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  1. Article ; Online: Osteosarcopenic adiposity syndrome update and the role of associated minerals and vitamins.

    Ilich, Jasminka Z

    The Proceedings of the Nutrition Society

    2021  Volume 80, Issue 3, Page(s) 344–355

    Abstract: The objectives are to present an updated synopsis on osteosarcopenic adiposity (OSA) syndrome and evaluate the roles of selected micronutrients in its prevention and management. OSA refers to the concurrent deterioration of bone (osteopenia/osteoporosis), ...

    Abstract The objectives are to present an updated synopsis on osteosarcopenic adiposity (OSA) syndrome and evaluate the roles of selected micronutrients in its prevention and management. OSA refers to the concurrent deterioration of bone (osteopenia/osteoporosis), muscle (sarcopenia) and adipose tissue expansion. It portrays the most advanced stage in a continuum of body composition disorders. Although OSA has been widely studied involving the populations of different backgrounds, its prevalence is hard to collate because different methodologies and criteria were used for its diagnosis. Another critical health aspect is the presence of low-grade chronic inflammation (LGCI) which contributes to OSA and vice versa. Nutrition is important in the prevention and management of both OSA and LGCI. Although micronutrients act in numerous metabolic and physiological processes, their roles here are presented in relation to OSA (and its components) and LGCI in general and relevant to the COVID-19 pandemic. These include calcium, magnesium, phosphorus, potassium, sodium and vitamins D and K; their interactions, physiological ratios and synergism/antagonism are discussed as well. In conclusion, calcium, magnesium and vitamin D have a profound impact on OSA and its components, and the latter two also on LGCI. Potassium and vitamin K are vital in bone, muscle functioning and possibly adipose tissue modification. Both, but particularly vitamin D, surfaced as important modulators of immune system with application in COVID-19 infections. While both phosphorus and sodium have important roles in bone, muscle and can impact adiposity, due to their abundance in food, their intake should be curbed to prevent possible damaging effects.
    MeSH term(s) Adiposity ; Bone Diseases, Metabolic/diet therapy ; Bone Diseases, Metabolic/prevention & control ; COVID-19/epidemiology ; Diet ; Humans ; Obesity/diet therapy ; Obesity/prevention & control ; Osteoporosis/diet therapy ; Osteoporosis/prevention & control ; Sarcopenia/diet therapy ; Sarcopenia/prevention & control ; Syndrome ; Trace Elements/administration & dosage ; Trace Elements/metabolism ; Vitamins/administration & dosage ; Vitamins/physiology
    Chemical Substances Trace Elements ; Vitamins
    Language English
    Publishing date 2021-03-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 391142-1
    ISSN 1475-2719 ; 0029-6651
    ISSN (online) 1475-2719
    ISSN 0029-6651
    DOI 10.1017/S0029665121000586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nutritional and Behavioral Approaches to Body Composition and Low-Grade Chronic Inflammation Management for Older Adults in the Ordinary and COVID-19 Times.

    Ilich, Jasminka Z

    Nutrients

    2020  Volume 12, Issue 12

    Abstract: As more insight is gained into personalized health care, the importance of personalized nutritional and behavioral approaches is even more relevant in the COVID-19 era, in addition to the need for further elucidation regarding several diseases/conditions. ...

    Abstract As more insight is gained into personalized health care, the importance of personalized nutritional and behavioral approaches is even more relevant in the COVID-19 era, in addition to the need for further elucidation regarding several diseases/conditions. One of these concerning body composition (in this context; bone, lean and adipose tissue) is osteosarcopenic adiposity (OSA) syndrome. OSA occurs most often with aging, but also in cases of some chronic diseases and is exacerbated with the presence of low-grade chronic inflammation (LGCI). OSA has been associated with poor nutrition, metabolic disorders and diminished functional abilities. This paper addresses various influences on OSA and LGCI, as well as their mutual action on each other, and provides nutritional and behavioral approaches which could be personalized to help with either preventing or managing OSA and LGCI in general, and specifically in the time of the COVID-19 pandemic. Addressed in more detail are nutritional recommendations for and roles of macro- and micronutrients and bioactive food components; the microbiome; and optimal physical activity regimens. Other issues, such as food insecurity and nutritional inadequacy, circadian misalignment and shift workers are addressed as well. Since there is still a lack of longer-term primary studies in COVID-19 patients (either acute or recovered) and interventions for OSA improvement, this discussion is based on the existing knowledge, scientific hypotheses and observations derived from similar conditions or studies just being published at the time of this writing.
    MeSH term(s) Adiposity/physiology ; Aged ; Aging ; Body Composition ; Bone Diseases, Metabolic/complications ; COVID-19/complications ; Diet/standards ; Food Supply ; Humans ; Inflammation/complications ; Inflammation/therapy ; Malnutrition ; Nutritional Status ; SARS-CoV-2 ; Sarcopenia/complications ; Syndrome
    Language English
    Publishing date 2020-12-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12123898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Osteosarcopenic adiposity syndrome update and the role of associated minerals and vitamins

    Ilich, Jasminka Z.

    Proceedings of the Nutrition Society. 2021 Aug., v. 80, no. 3

    2021  

    Abstract: The objectives are to present an updated synopsis on osteosarcopenic adiposity (OSA) syndrome and evaluate the roles of selected micronutrients in its prevention and management. OSA refers to the concurrent deterioration of bone (osteopenia/osteoporosis), ...

    Abstract The objectives are to present an updated synopsis on osteosarcopenic adiposity (OSA) syndrome and evaluate the roles of selected micronutrients in its prevention and management. OSA refers to the concurrent deterioration of bone (osteopenia/osteoporosis), muscle (sarcopenia) and adipose tissue expansion. It portrays the most advanced stage in a continuum of body composition disorders. Although OSA has been widely studied involving the populations of different backgrounds, its prevalence is hard to collate because different methodologies and criteria were used for its diagnosis. Another critical health aspect is the presence of low-grade chronic inflammation (LGCI) which contributes to OSA and vice versa. Nutrition is important in the prevention and management of both OSA and LGCI. Although micronutrients act in numerous metabolic and physiological processes, their roles here are presented in relation to OSA (and its components) and LGCI in general and relevant to the COVID-19 pandemic. These include calcium, magnesium, phosphorus, potassium, sodium and vitamins D and K; their interactions, physiological ratios and synergism/antagonism are discussed as well. In conclusion, calcium, magnesium and vitamin D have a profound impact on OSA and its components, and the latter two also on LGCI. Potassium and vitamin K are vital in bone, muscle functioning and possibly adipose tissue modification. Both, but particularly vitamin D, surfaced as important modulators of immune system with application in COVID-19 infections. While both phosphorus and sodium have important roles in bone, muscle and can impact adiposity, due to their abundance in food, their intake should be curbed to prevent possible damaging effects.
    Keywords COVID-19 infection ; adipose tissue ; adiposity ; antagonism ; calcium ; immune system ; inflammation ; magnesium ; muscles ; osteopenia ; osteoporosis ; phosphorus ; potassium ; sarcopenia ; sodium ; synergism ; vitamin D ; vitamin K
    Language English
    Dates of publication 2021-08
    Size p. 344-355.
    Publishing place Cambridge University Press
    Document type Article
    ZDB-ID 391142-1
    ISSN 1475-2719 ; 0029-6651
    ISSN (online) 1475-2719
    ISSN 0029-6651
    DOI 10.1017/S0029665121000586
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Another Impairment in Older Age: What Does Osteosarcopenic Obesity Syndrome Mean for Middle-Aged and Older Women?

    Ilich, Jasminka Z

    Journal of the American Medical Directors Association

    2017  Volume 18, Issue 8, Page(s) 648–650

    MeSH term(s) Aged ; Female ; Frailty ; Humans ; Middle Aged ; Obesity/epidemiology ; Physical Functional Performance ; Prevalence ; Sarcopenia/epidemiology
    Language English
    Publishing date 2017-06-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2017.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Body fat and muscle in relation to heart rate variability in young-to-middle age men: a cross sectional study.

    Cvijetic, Selma / Macan, Jelena / Boschiero, Dario / Ilich, Jasminka Z

    Annals of human biology

    2023  Volume 50, Issue 1, Page(s) 108–116

    Abstract: Background: While obesity is recognisably associated with changes in heart rate variability (HRV), the association between skeletal muscle mass and HRV is less clear.: Aims: In this cross sectional study, we analysed the association of body fat (four ...

    Abstract Background: While obesity is recognisably associated with changes in heart rate variability (HRV), the association between skeletal muscle mass and HRV is less clear.
    Aims: In this cross sectional study, we analysed the association of body fat (four parameters) and muscle mass (five parameters) with indicators of HRV activity.
    Subjects and methods: Assessment of body composition and HRV was performed in
    Results: Mean values of parameters of fat tissue were above normal/reference values. Muscle tissue indicators were higher or within the reference ranges. Fat tissue parameters were significantly higher in participants with lower parasympathetic nervous system (PNS) indicators. Weight-adjusted skeletal muscle index (wSMI) was significantly lower in men with reduced PNS parameters. Fat tissue parameters were negatively correlated with PNS parameters, while wSMI was positively correlated with PNS parameters.
    Conclusions: Participants with higher fat mass and lower muscle mass had poorer parasympathetic activity. Since mean values of HRV parameters indicated mild parasympathetic dominance, we conclude that physical activity and consequently good muscle mass potentially compensated for the negative interaction between fat tissue and HRV.
    MeSH term(s) Male ; Humans ; Middle Aged ; Heart Rate/physiology ; Cross-Sectional Studies ; Body Mass Index ; Adipose Tissue/physiology ; Muscle, Skeletal/physiology
    Language English
    Publishing date 2023-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 186656-4
    ISSN 1464-5033 ; 0301-4460
    ISSN (online) 1464-5033
    ISSN 0301-4460
    DOI 10.1080/03014460.2023.2180089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Osteosarcopenic Adiposity and Nutritional Status in Older Nursing Home Residents during the COVID-19 Pandemic.

    Cvijetić, Selma / Keser, Irena / Boschiero, Dario / Ilich, Jasminka Z

    Nutrients

    2023  Volume 15, Issue 1

    Abstract: The aim was to evaluate body composition and prevalence of osteosarcopenic adiposity (OSA) in nursing home residents (NHR) and to assess their nutritional status. This research builds on our pilot study (conducted prior COVID-19 pandemic) that revealed ... ...

    Abstract The aim was to evaluate body composition and prevalence of osteosarcopenic adiposity (OSA) in nursing home residents (NHR) and to assess their nutritional status. This research builds on our pilot study (conducted prior COVID-19 pandemic) that revealed high OSA prevalence and poor nutritional status in NHR. The current study included newly recruited n = 365 NHR; 296 women, 69 men, aged 84.3 ± 5.6 and 83.1 ± 7.3 years, respectively. Body composition was measured by bioelectrical impedance BIA-ACC®, yielding total bone mass along with all components of lean and adipose tissues. The Mini Nutritional Assessment-Short Form (MNA-SF) was used to assess nutritional status. Participants reported about their present/past diseases, including COVID-19. Mean duration of stay in nursing homes was 46.3 ± 47.0 months. Approximately 30% of participants had COVID-19 prior (median 6.7 months) to entering the study. OSA was diagnosed in 70.8% women and 47.8% men (p < 0.001). Malnourishment was detected in 5.8% women and 6.2% men while the risk of malnourishment was found in 30.8% women and 30.0% men. No significant differences in age, body composition parameters, prevalence of OSA, malnutrition/risk for malnutrition were found in participants who had COVID-19 compared to those who did not. Regression analysis showed that intramuscular adipose tissue (%) was significantly positively, while bone mass was significantly negatively associated with OSA. In this population, the high prevalence of OSA coincided with the high prevalence of malnutrition/risk of malnutrition. Such unfavorable body composition status is more likely a consequence of potentially poor diet quality in nursing homes, rather than of health hazards caused by COVID-19.
    MeSH term(s) Aged ; Female ; Humans ; Male ; Adiposity ; COVID-19/epidemiology ; Geriatric Assessment ; Homes for the Aged ; Malnutrition/epidemiology ; Malnutrition/diagnosis ; Nursing Homes ; Nutrition Assessment ; Nutritional Status ; Obesity/epidemiology ; Pandemics ; Pilot Projects ; Risk Factors ; Sarcopenia
    Language English
    Publishing date 2023-01-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15010227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Lower Life Satisfaction and Inflammation in African American Adults: Body Adiposity Mediation and Sex Moderation.

    Wickrama, Kandauda A S / Ralston, Penny A / Ilich, Jasminka Z

    Journal of personalized medicine

    2022  Volume 12, Issue 5

    Abstract: Both lower life satisfaction (LLS) and chronic inflammation are underlying conditions for numerous diseases. We investigated their associations in African American adults, within the context of three hypotheses: (a) perceived LLS will be positively ... ...

    Abstract Both lower life satisfaction (LLS) and chronic inflammation are underlying conditions for numerous diseases. We investigated their associations in African American adults, within the context of three hypotheses: (a) perceived LLS will be positively associated with inflammation measured by serum C-reactive protein (CRP); (b) this association will be mediated by body adiposity; and (c) these associations will be moderated by sex. Participants (n = 83; >45 years; 59% women) were a subsample of a larger church-based intervention to reduce cardiovascular risks and were assessed at baseline and after 6 months. Body adiposity (BMI/hip/waist circumferences) was measured by standardized methods and CRP with ELISA. LLS was self-reported. The analyses were conducted in the structural equation modeling (SEM) framework. The direct relationship between LLS and CRP was significant for all participants but was mediated by BMI/hip/waist circumferences. Multi-group SEM analysis provided evidence for sex moderation by showing that the mediating pathway from LLS to CRP through BMI, and to a lesser extent through hip/waist circumferences, was significant only in women. In conclusion, perceived LLS was positively associated with the level of inflammation mediated by BMI/hip/waist circumference, with the association between LLS and CRP being stronger in women. These findings contribute to the current literature untangling mediation/moderation processes in which perceived LLS may contribute to adiposity-related inflammation. They also add to precision medicine development, suggesting that stress and inflammation-reducing interventions should focus on African Americans, particularly women.
    Language English
    Publishing date 2022-05-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12050745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Body fat and muscle in relation to heart rate variability in young-to-middle age men

    Selma Cvijetic / Jelena Macan / Dario Boschiero / Jasminka Z. Ilich

    Annals of Human Biology, Vol 50, Iss 1, Pp 109-

    a cross sectional study

    2023  Volume 116

    Abstract: Background While obesity is recognisably associated with changes in heart rate variability (HRV), the association between skeletal muscle mass and HRV is less clear. Aims In this cross sectional study, we analysed the association of body fat (four ... ...

    Abstract Background While obesity is recognisably associated with changes in heart rate variability (HRV), the association between skeletal muscle mass and HRV is less clear. Aims In this cross sectional study, we analysed the association of body fat (four parameters) and muscle mass (five parameters) with indicators of HRV activity. Subjects and methods Assessment of body composition and HRV was performed in n = 180 young-to-middle age healthy men exposed to high occupational physical activity, using the multi-frequency bioelectrical impedance device and the PPG-StressFlow® HRV photoplethysmography device, respectively. Results Mean values of parameters of fat tissue were above normal/reference values. Muscle tissue indicators were higher or within the reference ranges. Fat tissue parameters were significantly higher in participants with lower parasympathetic nervous system (PNS) indicators. Weight-adjusted skeletal muscle index (wSMI) was significantly lower in men with reduced PNS parameters. Fat tissue parameters were negatively correlated with PNS parameters, while wSMI was positively correlated with PNS parameters. Conclusions Participants with higher fat mass and lower muscle mass had poorer parasympathetic activity. Since mean values of HRV parameters indicated mild parasympathetic dominance, we conclude that physical activity and consequently good muscle mass potentially compensated for the negative interaction between fat tissue and HRV.
    Keywords body composition ; autonomic nervous system ; bioimpedance ; heart rate variability ; Biology (General) ; QH301-705.5 ; Human anatomy ; QM1-695 ; Physiology ; QP1-981
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Lower Life Satisfaction and Inflammation in African American Adults

    Kandauda A. S. Wickrama / Penny A. Ralston / Jasminka Z. Ilich

    Journal of Personalized Medicine, Vol 12, Iss 745, p

    Body Adiposity Mediation and Sex Moderation

    2022  Volume 745

    Abstract: Both lower life satisfaction (LLS) and chronic inflammation are underlying conditions for numerous diseases. We investigated their associations in African American adults, within the context of three hypotheses: (a) perceived LLS will be positively ... ...

    Abstract Both lower life satisfaction (LLS) and chronic inflammation are underlying conditions for numerous diseases. We investigated their associations in African American adults, within the context of three hypotheses: (a) perceived LLS will be positively associated with inflammation measured by serum C-reactive protein (CRP); (b) this association will be mediated by body adiposity; and (c) these associations will be moderated by sex. Participants ( n = 83; >45 years; 59% women) were a subsample of a larger church-based intervention to reduce cardiovascular risks and were assessed at baseline and after 6 months. Body adiposity (BMI/hip/waist circumferences) was measured by standardized methods and CRP with ELISA. LLS was self-reported. The analyses were conducted in the structural equation modeling (SEM) framework. The direct relationship between LLS and CRP was significant for all participants but was mediated by BMI/hip/waist circumferences. Multi-group SEM analysis provided evidence for sex moderation by showing that the mediating pathway from LLS to CRP through BMI, and to a lesser extent through hip/waist circumferences, was significant only in women. In conclusion, perceived LLS was positively associated with the level of inflammation mediated by BMI/hip/waist circumference, with the association between LLS and CRP being stronger in women. These findings contribute to the current literature untangling mediation/moderation processes in which perceived LLS may contribute to adiposity-related inflammation. They also add to precision medicine development, suggesting that stress and inflammation-reducing interventions should focus on African Americans, particularly women.
    Keywords life satisfaction ; stress ; inflammation ; C-reactive protein ; African Americans ; body adiposity ; Medicine ; R
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Cardiometabolic Indices after Weight Loss with Calcium or Dairy Foods: Secondary Analyses from a Randomized Trial with Overweight/Obese Postmenopausal Women

    Ilich, Jasminka Z. / Liu, Pei-Yang / Shin, Hyehyung / Kim, Youjin / Chi, Yichih

    Nutrients. 2022 Mar. 04, v. 14, no. 5

    2022  

    Abstract: The role of dairy foods and calcium/vitamin D supplements in cardiometabolic diseases is unknown. The objective of this secondary analysis is to investigate cardiometabolic risk factors changes after a 6-month weight-loss intervention in overweight/obese ...

    Abstract The role of dairy foods and calcium/vitamin D supplements in cardiometabolic diseases is unknown. The objective of this secondary analysis is to investigate cardiometabolic risk factors changes after a 6-month weight-loss intervention in overweight/obese postmenopausal women divided in three groups: Ca+vitamin D supplements (S); low-fat dairy foods (D; 4–5 servings/day); or control/placebo pills (C), as complements to hypocaloric diets. The original study focused on bone/body composition. This analysis included blood pressure (BP), and serum triglycerides, lipids (including apoproteins Apo1 and ApoB), adipokines, and C-reactive protein in n = 97 participants who finished with complete data points. Systolic BP decreased 5.1%, 4.8%, and 1.8% in S, D, and C groups, respectively (p < 0.05 for S and D vs. baseline and vs. C at 6 months). Reduction in triglycerides and ratio of total cholesterol (TC)/high-density lipoproteins cholesterol (HDL-C) was the highest in S, while the reduction in TC and LDL-C was the highest in D group (all p < 0.05). Leptin and ApoB significantly decreased and adiponectin and ApoA1 increased in all groups. In conclusion, although the C group’s participants experienced an improvement in some of the cardiometabolic indices with weight loss, those in the S and D groups showed significantly better results in most of the outcomes, indicating the beneficial effects of low-fat dairy foods and/or Ca+vitamin D intake as complements to a hypocaloric diet.
    Keywords C-reactive protein ; adiponectin ; apoproteins ; blood pressure ; blood serum ; body composition ; calcium ; cholesterol ; leptin ; low calorie diet ; low fat dairy products ; overweight ; placebos ; postmenopause ; weight loss
    Language English
    Dates of publication 2022-0304
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14051082
    Database NAL-Catalogue (AGRICOLA)

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