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Article ; Online: Halogen Bond-Driven Aggregation-Induced Emission Skeleton:

Chang, Yongxin / Qin, Haijuan / Zhang, Fusheng / Yang, Zhiying / Zhang, Yahui / Wang, Dongdong / Bi, Ce / Guo, Miao / Sun, Wenjing / Qing, Guangyan

ACS applied materials & interfaces

2023

Abstract: Aggregation-induced emission (AIE) is a unique photophysical process, and its emergence brings a revolutionary change in luminescence. However, AIE-based research has been limited to a few classical molecular skeletons, which is unfavorable for in-depth ... ...

Abstract	Aggregation-induced emission (AIE) is a unique photophysical process, and its emergence brings a revolutionary change in luminescence. However, AIE-based research has been limited to a few classical molecular skeletons, which is unfavorable for in-depth studies of the photophysical characteristics of AIE and the full exploitation of their potential values. There is an urgent need to develop new skeletons to rise to the challenges of an insufficient number of AIE core structures and difficult modification. Here, we report a novel dumbbell AIE skeleton, in which two phenyls are connected through (
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c21073
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Article ; Online: ESCRT dysfunction compromises endoplasmic reticulum maturation and autophagosome biogenesis in Drosophila.

Wang, Ruoxi / Miao, Guangyan / Shen, James L / Fortier, Tina M / Baehrecke, Eric H

Current biology : CB

2022 Volume 32, Issue 6, Page(s) 1262–1274.e4

Abstract: Autophagy targets cytoplasmic materials for degradation and influences cell health. Organelle contact and trafficking systems provide membranes for autophagosome formation, but how different membrane systems are selected for use during autophagy remains ... ...

Abstract	Autophagy targets cytoplasmic materials for degradation and influences cell health. Organelle contact and trafficking systems provide membranes for autophagosome formation, but how different membrane systems are selected for use during autophagy remains unclear. Here, we report a novel function of the endosomal sorting complex required for transport (ESCRT) in the regulation of endoplasmic reticulum (ER) coat protein complex II (COPII) vesicle formation that influences autophagy. The ESCRT functions in a pathway upstream of Vps13D to influence COPII vesicle transport, ER-Golgi intermediate compartment (ERGIC) assembly, and autophagosome formation. Atg9 functions downstream of the ESCRT to facilitate ERGIC and autophagosome formation. Interestingly, cells lacking either ESCRT or Vps13D functions exhibit dilated ER structures that are similar to cranio-lenticulo-sutural dysplasia patient cells with SEC23A mutations, which encodes a component of COPII vesicles. Our data reveal a novel ESCRT-dependent pathway that influences the ERGIC and autophagosome formation.
MeSH term(s)	Animals ; Autophagosomes/metabolism ; Autophagy/physiology ; Autophagy-Related Proteins/genetics ; Autophagy-Related Proteins/metabolism ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Endoplasmic Reticulum/metabolism ; Endosomal Sorting Complexes Required for Transport/genetics ; Endosomal Sorting Complexes Required for Transport/metabolism ; Golgi Apparatus/metabolism ; Humans ; Membrane Proteins/metabolism ; Protein Transport/physiology ; Proteins/metabolism
Chemical Substances	Atg9 protein, Drosophila ; Autophagy-Related Proteins ; Drosophila Proteins ; Endosomal Sorting Complexes Required for Transport ; Membrane Proteins ; Proteins ; VPS13D protein, human
Language	English
Publishing date	2022-02-07
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2022.01.040
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Zs.A 3208: Show issues

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Article ; Online: The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.

Miao, Guangyan / Zhang, Yujie / Chen, Di / Zhang, Hong

Molecular cell

2019 Volume 77, Issue 3, Page(s) 618–632.e5

Abstract: TMEM39A, encoding an ER-localized transmembrane protein, is a susceptibility locus for multiple autoimmune diseases. The molecular function of TMEM39A remains completely unknown. Here we demonstrated that TMEM39A, also called SUSR2, modulates autophagy ... ...

Abstract	TMEM39A, encoding an ER-localized transmembrane protein, is a susceptibility locus for multiple autoimmune diseases. The molecular function of TMEM39A remains completely unknown. Here we demonstrated that TMEM39A, also called SUSR2, modulates autophagy activity by regulating the spatial distribution and levels of PtdIns(4)P. Depletion of SUSR2 elevates late endosomal/lysosomal PtdIns(4)P levels, facilitating recruitment of the HOPS complex to promote assembly of the SNARE complex for autophagosome maturation. SUSR2 knockdown also increases the degradative capability of lysosomes. Mechanistically, SUSR2 interacts with the ER-localized PtdIns(4)P phosphatase SAC1 and also the COPII SEC23/SEC24 subunits to promote the ER-to-Golgi transport of SAC1. Retention of SAC1 on the ER in SUSR2 knockdown cells increases the level of PtdIns(3)P produced by the VPS34 complex, promoting autophagosome formation. Our study reveals that TMEM39A/SUSR2 acts as an adaptor protein for efficient export of SAC1 from the ER and provides insights into the pathogenesis of diseases associated with TMEM39A mutations.
MeSH term(s)	Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Autophagy/physiology ; COS Cells ; Chlorocebus aethiops ; Endoplasmic Reticulum/metabolism ; Golgi Apparatus/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Lysosomes/metabolism ; Membrane Proteins/metabolism ; Membrane Proteins/physiology ; Phosphatidylinositol Phosphates/metabolism ; Phosphatidylinositols/metabolism ; Phosphoric Monoester Hydrolases/metabolism ; Phosphoric Monoester Hydrolases/physiology ; Protein Transport/physiology
Chemical Substances	Adaptor Proteins, Signal Transducing ; Membrane Proteins ; Phosphatidylinositol Phosphates ; Phosphatidylinositols ; TMEM39A protein, human ; Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; phosphatidylinositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66)
Language	English
Publishing date	2019-12-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2019.10.035
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Zs.A 5055: Show issues

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Article ; Online: PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development.

Wang, Ruoxi / Fortier, Tina M / Chai, Fei / Miao, Guangyan / Shen, James L / Restrepo, Lucas J / DiGiacomo, Jeromy J / Velentzas, Panagiotis D / Baehrecke, Eric H

Cell

2023 Volume 186, Issue 19, Page(s) 4172–4188.e18

Abstract: Selective clearance of organelles, including endoplasmic reticulum (ER) and mitochondria, by autophagy plays an important role in cell health. Here, we describe a developmentally programmed selective ER clearance by autophagy. We show that Parkinson's ... ...

Abstract	Selective clearance of organelles, including endoplasmic reticulum (ER) and mitochondria, by autophagy plays an important role in cell health. Here, we describe a developmentally programmed selective ER clearance by autophagy. We show that Parkinson's disease-associated PINK1, as well as Atl, Rtnl1, and Trp1 receptors, regulate ER clearance by autophagy. The E3 ubiquitin ligase Parkin functions downstream of PINK1 and is required for mitochondrial clearance while having the opposite function in ER clearance. By contrast, Keap1 and the E3 ubiquitin ligase Cullin3 function downstream of PINK1 to regulate ER clearance by influencing Rtnl1 and Atl. PINK1 regulates a change in Keap1 localization and Keap1-dependent ubiquitylation of the ER-phagy receptor Rtnl1 to facilitate ER clearance. Thus, PINK1 regulates the selective clearance of ER and mitochondria by influencing the balance of Keap1- and Parkin-dependent ubiquitylation of substrates that determine which organelle is removed by autophagy.
MeSH term(s)	Endoplasmic Reticulum/metabolism ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Protein Kinases ; Ubiquitin-Protein Ligases ; Drosophila melanogaster ; Animals
Chemical Substances	Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Protein Kinases (EC 2.7.-) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; PINK1 protein, Drosophila (EC 2.7.11.1) ; Keap1 protein, Drosophila ; Rtnl1 protein, Drosophila
Language	English
Publishing date	2023-08-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2023.08.008
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 58: Show issues

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Article ; Online: Halogen Bond-Driven Aggregation-Induced Emission Skeleton: N‑(3-(Phenylamino)allylidene) Aniline Hydrochloride

Chang, Yongxin / Qin, Haijuan / Zhang, Fusheng / Yang, Zhiying / Zhang, Yahui / Wang, Dongdong / Bi, Ce / Guo, Miao / Sun, Wenjing / Qing, Guangyan

ACS Applied Materials & Interfaces. 2023 Feb. 10, v. 15, no. 7 p.9751-9763

2023

Abstract	Aggregation-induced emission (AIE) is a unique photophysical process, and its emergence brings a revolutionary change in luminescence. However, AIE-based research has been limited to a few classical molecular skeletons, which is unfavorable for in-depth studies of the photophysical characteristics of AIE and the full exploitation of their potential values. There is an urgent need to develop new skeletons to rise to the challenges of an insufficient number of AIE core structures and difficult modification. Here, we report a novel dumbbell AIE skeleton, in which two phenyls are connected through (E)-3-iminoprop-1-en-1-amine. This skeleton shows extremely strong solid-state emission with an absolute quantum yield up to 69.5%, a large Stokes shift, and typical AIE characteristics, which well resolves the challenge of difficult modification and low luminous efficiency of the traditional AIE skeletons. One-step reaction, high yield, and diversified modification endow the skeleton with great scalability from simple to complicated, or from symmetrical to asymmetrical structures, which establishes the applicability of the skeleton in various scenarios. These molecules self-assemble into highly ordered layer-, rod-, petal-, hollow pipe-, or helix-like nanostructures, which contribute to strong AIE emission. Crystallographic data reveal the highly ordered layer structures of the aggregates with different substituents, and a novel halogen bond-driven self-assembly mechanism that restricts intramolecular motion is clearly discovered. Taking advantage of these merits, a full-band emission system from green to red is successfully established, which displays great potential in the construction of light-emitting films and advanced light-emitting diodes. The discovery of this AIE skeleton may motivate a huge potential application value in luminescent materials and lead to hitherto impossible technological innovations.
Keywords	aniline ; halogens ; luminescence ; nanomaterials ; skeleton ; AIEgens ; molecular skeleton ; fluorescence ; halogen bond ; luminescent substances ; self-assembly ; luminescent film ; light-emitting diodes
Language	English
Dates of publication	2023-0210
Size	p. 9751-9763.
Publishing place	American Chemical Society
Document type	Article ; Online
ISSN	1944-8252
DOI	10.1021/acsami.2c21073
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: TLR2/CXCR4 coassociation facilitates

Miao, Guolin / Zhao, Xi / Wang, Beibei / Zhang, Lijun / Wang, Guangyan / Zheng, Ningbo / Liu, Jingya / Xu, Zhelong

American journal of physiology. Heart and circulatory physiology

2020 Volume 318, Issue 6, Page(s) H1420–H1435

Abstract: Chlamydia ... ...

Abstract	Chlamydia pneumoniae
MeSH term(s)	Animals ; Atherosclerosis/metabolism ; Atherosclerosis/microbiology ; Cell Movement ; Chlamydophila Infections/complications ; Chlamydophila Infections/metabolism ; Chlamydophila Infections/microbiology ; Mice ; Muscle, Smooth, Vascular/metabolism ; Myocytes, Smooth Muscle/metabolism ; Phosphorylation ; Receptors, CXCR4/metabolism ; Toll-Like Receptor 2/metabolism
Chemical Substances	CXCR4 protein, mouse ; Receptors, CXCR4 ; Toll-Like Receptor 2
Language	English
Publishing date	2020-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00011.2020
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Uc I Zs.89: Show issues

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Article ; Online: Convergence on successive over-relaxed iterative methods for non-Hermitian positive definite linear systems

Cheng-yi Zhang / Guangyan Miao / Yan Zhu

Journal of Inequalities and Applications, Vol 2016, Iss 1, Pp 1-

2016 Volume 9

Abstract: Abstract Some convergence conditions on successive over-relaxed (SOR) iterative method and symmetric SOR (SSOR) iterative method are proposed for non-Hermitian positive definite linear systems. Some examples are given to demonstrate the results obtained. ...

Abstract	Abstract Some convergence conditions on successive over-relaxed (SOR) iterative method and symmetric SOR (SSOR) iterative method are proposed for non-Hermitian positive definite linear systems. Some examples are given to demonstrate the results obtained.
Keywords	SOR iterative method ; SSOR iterative method ; non-Hermitian positive definite linear system ; convergence ; Science ; Q ; Mathematics ; QA1-939
Language	English
Publishing date	2016-06-01T00:00:00Z
Publisher	Springer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Peripheral arterial stiffness is correlated with intrarenal arteriolosclerosis according to biopsies from patients with kidney disease.

Li, Yisha / Yang, Ying / Wang, Wenling / Miao, Hui / Zhang, Li / Cai, Guangyan / Chen, Xiangmei

Nephrology (Carlton, Vic.)

2019 Volume 25, Issue 5, Page(s) 371–378

Abstract: Aim: To investigate the possible associations between intrarenal arteriolosclerosis as determine by renal biopsy and endothelial function as well as arterial stiffness measured by peripheral arterial tonometry (EndoPAT).: Methods: This was a cross- ... ...

Abstract	Aim: To investigate the possible associations between intrarenal arteriolosclerosis as determine by renal biopsy and endothelial function as well as arterial stiffness measured by peripheral arterial tonometry (EndoPAT). Methods: This was a cross-sectional study. Patients who underwent both renal biopsy and EndoPAT were recruited, and intrarenal arteriolosclerosis was graded according to the pathological slice. Endothelial function and arterial stiffness were both measured by EndoPAT and were expressed by the reactive hyperemia index (RHI) and augmentation index (AIx), respectively. AIx@75, representing the AIx standardized to a heart rate of 75 bpm was also determined. Results: In total, 113 patients were assessed, the mean age was 51 ± 13, and 68.1% were men. The natural logarithm RHI (LnRHI), AIx and AIx@75 were significantly different among different grades of intrarenal arteriolosclerosis (P = .030, P < .001, P < .001, respectively). In the multivariable adjusted model, for every SD increase in the AIx and AIx@75, the odds of having more severe arteriolosclerosis were 2.506 times (95% confidence interval [CI] 1.464-4.288, P = .001] and 3.191 times (95% CI 1.780-5.719, P < .001) higher, respectively, and the association between the LnRHI and intrarenal arteriolosclerosis was nullified (P = .059). The positive values of the AIx and AIx@75 for the diagnosis of severe intrarenal arteriolosclerosis were 0.80 (95% CI 0.73-0.88, P < .001) and 0.78 (95% CI 0.70-0.87, P < .001), respectively. Conclusion: Subjects with more severe intrarenal arteriolosclerosis have greater peripheral vascular stiffness; AIx and AIx@75 reflected peripheral vascular stiffness could be used to identify patients with severe intrarenal arteriolosclerosis.
MeSH term(s)	Aged ; Arterioles/pathology ; Arteriolosclerosis/diagnosis ; Arteriolosclerosis/pathology ; Arteriolosclerosis/physiopathology ; Biopsy ; Cross-Sectional Studies ; Female ; Fingers/blood supply ; Humans ; Kidney/blood supply ; Kidney Diseases/pathology ; Male ; Manometry ; Middle Aged ; Plaque, Atherosclerotic ; Predictive Value of Tests ; Severity of Illness Index ; Vascular Stiffness
Language	English
Publishing date	2019-10-08
Publishing country	Australia
Document type	Journal Article ; Observational Study
ZDB-ID	1303661-0
ISSN	1440-1797 ; 1320-5358
ISSN (online)	1440-1797
ISSN	1320-5358
DOI	10.1111/nep.13665
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Zs.A 4822: Show issues

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Article ; Online: ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.

Miao, Guangyan / Zhao, Hongyu / Li, Yan / Ji, Mingming / Chen, Yong / Shi, Yi / Bi, Yuhai / Wang, Peihui / Zhang, Hong

Developmental cell

2020 Volume 56, Issue 4, Page(s) 427–442.e5

Abstract: Autophagy acts as a cellular surveillance mechanism to combat invading pathogens. Viruses have evolved various strategies to block autophagy and even subvert it for their replication and release. Here, we demonstrated that ORF3a of the COVID-19 virus ... ...

Abstract	Autophagy acts as a cellular surveillance mechanism to combat invading pathogens. Viruses have evolved various strategies to block autophagy and even subvert it for their replication and release. Here, we demonstrated that ORF3a of the COVID-19 virus SARS-CoV-2 inhibits autophagy activity by blocking fusion of autophagosomes/amphisomes with lysosomes. The late endosome-localized ORF3a directly interacts with and sequestrates the homotypic fusion and protein sorting (HOPS) component VPS39, thereby preventing HOPS complex from interacting with the autophagosomal SNARE protein STX17. This blocks assembly of the STX17-SNAP29-VAMP8 SNARE complex, which mediates autophagosome/amphisome fusion with lysosomes. Expression of ORF3a also damages lysosomes and impairs their function. SARS-CoV-2 virus infection blocks autophagy, resulting in accumulation of autophagosomes/amphisomes, and causes late endosomal sequestration of VPS39. Surprisingly, ORF3a from the SARS virus SARS-CoV fails to interact with HOPS or block autophagy. Our study reveals a mechanism by which SARS-CoV-2 evades lysosomal destruction and provides insights for developing new strategies to treat COVID-19.
MeSH term(s)	Autophagosomes/metabolism ; Autophagy ; Autophagy-Related Proteins/metabolism ; COVID-19/metabolism ; COVID-19/virology ; HEK293 Cells ; HeLa Cells ; Humans ; Lysosomes/metabolism ; Protein Binding ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; SNARE Proteins/metabolism ; Vesicular Transport Proteins/metabolism ; Viroporin Proteins/genetics ; Viroporin Proteins/metabolism
Chemical Substances	Autophagy-Related Proteins ; ORF3a protein, SARS-CoV-2 ; SNARE Proteins ; VPS39 protein, human ; Vesicular Transport Proteins ; Viroporin Proteins
Language	English
Publishing date	2020-12-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2020.12.010
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Zs.A 5742: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Efficacy and safety of Abelmoschus manihot in treating chronic kidney diseases: A multicentre, open-label and single-arm clinical trial.

Phytomedicine : international journal of phytotherapy and phytopharmacology

2022 Volume 99, Page(s) 154011

Abstract: Rationale and objective: The efficacy of Abelmoschus manihot (AM) in treating of chronic kidney disease (CKD) has been confirmed by prior trials. AM is also commonly combined to other medicines among CKD patients in clinic. This trial aimed at ... ...

Abstract	Rationale and objective: The efficacy of Abelmoschus manihot (AM) in treating of chronic kidney disease (CKD) has been confirmed by prior trials. AM is also commonly combined to other medicines among CKD patients in clinic. This trial aimed at evaluating the safety of AM combination application, and further verifying the efficacy of AM in treating various types of CKD. Study design: A multicentre, prospective, open-label, single-arm trial SETTING AND PARTICIPANTS: Approximately 2000 CKD patients with proteinuria (≥ 150 mg/d), from 105 centres across China INTERVENTIONS: AM was administered to patients three times per day for 24 weeks: the daily dose was based on age (> 12 years old: 2.5 g tid; 6∼12 years old: 1.5 g tid; 2∼6 years old: 1 g tid) OUTCOMES: The efficacy outcomes were the change in 24-hour proteinuria and estimated glomerular filtration rate (eGFR) from baseline to week 24. Safety outcomes included adverse events and laboratory tests. Results: 2054 CKD patients from 105 centres were enrolled in this trial, with 1843 (89.7%) completing the 24-week follow-up. The participants' median age was 44 years old and 44.6% were female. Compared to baseline, 24-hour proteinuria decreased 471 mg (95% confident interval, 367 to 575, p < 0.001) at week 24. eGFR did not change significantly relative to baseline with the mean increase as 1.7 ml/min/1.73 m Limitations: Single-arm clinical trial and short observation time CONCLUSION: We have provided safety information of AM on various types of CKD in a large trial, especially when combination to medications most commonly prescribed to CKD patients. AM also showed to decrease proteinuria with stable kidney function during follow up. AM is a promising treatment for CKD patients.
Language	English
Publishing date	2022-03-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.154011
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