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  1. Article ; Online: Protective effects of tanshinone IIA on Porphyromonas gingivalis-induced atherosclerosis via the downregulation of the NOX2/NOX4-ROS mediation of NF-κB signaling pathway.

    Xuan, Yan / Yu, Cai / Ni, Kang / Congcong, Lou / Lixin, Qiu / Qingxian, Luan

    Microbes and infection

    2023  Volume 25, Issue 8, Page(s) 105177

    Abstract: Tanshinone IIA (TSA), an active component isolated from Danshen, possess high medicinal values against atherosclerosis by reducing vascular oxidative stress, inhibiting platelet aggregation, and protecting the endothelium from damage. The periodontal ... ...

    Abstract Tanshinone IIA (TSA), an active component isolated from Danshen, possess high medicinal values against atherosclerosis by reducing vascular oxidative stress, inhibiting platelet aggregation, and protecting the endothelium from damage. The periodontal pathogen Porphyromonas gingivalis (P. gingivalis) has been proven to accelerate the development of atherosclerosis. We aim to determine the effects of TSA on P. gingivalis-induced atherosclerosis in ApoE-knockout (ApoE-/-) mice. After feeding with a high-lipid diet and infected with P. gingivalis three times per week for four weeks, TSA-treated (60 mg/kg/d) mice greatly inhibited atherosclerotic lesions both morphologically and biochemically and exhibited significantly reduction ROS, 8-OHdG, and ox-LDL levels in serum compared with P. gingivalis-infected mice. Additionally, TSA-treated mice were observed a marked reduction of ROS, 8-OHdG and ox-LDL in the serum, mRNA levels of COX-2, LOX-1, NOX2 and NOX4 in the aorta, as well as the levels of NOX2, NOX4, and NF-κB. These results suggest that TSA attenuates oxidative stress by decreasing NOX2 and NOX4 and downregulating NF-κB signaling pathway, which might be contributed to the amelioration of atherosclerosis.
    MeSH term(s) Animals ; Mice ; NF-kappa B/metabolism ; Reactive Oxygen Species/metabolism ; Porphyromonas gingivalis/metabolism ; Down-Regulation ; Signal Transduction ; Atherosclerosis/drug therapy ; Atherosclerosis/pathology ; Apolipoproteins E/genetics ; Apolipoproteins E/metabolism ; Apolipoproteins E/pharmacology
    Chemical Substances NF-kappa B ; tanshinone (03UUH3J385) ; Reactive Oxygen Species ; Apolipoproteins E
    Language English
    Publishing date 2023-06-29
    Publishing country France
    Document type Journal Article
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2023.105177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reply to: "Clinical characteristics of COVID-19 patients with abnormal liver tests".

    Cai, Qingxian / Chen, Jun

    Journal of hepatology

    2020  Volume 73, Issue 3, Page(s) 713–714

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Liver ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-06
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2020.04.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2027: Show issues Location:
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  3. Article ; Online: Evolving immune evasion and transmissibility of SARS-CoV-2: The emergence of JN.1 variant and its global impact.

    Ou, Guanyong / Yang, Yang / Zhang, Shengjie / Niu, Shiyu / Cai, Qingxian / Liu, Yingxia / Lu, Hongzhou

    Drug discoveries & therapeutics

    2024  Volume 18, Issue 1, Page(s) 67–70

    Abstract: The continuous evolution of SARS-CoV-2 variants constitutes a significant impediment to the public health. The World Health Organization (WHO) has designated the SARS-CoV-2 variant JN.1, which has evolved from its progenitor BA.2.86, as a Variant of ... ...

    Abstract The continuous evolution of SARS-CoV-2 variants constitutes a significant impediment to the public health. The World Health Organization (WHO) has designated the SARS-CoV-2 variant JN.1, which has evolved from its progenitor BA.2.86, as a Variant of Interest (VOI) in light of its enhanced immune evasion and transmissibility. The proliferating dissemination of JN.1 globally accentuates its competitive superiority and the potential to instigate fresh surges of infection, notably among cohorts previously infected by antecedent variants. Notably, prevailing evidence does not corroborate an increase in pathogenicity associated with JN.1, and antiviral agents retain their antiviral activity against both BA.2.86 and JN.1. The sustained effectiveness of antiviral agents offers a beacon of hope. Nonetheless, the variant's adeptness at eluding the immunoprotective effects conferred by extant vaccines highlights the imperative for the development of more effective vaccines and therapeutic approaches. Overall, the distinct evolutionary trajectories of BA.2.86 and JN.1 underscore the necessity for ongoing surveillance and scholarly inquiry to elucidate their implications for the pandemic's evolution, which requires the international communities to foster collaboration through the sharing of data, exchange of insights, and collective scientific endeavors.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Immune Evasion ; Vaccines ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use
    Chemical Substances Vaccines ; Antiviral Agents
    Language English
    Publishing date 2024-02-22
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2568828-5
    ISSN 1881-784X ; 1881-784X
    ISSN (online) 1881-784X
    ISSN 1881-784X
    DOI 10.5582/ddt.2024.01008
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  5. Article ; Online: Reply to

    Cai, Qingxian / Chen, Jun

    Journal of Hepatology

    “Clinical characteristics of COVID-19 patients with abnormal liver tests”

    2020  Volume 73, Issue 3, Page(s) 713–714

    Keywords Hepatology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2020.04.042
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  6. Article ; Online: Reply to: "Liver tests abnormalities in COVID-19: trick or treat?"

    Cai, Qingxian / Xu, Lin / Chen, Jun

    Journal of hepatology

    2020  Volume 73, Issue 5, Page(s) 1277–1278

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Liver/physiopathology ; Liver Function Tests ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-04
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2020.06.041
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  7. Article ; Online: Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes.

    Chen, FengJuan / Xing, YuFeng / Chen, ZhiJie / Chen, XiaoMan / Li, Jie / Gong, Si / Luo, Fang / Cai, QingXian

    European journal of medical research

    2024  Volume 29, Issue 1, Page(s) 250

    Abstract: Objective: There is a growing body of evidence indicating that pyroptosis, a programmed cell death mechanism, plays a crucial role in the exacerbation of inflammation and fibrosis in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). ... ...

    Abstract Objective: There is a growing body of evidence indicating that pyroptosis, a programmed cell death mechanism, plays a crucial role in the exacerbation of inflammation and fibrosis in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Circular RNAs (circRNAs), functioning as vital regulators within NAFLD, have been shown to mediate the process of cell pyroptosis. This study aims to elucidate the roles and mechanisms of circRNAs in NAFLD.
    Methods: Utilizing a high-fat diet (HFD)-induced rat model for in vivo experimentation and hepatocytes treated with palmitic acid (PA) for in vitro models, we identified circular RNA SOD2 (circSOD2) as our circRNA of interest through analysis with the circMine database. The expression levels of associated genes and pyroptosis-related proteins were determined using quantitative real-time polymerase chain reaction and Western blotting, alongside immunohistochemistry. Serum liver function markers, cellular inflammatory cytokines, malondialdehyde, lactate dehydrogenase levels, and mitochondrial membrane potential, were assessed using enzyme-linked immunosorbent assay, standard assay kits, or JC-1 staining. Flow cytometry was employed to detect pyroptotic cells, and lipid deposition in liver tissues was observed via Oil Red O staining. The interactions between miR-532-3p/circSOD2 and miR-532-3p/Thioredoxin Interacting Protein (TXNIP) were validated through dual-luciferase reporter assays and RNA immunoprecipitation experiments.
    Results: Our findings demonstrate that, in both in vivo and in vitro NAFLD models, there was an upregulation of circSOD2 and TXNIP, alongside a downregulation of miR-532-3p. Mechanistically, miR-532-3p directly bound to the 3'-UTR of TXNIP, thereby mediating inflammation and cell pyroptosis through targeting the TXNIP/NLR family pyrin domain containing 3 (NLRP3) inflammasome signaling pathway. circSOD2 directly interacted with miR-532-3p, relieving the suppression on the TXNIP/NLRP3 signaling pathway. Functionally, the knockdown of circSOD2 or TXNIP improved hepatocyte pyroptosis; the deletion of miR-532-3p reversed the effects of circSOD2 knockdown, and the deletion of TXNIP reversed the effects of circSOD2 overexpression. Furthermore, the knockdown of circSOD2 significantly mitigated the progression of NAFLD in vivo.
    Conclusion: circSOD2 competitively sponges miR-532-3p to activate the TXNIP/NLRP3 inflammasome signaling pathway, promoting pyroptosis in NAFLD.
    MeSH term(s) Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Circular/genetics ; RNA, Circular/metabolism ; Animals ; Pyroptosis/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Rats ; Hepatocytes/metabolism ; Male ; Humans ; Superoxide Dismutase/metabolism ; Superoxide Dismutase/genetics ; Carrier Proteins/metabolism ; Carrier Proteins/genetics ; Rats, Sprague-Dawley ; Diet, High-Fat/adverse effects ; Thioredoxins/metabolism ; Thioredoxins/genetics ; Signal Transduction ; Disease Models, Animal ; Cell Cycle Proteins
    Chemical Substances MicroRNAs ; RNA, Circular ; NLR Family, Pyrin Domain-Containing 3 Protein ; TXNIP protein, rat ; Superoxide Dismutase (EC 1.15.1.1) ; Carrier Proteins ; superoxide dismutase 2 (EC 1.15.1.1) ; Nlrp3 protein, rat ; Thioredoxins (52500-60-4) ; MIRN532 microRNA, human ; Cell Cycle Proteins
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1329381-3
    ISSN 2047-783X ; 0949-2321
    ISSN (online) 2047-783X
    ISSN 0949-2321
    DOI 10.1186/s40001-024-01817-4
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    Zs.A 4636: Show issues Location:
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  8. Article ; Online: Response to Comment on Cai et al. Obesity and COVID-19 Severity in a Designated Hospital in Shenzhen, China. Diabetes Care 2020;43:1392-1398.

    Cai, Qingxian / Chen, Jun / Xu, Lin

    Diabetes care

    2020  Volume 43, Issue 10, Page(s) e162

    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Coronavirus Infections ; Diabetes Mellitus ; Humans ; Obesity ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dci20-0034
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    Zs.A 1434: Show issues Location:
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    Zs.MO 365: Show issues

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  9. Article ; Online: Efficacy of concentrated growth factor (CGF) in the surgical treatment of oral diseases: a systematic review and meta-analysis.

    Chen, Liang / Cheng, Jing / Cai, Yu / Zhang, Jingran / Yin, Xiaohui / Luan, Qingxian

    BMC oral health

    2023  Volume 23, Issue 1, Page(s) 712

    Abstract: Background: Concentrated growth factor (CGF), a new autologous platelet concentrate, has been widely investigated to the adjunctive treatment of oral diseases. This study aims to evaluate the efficacy of CGF in the surgical treatment of oral diseases.!## ...

    Abstract Background: Concentrated growth factor (CGF), a new autologous platelet concentrate, has been widely investigated to the adjunctive treatment of oral diseases. This study aims to evaluate the efficacy of CGF in the surgical treatment of oral diseases.
    Methods: MEDLINE, Web of Science, Scopus, Cochrane, and EMBASE databases were searched up to July 2023. Only randomized clinical trials were included. The methodologic quality was evaluated by the Cochrane Risk of Bias Tool. RevMan 5.4 software was used for data analysis.
    Results: In the treatment of periodontal intrabony defects, bone graft combined with CGF was significantly superior to bone graft (P < 0.01), with mean intrabony defect depth reduction of 1.41 mm and mean clinical attachment level gain of 0.55 mm. In the regenerative surgery of furcation defects, the effect of CGF group was significantly better than control group (P < 0.0001), with mean probing depth reduction of 0.99 mm, vertical bone gain of 0.25 mm, and horizontal bone gain of 0.34 mm. CGF combined with coronally advanced flap (CAF) was more effective than CAF alone (mean keratinized tissue width increase of 0.41 mm, mean gingival thickness increase of 0.26 mm, P < 0.00001), but less effective than connective tissue graft (CTG) combined with CAF (mean root coverage difference of -15.1%, mean gingival thickness difference of -0.5 mm, P < 0.0001). In the alveolar ridge preservation, additional use of CGF reduced horizontal bone resorption by 1.41 mm and buccal vertical bone resorption by 1.01 mm compared to control group (P < 0.0001). The VAS score of CGF group was significantly lower than that of the control group at the 1st and 7th day after oral surgery (P < 0.0001).
    Conclusions: CGF can exert a positive adjunctive effect for the regenerative surgery of periodontal intrabony defects, furcation defects, and alveolar ridge preservation procedure. CGF combined with CAF has a better therapeutic effect on gingival recession compared to CAF alone, although it is not as effective as CTG combined with CAF. CGF could promote postoperative healing and pain relief in oral surgery within a week. There is currently not enough evidence to support the clinical benefits of CGF in other oral surgeries.
    MeSH term(s) Humans ; Surgical Flaps/transplantation ; Gingival Recession/surgery ; Gingiva ; Intercellular Signaling Peptides and Proteins/therapeutic use ; Furcation Defects ; Bone Resorption ; Treatment Outcome ; Tooth Root/surgery
    Chemical Substances Intercellular Signaling Peptides and Proteins
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2091511-1
    ISSN 1472-6831 ; 1472-6831
    ISSN (online) 1472-6831
    ISSN 1472-6831
    DOI 10.1186/s12903-023-03357-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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