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  1. Article ; Online: The Role of Immunonutrition in Patients.

    Cintoni, Marco / Mele, Maria Cristina

    Nutrients

    2023  Volume 15, Issue 3

    Abstract: Immunonutrition (IN) is defined as "the use of specific nutritional substrates, called «immunonutrients» having the ability of modulating specific mechanisms involved in several immune and inflammatory pathways" [ ... ]. ...

    Abstract Immunonutrition (IN) is defined as "the use of specific nutritional substrates, called «immunonutrients» having the ability of modulating specific mechanisms involved in several immune and inflammatory pathways" [...].
    MeSH term(s) Humans ; Immunonutrition Diet ; Postoperative Complications
    Language English
    Publishing date 2023-02-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15030780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Special Issue "Gastrointestinal Microbiota and Gut Barrier Impact Human Health and Disease": Editorial.

    Raoul, Pauline / Cintoni, Marco / Rinninella, Emanuele / Mele, Maria Cristina

    Microorganisms

    2023  Volume 11, Issue 4

    Abstract: The increasing incidence of non-communicable diseases is a worldwide public health issue, and the role of gut microbiota is becoming evident [ ... ]. ...

    Abstract The increasing incidence of non-communicable diseases is a worldwide public health issue, and the role of gut microbiota is becoming evident [...].
    Language English
    Publishing date 2023-04-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11040985
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  3. Article ; Online: Microbiota-Gastric Cancer Interactions and the Potential Influence of Nutritional Therapies.

    Raoul, Pauline / Maccauro, Valeria / Cintoni, Marco / Scarpellini, Emidio / Ianiro, Gianluca / Gasbarrini, Antonio / Mele, Maria Cristina / Rinninella, Emanuele

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: Gastric cancer (GC) is one of the most common causes of cancer deaths, and GC treatments represent a large area of research. Although initially regarded as a sterile organ and unsuitable for microbial communities, the discovery ... ...

    Abstract Gastric cancer (GC) is one of the most common causes of cancer deaths, and GC treatments represent a large area of research. Although initially regarded as a sterile organ and unsuitable for microbial communities, the discovery of
    MeSH term(s) Humans ; Stomach Neoplasms/metabolism ; Gastric Mucosa/metabolism ; Microbiota ; Helicobacter pylori ; Helicobacter Infections/microbiology
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031679
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  4. Article ; Online: The role of diet in shaping human gut microbiota.

    Rinninella, Emanuele / Tohumcu, Ege / Raoul, Pauline / Fiorani, Marcello / Cintoni, Marco / Mele, Maria Cristina / Cammarota, Giovanni / Gasbarrini, Antonio / Ianiro, Gianluca

    Best practice & research. Clinical gastroenterology

    2023  Volume 62-63, Page(s) 101828

    Abstract: Gut microbiota plays a fundamental role within human health, and exerts key functions within the human body. Diet is one of the most powerful modulators of gut microbiota functions and composition. This complex interplay involves also the immune system ... ...

    Abstract Gut microbiota plays a fundamental role within human health, and exerts key functions within the human body. Diet is one of the most powerful modulators of gut microbiota functions and composition. This complex interplay involves also the immune system and the intestinal barrier, highlighting the central role of diet in the pathogenesis and treatment of multiple diseases. In this review article we will paint the landscape of the effects of specific dietary nutrients, and of the detrimental or beneficial outcomes of different dietary patterns, on the composition of human gut microbiota. Moreover, we will discuss the potential application of diet as a therapeutic modulator of gut microbiota, including cutting-edge ways of exploitation, including the use of dietary components as adjuvants to promote microbial engraftment after fecal microbiota transplantation, or personalized nutritional approaches, targeted to the patient microbiome.
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Diet ; Microbiota ; Intestines
    Language English
    Publishing date 2023-02-19
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2048181-0
    ISSN 1532-1916 ; 1521-6918
    ISSN (online) 1532-1916
    ISSN 1521-6918
    DOI 10.1016/j.bpg.2023.101828
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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Hospital Services to Improve Nutritional Intake and Reduce Food Waste: A Systematic Review.

    Rinninella, Emanuele / Raoul, Pauline / Maccauro, Valeria / Cintoni, Marco / Cambieri, Andrea / Fiore, Alberto / Zega, Maurizio / Gasbarrini, Antonio / Mele, Maria Cristina

    Nutrients

    2023  Volume 15, Issue 2

    Abstract: Background and aims: Patients' nutritional intake is a crucial issue in modern hospitals, where the high prevalence of disease-related malnutrition may worsen clinical outcomes. On the other hand, food waste raises concerns in terms of sustainability ... ...

    Abstract Background and aims: Patients' nutritional intake is a crucial issue in modern hospitals, where the high prevalence of disease-related malnutrition may worsen clinical outcomes. On the other hand, food waste raises concerns in terms of sustainability and environmental burden. We conducted a systematic review to ascertain which hospital services could overcome both issues.
    Methods: A systematic literature search following PRISMA guidelines was conducted across MEDLINE, Web of Science, and Scopus for randomised controlled trials (RCTs) and observational studies comparing the effect of hospital strategies on energy intake, protein intake, and plate/food waste. The quality of included studies was assessed using the Newcastle-Ottawa Scale for cohort studies and the Cochrane Risk of Bias tool from the Cochrane Handbook for Systematic Reviews of Interventions for RCTs.
    Results: Nineteen studies were included, assessing as many hospital strategies such as food service systems-including catering and room service-(
    Conclusions: Although the results should be confirmed by prospective and large sample-size studies, the personalisation of the meal and efficient room service may improve nutritional intake while decreasing food waste. Clinical nutritionist staff-especially dietitians-may increase food intake reducing food waste through active monitoring of the patients' nutritional needs.
    MeSH term(s) Humans ; Eating ; Energy Intake ; Malnutrition/prevention & control ; Meals/psychology ; Hospitals
    Language English
    Publishing date 2023-01-07
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15020310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nutritional management in hospital setting during SARS-CoV-2 pandemic: a real-life experience.

    Cintoni, Marco / Rinninella, Emanuele / Annetta, Maria Giuseppina / Mele, Maria Cristina

    European journal of clinical nutrition

    2020  Volume 74, Issue 5, Page(s) 846–847

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Intensive Care Units ; Pandemics ; Pneumonia, Viral ; SARS Virus ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-06
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639358-5
    ISSN 1476-5640 ; 0954-3007
    ISSN (online) 1476-5640
    ISSN 0954-3007
    DOI 10.1038/s41430-020-0625-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1045: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: COntrolling NUTritional Status (CONUT) as Predictive Score of Hospital Length of Stay (LOS) and Mortality: A Prospective Cohort Study in an Internal Medicine and Gastroenterology Unit in Italy.

    Rinninella, Emanuele / Borriello, Raffaele / D'Angelo, Marco / Galasso, Tiziano / Cintoni, Marco / Raoul, Pauline / Impagnatiello, Michele / Annicchiarico, Brigida Eleonora / Gasbarrini, Antonio / Mele, Maria Cristina

    Nutrients

    2023  Volume 15, Issue 6

    Abstract: Background: Hospital malnutrition affects nearly 30% of patients in medical wards and correlates with worse outcomes. An early assessment is necessary to stratify the risk of short-term outcomes and mortality. The predictive role of COntrolling ... ...

    Abstract Background: Hospital malnutrition affects nearly 30% of patients in medical wards and correlates with worse outcomes. An early assessment is necessary to stratify the risk of short-term outcomes and mortality. The predictive role of COntrolling NUTritional status (CONUT) score in this context has not yet been elucidated in Western countries. We aimed to test CONUT at admission as a predictive score of hospital outcomes, in an Internal Medicine and Gastroenterology Department of an Italian Tertiary Care University hospital.
    Methods: We prospectively enrolled patients admitted to our center, stratifying them into the four CONUT classes (normal = 0-1; mild = 2-4; moderate = 5-8; severe = 9-12 points) according to serum albumin (g/dL), total lymphocyte count (/mm
    Results: Out of a total of 203 patients enrolled, 44 (21.7%) patients had a normal status (0-1), 66 (32.5%) had a mild impairment (2-4), 68 (33.5%) had a moderate impairment (5-8), and 25 (12.3%) a severe impairment (9-12). The mean LOS was 8.24 ± 5.75 days; nine patients died. A moderate-severe CONUT correlated with a higher LOS at the univariate [HR 1.86 (95% CI 13.9-3.47);
    Conclusions: CONUT is a reliable and simple predictor of LOS and in-hospital mortality in medical wards.
    MeSH term(s) Humans ; Nutritional Status ; Length of Stay ; Gastroenterology ; Prospective Studies ; Malnutrition/diagnosis ; Hospitals ; Retrospective Studies ; Prognosis ; Nutrition Assessment
    Language English
    Publishing date 2023-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15061472
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  8. Article ; Online: Impact of Food Additive Titanium Dioxide on Gut Microbiota Composition, Microbiota-Associated Functions, and Gut Barrier: A Systematic Review of In Vivo Animal Studies.

    Rinninella, Emanuele / Cintoni, Marco / Raoul, Pauline / Mora, Vincenzina / Gasbarrini, Antonio / Mele, Maria Cristina

    International journal of environmental research and public health

    2021  Volume 18, Issue 4

    Abstract: Background: Titanium dioxide (TiO: Methods: A systematic literature search was performed up to December 2020 in PubMed, Web of Science, and Scopus databases. The PRISMA guidelines followed. The risk of bias was assessed from ARRIVE and SYRCLE tools.!# ...

    Abstract Background: Titanium dioxide (TiO
    Methods: A systematic literature search was performed up to December 2020 in PubMed, Web of Science, and Scopus databases. The PRISMA guidelines followed. The risk of bias was assessed from ARRIVE and SYRCLE tools.
    Results: A total of 18 animal studies were included (n = 10 mice, n = 5 rats, n = 2 fruit flies, n = 1 silkworm). Studies varied significantly in protocols and outcomes assessment. TiO
    Conclusions: Although the extrapolation of these results from animals to humans remains difficult, this review highlights the key role of gut microbiota in gut nanotoxicology and stimulates discussions on the safe TiO
    MeSH term(s) Animals ; Food Additives/toxicity ; Gastrointestinal Microbiome ; Mice ; Microbiota ; Rats ; Titanium/toxicity
    Chemical Substances Food Additives ; titanium dioxide (15FIX9V2JP) ; Titanium (D1JT611TNE)
    Language English
    Publishing date 2021-02-19
    Publishing country Switzerland
    Document type Journal Article ; Review ; Systematic Review
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18042008
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  9. Article ; Online: Vitamin D and colorectal cancer: Chemopreventive perspectives through the gut microbiota and the immune system.

    Rinninella, Emanuele / Mele, Maria Cristina / Raoul, Pauline / Cintoni, Marco / Gasbarrini, Antonio

    BioFactors (Oxford, England)

    2021  Volume 48, Issue 2, Page(s) 285–293

    Abstract: Vitamin D and its receptor are involved in health and diseases through multiple mechanisms including the immune system and gut microbiota modulations. Gut microbiota variations have huge implications in intestinal and extra-intestinal disorders such as ... ...

    Abstract Vitamin D and its receptor are involved in health and diseases through multiple mechanisms including the immune system and gut microbiota modulations. Gut microbiota variations have huge implications in intestinal and extra-intestinal disorders such as colorectal cancer (CRC). This review highlights the preventive role of vitamin D in colorectal tumorigenesis through the effects on the immune system and gut microbiota modulation. The different associations between vitamin D, gut microbial homeostasis, immune system, and CRC, are dissected. Vitamin D is supposed to exert several chemopreventive effects on CRC including direct antineoplastic mechanisms, the effects on the immune system, and gut microbiota modulation. Large clinical studies with a randomized design, are required to confirm the role of vitamin D in CRC, confirming its key role in the complex interplay between the gut immune system and microbiota.
    MeSH term(s) Colorectal Neoplasms/prevention & control ; Gastrointestinal Microbiome ; Humans ; Immune System ; Microbiota ; Vitamin D/pharmacology ; Vitamin D/therapeutic use
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-09-24
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 59230-4
    ISSN 1872-8081 ; 0951-6433
    ISSN (online) 1872-8081
    ISSN 0951-6433
    DOI 10.1002/biof.1786
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2473: Show issues Location:
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  10. Article ; Online: Prognostic impact of sarcopenia in children with cancer: a focus on the psoas muscle area (PMA) imaging in the clinical practice.

    Triarico, Silvia / Rinninella, Emanuele / Mele, Maria Cristina / Cintoni, Marco / Attinà, Giorgio / Ruggiero, Antonio

    European journal of clinical nutrition

    2021  Volume 76, Issue 6, Page(s) 783–788

    Abstract: Skeletal muscle plays a crucial part in the metabolic and inflammatory response. "Sarcopenia", defined as a pathological condition of reduced strength, quantity and quality of skeletal muscle mass, may often develop in the young age as the secondary ... ...

    Abstract Skeletal muscle plays a crucial part in the metabolic and inflammatory response. "Sarcopenia", defined as a pathological condition of reduced strength, quantity and quality of skeletal muscle mass, may often develop in the young age as the secondary consequence of a systemic inflammatory illness, like cancer. In children with cancer, sarcopenia is a common finding, playing a negative role in their prognosis. However, its prevalence in clinical practice is underestimated. Moreover, several pre- and post-natal factors may influence skeletal muscle development in childhood, making the issue more complex. Given the frequent use of radiological imaging in clinical practice, prompt analysis of body composition is feasible and able to detect the presence of reduced fat-free mass (FFM) among pediatric patients with cancer. We discuss the recent advances in the study of body composition in children with cancer, dissecting the role of the psoas muscle area (PMA) measure, obtained from computerized tomography (CT) or magnetic resonance images (MRI) as a marker of sarcopenia in this setting. Since age and sex-specific percentile curves for PMA and a PMA z-scores calculator are available online, such a tool may be useful to simply detect and treat sarcopenia and its consequences in childhood cancer.
    MeSH term(s) Child ; Female ; Humans ; Male ; Muscle, Skeletal/diagnostic imaging ; Muscle, Skeletal/pathology ; Neoplasms/complications ; Prognosis ; Psoas Muscles/diagnostic imaging ; Psoas Muscles/pathology ; Retrospective Studies ; Sarcopenia/complications ; Sarcopenia/etiology
    Language English
    Publishing date 2021-10-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639358-5
    ISSN 1476-5640 ; 0954-3007
    ISSN (online) 1476-5640
    ISSN 0954-3007
    DOI 10.1038/s41430-021-01016-y
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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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