprotective potential as an efficient inhibitor of free radicals with good antioxidant properties. The study provides scientific evidence of the therapeutic ability of the extract of G. latifolium in the treatment of DEX-induced myocardial injury and could be a drug candidate for the treatment of myocardial injury and inflammation in humans.
    Language English
    Publishing date 2022-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 433846-7
    ISSN 1745-4514 ; 0145-8884
    ISSN (online) 1745-4514
    ISSN 0145-8884
    DOI 10.1111/jfbc.14378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Angiotensin converting enzyme inhibitor potentiates the hypoglycaemic effect of NG-nitro-L-arginine methyl ester (L-NAME) in rats.

    Aluko, Esther Oluwasola / Nna, Victor Udo / Fasanmade, Adesoji Adedipe

    Archives of physiology and biochemistry

    2020  Volume 128, Issue 6, Page(s) 1524–1532

    Abstract: The inhibition of renin angiotensin system pathway has been largely documented to be effective in the control of cardiovascular events. The present study investigated the effect of angiotensin converting enzyme (ACE) inhibitor on fasting blood glucose ... ...

    Abstract The inhibition of renin angiotensin system pathway has been largely documented to be effective in the control of cardiovascular events. The present study investigated the effect of angiotensin converting enzyme (ACE) inhibitor on fasting blood glucose level in hypertension induced by the inhibition of nitric oxide synthase (NOS) in male Wistar rats. Hypertension was induced by the inhibition of NOS using a non-selective NOS inhibitor, NG-nitro-L-arginine methyl ester (L-NAME). The blockade of NOS resulted in an increase in blood pressure, ACE, angiotensin II and endothelin-1 levels, and a decrease in fasting blood glucose and nitric oxide (NO) levels. The hypertensive rats treated with ACE inhibitor (ramipril) recorded a decrease in blood pressure, ACE, angiotensin II, endothelin-1, NO and fasting blood glucose levels, and an increase in prostacyclin level. In conclusion, ACE inhibitor potentiated the hypoglycaemic effect of NOS inhibitor and this effect is independent of NO and pancreatic insulin release.
    MeSH term(s) Male ; Rats ; Animals ; NG-Nitroarginine Methyl Ester/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Peptidyl-Dipeptidase A/metabolism ; Nitric Oxide/metabolism ; Angiotensin II/pharmacology ; Hypoglycemic Agents/pharmacology ; Ramipril/adverse effects ; Endothelin-1 ; Blood Glucose ; Rats, Wistar ; Hypertension/chemically induced ; Hypertension/drug therapy ; Blood Pressure ; Nitric Oxide Synthase/metabolism ; Nitric Oxide Synthase/pharmacology ; Enzyme Inhibitors/pharmacology ; Prostaglandins I/adverse effects ; Insulins/adverse effects
    Chemical Substances NG-Nitroarginine Methyl Ester (V55S2QJN2X) ; Angiotensin-Converting Enzyme Inhibitors ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Nitric Oxide (31C4KY9ESH) ; Angiotensin II (11128-99-7) ; Hypoglycemic Agents ; Ramipril (L35JN3I7SJ) ; Endothelin-1 ; Blood Glucose ; Nitric Oxide Synthase (EC 1.14.13.39) ; Enzyme Inhibitors ; Prostaglandins I ; Insulins
    Language English
    Publishing date 2020-06-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1238320-x
    ISSN 1744-4160 ; 1381-3455
    ISSN (online) 1744-4160
    ISSN 1381-3455
    DOI 10.1080/13813455.2020.1780263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The promising roles of medicinal plants and bioactive compounds on hepatic lipid metabolism in the treatment of non-alcoholic fatty liver disease in animal models: molecular targets.

    Zakaria, Zaida / Othman, Zaidatul Akmal / Nna, Victor Udo / Mohamed, Mahaneem

    Archives of physiology and biochemistry

    2021  Volume 129, Issue 6, Page(s) 1262–1278

    Abstract: Imbalance in hepatic lipid metabolism can lead to an abnormal triglycerides deposition in the hepatocytes which can cause non-alcoholic fatty liver disease (NAFLD). Four main mechanisms responsible for regulating hepatic lipid metabolism are fatty acid ... ...

    Abstract Imbalance in hepatic lipid metabolism can lead to an abnormal triglycerides deposition in the hepatocytes which can cause non-alcoholic fatty liver disease (NAFLD). Four main mechanisms responsible for regulating hepatic lipid metabolism are fatty acid uptake, de novo lipogenesis, lipolysis and fatty acid oxidation. Controlling the expression of transcription factors at molecular level plays a crucial role in NAFLD management. This paper reviews various medicinal plants and their bioactive compounds emphasising mechanisms involved in hepatic lipid metabolism, other important NAFLD pathological features, and their promising roles in managing NAFLD through regulating key transcription factors. Although there are many medicinal plants popularly investigated for NAFLD treatment, there is still little information and scientific evidence available and there has been no research on clinical trials scrutinised on this matter. This review also aims to provide molecular information of medicinal plants in NALFD treatment that might have potentials for future scientifically controlled studies.
    MeSH term(s) Animals ; Non-alcoholic Fatty Liver Disease/metabolism ; Lipid Metabolism ; Plants, Medicinal ; Liver/metabolism ; Lipogenesis ; Fatty Acids/metabolism ; Transcription Factors/metabolism
    Chemical Substances Fatty Acids ; Transcription Factors
    Language English
    Publishing date 2021-06-21
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1238320-x
    ISSN 1744-4160 ; 1381-3455
    ISSN (online) 1744-4160
    ISSN 1381-3455
    DOI 10.1080/13813455.2021.1939387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Therapeutic Effects of Bee Bread on Obesity-Induced Testicular-Derived Oxidative Stress, Inflammation, and Apoptosis in High-Fat Diet Obese Rat Model.

    Suleiman, Joseph Bagi / Mohamed, Mahaneem / Abu Bakar, Ainul Bahiyah / Zakaria, Zaida / Othman, Zaidatul Akmal / Nna, Victor Udo

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 2

    Abstract: Obesity is a debilitating disorder with a variety of problems including oxidative stress, inflammation, and apoptosis. The aim of our study was to investigate the therapeutic role of bee bread on oxidative stress, apoptosis, and inflammation in the ... ...

    Abstract Obesity is a debilitating disorder with a variety of problems including oxidative stress, inflammation, and apoptosis. The aim of our study was to investigate the therapeutic role of bee bread on oxidative stress, apoptosis, and inflammation in the testis of obese rats. Thirty-two adult male
    Language English
    Publishing date 2022-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11020255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Oxidant-induced disruption of vascular K

    Nwokocha, Chukwuemeka / Palacios, Javier / Ojukwu, Victoria E / Nna, Victor Udo / Owu, Daniel Udofia / Nwokocha, Magdalene / McGrowder, Donovan / Orie, Nelson N

    Archives of physiology and biochemistry

    2022  , Page(s) 1–12

    Abstract: Diabetes in humans a chronic metabolic disorder characterised by hyperglycaemia, it is associated with an increased risk of cardiovascular disease, disruptions to metabolism and vascular functions. It is also linked to oxidative stress and its ... ...

    Abstract Diabetes in humans a chronic metabolic disorder characterised by hyperglycaemia, it is associated with an increased risk of cardiovascular disease, disruptions to metabolism and vascular functions. It is also linked to oxidative stress and its complications. Its role in vascular dysfunctions is generally reported without detailed impact on the molecular mechanisms. Potassium ion channel (K
    Language English
    Publishing date 2022-06-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1238320-x
    ISSN 1744-4160 ; 1381-3455
    ISSN (online) 1744-4160
    ISSN 1381-3455
    DOI 10.1080/13813455.2022.2090578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Gongronema latifolium leaf extract protects against dexamethasone‐induced myocardial cell injury via cardiac oxido‐inflammatory molecules modulation

    Okon, Idara Asuquo / Beshel, Justin Atiang / Nna, Victor Udo / Owu, Daniel Udofia

    Journal of Food Biochemistry. 2022 Dec., v. 46, no. 12 p.e14378-

    2022  

    Abstract: The use of glucocorticoids in the treatment of inflammatory disorders can result in myocardial injury. This study was carried out to investigate the protective effects of ethanolic leaf extract of Gongronema latifolium (GL) in dexamethasone (DEX)‐induced ...

    Abstract The use of glucocorticoids in the treatment of inflammatory disorders can result in myocardial injury. This study was carried out to investigate the protective effects of ethanolic leaf extract of Gongronema latifolium (GL) in dexamethasone (DEX)‐induced myocardial injury. Wistar rats were assigned to 4 groups (n = 6) namely, control, GL, DEX, and DEX+GL groups. DEX (35 μg/kg body weight) was administered subcutaneously to induce myocardial injury, while GL leaf extract (200 mg/kg body weight) was administered orally. Both agents were administered to their respective groups for 14 days. DEX (p < .05) decreased nitric oxide and increased angiotensin‐converting enzyme activity compared with the control. Serum superoxide dismutase activity and bilirubin level were decreased (p < .05), while malondialdehyde level was increased (p < .05) in the DEX group. Serum liver enzymes, inflammatory biomarkers (C‐reactive protein and interleukin‐6), and cardiac injury biomarkers (creatinine kinase, cardiac troponin‐T, and lactate dehydrogenase) were significantly (p < .05) increased in the DEX group relative to the control. Administration of GL leaf extract attenuated these changes significantly. The study therefore suggests that GL is beneficial in the treatment of myocardial injury via the downregulation of high serum concentration of cardiac biomarkers, oxidative stress markers, and inflammatory biomarkers released as a result of the insult caused by glucocorticoid administration. PRACTICAL APPLICATIONS: In this study, we demonstrated that prolonged use of dexamethasone resulted in myocardial cell injury via increased production of reactive oxygen species, inflammatory biomarkers, and inhibition of nitric oxide, a potent vasodilator. The leaves extract of Gongronema latifolium elicits the anti‐inflammatory and cardioprotective potential as an efficient inhibitor of free radicals with good antioxidant properties. The study provides scientific evidence of the therapeutic ability of the extract of G. latifolium in the treatment of DEX‐induced myocardial injury and could be a drug candidate for the treatment of myocardial injury and inflammation in humans.
    Keywords C-reactive protein ; bilirubin ; biomarkers ; blood serum ; body weight ; creatinine ; dexamethasone ; enzyme activity ; glucocorticoids ; inflammation ; interleukin-6 ; lactate dehydrogenase ; leaf extracts ; liver ; malondialdehyde ; nitric oxide ; oxidative stress ; peptidyl-dipeptidase A ; reactive oxygen species ; superoxide dismutase ; therapeutics ; troponin T
    Language English
    Dates of publication 2022-12
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 433846-7
    ISSN 1745-4514 ; 0145-8884
    ISSN (online) 1745-4514
    ISSN 0145-8884
    DOI 10.1111/jfbc.14378
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Hepatoprotective Effect of Bee Bread in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) Rats: Impact on Oxidative Stress and Inflammation.

    Zakaria, Zaida / Othman, Zaidatul Akmal / Suleiman, Joseph Bagi / Che Jalil, Nur Asyilla / Ghazali, Wan Syaheedah Wan / Nna, Victor Udo / Mohamed, Mahaneem

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 12

    Abstract: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a pathological accumulation of hepatic lipid closely linked with many metabolic disorders, oxidative stress and inflammation. We aimed to evaluate the hepatoprotective effect of bee bread on ...

    Abstract Metabolic dysfunction-associated fatty liver disease (MAFLD) is a pathological accumulation of hepatic lipid closely linked with many metabolic disorders, oxidative stress and inflammation. We aimed to evaluate the hepatoprotective effect of bee bread on oxidative stress and inflammatory parameters in MAFLD rats. Twenty-eight male
    Language English
    Publishing date 2021-12-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10122031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Malaysian propolis, metformin and their combination, exert hepatoprotective effect in streptozotocin-induced diabetic rats.

    Nna, Victor Udo / Bakar, Ainul Bahiyah Abu / Mohamed, Mahaneem

    Life sciences

    2018  Volume 211, Page(s) 40–50

    Abstract: Aims: Hepatic oxidative stress and weak antioxidant defence system resulting in hepatic lesion, has been reported in diabetic rats. The present study investigated the possible hepatoprotective effects of Malaysian propolis (MP) in diabetic rats, on the ... ...

    Abstract Aims: Hepatic oxidative stress and weak antioxidant defence system resulting in hepatic lesion, has been reported in diabetic rats. The present study investigated the possible hepatoprotective effects of Malaysian propolis (MP) in diabetic rats, on the background that MP has been reported to have anti-hyperglycemic, antioxidant and anti-inflammatory effects.
    Materials and methods: Sprague-Dawley rats were randomly divided into 5 groups, namely: normal control (NC), diabetic control (DC), diabetic on 300 mg/kg b.w. MP, diabetic on 300 mg/kg b.w. metformin, and diabetic on MP and metformin combined therapy. Treatment was done orally for 4 weeks, and NC and DC groups received distilled water as vehicle.
    Key findings: Results showed increased fasting blood glucose and serum markers of hepatic lesion (aspartate aminotransferase, alkaline phosphatase, alanine aminotransferase and gamma-glutamyl transferase), increased hepatic lactate dehydrogenase activity, decreased hepatic superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and glutathione reductase activities, increased immunoexpressions of nuclear factor kappa B, tumor necrosis factor-α, interleukin(IL)-1β and caspase-3, and decreased immunoexpressions of IL-10 and proliferating cell nuclear antigen in the liver of DC group. Histopathology of the liver revealed numerous hepatocytes with pyknotic nuclei and inflammatory infiltration, while periodic acid-schiff staining decreased in the liver of DC group. Treatment with MP attenuated these negative effects and was comparable to metformin. Furthermore, these effects were better attenuated in the combined therapy-treated diabetic rats.
    Significance: Malaysian propolis attenuates hepatic lesion in DM and exerts a synergistic protective effect with the anti-hyperglycemic medication, metformin.
    MeSH term(s) Animals ; Anti-Infective Agents/therapeutic use ; Anti-Inflammatory Agents/therapeutic use ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Drug Combinations ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Hypoglycemic Agents/therapeutic use ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Malaysia ; Male ; Metformin/therapeutic use ; Oxidative Stress/drug effects ; Propolis/therapeutic use ; Protective Agents/therapeutic use ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Anti-Infective Agents ; Anti-Inflammatory Agents ; Drug Combinations ; Hypoglycemic Agents ; Protective Agents ; Propolis (9009-62-5) ; Metformin (9100L32L2N)
    Language English
    Publishing date 2018-09-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2018.09.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Metformin mitigates impaired testicular lactate transport/utilisation and improves sexual behaviour in streptozotocin-induced diabetic rats.

    Nna, Victor Udo / Abu Bakar, Ainul Bahiyah / Ahmad, Azlina / Mohamed, Mahaneem

    Archives of physiology and biochemistry

    2019  Volume 127, Issue 1, Page(s) 51–60

    Abstract: Context: Lactate is the preferred energy substrate for developing testicular germ cells. Diabetes is associated with impaired testicular lactate transport/utilisation, and poor sexual behaviour.: Objective: To examine the effects of metformin on ... ...

    Abstract Context: Lactate is the preferred energy substrate for developing testicular germ cells. Diabetes is associated with impaired testicular lactate transport/utilisation, and poor sexual behaviour.
    Objective: To examine the effects of metformin on parameters involved in testicular lactate production, transport/utilisation, and sexual behaviour in diabetic state.
    Methods: Male
    Results: Intra-testicular glucose and lactate levels, and lactate dehydrogenase (LDH) activity increased, while the mRNA transcript levels of genes responsible for testicular glucose and lactate transport/utilisation (glucose transporter 3, monocarboxylate transporter 4 (MCT4), MCT2, and LDH type C) decreased in DC group. Furthermore, penile nitric oxide increased, while cyclic guanosine monophosphate decreased, with impaired sexual behaviour in DC group. Treatment with metformin improved these parameters.
    Conclusions: Metformin increases testicular lactate transport/utilisation and improves sexual behaviour in diabetic state.
    MeSH term(s) Animals ; Biological Transport ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Type 1/drug therapy ; Glucose Tolerance Test ; Glucose Transporter Type 1/biosynthesis ; Glucose Transporter Type 3/biosynthesis ; Hypoglycemic Agents/pharmacology ; Insulin/blood ; Lactic Acid/metabolism ; Male ; Metformin/pharmacology ; Nitric Oxide/metabolism ; Penis/metabolism ; Rats ; Rats, Sprague-Dawley ; Sexual Behavior, Animal/drug effects ; Streptozocin ; Testis/metabolism
    Chemical Substances Glucose Transporter Type 1 ; Glucose Transporter Type 3 ; Hypoglycemic Agents ; Insulin ; Slc2a1 protein, rat ; Slc2a3 protein, rat ; Nitric Oxide (31C4KY9ESH) ; Lactic Acid (33X04XA5AT) ; Streptozocin (5W494URQ81) ; Metformin (9100L32L2N)
    Language English
    Publishing date 2019-05-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1238320-x
    ISSN 1744-4160 ; 1381-3455
    ISSN (online) 1744-4160
    ISSN 1381-3455
    DOI 10.1080/13813455.2019.1610778
    Database MEDical Literature Analysis and Retrieval System OnLINE

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