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  1. Article ; Online: COVID-19-induced postural orthostatic tachycardia syndrome treated with ivabradine.

    O'Sullivan, Jenna Stephanie / Lyne, Andrew / Vaughan, Carl J

    BMJ case reports

    2021  Volume 14, Issue 6

    Abstract: A 22-year-old woman was referred with exertional dyspnoea and chest tightness 3 weeks following a diagnosis of COVID-19. Evaluation revealed a resting sinus tachycardia and criteria for postural orthostatic tachycardia syndrome were met. After non- ... ...

    Abstract A 22-year-old woman was referred with exertional dyspnoea and chest tightness 3 weeks following a diagnosis of COVID-19. Evaluation revealed a resting sinus tachycardia and criteria for postural orthostatic tachycardia syndrome were met. After non-pharmacological interventions failed to yield symptomatic improvement, ivabradine was commenced. This intervention was followed by a substantial improvement in the patient's exercise tolerance and energy levels and an objective reduction in supine and standing heart rate.
    MeSH term(s) Adult ; COVID-19 ; Female ; Humans ; Ivabradine ; Postural Orthostatic Tachycardia Syndrome/diagnosis ; Postural Orthostatic Tachycardia Syndrome/drug therapy ; SARS-CoV-2 ; Tachycardia, Sinus/chemically induced ; Tachycardia, Sinus/diagnosis ; Tachycardia, Sinus/drug therapy ; Young Adult
    Chemical Substances Ivabradine (3H48L0LPZQ)
    Language English
    Publishing date 2021-06-14
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-243585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Social and Cultural Constraints on Football Player Development in Stockholm: Influencing Skill, Learning, and Wellbeing.

    Vaughan, James / Mallett, Clifford J / Potrac, Paul / Woods, Carl / O'Sullivan, Mark / Davids, Keith

    Frontiers in sports and active living

    2022  Volume 4, Page(s) 832111

    Abstract: In this paper, we consider how youth sport and (talent) development environments have adapted to, and are constrained by, social and cultural forces. Empirical evidence from an 18-month ethnographic case study highlights how social and cultural ... ...

    Abstract In this paper, we consider how youth sport and (talent) development environments have adapted to, and are constrained by, social and cultural forces. Empirical evidence from an 18-month ethnographic case study highlights how social and cultural constraints influence the skill development and psychological wellbeing of young football players. We utilized novel ways of knowing (i.e., epistemologies) coupled to ecological frameworks (e.g., the theory of ecological dynamics and the skilled intentionality framework). A transdisciplinary inquiry was used to demonstrate that the values which athletes embody in sports are
    Language English
    Publishing date 2022-05-20
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2624-9367
    ISSN (online) 2624-9367
    DOI 10.3389/fspor.2022.832111
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  3. Article ; Online: Obesity and COVID-19: A Virchow's Triad for the 21st Century.

    Vaughan, Carl J / Cronin, Heather / Ryan, Paul MacDaragh / Caplice, Noel M

    Thrombosis and haemostasis

    2020  Volume 120, Issue 11, Page(s) 1590–1593

    Keywords covid19
    Language English
    Publishing date 2020-07-17
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0040-1714216
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  4. Article ; Online: A review of top cardiology and cardiovascular medicine journal guidelines regarding the use of generative artificial intelligence tools in scientific writing.

    Inam, Maha / Sheikh, Sana / Minhas, Abdul Mannan Khan / Vaughan, Elizabeth M / Krittanawong, Chayakrit / Samad, Zainab / Lavie, Carl J / Khoja, Adeel / D'Cruze, Melaine / Slipczuk, Leandro / Alarakhiya, Farhana / Naseem, Azra / Haider, Adil H / Virani, Salim S

    Current problems in cardiology

    2024  Volume 49, Issue 3, Page(s) 102387

    Abstract: Background: Generative Artificial Intelligence (AI) tools have experienced rapid development over the last decade and are gaining increasing popularity as assistive models in academic writing. However, the ability of AI to generate reliable and accurate ...

    Abstract Background: Generative Artificial Intelligence (AI) tools have experienced rapid development over the last decade and are gaining increasing popularity as assistive models in academic writing. However, the ability of AI to generate reliable and accurate research articles is a topic of debate. Major scientific journals have issued policies regarding the contribution of AI tools in scientific writing.
    Methods: We conducted a review of the author and peer reviewer guidelines of the top 25 Cardiology and Cardiovascular Medicine journals as per the 2023 SCImago rankings. Data were obtained though reviewing journal websites and directly emailing the editorial office. Descriptive data regarding journal characteristics were coded on SPSS. Subgroup analyses of the journal guidelines were conducted based on the publishing company policies.
    Results: Our analysis revealed that all scientific journals in our study permitted the documented use of AI in scientific writing with certain limitations as per ICMJE recommendations. We found that AI tools cannot be included in the authorship or be used for image generation, and that all authors are required to assume full responsibility of their submitted and published work. The use of generative AI tools in the peer review process is strictly prohibited.
    Conclusion: Guidelines regarding the use of generative AI in scientific writing are standardized, detailed, and unanimously followed by all journals in our study according to the recommendations set forth by international forums. It is imperative to ensure that these policies are carefully followed and updated to maintain scientific integrity.
    MeSH term(s) Humans ; Publishing ; Editorial Policies ; Artificial Intelligence ; Writing ; Cardiology
    Language English
    Publishing date 2024-01-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 441230-8
    ISSN 1535-6280 ; 0146-2806
    ISSN (online) 1535-6280
    ISSN 0146-2806
    DOI 10.1016/j.cpcardiol.2024.102387
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  5. Article ; Online: There is no copy and paste, but there is resonation and inhabitation: Integrating a contemporary player development framework in football from a complexity sciences perspective.

    O'Sullivan, Mark / Vaughan, James / Woods, Carl T / Davids, Keith

    Journal of sports sciences

    2023  , Page(s) 1–10

    Abstract: Socio-cultural constraints shape behaviour in complexifying ways. In sport, for example, interconnected constraints play an important role in shaping the way a game is played, coached, and spectated. Here, we contend that player development frameworks in ...

    Abstract Socio-cultural constraints shape behaviour in complexifying ways. In sport, for example, interconnected constraints play an important role in shaping the way a game is played, coached, and spectated. Here, we contend that player development frameworks in sport cannot be operationalised without careful consideration of the complex ecosystem in which they reside. Concurrently, we highlight issues associated with frameworks designed in isolation from the contexts in which they are introduced for integration, guised as trying to "copy and paste" templates from country to country. As such, there is a need to understand the oft-shrouded socio-cultural dynamics that continuously influence practice in order to maximize the utility of player development frameworks in sport. Ecological dynamics offers a complexity-oriented theoretical lens that supports the evolution of context-dependent player development frameworks. Further, tenets of the Learning in Development Research Framework can show how affordances are not just material invitations but constitute a vital component of a broader socio-cultural form of life. These ideas have the potential to: (1) push against a desire to "copy and paste" what is perceived to be "successful" elsewhere, and (2), guide the integration of player development frameworks by learning to resonate with the nuanced complexities of the broader environment inhabited.
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 995528-8
    ISSN 1466-447X ; 0264-0414
    ISSN (online) 1466-447X
    ISSN 0264-0414
    DOI 10.1080/02640414.2023.2288979
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  7. Article: Obesity and COVID-19: A Virchow's Triad for the 21st Century

    Vaughan, Carl J. / Cronin, Heather / Ryan, Paul MacDaragh / Caplice, Noel M.

    Thrombosis and Haemostasis

    2020  Volume 120, Issue 11, Page(s) 1590–1593

    Language English
    Publishing date 2020-07-17
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0040-1714216
    Database Thieme publisher's database

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  8. Article ; Online: Obesity and COVID-19

    Vaughan, Carl J. / Cronin, Heather / Ryan, Paul MacDaragh / Caplice, Noel M.

    Thrombosis and Haemostasis ; ISSN 0340-6245 2567-689X

    A Virchow's Triad for the 21st Century

    2020  

    Keywords Hematology ; covid19
    Language English
    Publisher Georg Thieme Verlag KG
    Publishing country de
    Document type Article ; Online
    DOI 10.1055/s-0040-1714216
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Inferolateral T wave inversion in athletes: phenotype-genotype correlation.

    Cronin, Heather / Crinion, Derek / Kerins, David / Fahy, Gerry / Vaughan, Carl J

    Irish journal of medical science

    2020  Volume 189, Issue 4, Page(s) 1283–1287

    Abstract: Aims: Significant T wave inversion in young asymptomatic athletes is rare but poses a significant clinical challenge. Pre-participation sports screening programs identify such subjects. Clinical concern that such ECG changes represent an occult ... ...

    Abstract Aims: Significant T wave inversion in young asymptomatic athletes is rare but poses a significant clinical challenge. Pre-participation sports screening programs identify such subjects. Clinical concern that such ECG changes represent an occult cardiomyopathy or forme fruste hypertrophic cardiomyopathy leads to diagnostic and therapeutic dilemma. We sought to genotype a cohort of such subjects with a normal cardiac phenotype identified in our unit over a 3-year period.
    Methods: Ten athletes were referred from external screening. All exhibited deep T wave inversion inferolaterally. All had negative family history for sudden death and had a normal phenotype. A panel of 133 cardiac genes were screened.
    Results: Ten male subjects with mean age of 39 years were screened. Seven had no evidence of mutations. Three subjects demonstrated variants of uncertain significance in 5 different genes: alpha-2-actinin (ACTN2), myopalladin (MYPN), the calcium channel genes CACNA1C and TRPM4 and potassium channel gene KCNQ1. The variants found have not been described in cardiomyopathies or channelopathies. At 3-year follow-up, one patient had undergone detraining, and his ECG showed complete resolution of all T wave changes. He did not have any demonstrated variants.
    Conclusions: The absence of mutations in target genes and heterogeneous sequence variations identified in this study suggest that inferolateral T wave inversion in athletes without a phenotype may potentially represent a benign repolarization syndrome related to athletic adaptation. This was the first study to assess a phenotype-genotype correlation in this population. Further genetic studies need to be undertaken in this area.
    MeSH term(s) Adult ; Arrhythmias, Cardiac/diagnosis ; Athletes/statistics & numerical data ; Electrocardiography/methods ; Genotype ; Humans ; Male ; Phenotype
    Language English
    Publishing date 2020-05-14
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 390895-1
    ISSN 1863-4362 ; 0021-1265
    ISSN (online) 1863-4362
    ISSN 0021-1265
    DOI 10.1007/s11845-020-02239-x
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    Zs.B 323: Show issues Location:
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  10. Article ; Online: Utilization Rates of SGLT2 Inhibitors and GLP-1 Receptor Agonists and Their Facility-Level Variation Among Patients With Atherosclerotic Cardiovascular Disease and Type 2 Diabetes: Insights From the Department of Veterans Affairs.

    Mahtta, Dhruv / Ramsey, David J / Lee, Michelle T / Chen, Liang / Al Rifai, Mahmoud / Akeroyd, Julia M / Vaughan, Elizabeth M / Matheny, Michael E / Santo, Karla Rodrigues do Espirito / Navaneethan, Sankar D / Lavie, Carl J / Birnbaum, Yochai / Ballantyne, Christie M / Petersen, Laura A / Virani, Salim S

    Diabetes care

    2022  Volume 45, Issue 2, Page(s) 372–380

    Abstract: Objective: There is mounting evidence regarding the cardiovascular benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP-1 RA) among patients with atherosclerotic cardiovascular disease (ASCVD) ...

    Abstract Objective: There is mounting evidence regarding the cardiovascular benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP-1 RA) among patients with atherosclerotic cardiovascular disease (ASCVD) and type 2 diabetes mellitus (T2DM). There is paucity of data assessing real-world practice patterns for these drug classes. We aimed to assess utilization rates of these drug classes and facility-level variation in their use.
    Research design and methods: We used the nationwide Veterans Affairs (VA) health care system data set from 1 January 2020 to 31 December 2020 and included patients with established ASCVD and T2DM. Among these patients, we assessed the use of SGLT2i and GLP-1 RA and the facility-level variation in their use. Facility-level variation was computed using median rate ratios (MRR), a measure of likelihood that two random facilities differ in use of SGLT2i and GLP-1 RA in patients with ASCVD and T2DM.
    Results: Among 537,980 patients with ASCVD and T2DM across 130 VA facilities, 11.2% of patients received an SGLT2i while 8.0% of patients received a GLP-1 RA. Patients receiving these cardioprotective glucose-lowering drug classes were on average younger and had a higher proportion of non-Hispanic Whites. Overall, median (10th-90th percentile) facility-level rates were 14.92% (9.31-22.50) for SGLT2i and 10.88% (4.44-17.07) for GLP-1 RA. There was significant facility-level variation among SGLT2i use-MRRunadjusted: 1.41 (95% CI 1.35-1.47) and MRRadjusted: 1.55 (95% CI 1.46 -1.63). Similar facility-level variation was observed for use of GLP-1 RA-MRRunadjusted: 1.34 (95% CI 1.29-1.38) and MRRadjusted: 1.78 (95% CI 1.65-1.90).
    Conclusions: Overall utilization rates of SGLT2i and GLP-1 RA among eligible patients are low, with significantly higher residual facility-level variation in the use of these drug classes. Our results suggest opportunities to optimize their use to prevent future adverse cardiovascular events among these patients.
    MeSH term(s) Cardiovascular Diseases/prevention & control ; Diabetes Mellitus, Type 2/chemically induced ; Diabetes Mellitus, Type 2/drug therapy ; Glucagon-Like Peptide-1 Receptor/agonists ; Humans ; Hypoglycemic Agents/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Veterans
    Chemical Substances Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc21-1815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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