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Article: Sensory acceptability of value added cookies incorporated with

Tyagi, Prachi / Chauhan, Anil Kumar / Singh, Som Nath

2020 Volume 57, Issue 8, Page(s) 2934–2940

Abstract: Tinospora ... ...

Abstract	Tinospora cordifolia
Language	English
Publishing date	2020-03-13
Publishing country	India
Document type	Journal Article
ZDB-ID	242498-8
ISSN	0975-8402 ; 0022-1155
ISSN (online)	0975-8402
ISSN	0022-1155
DOI	10.1007/s13197-020-04325-5
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Article: Mung-Oat snack of high protein content by twin screw extrusion using response surface methodology

Jain, Radhika / Goomer, Sangeeta / Singh, Som Nath

Applied food research. 2022 June, v. 2, no. 1

2022

Abstract: Mung bean and oat flour were utilized to extrude snacks with high protein content using response surface methodology. Raw material ratio was standardized using NDpCal% to ensure mutual supplementation of essential amino acids such as lysine, methionine, ... ...

Abstract	Mung bean and oat flour were utilized to extrude snacks with high protein content using response surface methodology. Raw material ratio was standardized using NDpCal% to ensure mutual supplementation of essential amino acids such as lysine, methionine, cysteine, threonine and tryptophan. Moisture content ranging between 11% to 20% and barrel temperature 95 °C to 180 °C had shown significant influence on the development of extrudates. Parameters such as moisture content (4.94–6.21%), moisture retention (17.53–59.58%), expansion ratio (2.60–3.82), bulk density (0.021–0.79 g/cm³), water absorption index (4.86–7.53%), water solubility index (18.3–25.2%), water holding capacity (74.65–88.65%) were analyzed. Addition of moisture to feed mixture has significantly affected the expansion ratio, bulk density, water absorption index, water solubility index and water holding capacity (p < 0.05) and coefficient of regression R²0.8802, 0.8920, 0.5042, 0.5925 and 0.9197, respectively. Sensory evaluation using 9-point hedonic scale was also conducted.
Keywords	bulk density ; cysteine ; extrusion ; food research ; hedonic scales ; lysine ; methionine ; mung beans ; oat flour ; protein content ; raw materials ; response surface methodology ; sensory evaluation ; temperature ; threonine ; tryptophan ; water content ; water solubility ; water uptake
Language	English
Dates of publication	2022-06
Publishing place	Elsevier B.V.
Document type	Article
ISSN	2772-5022
DOI	10.1016/j.afres.2022.100099
Database	NAL-Catalogue (AGRICOLA)

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Article: Optimal Cut-Off Values for Body Mass Index and Fat Mass Index Based on Age in Physically Active Males Using Receiver Operating Characteristic Curve.

Masih, Daisy / Rakhra, Gurseen / Vats, Annu / Verma, Saroj Kumar / Singh, Vijay Kumar / Kirar, Vandana / Tripathi, Jitendra Kumar / Singh, Som Nath

Diseases (Basel, Switzerland)

2023 Volume 11, Issue 4

Abstract: This study aims to redefine obesity cut-off points for body mass index (BMI) and fat mass index (FMI) according to the different age groups of physically active males. Healthy physically active volunteers (N = 1442) aged 18-57 years (y), with a mean BMI = ...

Abstract	This study aims to redefine obesity cut-off points for body mass index (BMI) and fat mass index (FMI) according to the different age groups of physically active males. Healthy physically active volunteers (N = 1442) aged 18-57 years (y), with a mean BMI = 22.7 ± 2.8 kg/m
Language	English
Publishing date	2023-10-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720869-2
ISSN	2079-9721
ISSN	2079-9721
DOI	10.3390/diseases11040137
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Article: Multipotent antioxidant and antitoxicant potentiality of an indigenous probiotic

Ray, Mousumi / Hor, Papan / Singh, Som Nath / Mondal, Keshab Chandra

Journal of food science and technology

2021 Volume 58, Issue 12, Page(s) 4795–4804

Abstract: Probiotic bacteria are now becoming an effective natural medicine for alleviating many non-communicable lifestyle-related diseases. The present study was conducted to evaluate the antioxidant and antitoxicant properties of a foodborne ... ...

Abstract	Probiotic bacteria are now becoming an effective natural medicine for alleviating many non-communicable lifestyle-related diseases. The present study was conducted to evaluate the antioxidant and antitoxicant properties of a foodborne probiotic
Language	English
Publishing date	2021-01-31
Publishing country	India
Document type	Journal Article
ZDB-ID	242498-8
ISSN	0975-8402 ; 0022-1155
ISSN (online)	0975-8402
ISSN	0022-1155
DOI	10.1007/s13197-021-04975-z
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Article ; Online: Insight into the role of myokines and myogenic regulatory factors under hypobaric hypoxia induced skeletal muscle loss.

Srivastava, Sukanya / Rathor, Richa / Singh, Som Nath / Suryakumar, Geetha

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

2022 Volume 27, Issue 8, Page(s) 753–763

Abstract: Background: The present study aimed to analyse the role of myokines and the regeneration capacity of skeletal muscle during chronic hypobaric hypoxia (CHH).: Methods: Male Sprague-Dawley rats were exposed to hypobaric hypoxia (HH) for 1d, 3d and 7d.!# ...

Abstract	Background: The present study aimed to analyse the role of myokines and the regeneration capacity of skeletal muscle during chronic hypobaric hypoxia (CHH). Methods: Male Sprague-Dawley rats were exposed to hypobaric hypoxia (HH) for 1d, 3d and 7d. Results: Exposure to HH enhanced the levels of decorin, irisin, IL-6 and IL-15 till 3 days of hypoxia and on 7 day of exposure, no significant changes were observed in relation to control. A significant upregulation in myostatin, activated protein kinase, SMAD3, SMAD4, FOXO-1, MURF-1 expression was observed with prolonged HH exposure as compared to normoxic control. Further, myogenesis-related markers, PAX-7, Cyclin D1 and myogenin were downregulated during CHH exposure in comparison to control. Energy metabolism regulators such as Sirtuin 1, proliferator-activated receptor gamma coactivator-1α and GLUT-4, were also increased on 1-d HH exposure that showed a declining trend on CHH exposure. Conclusions: These results indicated the impairment in the levels of myokines and myogenesis during prolonged hypoxia. CHH exposure enhanced the levels of myostatin and reduced the regeneration or repair capacity of the skeletal muscles. Myokine levels could be a predictive biomarker for evaluating skeletal muscle performance and loss at high altitudes.
MeSH term(s)	Rats ; Animals ; Male ; Myostatin ; Myogenic Regulatory Factors/genetics ; Myogenic Regulatory Factors/metabolism ; Rats, Sprague-Dawley ; Hypoxia ; Muscle, Skeletal
Chemical Substances	Myostatin ; Myogenic Regulatory Factors
Language	English
Publishing date	2022-08-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1324372-x
ISSN	1366-5804 ; 1354-750X
ISSN (online)	1366-5804
ISSN	1354-750X
DOI	10.1080/1354750X.2022.2112290
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Article ; Online: Diet and redox state in maintaining skeletal muscle health and performance at high altitude.

Rathor, Richa / Suryakumar, Geetha / Singh, Som Nath

Free radical biology & medicine

2021 Volume 174, Page(s) 305–320

Abstract: High altitude exposure leads to compromised physical performance with considerable weight loss. The major stressor at high altitude is hypobaric hypoxia which leads to disturbance in redox homeostasis. Oxidative stress is a well-known trigger for many ... ...

Abstract	High altitude exposure leads to compromised physical performance with considerable weight loss. The major stressor at high altitude is hypobaric hypoxia which leads to disturbance in redox homeostasis. Oxidative stress is a well-known trigger for many high altitude illnesses and regulates several key signaling pathways under stressful conditions. Altered redox homeostasis is considered the prime culprit of high altitude linked skeletal muscle atrophy. Hypobaric hypoxia disturbs redox homeostasis through increased RONS production and compromised antioxidant system. Increased RONS disturbs the cellular homeostasis via multiple ways such as inflammation generation, altered protein anabolic pathways, redox remodeling of RyR1 that contributed to dysregulated calcium homeostasis, enhanced protein degradation pathways via activation calcium-regulated protein, calpain, and apoptosis. Ultimately, all the cellular signaling pathways aggregately result in skeletal muscle atrophy. Dietary supplementation of phytochemicals could become a safe and effective intervention to ameliorate skeletal muscle atrophy and enhance the physical performance of the personnel who are staying at high altitude regions. The present evidence-based review explores few dietary supplementations which regulate several signaling mechanisms and ameliorate hypobaric hypoxia induced muscle atrophy and enhances physical performance. However, a clinical research trial is required to establish proof-of-concept.
MeSH term(s)	Altitude ; Altitude Sickness/metabolism ; Diet ; Humans ; Hypoxia/metabolism ; Muscle, Skeletal/metabolism ; Oxidation-Reduction
Language	English
Publishing date	2021-08-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2021.07.024
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Article ; Online: KCMF1 regulates autophagy and ion channels' function in renal cell carcinoma: a future therapeutic target.

Singh, Ashu / Choudhury, Saumitra Dey / Singh, Prabhjot / Singh, Vishwendra Vikram / Singh, Som Nath / Sharma, Alpana

Journal of cancer research and clinical oncology

2022 Volume 149, Issue 9, Page(s) 5617–5626

Abstract: Introduction: In RCC, systematic procedures such as surgery, chemo-radiation therapy, and application of target-based inhibitors increase the risk of several comorbidities such as chronic kidney disease, hemorrhage, and cardiac arrest that may increase ... ...

Abstract	Introduction: In RCC, systematic procedures such as surgery, chemo-radiation therapy, and application of target-based inhibitors increase the risk of several comorbidities such as chronic kidney disease, hemorrhage, and cardiac arrest that may increase the mortality rate. Even though immune-based checkpoint inhibitor therapies have an overall good response rate, it is restricted to only 30-40% of patients. Hence, an in-depth study of tumor pathophysiology in RCC is needed to identify the new therapeutic target. In RCC, persisted hypoxia is an essential phenomenon for tumor growth and progression. KCMF1 is a newly identified ubiquitin ligase whose domain interacts with destabilized proteins and reprogrammed the ubiquitin coding for lysosome-mediated degradation and autophagy under hypoxic conditions/oxidative stress and maintaining cellular homeostasis. But in RCC, the functional role of KCMF1 remains undefined to date. Method: We determined KCMF1 and its associated proteins RAD6 and UBR4 expression and their co-localization using confocal microscopy in tumor and non-tumor tissues samples. Further, immunofluorescence staining was performed to determine autophagy (LC3B, p62), hypoxia-inducible factor (HIF-1A) and ion channel markers (Kv1.3, KCNN4) in RCC patients (n-10). Inductively coupled plasma mass spectrophotometry (ICPMS) was performed to estimate the concentration of potassium (K Result and conclusion: We observed a discrepancy in the formation of ubiquitin ligase, autophagosome via KCMF1, and ionic concentration in tumor cells, which might be one of the possible factors for cancer evolution. KCMF1-associated ubiquitin ligase system could be considered as a novel therapeutic target for RCC in the future.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/pathology ; Proteins ; Ligases ; Kidney Neoplasms/pathology ; Autophagy ; Hypoxia ; Ubiquitins ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	Proteins ; Ligases (EC 6.-) ; Ubiquitins ; KCMF1 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2022-12-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-022-04507-y
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Article ; Online: Optimal Cut-Off Values for Body Mass Index and Fat Mass Index Based on Age in Physically Active Males Using Receiver Operating Characteristic Curve

Daisy Masih / Gurseen Rakhra / Annu Vats / Saroj Kumar Verma / Vijay Kumar Singh / Vandana Kirar / Jitendra Kumar Tripathi / Som Nath Singh

Diseases, Vol 11, Iss 4, p

2023 Volume 137

Abstract	This study aims to redefine obesity cut-off points for body mass index (BMI) and fat mass index (FMI) according to the different age groups of physically active males. Healthy physically active volunteers (N = 1442) aged 18–57 years (y), with a mean BMI = 22.7 ± 2.8 kg/m 2 , and mean FMI = 4.3 ± 1.7 kg/m 2 were recruited from various fitness centers. BMI was calculated and individuals were categorized according to the Asia–Pacific BMI criterion of ≤22.9 kg/m 2 and the previous WHO-guided BMI criterion of ≤24.9 kg/m 2 . FMI was also calculated for the study participants with a cut-off of 6.6 kg/m 2 . Redefining of BMI and FMI cut-off values was carried out based on different age groups categorized with a difference of 10 y and 5 y using the receiver operating characteristic (ROC) curve and Youden’s index. For the entire study population, BMI redefined cut-off points for overweight and obesity were 23.7 kg/m 2 and 24.5 kg/m 2 , respectively, while FMI redefined cut-off points for overweight and obesity were 4.6 kg/m 2 and 5.7 kg/m 2 , respectively. With 10 y of age group difference, a constant BMI and FMI values were observed, while with 5 y of age group difference, a constant increase in the BMI cut-offs was observed as the age group increased, i.e., from 23.3 kg/m 2 in 20–24 y to 26.6 kg/m 2 in ≥45 y and a similar trend was seen in FMI cut-offs. To conclude, our study suggests that age-dependent BMI and FMI cut-off points may provide appropriate measurements for physically active males as the age group increases.
Keywords	bioelectric impedance analysis ; fat mass ; obesity ; overweight ; Youden index ; Medicine ; R
Subject code	333
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Emerging role of MyomiRs as biomarkers and therapeutic targets in skeletal muscle diseases.

Srivastava, Sukanya / Rathor, Richa / Singh, Som Nath / Suryakumar, Geetha

American journal of physiology. Cell physiology

2021 Volume 321, Issue 5, Page(s) C859–C875

Abstract: Several chronic diseases lead to skeletal muscle loss and a decline in physical performance. MicroRNAs (miRNAs) are small, noncoding RNAs, which have exhibited their role in the development and diseased state of the skeletal muscle. miRNA regulates gene ... ...

Abstract	Several chronic diseases lead to skeletal muscle loss and a decline in physical performance. MicroRNAs (miRNAs) are small, noncoding RNAs, which have exhibited their role in the development and diseased state of the skeletal muscle. miRNA regulates gene expression by binding to the 3' untranslated region of its target mRNA. Due to the robust stability in biological fluids, miRNAs are ideal candidate as biomarker. These miRNAs provide a novel avenue in strengthening our awareness and knowledge about the factors governing skeletal muscle functions such as development, growth, metabolism, differentiation, and cell proliferation. It also helps in understanding the therapeutic strategies in improving or conserving skeletal muscle health. This review outlines the evidence regarding the present knowledge on the role miRNA as a potential biomarker in skeletal muscle diseases and their exploration might be a unique and potential therapeutic strategy for various skeletal muscle disorders.
MeSH term(s)	Animals ; Biomarkers/metabolism ; Cell Differentiation ; Cell Proliferation ; Gene Expression Regulation ; Gene Regulatory Networks ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Muscle Development ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Muscle, Skeletal/physiopathology ; Muscular Atrophy/diagnosis ; Muscular Atrophy/genetics ; Muscular Atrophy/metabolism ; Muscular Atrophy/therapy ; Muscular Diseases/diagnosis ; Muscular Diseases/genetics ; Muscular Diseases/metabolism ; Muscular Diseases/therapy ; Protein Interaction Maps ; Signal Transduction
Chemical Substances	Biomarkers ; MicroRNAs
Language	English
Publishing date	2021-09-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	392098-7
ISSN	1522-1563 ; 0363-6143
ISSN (online)	1522-1563
ISSN	0363-6143
DOI	10.1152/ajpcell.00057.2021
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Article ; Online: Coronavirus Disease 2019 (COVID-19): Research, Clinical Knowledge, and Preventive Measures.

Rathor, Richa / Suryakumar, Geetha / Singh, Som Nath / Kumar, Bhuvnesh

Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer

2021 Volume 40, Issue 1, Page(s) 29–42

Abstract: In early December 2019, a novel coronavirus disease 2019 (COVID-19), the global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) commenced in Wuhan, China, and WHO declared the outbreak a pandemic and Public Health ... ...

Abstract	In early December 2019, a novel coronavirus disease 2019 (COVID-19), the global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) commenced in Wuhan, China, and WHO declared the outbreak a pandemic and Public Health Emergency of International Concern. An ample number of clinical trials with multiple drugs is underway to overcome the current perilous condition. Still, the situation is alarming with no therapeutic measure in our hand at present. Keeping the present scenario in mind, this review comprises the research, clinical knowledge, and repurposed herbals with regard to COVID-19. Preventive measures such as yoga, nasal breathing, and herbal administration could also provide protection and beneficial effects against coronavirus. Innumerable clinical trials are ongoing to manage COVID-19 and the drugs were selected on the basis of life cycle of coronavirus. The selection of herbals was done on the basis of the previous reported pharmacological activities and docking study. The results concluded that garlic, liquorice, and Ashwagandha have a potential against SARS-CoV-2, which was further proved via a docking study and their reported biological functions. The very well-known fact "prevention is always better than cure" is applied to overcome with coronavirus infection. It is expected that following the preventive measures could impede or lessen the adverse effect of SARS-CoV-2.
MeSH term(s)	COVID-19/drug therapy ; COVID-19/prevention & control ; Humans ; Life Cycle Stages ; Nitric Oxide/therapeutic use ; Phytotherapy ; Plants, Medicinal ; SARS-CoV-2/chemistry ; Yoga
Chemical Substances	Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2021-02-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	441790-2
ISSN	2162-6537 ; 0731-8898 ; 0146-4779
ISSN (online)	2162-6537
ISSN	0731-8898 ; 0146-4779
DOI	10.1615/JEnvironPatholToxicolOncol.2020036207
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