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  1. Article ; Online: Senescence: A new kid in the block of the metabolic response to surgical trauma.

    Laviano, Alessandro

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2023  , Page(s) 107048

    Abstract: Tumor growth is associated to chronic metabolic changes which inform the clinical phenotype and the outcome of patients with cancer. Surgery further triggers a cascade of acute neuro-immune responses leading to hypermetabolic and catabolic state. The ... ...

    Abstract Tumor growth is associated to chronic metabolic changes which inform the clinical phenotype and the outcome of patients with cancer. Surgery further triggers a cascade of acute neuro-immune responses leading to hypermetabolic and catabolic state. The metabolic mechanisms associated to surgical stress are well described. Preventive and therapeutic strategies have been developed, yet they appear not to benefit all surgical patients with cancer, even in the presence of a similar tumor type as well surgical procedures. Recent studies show that aging is associated with enrichment of senescent cells in different organs and tissues. Senescent cells are characterized by a specific senescence-associated secretory phenotype (SASP), which limits the potential for resilience of tissues and organs. Enhancement of the metabolic and functional recovery of patients with cancer undergoing surgery may therefore require additional therapies addressing SASP and senescent cells. Preliminary results obtained in experimental models recommend to further explore the role of senescence in mediating the metabolic changes and tissue resistance to efficient recovery.
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2023.107048
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1149: Show issues Location:
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  2. Article ; Online: Current guidelines for nutrition therapy in cancer: The arrival of a long journey or the starting point?

    Laviano, Alessandro

    JPEN. Journal of parenteral and enteral nutrition

    2022  Volume 45, Issue S2, Page(s) 12–15

    Abstract: Large epidemiological data reveal that cancer is progressively becoming a chronic and disabling disease. Implementation in daily practice of early therapies aiming at addressing patients' needs is imperative. Nutrition is a major determinant of patients' ...

    Abstract Large epidemiological data reveal that cancer is progressively becoming a chronic and disabling disease. Implementation in daily practice of early therapies aiming at addressing patients' needs is imperative. Nutrition is a major determinant of patients' quality of life, yet it is frequently neglected. Hopefully, reverting this skeptical clinical approach to nutrition, clinical practice guidelines of nutrition care in patients with cancer have been developed and published by international oncology and nutrition societies. By analyzing the more recent guidelines, it appears that a number of issues may contribute to their insufficient implementation in daily practice. Among them are heterogeneity of recommendations across different guidelines and insufficient robustness of evidence, as well as questionable generalization of recommendations. Future guidelines should aim at providing tumor-specific recommendations for the whole clinical journey of patients with cancer. Also, new, interesting areas should be covered, including fasting metabolism and circadian rhythmicity.
    MeSH term(s) Humans ; Neoplasms/therapy ; Nutrition Therapy ; Nutritional Status ; Nutritional Support ; Quality of Life
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 800861-9
    ISSN 1941-2444 ; 0148-6071
    ISSN (online) 1941-2444
    ISSN 0148-6071
    DOI 10.1002/jpen.2288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1524: Show issues Location:
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  3. Article ; Online: High protein diet in digestive cancers.

    Laviano, Alessandro

    Current opinion in clinical nutrition and metabolic care

    2022  Volume 25, Issue 5, Page(s) 348–353

    Abstract: Purpose of review: Recent advances in the nutritional management of patients with digestive cancers suggest that modulation of protein intake may significantly contribute to achieve nutritional and clinical benefits. By reviewing the available evidence, ...

    Abstract Purpose of review: Recent advances in the nutritional management of patients with digestive cancers suggest that modulation of protein intake may significantly contribute to achieve nutritional and clinical benefits. By reviewing the available evidence, a quantitatively and qualitatively optimal protein intake could be derived.
    Recent findings: High protein diets (i.e., 1-1.5 g/kg body weight/day) appear key to maintain the adequate nutritional status, and may also contribute to achieve clinical benefits. This target appears particularly relevant in patients with digestive cancers at risk or already malnourished, or in older patients. During active cancer treatments, protein intake should be closer to the upper limit of the recommended intake. Also, high protein intake should be maintained beyond the periods of catabolic crisis associated with active treatments. In contrast with general reasoning, animal proteins should represent the majority of the recommended intake. Based on the available evidence, the intake of no specific amino acid can be strongly recommended to enhance anabolic potentials or the immune modulating effects of high protein diets.
    Summary: High protein intake, mostly based on animal proteins, should be recommended to patients with digestive cancers. However, this target should be translated into clinical prescription after considering the clinical and metabolic needs of the patients. The quest for the optimal protein intake of patients with cancer at different time points of their clinical journey is still open.
    MeSH term(s) Amino Acids ; Animals ; Diet ; Diet, High-Protein ; Dietary Proteins/metabolism ; Humans ; Malnutrition ; Neoplasms ; Nutritional Status
    Chemical Substances Amino Acids ; Dietary Proteins
    Language English
    Publishing date 2022-07-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1460178-3
    ISSN 1473-6519 ; 1363-1950
    ISSN (online) 1473-6519
    ISSN 1363-1950
    DOI 10.1097/MCO.0000000000000857
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    Zs.A 5586: Show issues Location:
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  4. Article ; Online: Sarcopenia, biological age and treatment eligibility in patients with cancer.

    Laviano, Alessandro

    Current opinion in clinical nutrition and metabolic care

    2022  Volume 26, Issue 1, Page(s) 59–63

    Abstract: Purpose of review: Cancer incidence will dramatically increase, especially among older adults, during the next few decades. This may lead to bankruptcy of the healthcare systems worldwide if the current approach to treatment eligibility is not improved. ...

    Abstract Purpose of review: Cancer incidence will dramatically increase, especially among older adults, during the next few decades. This may lead to bankruptcy of the healthcare systems worldwide if the current approach to treatment eligibility is not improved. In fact, current treatment personalization is mostly focusing on the genetic and molecular characteristics of cancer cells, whereas clinical characterization of patients is still dependent on gross variables (i.e. chronological age, BMI, comorbidities, Performance Status and so on). This could have contributed to the poor performance of many anticancer drugs in the real-world setting when compared with the results obtained in prospective, randomized clinical trials.
    Recent findings: The role of chronological age in identifying patients with increased likelihood to respond to therapies has been challenged, pointing to biological age (i.e. accumulated damage to biological systems over the life course, leading to loss of reserve and capacity to respond to challenges) as a robust predictor of outcome encompassing genetic, phenotypic and clinical factors. Sarcopenia has been proposed as a reliable clinical index of biological age, but the complexity of body composition changes occurring during tumour growth appears to preclude its routine use when assessing eligibility in cancer patients.
    Summary: Integration of sarcopenia measures within scores of allostatic load may further increase the clinical relevance of changes of body composition, highlight its sensitivity to early nutritional intervention leading to mitigation of accelerated ageing, and contribute to wide delivery of precision oncology.
    MeSH term(s) Humans ; Aged ; Sarcopenia/etiology ; Sarcopenia/epidemiology ; Neoplasms/complications ; Prospective Studies ; Precision Medicine ; Aging
    Language English
    Publishing date 2022-12-06
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1460178-3
    ISSN 1473-6519 ; 1363-1950
    ISSN (online) 1473-6519
    ISSN 1363-1950
    DOI 10.1097/MCO.0000000000000888
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  5. Book: Oxidative stress in disease

    Laviano, Alessandro

    (Current nutrition & food science ; 3,3)

    2007  

    Author's details guest ed.: Alessandro Laviano
    Series title Current nutrition & food science ; 3,3
    Collection
    Language English
    Size S. 183 - 235 : graph. Darst.
    Publisher Bentham Science
    Publishing place San Francisco, Calif
    Publishing country United States
    Document type Book
    HBZ-ID HT015265342
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    Z 7566 (3,3) available for loan (reading room) Freihandmagazin (U1)

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  6. Article ; Online: Reply - Letter to the Editor - Malnutrition: The kiss of grim reaper.

    Laviano, Alessandro

    Clinical nutrition (Edinburgh, Scotland)

    2016  Volume 35, Issue 4, Page(s) 982

    MeSH term(s) Apoptosis ; Humans ; Malnutrition ; Peptides
    Chemical Substances Peptides
    Language English
    Publishing date 2016
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2016.04.030
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  7. Article ; Online: Nutrition: New challenges for a venerable vision.

    Laviano, Alessandro

    Nutrition (Burbank, Los Angeles County, Calif.)

    2016  Volume 32, Issue 1, Page(s) 2

    MeSH term(s) Humans ; Nutritional Sciences ; Periodicals as Topic ; Publishing
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2015.10.002
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    Zs.A 2290: Show issues Location:
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  8. Article ; Online: Numbers which count.

    Laviano, Alessandro

    Clinical nutrition (Edinburgh, Scotland)

    2016  Volume 35, Issue 1, Page(s) 5–6

    MeSH term(s) Dietary Proteins/administration & dosage ; Hospitalization ; Humans ; Malnutrition/diet therapy ; Nutrition Therapy/methods
    Chemical Substances Dietary Proteins
    Language English
    Publishing date 2016-01-18
    Publishing country England
    Document type Editorial
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2016.01.011
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  9. Article ; Online: Living in interesting times--challenging protein metabolism in the era of the epidemiological shift.

    Laviano, Alessandro

    Current opinion in clinical nutrition and metabolic care

    2016  Volume 19, Issue 1, Page(s) 37–38

    MeSH term(s) Aging/physiology ; Diet ; Dietary Proteins/metabolism ; Humans ; Proteins/metabolism
    Chemical Substances Dietary Proteins ; Proteins
    Language English
    Publishing date 2016-01
    Publishing country England
    Document type Editorial
    ZDB-ID 1460178-3
    ISSN 1473-6519 ; 1363-1950
    ISSN (online) 1473-6519
    ISSN 1363-1950
    DOI 10.1097/MCO.0000000000000244
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  10. Article: Current Screening Methods for the Risk or Presence of Malnutrition in Cancer Patients.

    Molfino, Alessio / Imbimbo, Giovanni / Laviano, Alessandro

    Cancer management and research

    2022  Volume 14, Page(s) 561–567

    Abstract: Malnutrition is highly common among cancer patients and is associated with a poor quality of life, increased treatment toxicities and decreased survival. The screening of malnutrition should be performed in an early stage of cancer disease and should be ... ...

    Abstract Malnutrition is highly common among cancer patients and is associated with a poor quality of life, increased treatment toxicities and decreased survival. The screening of malnutrition should be performed in an early stage of cancer disease and should be rapid, not expensive and highly sensitive to identify the risk of developing malnutrition. Importantly, international clinical guidelines suggest to perform screening for malnutrition in all cancer patients and if the risk is present, they recommend to perform a full nutritional assessment. During the screening phase, different nutritional parameters are considered including the loss of appetite, low food intake, body weight loss and burden of the disease. These items are present in several screening tools, such as the Nutrition Risk Screening (NRS)-2002, the Malnutrition Universal Screening Tool (MUST) and the Mini Nutritional Assessment (MNA) which represent the most widely used tools to screen for an altered nutritional status in cancer patients. Recently, the Global Leadership Initiative on Malnutrition (GLIM) developed an assessment tool for the diagnosis of malnutrition taking into account the presence of i) involuntary body weight loss, ii) body mass index, iii) low muscle mass, iv) low food intake and disease burden/inflammation; in particular, body weight loss, decreased body mass index (BMI), and low muscle mass are considered as phenotypic criteria, whereas reduced food intake, disease burden and inflammation are defined as etiologic criteria. To perform the diagnosis of malnutrition, GLIM consensus considered the presence of at least one phenotypic and one etiologic criterion. The above-mentioned screening tools were validated in different clinical settings and suggesting the use of one tool vs another is challenging considering, among others, different factors including the type and stage of cancer and the setting (i.e., inpatient or outpatient care). Recent data obtained among large cohorts of cancer patients indicate that personalized nutritional therapy reduced mortality risk and ameliorated quality of life and functionality among cancer patients with high nutritional risk, supporting the urgent need for implementing screening and diagnosis of malnutrition in this context.
    Language English
    Publishing date 2022-02-15
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2508013-1
    ISSN 1179-1322
    ISSN 1179-1322
    DOI 10.2147/CMAR.S294105
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