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  1. Article ; Online: Historical perspectives of the metabolic syndrome.

    Oda, Eiji

    Clinics in dermatology

    2018  Volume 36, Issue 1, Page(s) 3–8

    Abstract: The metabolic syndrome (MetS) or insulin resistance syndrome is a constellation of obesity-related metabolic derangements predisposing to type 2 diabetes and cardiovascular disease. In 1998, WHO defined the first criteria of MetS. Three years later, the ... ...

    Abstract The metabolic syndrome (MetS) or insulin resistance syndrome is a constellation of obesity-related metabolic derangements predisposing to type 2 diabetes and cardiovascular disease. In 1998, WHO defined the first criteria of MetS. Three years later, the user-friendly National Cholesterol Education Program criteria of MetS were proposed. Different criteria were issued by the International Diabetes Federation in 2005, making abdominal obesity a necessary component. Several international societies, including The International Diabetes Federation, jointly adopted the revised National Cholesterol Education Program criteria as harmonizing criteria of MetS in 2009. WHO warned the next year that MetS has limited practical utility as a management tool. Adipose tissue inflammation has been shown to be a fundamental mechanism of metabolic derangements, associated with ectopic lipid deposit and mitochondrial dysfunction in skeletal muscle and the liver.
    MeSH term(s) Diabetes Mellitus/blood ; Dyslipidemias/blood ; History, 20th Century ; History, 21st Century ; Humans ; Hypertension/physiopathology ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/history ; Metabolic Syndrome/physiopathology ; Obesity, Abdominal/diagnosis ; Practice Guidelines as Topic
    Language English
    Publishing date 2018-01
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 1064149-x
    ISSN 1879-1131 ; 0738-081X
    ISSN (online) 1879-1131
    ISSN 0738-081X
    DOI 10.1016/j.clindermatol.2017.09.002
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  2. Article: Pre-Administration of Blackberry Extracts in Induced Ischemia Reperfusion Events in Rodents.

    Oda, Asahi / Hakamata, Yoji / Kobayashi, Eiji

    Metabolites

    2023  Volume 13, Issue 11

    Abstract: Blackberries are abundant in substances that have antioxidative and other effects, and technologies for enhancing the effectiveness of their incorporation into the body are being developed. The effectiveness of such substances has been investigated in ... ...

    Abstract Blackberries are abundant in substances that have antioxidative and other effects, and technologies for enhancing the effectiveness of their incorporation into the body are being developed. The effectiveness of such substances has been investigated in various models, including rodent ischemia models. While a test substance can be administered either before or after an event, healthy foods are generally pre-administered prophylactically in experiments. Pre-administration may have the potential to elevate the blood concentration of the active substance sufficiently prior to the event and/or induce adaptive changes in the ischemic tolerance of the recipient through long-term pre-administration. Based on the recently reported 2-week pre-administration of blackberries in a rat model, we investigated the pre-administration of blackberry extracts in a hyperlipidemia model using Mongolian gerbils. We then discussed the effects of the pre-administration on the treated animals before an ischemic event.
    Language English
    Publishing date 2023-10-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13111114
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  3. Article ; Online: Serum Cholinesterase (Butyrylcholinesterase) May Play a Role in Body Weight Homeostasis via the Inactivation of Ghrelin.

    Oda, Eiji

    Internal medicine (Tokyo, Japan)

    2016  Volume 55, Issue 9, Page(s) 1245

    Language English
    Publishing date 2016
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.55.6637
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  4. Article ; Online: Structural Impact Assessment of Cytochrome P450 2A13 Polymorphisms Using Molecular Dynamics Simulations.

    Kato, Koichi / Nakayoshi, Tomoki / Hioki, Sho / Hiratsuka, Masahiro / Ishikawa, Yoshinobu / Kurimoto, Eiji / Oda, Akifumi

    Biological & pharmaceutical bulletin

    2024  Volume 47, Issue 3, Page(s) 620–628

    Abstract: One of the members of CYP, a monooxygenase, CYP2A13 is involved in the metabolism of nicotine, coumarin, and tobacco-specific nitrosamine. Genetic polymorphisms have been identified in CYP2A13, with reported loss or reduction in enzymatic activity in ... ...

    Abstract One of the members of CYP, a monooxygenase, CYP2A13 is involved in the metabolism of nicotine, coumarin, and tobacco-specific nitrosamine. Genetic polymorphisms have been identified in CYP2A13, with reported loss or reduction in enzymatic activity in CYP2A13 allelic variants. This study aimed to unravel the mechanism underlying the diminished enzymatic activity of CYP2A13 variants by investigating their three-dimensional structures through molecular dynamics (MD) simulations. For each variant, MD simulations of 1000 ns were performed, and the obtained results were compared with those of the wild type. The findings indicated alterations in the interaction with heme in CYP2A13.4, .6, .8, and .9. In the case of CYP2A13.5, observable effects on the helix structure related to the interaction with the redox partner were identified. These conformational changes were sufficient to cause a decrease in enzyme activity in the variants. Our findings provide valuable insights into the molecular mechanisms associated with the diminished activity in the CYP2A13 polymorphisms.
    MeSH term(s) Molecular Dynamics Simulation ; Polymorphism, Genetic ; Nitrosamines ; Nicotine ; Oxidation-Reduction ; Cytochrome P-450 CYP2A6/genetics
    Chemical Substances Nitrosamines ; Nicotine (6M3C89ZY6R) ; Cytochrome P-450 CYP2A6 (EC 1.14.14.1)
    Language English
    Publishing date 2024-01-18
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.b23-00908
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  5. Article: LDL cholesterol was more strongly associated with percent body fat than body mass index and waist circumference in a health screening population.

    Oda, Eiji

    Obesity research & clinical practice

    2017  Volume 12, Issue 2, Page(s) 195–203

    Abstract: Aims: To compare correlations between changes in cardiovascular risk factors and those in obesity indices and to compare associations with incident hyper-LDL cholesterolemia among obesity indices.: Methods: Correlation coefficients were calculated ... ...

    Abstract Aims: To compare correlations between changes in cardiovascular risk factors and those in obesity indices and to compare associations with incident hyper-LDL cholesterolemia among obesity indices.
    Methods: Correlation coefficients were calculated between 7-year changes in cardiovascular risk factors and those in body mass index (BMI), waist circumference (WC) and percent body fat (PBF) in 634 men and 396 women who used no antihypertensive, antidiabetic or antihyperlipidemic drugs. Odds ratios of incident hyper-LDL cholesterolemia after 7 years were calculated for BMI, WC and PBF in 738 men and 388 women.
    Results: There were no significant differences in the correlations with 7-year changes in cardiovascular risk factors between 7-year changes in BMI and WC. The correlation with 7-year change in LDL cholesterol was stronger for that in PBF than that in BMI or WC (p=0.021 or 0.089, respectively in men and 0.022 or 0.020, respectively in women). The correlations with 7-year changes in log triglycerides, HDL cholesterol and log high-sensitivity CRP were stronger for those in BMI and WC than that in PBF in men. Incident hyper-LDL cholesterolemia after 7 years was significantly associated with PBF, but not BMI or WC, in men after adjusted for age and other covariates. However, the association was not significant after further adjusted for LDL cholesterol.
    Conclusions: The correlation with 7-year change in LDL cholesterol was stronger for that in PBF than that in BMI or WC. Incident hyper-LDL cholesterolemia was significantly associated with PBF, but not with BMI or WC, in men.
    MeSH term(s) Adiposity/physiology ; Adult ; Biomarkers/blood ; Body Mass Index ; Cholesterol, LDL/blood ; Female ; Glycated Hemoglobin A ; Health Surveys ; Humans ; Male ; Mass Screening ; Middle Aged ; Predictive Value of Tests ; Risk Factors ; Time Factors ; Waist Circumference
    Chemical Substances Biomarkers ; Cholesterol, LDL ; Glycated Hemoglobin A ; hemoglobin A1c protein, human
    Language English
    Publishing date 2017-06-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2274031-4
    ISSN 1878-0318 ; 1871-403X
    ISSN (online) 1878-0318
    ISSN 1871-403X
    DOI 10.1016/j.orcp.2017.05.005
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  6. Article ; Online: Does serum bilirubin predict incident metabolic syndrome?

    Oda, Eiji

    The American journal of medicine

    2015  Volume 128, Issue 10, Page(s) 1047

    MeSH term(s) Bilirubin/blood ; Humans ; Male ; Metabolic Syndrome/etiology
    Chemical Substances Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2015.05.022
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  7. Article: Problems in the Japanese criteria for metabolic syndrome.

    Oda, Eiji

    Journal of diabetes investigation

    2014  Volume 2, Issue 2, Page(s) 154

    Language English
    Publishing date 2014-04-22
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/j.2040-1124.2010.00067.x
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    Zs.A 6920: Show issues Location:
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  8. Article ; Online: Cross-Sectional and Longitudinal Associations between Serum Bilirubin and Prediabetes in a Health Screening Population.

    Oda, Eiji

    Canadian journal of diabetes

    2016  Volume 40, Issue 3, Page(s) 270–275

    Abstract: Objectives: Longitudinal associations between total bilirubin (TB) and prediabetes have not been reported. This study investigated cross-sectional and longitudinal associations between TB and prediabetes.: Methods: Cross-sectional associations ... ...

    Abstract Objectives: Longitudinal associations between total bilirubin (TB) and prediabetes have not been reported. This study investigated cross-sectional and longitudinal associations between TB and prediabetes.
    Methods: Cross-sectional associations between TB and prediabetes were investigated in 3681 nondiabetic subjects. Longitudinal associations between TB and prediabetes over 6 years were investigated in 2149 subjects who were normoglycemic at baseline. Prediabetes was defined as fasting plasma glucose (FPG) levels of ≥5.6 mmol/L or glycated hemoglobin levels of ≥5.7% excluding diabetes.
    Results: The prevalence of prediabetes was 25.4%, and the cumulative incidence of prediabetes during 6 years was 25.5% in a Japanese health screening population. Prevalent prediabetes was significantly associated with the quintiles of TB in nonsmoking men (trend, p<0.001) and women (trend, p=0.012), but not in smoking men (trend, p=0.689). Incident prediabetes was not significantly associated with the quintiles of TB, while it was positively associated with 1 standard deviation increase in TB in nonsmoking men (hazard ratio [95% confidence interval]; 1.21 [1.07 to 1.37], p=0.002).
    Conclusions: TB levels were significantly inversely associated with prevalent prediabetes in nonsmokers, but not in smokers, whereas an inverse association between TB levels and incident prediabetes seemed to be unlikely.
    MeSH term(s) Bilirubin/blood ; Blood Glucose ; Cross-Sectional Studies ; Female ; Humans ; Incidence ; Japan/epidemiology ; Longitudinal Studies ; Male ; Mass Screening ; Prediabetic State/blood ; Prediabetic State/diagnosis ; Prediabetic State/epidemiology ; Proportional Hazards Models ; Regression Analysis
    Chemical Substances Blood Glucose ; Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2016-06
    Publishing country Canada
    Document type Journal Article
    ISSN 2352-3840
    ISSN (online) 2352-3840
    DOI 10.1016/j.jcjd.2016.01.001
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  9. Article ; Online: Low Vital Capacity Was Associated with Incident Diabetes in a Japanese Health Screening Population in Whom Obesity Was Not Prevalent.

    Oda, Eiji

    Canadian journal of diabetes

    2016  Volume 40, Issue 2, Page(s) 143–148

    Abstract: Objectives: There have been few studies regarding the relationship between respiratory function and incident diabetes in East Asian populations in whom obesity is not prevalent.: Methods: This is a 6-year follow-up study in a Japanese health- ... ...

    Abstract Objectives: There have been few studies regarding the relationship between respiratory function and incident diabetes in East Asian populations in whom obesity is not prevalent.
    Methods: This is a 6-year follow-up study in a Japanese health-screening population that included 1874 men and 1093 women. Using Cox regression models, hazard ratios (HRs) of incident diabetes for percent vital capacity (%VC) and forced expiratory volume in 1 second divided by forced vital capacity (FEV1/FVC) were calculated. Diabetes was defined as simultaneous fasting plasma glucose (FPG) ≥7.0 mmol/L and glycated hemoglobin (A1C) ≥6.5% or use of antidiabetic medications.
    Results: During the 6-year follow-up period (mean of 4.8 years), 71 men (3.8%) and 18 women (1.7%) developed diabetes. The HRs (95% confidence intervals [CIs]) of incident diabetes for each 1 SD increase in %VC and the lowest tertile of %VC compared with the highest tertile were 0.81 (0.66 to 1.00) (p=0.045) and 1.78 (1.01 to 3.16) (p=0.048), respectively, adjusted for sex, age, body mass index, antihypertensive drug use and A1C levels. After further adjustment for log high-sensitivity C-reactive protein, the HRs (95% CI) of incident diabetes for each 1 SD increase in %VC and the lowest tertile of %VC were 0.82 (0.67 to 1.01) (p=0.063) and 1.69 (0.95 to 3.01) (p=0.073), respectively. The association between FEV1/FVC and incident diabetes was not significant.
    Conclusions: %VC, but not FEV1/FVC, was significantly associated with incident diabetes in a Japanese health-screening population in whom obesity was not prevalent.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Blood Glucose/analysis ; Cohort Studies ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/metabolism ; Diabetes Mellitus/physiopathology ; Female ; Follow-Up Studies ; Forced Expiratory Volume ; Glycated Hemoglobin A/analysis ; Humans ; Incidence ; Japan/epidemiology ; Male ; Mass Screening ; Middle Aged ; Obesity/physiopathology ; Prognosis ; Respiratory Function Tests/methods ; Vital Capacity/physiology
    Chemical Substances Blood Glucose ; Glycated Hemoglobin A ; hemoglobin A1c protein, human
    Language English
    Publishing date 2016-04
    Publishing country Canada
    Document type Journal Article
    ISSN 2352-3840
    ISSN (online) 2352-3840
    DOI 10.1016/j.jcjd.2015.09.003
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  10. Article ; Online: Tracheomediastinal fistula induced by concurrent chemoradiotherapy in small cell lung cancer: A case report and literature review.

    Yamamoto, Yoshihiro / Shibahara, Daisuke / Mori, Taro / Otsubo, Kohei / Shiraishi, Yoshimasa / Yoneshima, Yasuto / Iwama, Eiji / Tanaka, Kentaro / Oda, Yoshinao / Okamoto, Isamu

    Thoracic cancer

    2024  

    Abstract: Tracheomediastinal fistula is a rare but life-threatening complication of cancer. We report a case of tracheomediastinal fistula induced by concurrent chemoradiotherapy in limited stage small cell lung cancer. Despite the treatment response, the ... ...

    Abstract Tracheomediastinal fistula is a rare but life-threatening complication of cancer. We report a case of tracheomediastinal fistula induced by concurrent chemoradiotherapy in limited stage small cell lung cancer. Despite the treatment response, the metastatic paratracheal lymph node increased gradually during concurrent chemoradiotherapy, resulting in the occurrence of tracheomediastinal fistula and mediastinitis. Without any surgical intervention, the patient achieved successful recovery from mediastinitis through antibiotic treatment, although the tracheomediastinal fistula remained open. In this report, we also review previous studies of tracheomediastinal and bronchomediastinal fistulas and summarize the clinical features.
    Language English
    Publishing date 2024-03-25
    Publishing country Singapore
    Document type Case Reports
    ZDB-ID 2625856-0
    ISSN 1759-7714 ; 1759-7706
    ISSN (online) 1759-7714
    ISSN 1759-7706
    DOI 10.1111/1759-7714.15270
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