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  1. Article ; Online: Malnutrition in older adults: a wider view.

    Azzolino, Domenico / Lucchi, Tiziano

    Lancet (London, England)

    2023  Volume 402, Issue 10416, Page(s) 1976

    MeSH term(s) Humans ; Aged ; Malnutrition/epidemiology ; Nutritional Status ; Geriatric Assessment
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)01780-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fatigue in the COVID-19 pandemic.

    Azzolino, Domenico / Cesari, Matteo

    The Lancet. Healthy longevity

    2022  Volume 3, Issue 3, Page(s) e128–e129

    MeSH term(s) COVID-19 ; Fatigue ; Humans ; Pandemics
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Journal Article
    ISSN 2666-7568
    ISSN (online) 2666-7568
    DOI 10.1016/S2666-7568(22)00029-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Obesity and COVID-19.

    Azzolino, Domenico / Cesari, Matteo

    Frontiers in endocrinology

    2020  Volume 11, Page(s) 581356

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Humans ; Inflammation/complications ; Italy/epidemiology ; Obesity/physiopathology ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; Renin-Angiotensin System ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2020.581356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Obesity and COVID-19

    Domenico Azzolino / Matteo Cesari

    Frontiers in Endocrinology, Vol

    2020  Volume 11

    Keywords aging ; inflammation ; nutrition ; SARS - CoV-2 ; body mass Index ; sarcopenic obesity ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; covid19
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Obesity and COVID-19

    Azzolino, Domenico / Cesari, Matteo

    Frontiers in Endocrinology

    2020  Volume 11

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2020.581356
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: When the Pandemic Will Be Over: Lots of Hope and Some Concerns.

    Azzolino, Domenico / Spolidoro, Giulia Carla Immacolata / Mazzocchi, Alessandra / Agostoni, Carlo / Cesari, Matteo

    Geriatrics (Basel, Switzerland)

    2022  Volume 7, Issue 5

    Abstract: The COVID-19 pandemic significantly threatened healthcare systems worldwide. The worst-hit population has been represented by older people with underlying chronic comorbidities, while children and adolescents developed mild or asymptomatic forms of the ... ...

    Abstract The COVID-19 pandemic significantly threatened healthcare systems worldwide. The worst-hit population has been represented by older people with underlying chronic comorbidities, while children and adolescents developed mild or asymptomatic forms of the disease. However, certain medical conditions (i.e., obesity, respiratory, or neurological or immune disorders) may increase the risk for poor health outcomes even in young and middle-aged people. Beyond the direct negative effects of the infection, the pandemic posed several health challenges through an increase in psycho-social issues (i.e., anxiety, depression, fatigue, sleep alterations, loneliness, reduced assistance, and loss of income). Accordingly, the pandemic is negatively impacting the accumulation of the functional reserves of each individual, starting from early life. With the long-term effects of the pandemic to be seen in the coming years, clinicians must be prepared to manage such high clinical complexity of people they encounter, through the implementation of multidimensional and multidisciplinary interventions.
    Language English
    Publishing date 2022-10-18
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2308-3417
    ISSN (online) 2308-3417
    DOI 10.3390/geriatrics7050116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Diet Diversity Through the Life-Course as an Opportunity Toward Food Allergy Prevention.

    Spolidoro, Giulia C I / Azzolino, Domenico / Cesari, Matteo / Agostoni, Carlo

    Frontiers in allergy

    2021  Volume 2, Page(s) 711945

    Abstract: The prevalence of food allergies (FA) is increasing worldwide. Generally, the onset of allergies, including FA, begins in early childhood and may persist and/or develop through the life-course. Even though epidemiological studies have focused mainly on ... ...

    Abstract The prevalence of food allergies (FA) is increasing worldwide. Generally, the onset of allergies, including FA, begins in early childhood and may persist and/or develop through the life-course. Even though epidemiological studies have focused mainly on children, allergies can also occur for the first-time during adulthood. Within the prolongation of life, it is expected that allergies will be encountered more often even in older people. Recent findings suggest that an early exposure to diverse food antigens may promote the development of immune tolerance. Accordingly, diet diversity during the first year of life or even earlier may have a positive impact on the prevention of allergies. The anti-inflammatory properties of some dietary nutrients may positively contribute to a tolerogenic immune environment too. Diet diversity is associated with a more favorable microbiome, and increasing evidence suggests a promising role of gut microbiota manipulation in inducing immune tolerance. Unjustified avoidance of allergenic foods may expose to intakes of some nutrients below recommended levels through the life-course, even more in cases of self-diagnosis and treatment of presumed forms of food intolerance. Nutritional strategies including the early exposure to a variety of food antigens are a promising area of research for preventive purposes through the life-course possibly extending positive outcomes to older stages. The aim of this paper is to highlight the role of diet diversity in preventing the development of FA starting in early life, as well as to provide an overview of the main strategies to prevent related nutritional issues throughout the life-course.
    Language English
    Publishing date 2021-09-24
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-6101
    ISSN (online) 2673-6101
    DOI 10.3389/falgy.2021.711945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Clinical research on extreme longevity: The FACET experience.

    Azzolino, Domenico / Rodrigues, Gabriel Dias / Manzini, Valentina Maria / Proietti, Marco / Arosio, Beatrice / Montano, Nicola / Cesari, Matteo

    Ageing research reviews

    2023  Volume 93, Page(s) 102170

    Abstract: People with extreme longevity represent a unique model to study the biology of aging. Unfortunately, their inclusion in research projects is challenging with the consequent lack of evidence and the need to rely on small convenience samples. Given the ... ...

    Abstract People with extreme longevity represent a unique model to study the biology of aging. Unfortunately, their inclusion in research projects is challenging with the consequent lack of evidence and the need to rely on small convenience samples. Given the growing global aging population, especially in the segment of the oldest old (i.e., aged 90 and older), research in this population has become crucial. Furthermore, by studying the characteristics of extremely longeval persons, it might be possible to 1) better understand the mechanisms of aging, and 2) identify endogenous or exogenous factors contributing to a long life. The design and implementation of research activities in the oldest people need special consideration and a pragmatic approach. Possible implementable solutions and suggestions are provided from experience gained during the conduction of the FAtigue in CEnTenarians (FACET) study.
    MeSH term(s) Aged, 80 and over ; Humans ; Aging ; Longevity
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2023.102170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Fatigue in older persons: the role of nutrition.

    Azzolino, Domenico / Coelho-Junior, Hélio José / Proietti, Marco / Manzini, Valentina Maria / Cesari, Matteo

    The Proceedings of the Nutrition Society

    2022  Volume 82, Issue 1, Page(s) 39–46

    Abstract: Fatigue is defined as a symptom leading to the inability to continue functioning at the expected activity level. It is a highly prevalent symptom, challenging to frame into monodimensional pathophysiological mechanisms. As a result, fatigue is often ... ...

    Abstract Fatigue is defined as a symptom leading to the inability to continue functioning at the expected activity level. It is a highly prevalent symptom, challenging to frame into monodimensional pathophysiological mechanisms. As a result, fatigue is often underestimated in the clinical setting and is wrongly considered an unavoidable consequence of ageing. Several potential mechanisms responsible for fatigue have been proposed, including sleep patterns, autonomic nervous system abnormalities and biological complexity. Inflammation and mitochondrial dysfunction are among the most promising mechanisms through which malnutrition may cause fatigue. Not surprisingly, fatigue is highly prevalent in inflammatory conditions (e.g. COVID-19 infection). The nutritional status may also represent a critical factor in the development and presentation of fatigue, which may mimic the exhaustion of the individual's metabolic reserves. For example, the insufficient dietary intake of energy and proteins may determine the catabolism of body fat and muscles, disrupt the homeostatic balance and cause the onset of fatigue. It is necessary to conduct research on fatigue. By characterising its pathophysiological mechanisms, it will be possible to (1) support the design and development of targeted interventions, (2) improve the quality of life of many persons by acting on the symptom and (3) reduce the direct and indirect costs of a burdening condition typical of advancing age. In the present review, we provide an overview of the role that nutrition may play as a determinant of fatigue in older people, also in the context of the COVID-19 pandemic.
    MeSH term(s) Humans ; Aged ; Nutritional Status ; Quality of Life ; Pandemics ; COVID-19/complications ; Fatigue/etiology ; Fatigue/diagnosis ; Sarcopenia
    Language English
    Publishing date 2022-08-23
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 391142-1
    ISSN 1475-2719 ; 0029-6651
    ISSN (online) 1475-2719
    ISSN 0029-6651
    DOI 10.1017/S0029665122002683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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