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  1. Article ; Online: Neural Circuits Underlying Reciprocal Cardiometabolic Crosstalk: 2023 Arthur C. Corcoran Memorial Lecture.

    Rahmouni, Kamal

    Hypertension (Dallas, Tex. : 1979)

    2024  

    Abstract: The interplay of various body systems, encompassing those that govern cardiovascular and metabolic functions, has evolved alongside the development of multicellular organisms. This evolutionary process is essential for the coordination and maintenance of ...

    Abstract The interplay of various body systems, encompassing those that govern cardiovascular and metabolic functions, has evolved alongside the development of multicellular organisms. This evolutionary process is essential for the coordination and maintenance of homeostasis and overall health by facilitating the adaptation of the organism to internal and external cues. Disruption of these complex interactions contributes to the development and progression of pathologies that involve multiple organs. Obesity-associated cardiovascular risks, such as hypertension, highlight the significant influence that metabolic processes exert on the cardiovascular system. This cardiometabolic communication is reciprocal, as indicated by substantial evidence pointing to the ability of the cardiovascular system to affect metabolic processes, with pathophysiological implications in disease conditions. In this review, I outline the bidirectional nature of the cardiometabolic interaction, with special emphasis on the impact that metabolic organs have on the cardiovascular system. I also discuss the contribution of the neural circuits and autonomic nervous system in mediating the crosstalk between cardiovascular and metabolic functions in health and disease, along with the molecular mechanisms involved.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.124.22066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1488: Show issues Location:
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  2. Article ; Online: Energy metabolism and syncope.

    Rahmouni, Kamal

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2022  Volume 32, Issue 6, Page(s) 391–393

    MeSH term(s) Humans ; Syncope/etiology ; Hypotension, Orthostatic ; Energy Metabolism
    Language English
    Publishing date 2022-11-03
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-022-00906-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Methods and applications in metabolic physiology.

    Arnold, Amy C / Rahmouni, Kamal

    Frontiers in physiology

    2023  Volume 14, Page(s) 1156826

    Language English
    Publishing date 2023-02-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1156826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: BBSome: a New Player in Hypertension and Other Cardiovascular Risks.

    Zhao, Yuying / Rahmouni, Kamal

    Hypertension (Dallas, Tex. : 1979)

    2021  Volume 79, Issue 2, Page(s) 303–313

    Abstract: The BBSome is an octameric protein complex involved in Bardet-Biedl syndrome (BBS), a human pleiotropic, autosomal recessive condition. Patients with BBS display various clinical features including obesity, hypertension, and renal abnormalities. ... ...

    Abstract The BBSome is an octameric protein complex involved in Bardet-Biedl syndrome (BBS), a human pleiotropic, autosomal recessive condition. Patients with BBS display various clinical features including obesity, hypertension, and renal abnormalities. Association studies have also linked the
    MeSH term(s) Animals ; Bardet-Biedl Syndrome/metabolism ; Blood Pressure/physiology ; Cell Line ; Humans ; Hypertension/metabolism ; Risk Factors
    Language English
    Publishing date 2021-12-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.121.17946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cardiovascular Regulation by the Arcuate Nucleus of the Hypothalamus: Neurocircuitry and Signaling Systems.

    Rahmouni, Kamal

    Hypertension (Dallas, Tex. : 1979)

    2016  Volume 67, Issue 6, Page(s) 1064–1071

    MeSH term(s) Animals ; Arcuate Nucleus of Hypothalamus/pathology ; Arcuate Nucleus of Hypothalamus/physiology ; Blood Pressure/physiology ; Cardiovascular System/innervation ; Cardiovascular System/pathology ; Cardiovascular System/physiopathology ; Hemodynamics/physiology ; Humans ; Hypertension/metabolism ; Hypertension/physiopathology ; Signal Transduction/physiology ; Sympathetic Nervous System/physiology ; Sympathetic Nervous System/physiopathology ; Synaptic Transmission/physiology
    Language English
    Publishing date 2016-04-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.115.06425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1488: Show issues Location:
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  6. Article ; Online: Metabolic consequences of skeletal muscle- and liver-specific BBSome deficiency.

    Rouabhi, Younes / Guo, Deng-Fu / Zhao, Yuying / Rahmouni, Kamal

    American journal of physiology. Endocrinology and metabolism

    2023  Volume 325, Issue 6, Page(s) E711–E722

    Abstract: The BBSome is a protein complex composed of eight Bardet-Biedl syndrome (BBS) proteins including BBS1. Humans and mice lacking a functional BBSome display obesity and type 2 diabetes, highlighting the importance of this protein complex for metabolic ... ...

    Abstract The BBSome is a protein complex composed of eight Bardet-Biedl syndrome (BBS) proteins including BBS1. Humans and mice lacking a functional BBSome display obesity and type 2 diabetes, highlighting the importance of this protein complex for metabolic regulation. However, the contribution of the BBSome in insulin-sensitive tissues such as skeletal muscle and liver to metabolic regulation is ill-defined. Here, we show that disruption of the BBSome through
    MeSH term(s) Humans ; Mice ; Male ; Female ; Animals ; Microtubule-Associated Proteins/metabolism ; Receptor, Insulin ; Insulin Resistance/genetics ; Diabetes Mellitus, Type 2/genetics ; Obesity/genetics ; Obesity/metabolism ; Body Weight/genetics ; Liver/metabolism ; Glucose ; Insulins ; Muscle, Skeletal/metabolism
    Chemical Substances Microtubule-Associated Proteins ; Receptor, Insulin (EC 2.7.10.1) ; Glucose (IY9XDZ35W2) ; Insulins ; Bbs1 protein, human
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 603841-4
    ISSN 1522-1555 ; 0193-1849
    ISSN (online) 1522-1555
    ISSN 0193-1849
    DOI 10.1152/ajpendo.00174.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.89: Show issues Location:
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  7. Article ; Online: T cell-specific deficiency in BBSome component BBS1 interferes with selective immune responses.

    Stump, Madeliene / Guo, Deng Fu / Rahmouni, Kamal

    American journal of physiology. Regulatory, integrative and comparative physiology

    2022  Volume 324, Issue 2, Page(s) R161–R170

    Abstract: Bsardet Biedl syndrome (BBS) is a genetic condition associated with various clinical features including cutaneous disorders and certain autoimmune and inflammatory diseases pointing to a potential role of BBS proteins in the regulation of immune function. ...

    Abstract Bsardet Biedl syndrome (BBS) is a genetic condition associated with various clinical features including cutaneous disorders and certain autoimmune and inflammatory diseases pointing to a potential role of BBS proteins in the regulation of immune function. BBS1 protein, which is a key component of the BBSome, a protein complex involved in the regulation of cilia function and other cellular processes, has been implicated in the immune synapse assembly by promoting the centrosome polarization to the antigen-presenting cells. Here, we assessed the effect of disrupting the BBSome, through
    MeSH term(s) Animals ; Male ; Mice ; Adiposity ; Cilia/metabolism ; Cilia/pathology ; Immunity/genetics ; Microtubule-Associated Proteins/genetics ; Bardet-Biedl Syndrome/genetics ; Bardet-Biedl Syndrome/metabolism
    Chemical Substances Bbs1 protein, mouse ; Microtubule-Associated Proteins
    Language English
    Publishing date 2022-12-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 603839-6
    ISSN 1522-1490 ; 0363-6119
    ISSN (online) 1522-1490
    ISSN 0363-6119
    DOI 10.1152/ajpregu.00243.2022
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  8. Article ; Online: Obesity-associated hypertension: recent progress in deciphering the pathogenesis.

    Rahmouni, Kamal

    Hypertension (Dallas, Tex. : 1979)

    2014  Volume 64, Issue 2, Page(s) 215–221

    MeSH term(s) Humans ; Hypertension/etiology ; Hypertension/physiopathology ; Obesity/complications ; Obesity/physiopathology
    Language English
    Publishing date 2014-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.114.00920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1488: Show issues Location:
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  9. Article: Involvement of a serotonin/GLP-1 circuit in adolescent isolation-induced diabetes.

    Kolling, Louis J / Khan, Kanza / Balasubramanian, Nagalakshmi / Guo, Deng-Fu / Rahmouni, Kamal / Marcinkiewcz, Catherine A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: In 2020, stay-at-home orders were implemented to stem the spread of SARS-CoV-2 worldwide. Social isolation can be particularly harmful to children and adolescents-during the pandemic, the prevalence of obesity increased by ∼37% in persons aged 2-19. ... ...

    Abstract In 2020, stay-at-home orders were implemented to stem the spread of SARS-CoV-2 worldwide. Social isolation can be particularly harmful to children and adolescents-during the pandemic, the prevalence of obesity increased by ∼37% in persons aged 2-19. Obesity is often comorbid with type 2 diabetes, which was not assessed in this human pandemic cohort. Here, we investigated whether male mice isolated throughout adolescence develop type 2 diabetes in a manner consistent with human obesity-induced diabetes, and explored neural changes that may underlie such an interaction. We find that isolating C57BL/6J mice throughout adolescence is sufficient to induce type 2 diabetes. We observed fasted hyperglycemia, diminished glucose clearance in response to an insulin tolerance test, decreased insulin signaling in skeletal muscle, decreased insulin staining of pancreatic islets, increased nociception, and diminished plasma cortisol levels compared to group-housed control mice. Using Promethion metabolic phenotyping chambers, we observed dysregulation of sleep and eating behaviors, as well as a time-dependent shift in respiratory exchange ratio of the adolescent-isolation mice. We profiled changes in neural gene transcription from several brain areas and found that a neural circuit between serotonin-producing and GLP-1-producing neurons is affected by this isolation paradigm. Overall, spatial transcription data suggest decreased serotonin neuron activity (via decreased GLP-1-mediated excitation) and increased GLP-1 neuron activity (via decreased serotonin-mediated inhibition). This circuit may represent an intersectional target to further investigate the relationship between social isolation and type 2 diabetes, as well as a pharmacologically-relevant circuit to explore the effects of serotonin and GLP-1 receptor agonists.
    Article highlights: Isolating C57BL/6J mice throughout adolescence is sufficient to induce type 2 diabetes, presenting with fasted hyperglycemia.Adolescent-isolation mice have deficits in insulin responsiveness, impaired peripheral insulin signaling, and decreased pancreatic insulin production.Transcriptional changes across the brain include the endocannabinoid, serotonin, and GLP-1 neurotransmitters and associated receptors. The neural serotonin/GLP-1 circuit may represent an intersectional target to further investigate the relationship between social isolation and type 2 diabetes. Serotonin-producing neurons of adolescent-isolation mice produce fewer transcripts for the GLP-1 receptor, and GLP-1 neurons produce fewer transcripts for the 5-HT
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.12.544498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Bardet-Biedl syndrome protein complex regulates cell migration and tissue repair through a Cullin-3/RhoA pathway.

    Guo, Deng-Fu / Rahmouni, Kamal

    American journal of physiology. Cell physiology

    2019  Volume 317, Issue 3, Page(s) C457–C465

    Abstract: Cell motility and migration play critical roles in various physiological processes and disease states. Here, we show that the BBBsome, a macromolecule composed of eight Bardet-Biedl syndrome (BBS) proteins including BBS1, is a critical determinant of ... ...

    Abstract Cell motility and migration play critical roles in various physiological processes and disease states. Here, we show that the BBBsome, a macromolecule composed of eight Bardet-Biedl syndrome (BBS) proteins including BBS1, is a critical determinant of cell migration and wound healing. Fibroblast cells derived from mice or humans harboring a homozygous missense mutation (BBS1
    MeSH term(s) Animals ; Bardet-Biedl Syndrome/genetics ; Cell Movement/drug effects ; Cell Movement/physiology ; Cells, Cultured ; Cullin Proteins/antagonists & inhibitors ; Cullin Proteins/physiology ; Cyclopentanes/pharmacology ; Enzyme Inhibitors/pharmacology ; Female ; Gene Knock-In Techniques/methods ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microtubule-Associated Proteins/physiology ; Pyrimidines/pharmacology ; Signal Transduction/physiology ; rhoA GTP-Binding Protein/antagonists & inhibitors ; rhoA GTP-Binding Protein/physiology
    Chemical Substances Bbs1 protein, human ; Cul3 protein, mouse ; Cullin Proteins ; Cyclopentanes ; Enzyme Inhibitors ; Microtubule-Associated Proteins ; Pyrimidines ; RhoA protein, mouse (EC 3.6.5.2) ; rhoA GTP-Binding Protein (EC 3.6.5.2) ; pevonedistat (S3AZD8D215)
    Language English
    Publishing date 2019-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00498.2018
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