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  1. Article ; Online: Spotlight on contributory role of host immunogenetic profiling in SARS-CoV-2 infection: Susceptibility, severity, mortality, and vaccine effectiveness.

    Yazdanparast, Somayeh / Bakhtiyaridovvombaygi, Mehdi / Mikanik, Fatemeh / Ahmadi, Reza / Ghorbani, Mohammad / Mansoorian, Mohammad Reza / Mansoorian, Mozhgan / Chegni, Hamid / Moshari, Jalil / Gharehbaghian, Ahmad

    Life sciences

    2023  Volume 328, Page(s) 121907

    Abstract: Background: The SARS-CoV-2 virus has spread continuously worldwide, characterized by various clinical symptoms. The immune system responds to SARS-CoV-2 infection by producing Abs and secreting cytokines. Recently, numerous studies have highlighted that ...

    Abstract Background: The SARS-CoV-2 virus has spread continuously worldwide, characterized by various clinical symptoms. The immune system responds to SARS-CoV-2 infection by producing Abs and secreting cytokines. Recently, numerous studies have highlighted that immunogenetic factors perform a putative role in COVID-19 pathogenesis and implicate vaccination effectiveness.
    Aim: This review summarizes the relevant articles and evaluates the significance of mutation and polymorphism in immune-related genes regarding susceptibility, severity, mortality, and vaccination effectiveness of COVID-19. Furthermore, the correlation between host immunogenetic and SARS-CoV-2 reinfection is discussed.
    Method: A comprehensive search was conducted to identify relevant articles using five databases until January 2023, which resulted in 105 total articles.
    Key findings: Taken to gather this review summarized that: (a) there is a plausible correlation between immune-related genes and COVID-19 outcomes, (b) the HLAs, cytokines, chemokines, and other immune-related genes expression profiles can be a prognostic factor in COVID-19-infected patients, and (c) polymorphisms in immune-related genes have been associated with the effectiveness of vaccination.
    Significance: Regarding the importance of mutation and polymorphisms in immune-related genes in COVID-19 outcomes, modulating candidate genes is expected to help clinical decisions, patient outcomes management, and innovative therapeutic approach development. In addition, the manipulation of host immunogenetics is hypothesized to induce more robust cellular and humoral immune responses, effectively increase the efficacy of vaccines, and subsequently reduce the incidence rates of reinfection-associated COVID-19.
    MeSH term(s) Humans ; COVID-19/genetics ; SARS-CoV-2 ; Vaccine Efficacy ; Immunogenetics ; Reinfection ; Cytokines/genetics
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-06-30
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2023.121907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Knowledge, Anxiety, and Fear of the Unknown Among Pregnant Women During COVID-19 Pandemic

    Shahla Khosravan / Fatemeh Mohammadzadeh / Elham Hassannia / Mozhgan Mansoorian / Zohreh Zamani / Narjes Bahri

    Journal of Research & Health, Vol 12, Iss 6, Pp 397-

    2022  Volume 406

    Abstract: Background: This study aimed to determine pregnant women’s knowledge about COVID-19 and their anxiety and fear of the unknown. Methods: This online cross-sectional study was conducted in March and April 2020 on Iranian pregnant women visiting ... ...

    Abstract Background: This study aimed to determine pregnant women’s knowledge about COVID-19 and their anxiety and fear of the unknown. Methods: This online cross-sectional study was conducted in March and April 2020 on Iranian pregnant women visiting comprehensive healthcare centers affiliated with the Gonabad University of Medical Sciences. Participants were selected using a stratified random sampling strategy among pregnant women who agreed to participate, had a Telegram or WhatsApp account or phone number, and had no history of pregnancy complications. A demographic questionnaire, Spielberger’s state-trait anxiety inventory, fearing the unknown questionnaire, and an uncertainty scale was used to collect data. Data were analyzed using simple and multiple linear regression models using SPSS software, version 16. Results: A total of 190 pregnant women were included in the analysis. The Mean±SD for knowledge of COVID-19 was 8.82±1.72. The knowledge of 71.1% of participants was moderate. The Mean±SD for fearing the unknown was 36.2±9.1. The Mean±SD for the state anxiety about COVID-19 incidence in pregnant women was 47.6±10.2. The results showed that 65.3% of the participants had a moderate level of anxiety. Multiple regression analysis showed an increase of 0.16 (P=0.029) in the fearing the unknown score for each week of increase in the gestational age. Similarly, the anxiety increased by 0.56 (P<0.001) for each unit of increase in fearing the unknown. Moreover, the results showed that the anxiety of people using Telegram or WhatsApp was 3.44 units more than others (P<0.018) Conclusion: The findings showed that the pregnant women’s knowledge was moderate at the time of research. However, with increasing gestational age, fear of the unknown, and sources of knowledge were associated with anxiety. This points to the essentiality of increasing supportive programs and it is required to screen pregnant women to prevent the adverse effects of anxiety.
    Keywords knowledge ; anxiety ; fear ; covid-19 ; pregnancy ; Public aspects of medicine ; RA1-1270
    Subject code 150
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher Gonabad University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Spotlight on contributory role of host immunogenetic profiling in SARS-CoV-2 infection: Susceptibility, severity, mortality, and vaccine effectiveness

    Yazdanparast, Somayeh / Bakhtiyaridovvombaygi, Mehdi / Mikanik, Fatemeh / Ahmadi, Reza / Ghorbani, Mohammad / Mansoorian, Mohammad Reza / Mansoorian, Mozhgan / Chegni, Hamid / Moshari, Jalil / Gharehbaghian, Ahmad

    Life Sciences. 2023 Sept., v. 328 p.121907-

    2023  

    Abstract: The SARS-CoV-2 virus has spread continuously worldwide, characterized by various clinical symptoms. The immune system responds to SARS-CoV-2 infection by producing Abs and secreting cytokines. Recently, numerous studies have highlighted that ... ...

    Abstract The SARS-CoV-2 virus has spread continuously worldwide, characterized by various clinical symptoms. The immune system responds to SARS-CoV-2 infection by producing Abs and secreting cytokines. Recently, numerous studies have highlighted that immunogenetic factors perform a putative role in COVID-19 pathogenesis and implicate vaccination effectiveness. This review summarizes the relevant articles and evaluates the significance of mutation and polymorphism in immune-related genes regarding susceptibility, severity, mortality, and vaccination effectiveness of COVID-19. Furthermore, the correlation between host immunogenetic and SARS-CoV-2 reinfection is discussed. A comprehensive search was conducted to identify relevant articles using five databases until January 2023, which resulted in 105 total articles. Taken to gather this review summarized that: (a) there is a plausible correlation between immune-related genes and COVID-19 outcomes, (b) the HLAs, cytokines, chemokines, and other immune-related genes expression profiles can be a prognostic factor in COVID-19-infected patients, and (c) polymorphisms in immune-related genes have been associated with the effectiveness of vaccination. Regarding the importance of mutation and polymorphisms in immune-related genes in COVID-19 outcomes, modulating candidate genes is expected to help clinical decisions, patient outcomes management, and innovative therapeutic approach development. In addition, the manipulation of host immunogenetics is hypothesized to induce more robust cellular and humoral immune responses, effectively increase the efficacy of vaccines, and subsequently reduce the incidence rates of reinfection-associated COVID-19.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; chemokines ; immune system ; immunogenetics ; mortality ; mutation ; pathogenesis ; patients ; vaccination ; vaccines ; viruses ; Ab ; ACE2 ; ADCC ; ADCP ; ADE ; AIM2 ; AMs ; Ang ; APCs ; APOE ; ARDS ; BAFF ; BALFs ; CBC ; CCL ; CDC ; COVID-19 ; COVs ; CT ; CTL ; CXCL ; cDC ; cGAS ; DAMPs ; DBP ; DCs ; DPPs ; dsRNA ; ECG ; Fc ; GM-CSF ; GSDM ; GST ; GSTA ; GSTM ; GNB3 ; GSTP ; GSTT ; GSH ; GWAS ; G-actin ; HLA ; ICU ; IFITM ; IFI16 ; IFNs ; IFNAR ; IFNL ; IKKε ; IL ; ILCs ; IPF ; IRF ; ISGF ; ISREs ; JAK1 ; KIRs ; LDH ; LP ; MAC ; MAVS ; MBL ; MCP-1 ; MDA5 ; MERS-CoV ; MHC ; MUC5B ; MyD88 ; NETs ; NF-κB ; NK cells ; NLRs ; NLRP3 ; NOD ; NTD ; OAS ; ORFs ; PAMPs ; PE ; PRRs ; pDCs ; RBD ; RIG-I ; RNase L ; ROS ; SARS-CoV-2 ; SLE ; SNP ; SOCS ; STAT ; STING ; ssRNA ; TBK-1 ; TLRs ; TMPRSS2 ; TNF ; TNFR ; TNFRSF ; TRIF ; TYK2 ; URT ; WHS ; 5′ UTR ; Immunopathology ; Host immunogenetic diversity ; COVID-19 susceptibility and outcome ; Vaccine ; Reinfection
    Language English
    Dates of publication 2023-09
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2023.121907
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  4. Article: Nutritional knowledge, attitude and behaviours regarding Coronavirus Disease 2019 among residents of Gonabad, Iran

    Mansoorian, Mozhgan / Noori, Reza / Khosravan, Shahla / Tabatabaeizadeh, Seyed-Amir / Khajavian, Nasim

    Public health nutrition. 2021 Apr., v. 24, no. 5

    2021  

    Abstract: Coronavirus Disease 2019 (COVID-19) is a respiratory disease and a major global health-related issue. Knowledge, attitude and behaviours associated with this disease are being developed. Infected animals and consumption of contaminated foods are probably ...

    Abstract Coronavirus Disease 2019 (COVID-19) is a respiratory disease and a major global health-related issue. Knowledge, attitude and behaviours associated with this disease are being developed. Infected animals and consumption of contaminated foods are probably the main sources of this viral infection. Adhering to a healthy diet is effective in preventing patient affliction and recovery. Thus, the present research aims to determine the nutritional knowledge, attitude and behaviours associated with COVID-19 among Residents of Gonabad, Iran. The present online cross-sectional survey was conducted in March 2020 on 389 people selected through convenient sampling method. The data collection instrument was a questionnaire developed by the present researchers comprising four sections: demographic information, knowledge, attitude and nutritional behaviour. The collected data were analysed statistically in SPSS. Gonabad city in Khorasan Razavi in the Northeast of Iran. All people at or above 18 years of age. The present results revealed that the mean age of the participants was 37·3 ± 11·3 years. The mean scores for knowledge, attitude and nutritional behaviour were, respectively, 9·7 ± 1·4, 14·3 ± 3·5 and 29·6 ± 4·2. The mean scores for nutritional knowledge and attitude showed no statistically significant correlation with age, education, occupation, marital status and economic status. However, the mean nutritional behaviour score was significantly higher among women than men (P = 0·004). Participants’ nutritional attitude and behaviour regarding COVID-19, at its early stage in Iran, were average and above average. The public education provided with this regard can have affected this result.
    Keywords COVID-19 infection ; cross-sectional studies ; data collection ; education ; healthy diet ; marital status ; nutrition knowledge ; nutritional behavior ; occupations ; patients ; questionnaires ; respiratory tract diseases ; socioeconomic status ; Iran
    Language English
    Dates of publication 2021-04
    Size p. 1088-1094.
    Publishing place Cambridge University Press
    Document type Article
    ZDB-ID 1436024-x
    ISSN 1475-2727 ; 1368-9800
    ISSN (online) 1475-2727
    ISSN 1368-9800
    DOI 10.1017/S1368980021000033
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  5. Article ; Online: Nutritional knowledge, attitude and behaviours regarding Coronavirus Disease 2019 among residents of Gonabad, Iran.

    Mansoorian, Mozhgan / Noori, Reza / Khosravan, Shahla / Tabatabaeizadeh, Seyed-Amir / Khajavian, Nasim

    Public health nutrition

    2021  Volume 24, Issue 5, Page(s) 1088–1094

    Abstract: Objective: Coronavirus Disease 2019 (COVID-19) is a respiratory disease and a major global health-related issue. Knowledge, attitude and behaviours associated with this disease are being developed. Infected animals and consumption of contaminated foods ... ...

    Abstract Objective: Coronavirus Disease 2019 (COVID-19) is a respiratory disease and a major global health-related issue. Knowledge, attitude and behaviours associated with this disease are being developed. Infected animals and consumption of contaminated foods are probably the main sources of this viral infection. Adhering to a healthy diet is effective in preventing patient affliction and recovery. Thus, the present research aims to determine the nutritional knowledge, attitude and behaviours associated with COVID-19 among Residents of Gonabad, Iran.
    Design: The present online cross-sectional survey was conducted in March 2020 on 389 people selected through convenient sampling method. The data collection instrument was a questionnaire developed by the present researchers comprising four sections: demographic information, knowledge, attitude and nutritional behaviour. The collected data were analysed statistically in SPSS.
    Setting: Gonabad city in Khorasan Razavi in the Northeast of Iran.
    Participants: All people at or above 18 years of age.
    Results: The present results revealed that the mean age of the participants was 37·3 ± 11·3 years. The mean scores for knowledge, attitude and nutritional behaviour were, respectively, 9·7 ± 1·4, 14·3 ± 3·5 and 29·6 ± 4·2. The mean scores for nutritional knowledge and attitude showed no statistically significant correlation with age, education, occupation, marital status and economic status. However, the mean nutritional behaviour score was significantly higher among women than men (P = 0·004).
    Conclusions: Participants' nutritional attitude and behaviour regarding COVID-19, at its early stage in Iran, were average and above average. The public education provided with this regard can have affected this result.
    MeSH term(s) Adolescent ; Adult ; COVID-19/prevention & control ; Cross-Sectional Studies ; Diet, Healthy/psychology ; Educational Status ; Feeding Behavior/psychology ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Iran ; Male ; Marital Status ; Middle Aged ; SARS-CoV-2 ; Socioeconomic Factors ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2021-01-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1436024-x
    ISSN 1475-2727 ; 1368-9800
    ISSN (online) 1475-2727
    ISSN 1368-9800
    DOI 10.1017/S1368980021000033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  6. Article: Vitamin C improves liver and renal functions in hypothyroid rats by reducing tissue oxidative injury.

    Esmaeilizadeh, Mahdi / Hosseini, Mahmoud / Beheshti, Farimah / Alikhani, Vajihe / Keshavarzi, Zakieh / Shoja, Mohsen / Mansoorian, Mozhgan / Sadeghnia, Hamid Reza

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition

    2019  Volume 90, Issue 1-2, Page(s) 84–94

    MeSH term(s) Animals ; Antioxidants/therapeutic use ; Ascorbic Acid/therapeutic use ; Female ; Hypothyroidism/physiopathology ; Liver/drug effects ; Male ; Oxidative Stress/drug effects ; Pregnancy ; Rats ; Rats, Wistar
    Chemical Substances Antioxidants ; Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2019-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 120692-8
    ISSN 0300-9831
    ISSN 0300-9831
    DOI 10.1024/0300-9831/a000495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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