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  1. Book ; Online: Ending the U.S. War in Iraq

    Brennan, Richard R. Jr / Ries, Charles P / Hanauer, Larry / Connable, Ben / Kelly, Terrence K

    The Final Transition, Operational Maneuver, and Disestablishment of United States Forces-Iraq

    2013  

    Keywords Diplomacy ; Military engineering ; Political Science ; Technology
    Language English
    Size 1 Online-Ressource
    Publisher RAND Corporation
    Document type Book ; Online
    Note English
    HBZ-ID HT030610547
    ISBN 9780833080479 ; 0833080474
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Audio / Video: Regulation von Matrix-Metalloproteinasen nach S-Lost-Exposition in Haut-, Stroma- und Stammzellen

    Ries, Christian

    = regulation of matrix metalloproteinases in skin-, stromal and stem cells after exposure to sulfur mustard

    (Forschungsbericht aus der Wehrmedizin ; 2008,9)

    2008  

    Title variant regulation of matrix metalloproteinases in skin-, stromal and stem cells after exposure to sulfur mustard
    Author's details Bearb. C. Ries
    Series title Forschungsbericht aus der Wehrmedizin ; 2008,9
    Collection
    Language German
    Size V, 42 S. : graph. Darst.
    Edition Als Ms. gedr.
    Publisher Streitkräfteamt, Abt. 3, FIZBw
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Audio / Video
    Note Zsfassung in engl. Sprache
    HBZ-ID HT015809596
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 432 -2008,9- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Photon-free (s)CMOS camera characterization for artifact reduction in high- and super-resolution microscopy.

    Diekmann, Robin / Deschamps, Joran / Li, Yiming / Deguchi, Takahiro / Tschanz, Aline / Kahnwald, Maurice / Matti, Ulf / Ries, Jonas

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 3362

    Abstract: Modern implementations of widefield fluorescence microscopy often rely on sCMOS cameras, but this camera architecture inherently features pixel-to-pixel variations. Such variations lead to image artifacts and render quantitative image interpretation ... ...

    Abstract Modern implementations of widefield fluorescence microscopy often rely on sCMOS cameras, but this camera architecture inherently features pixel-to-pixel variations. Such variations lead to image artifacts and render quantitative image interpretation difficult. Although a variety of algorithmic corrections exists, they require a thorough characterization of the camera, which typically is not easy to access or perform. Here, we developed a fully automated pipeline for camera characterization based solely on thermally generated signal, and implemented it in the popular open-source software Micro-Manager and ImageJ/Fiji. Besides supplying the conventional camera maps of noise, offset and gain, our pipeline also gives access to dark current and thermal noise as functions of the exposure time. This allowed us to avoid structural bias in single-molecule localization microscopy (SMLM), which without correction is substantial even for scientific-grade, cooled cameras. In addition, our approach enables high-quality 3D super-resolution as well as live-cell time-lapse microscopy with cheap, industry-grade cameras. As our approach for camera characterization does not require any user interventions or additional hardware implementations, numerous correction algorithms that rely on camera characterization become easily applicable.
    MeSH term(s) Algorithms ; Artifacts ; Microscopy, Fluorescence/methods ; Photons ; Single Molecule Imaging
    Language English
    Publishing date 2022-06-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-30907-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Photon-free (s)CMOS camera characterization for artifact reduction in high- and super-resolution microscopy

    Robin Diekmann / Joran Deschamps / Yiming Li / Takahiro Deguchi / Aline Tschanz / Maurice Kahnwald / Ulf Matti / Jonas Ries

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 9

    Abstract: Pixel-to-pixel variations in sCMOS cameras lead to image artifacts in widefield fluorescence microscopy, and algorithmic corrections require thorough camera characterization. Here, the authors present an open source automated pipeline for camera ... ...

    Abstract Pixel-to-pixel variations in sCMOS cameras lead to image artifacts in widefield fluorescence microscopy, and algorithmic corrections require thorough camera characterization. Here, the authors present an open source automated pipeline for camera characterization based solely on thermally generated signal.
    Keywords Science ; Q
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Time Trends in the Global Prevalence of Mental Disorders in Children and Adolescents: Gap in Data on U.S. Youth.

    Merikangas, Kathleen Ries

    Journal of the American Academy of Child and Adolescent Psychiatry

    2018  Volume 57, Issue 5, Page(s) 306–307

    Abstract: ... mental health symptoms and conditions in U.S. youth, including severe anxiety. ...

    Abstract There have been numerous reports in the media of alarming increases in the rates of childhood mental health symptoms and conditions in U.S. youth, including severe anxiety.
    MeSH term(s) Adolescent ; Anxiety ; Anxiety Disorders ; Australia ; Child ; Humans ; Mental Disorders ; Mental Health ; Prevalence ; United States
    Language English
    Publishing date 2018-05-23
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 392535-3
    ISSN 1527-5418 ; 0890-8567
    ISSN (online) 1527-5418
    ISSN 0890-8567
    DOI 10.1016/j.jaac.2018.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.163: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: «Und plötzlich habe ich einen Tumor» - Die Situation von Frau S. und ihrer Familie.

    Ries-Gisler, Tobias / Spirig, Rebecca

    Pflege

    2014  Volume 27, Issue 2, Page(s) 117–128

    Abstract: ... hence to offer appropriate interventions.: Purpose: In an instrumental case study the situation of Mrs. S.2 ... and her family was analyzed. Mrs. S. is suffering from an inoperable adenocarcinoma.: Method ...

    Title translation "And suddenly I have a tumor" - the situation of family S./N.
    Abstract Background: Many families affected by a terminal illness need professional help and support. In order to be able to cope with emotional stress, loss of light-heartedness and changes in family structure thorough information is important for patients and their families. The Calgary Family-Assessment and Calgary Family Intervention-Model are suitable to determine the needs of concerned families and hence to offer appropriate interventions.
    Purpose: In an instrumental case study the situation of Mrs. S.2 and her family was analyzed. Mrs. S. is suffering from an inoperable adenocarcinoma.
    Method: An assessment classified the different information given during the first meeting and determined the focus of the interventions.
    Results: Interventions concentrated on cognitive and emotional support.
    Conclusions: The case study showed how family models for nurses could systematically guide professionals in supporting families. Listening and spending time with the concerned person and their families showed to offer important factors, which were perceived as very helpful by the families.
    MeSH term(s) Adaptation, Psychological ; Adenocarcinoma/nursing ; Adenocarcinoma/pathology ; Adenocarcinoma/psychology ; Attitude to Health ; Caregivers/psychology ; Colonic Neoplasms/nursing ; Colonic Neoplasms/pathology ; Colonic Neoplasms/psychology ; Female ; Humans ; Interview, Psychological ; Middle Aged ; Models, Nursing ; Needs Assessment ; Neoplasm Staging ; Nursing Assessment ; Palliative Care ; Professional-Family Relations ; Social Support ; Terminal Care/psychology
    Language German
    Publishing date 2014-04
    Publishing country Switzerland
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 645005-2
    ISSN 1664-283X ; 1012-5302
    ISSN (online) 1664-283X
    ISSN 1012-5302
    DOI 10.1024/1012-5302/a000351
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2399: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book ; Online: Ending the U.S. War in Iraq

    Brennan, Richard R. Jr / Connable, Ben / Hanauer, Larry / Kelly, Terrence K / Ries, Charles P

    The Final Transition, Operational Maneuver, and Disestablishment of United States Forces-Iraq

    2013  

    Abstract: This book looks at the planning and execution of the U.S. military's exit from Iraq and ... the transition of responsibilities to the Iraqi government, U.S. embassy, Office of Security Cooperation ... USCENTCOM, and other U.S. departments and agencies ...

    Abstract This book looks at the planning and execution of the U.S. military's exit from Iraq and the transition of responsibilities to the Iraqi government, U.S. embassy, Office of Security Cooperation, USCENTCOM, and other U.S. departments and agencies
    Language English
    Size Online-Ressource (607 p)
    Publisher RAND Corporation
    Publishing place Santa Monica
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780833080479 ; 0833080474
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Article ; Online: Novel Treatments for Rare Cancers: The U.S. Orphan Drug Act Is Delivering-A Cross-Sectional Analysis.

    Stockklausner, Clemens / Lampert, Anette / Hoffmann, Georg F / Ries, Markus

    The oncologist

    2016  Volume 21, Issue 4, Page(s) 487–493

    Abstract: ... Therefore, we systematically analyzed the impact of the U.S. Orphan Drug Act of 1983 on delivery of novel treatments for rare cancers ... Methods: Quantitative cross-sectional analysis was conducted on the U.S. Food and Drug Administration ... within the U.S. orphan drug act (n = 492). Two compounds (1%) to treat rare cancer were withdrawn after ...

    Abstract Background: Rare cancers are a heterogeneous group of conditions with highly unmet medical needs. Although infrequent in individuals, rare cancers affect millions of people who deserve effective treatments. Therefore, we systematically analyzed the impact of the U.S. Orphan Drug Act of 1983 on delivery of novel treatments for rare cancers.
    Methods: Quantitative cross-sectional analysis was conducted on the U.S. Food and Drug Administration Orphan Drug Product database according to Strengthening the Reporting of Observational Studies in Epidemiology Statement criteria between 1983 and 2015.
    Results: Since 1983, a total of 177 approvals have originated from 1,391 orphan drug designations to treat rare cancers, which represents 36% of all approvals within the U.S. orphan drug act (n = 492). Two compounds (1%) to treat rare cancer were withdrawn after approval. Median time from designation to approval was 2.49 years (interquartile range 1.13-4.64) and decreased significantly over time (p < .001, linear regression). Over the last decade, rare cancer treatments have been transformed from nonspecific cytotoxic agents toward targeted therapies, such as protein kinase inhibitors and monoclonal antibodies, representing the largest groups of innovative rare cancer treatments today. Most compounds were approved to treat solid tumors and hematological malignancies.
    Conclusion: The U.S. Orphan Drug Act and associated incentives, such as 7 years of marketing exclusivity, have fostered delivery of novel treatments for rare cancers. More than one-third of all orphan drug approvals address needs of patients suffering from rare cancers. Over the last decade, the understanding of tumorigenesis and genetic driver mutations in different tumor entities has produced innovative treatments, of which many were first approved within the U.S. Orphan Drug Act.
    Implications for practice: Over the last 30 years, the U.S. Orphan Drug Act successfully delivered numerous novel treatments for rare cancers, of which some were subsequently used in other, nonorphan indications. The understanding of molecular mechanisms of diseases is directly connected to the search for novel therapies. The constant pursuit to translate basic research findings into clinical practice is a crucial prerequisite to address unmet medical needs in rare cancers, as in other rare diseases. Oncological drug development proves to be a major player in overall orphan drug research, displayed by more than one-third of all U.S. Food and Drug Administration-approved orphan drugs with oncological indications.
    MeSH term(s) Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Clinical Trials as Topic ; Cross-Sectional Studies ; Drug Approval ; Humans ; Neoplasms/drug therapy ; Neoplasms/pathology ; Orphan Drug Production ; Rare Diseases/drug therapy ; Rare Diseases/pathology ; United States ; United States Food and Drug Administration
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1634/theoncologist.2015-0397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4845: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 494: Show issues

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  9. Article ; Online: It’s a matter of design—how pitfall trap design affects trap samples and possible predictions

    Fabian A. Boetzl / Elena Ries / Gudrun Schneider / Jochen Krauss

    PeerJ, Vol 6, p e

    2018  Volume 5078

    Abstract: Background Pitfall traps are commonly used to assess ground dwelling arthropod communities. The effects of different pitfall trap designs on the trapping outcome are poorly investigated however they might affect conclusions drawn from pitfall trap data ... ...

    Abstract Background Pitfall traps are commonly used to assess ground dwelling arthropod communities. The effects of different pitfall trap designs on the trapping outcome are poorly investigated however they might affect conclusions drawn from pitfall trap data greatly. Methods We tested four pitfall trap types which have been used in previous studies for their effectiveness: a simple type, a faster exchangeable type with an extended plastic rim plate and two types with guidance barriers (V- and X-shaped). About 20 traps were active for 10 weeks and emptied biweekly resulting in 100 trap samples. Results Pitfall traps with guidance barriers were up to five times more effective than simple pitfall traps and trap samples resulted in more similar assemblage approximations. Pitfall traps with extended plastic rim plates did not only perform poorly but also resulted in distinct carabid assemblages with less individuals of small species and a larger variation. Discussion Due to the obvious trait filtering and resulting altered assemblages, we suggest not to use pitfall traps with extended plastic rim plates. In comprehensive biodiversity inventories, a smaller number of pitfall traps with guidance barriers and a larger number of spatial replicates is of advantage, while due to comparability reasons, the use of simple pitfall traps will be recommended in most other cases.
    Keywords Biodiversity estimation ; Spiders ; Carabid beetles ; Ground dwelling predators ; Staphylinid beetles ; Sampling method ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 621
    Language English
    Publishing date 2018-06-01T00:00:00Z
    Publisher PeerJ Inc.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: "Und plätzlich habe ich einen Tumor" - Die Situation von Frau S. und ihrer Familie

    Ries-Gisler, Tobias / Spirig, Rebecca

    Pflege : die wissenschaftliche Zeitschrift für Pflegeberufe

    2014  Volume 27, Issue 2, Page(s) 117–128

    Keywords Krebs ; Familie ; Pflegemodell ; Assessment ; Intervention
    Language German
    Document type Article
    ZDB-ID 645005-2
    ISSN 1664-283X ; 1012-5302
    ISSN (online) 1664-283X
    ISSN 1012-5302
    DOI 10.1024/1012-5302/a000351
    Database bibnet.org

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2399: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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