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  1. Article ; Online: Psychological interventions to enhance positive outcomes in adult cancer caregivers: A systematic review.

    Christodoulou, Loukas / Parpottas, Panagiotis / Petkari, Eleni

    Journal of health psychology

    2024  , Page(s) 13591053241236254

    Abstract: This systematic review aims to examine the characteristics of psychological interventions that aim to enhance positive outcomes, such as wellbeing, post-traumatic growth, or hope in cancer caregivers. Studies published until December 2023 were searched ... ...

    Abstract This systematic review aims to examine the characteristics of psychological interventions that aim to enhance positive outcomes, such as wellbeing, post-traumatic growth, or hope in cancer caregivers. Studies published until December 2023 were searched on PubMed, Scopus, PsycINFO, WOS, PsycARTICLES and were included when examining interventions targeting positive outcomes with adult cancer caregivers. Of the 1424 articles retrieved through the databases, 16 studies were eligible for inclusion in this review, targeting 908 caregivers (70.2% female;
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2021897-7
    ISSN 1461-7277 ; 1359-1053
    ISSN (online) 1461-7277
    ISSN 1359-1053
    DOI 10.1177/13591053241236254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Computational Approach for the Discovery of Novel DNA Methyltransferase Inhibitors.

    Kritsi, Eftichia / Christodoulou, Paris / Tsiaka, Thalia / Georgiadis, Panagiotis / Zervou, Maria

    Current issues in molecular biology

    2024  Volume 46, Issue 4, Page(s) 3394–3407

    Abstract: Nowadays, the explosion of knowledge in the field of epigenetics has revealed new pathways toward the treatment of multifactorial diseases, rendering the key players of the epigenetic machinery the focus of today's pharmaceutical landscape. Among ... ...

    Abstract Nowadays, the explosion of knowledge in the field of epigenetics has revealed new pathways toward the treatment of multifactorial diseases, rendering the key players of the epigenetic machinery the focus of today's pharmaceutical landscape. Among epigenetic enzymes, DNA methyltransferases (DNMTs) are first studied as inhibition targets for cancer treatment. The increasing clinical interest in DNMTs has led to advanced experimental and computational strategies in the search for novel DNMT inhibitors. Considering the importance of epigenetic targets as a novel and promising pharmaceutical trend, the present study attempted to discover novel inhibitors of natural origin against DNMTs using a combination of structure and ligand-based computational approaches. Particularly, a pharmacophore-based virtual screening was performed, followed by molecular docking and molecular dynamics simulations in order to establish an accurate and robust selection methodology. Our screening protocol prioritized five natural-derived compounds, derivatives of coumarins, flavones, chalcones, benzoic acids, and phenazine, bearing completely diverse chemical scaffolds from FDA-approved "Epi-drugs". Their total DNMT inhibitory activity was evaluated, revealing promising results for the derived hits with an inhibitory activity ranging within 30-45% at 100 µM of the tested compounds.
    Language English
    Publishing date 2024-04-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb46040213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5122: Show issues Location:
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  3. Article: Diagnosing and Treating IgAN: Steroids, Budesonide, or Maybe Both?

    Keskinis, Christodoulos / Moysidou, Eleni / Christodoulou, Michalis / Pateinakis, Panagiotis / Stangou, Maria

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 5

    Abstract: IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, is characterized by a mesangial IgA deposit and a variety of histological lesions, as described by the Oxford classification system. Despite the well-described "four-hit ... ...

    Abstract IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, is characterized by a mesangial IgA deposit and a variety of histological lesions, as described by the Oxford classification system. Despite the well-described "four-hit hypothesis", there are still plenty of less or undescribed mechanisms that participate in the disease pathogenesis, such as B-cell priming, which seems to be initiated by different antigens in the intestinal microbiota. Diagnosis of the disease is currently based on kidney biopsy findings, as the sensitivity and specificity of the many serum and urinary biomarkers described so far do not seem to have diagnostic accuracy. Therapeutic strategies consist of the initial step of non-immune medication, aiming to reduce both the intraglomerular pressure and proteinuria to below 0.5 g/day, followed by systemic corticosteroid administration in patients who remain at high risk for progressive chronic kidney disease despite the maximum non-immune treatment. The 6-month systemic corticosteroid treatment reduces proteinuria levels; however, the increased possibility of adverse events and increased relapse rate after treatment raises the need for a new therapeutic approach. Targeted-release budesonide is a therapeutic modality that aims to inhibit disease pathogenetic pathways at early stages; it has minor systemic absorption and proven beneficial effects on renal function and proteinuria. In the present systemic review, the benefits and adverse events of steroids and budesonide are described, and the possibility of combined treatment is questioned in selected cases with active histologic lesions.
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14050512
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  4. Article ; Online: Qualities of Culturally and Religiously Sensitive Practice: A Cross-Sectional Study.

    Pentaris, Panagiotis / Christodoulou, Panayiota

    Journal of palliative care

    2021  , Page(s) 8258597211050742

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639326-3
    ISSN 2369-5293 ; 0825-8597
    ISSN (online) 2369-5293
    ISSN 0825-8597
    DOI 10.1177/08258597211050742
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3203: Show issues Location:
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    Zs.MO 207: Show issues

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  5. Article ; Online: Spin- and Momentum-Correlated Atom Pairs Mediated by Photon Exchange and Seeded by Vacuum Fluctuations.

    Finger, Fabian / Rosa-Medina, Rodrigo / Reiter, Nicola / Christodoulou, Panagiotis / Donner, Tobias / Esslinger, Tilman

    Physical review letters

    2024  Volume 132, Issue 9, Page(s) 93402

    Abstract: Engineering pairs of massive particles that are simultaneously correlated in their external and internal degrees of freedom is a major challenge, yet essential for advancing fundamental tests of physics and quantum technologies. In this Letter, we ... ...

    Abstract Engineering pairs of massive particles that are simultaneously correlated in their external and internal degrees of freedom is a major challenge, yet essential for advancing fundamental tests of physics and quantum technologies. In this Letter, we experimentally demonstrate a mechanism for generating pairs of atoms in well-defined spin and momentum modes. This mechanism couples atoms from a degenerate Bose gas via a superradiant photon-exchange process in an optical cavity, producing pairs via a single channel or two discernible channels. The scheme is independent of collisional interactions, fast, and tunable. We observe a collectively enhanced production of pairs and probe interspin correlations in momentum space. We characterize the emergent pair statistics and find that the observed dynamics is consistent with being primarily seeded by vacuum fluctuations in the corresponding atomic modes. Together with our observations of coherent many-body oscillations involving well-defined momentum modes, our results offer promising prospects for quantum-enhanced interferometry and quantum simulation experiments using entangled matter waves.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.132.093402
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    In stock of ZB MED Bonn / Germany

    Z 4' 58/153: Show issues

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  6. Article ; Online: In Vivo Investigation of the Effect of Dietary Acrylamide and Evaluation of Its Clinical Relevance in Colon Cancer.

    Neophytou, Christiana M / Katsonouri, Andromachi / Christodoulou, Maria-Ioanna / Papageorgis, Panagiotis

    Toxics

    2023  Volume 11, Issue 10

    Abstract: Dietary exposure to acrylamide (AA) has been linked with carcinogenicity in the gastrointestinal (GI) tract. However, epidemiologic data on AA intake in relation to cancer risk are limited and contradictory, while the potential cancer-inducing molecular ... ...

    Abstract Dietary exposure to acrylamide (AA) has been linked with carcinogenicity in the gastrointestinal (GI) tract. However, epidemiologic data on AA intake in relation to cancer risk are limited and contradictory, while the potential cancer-inducing molecular pathways following AA exposure remain elusive. In this study, we collected mechanistic information regarding the induction of carcinogenesis by dietary AA in the colon, using an established animal model. Male Balb/c mice received AA orally (0.1 mg/kg/day) daily for 4 weeks. RNA was extracted from colon tissue samples, followed by RNA sequencing. Comparative transcriptomic analysis between AA and mock-treated groups revealed a set of differentially expressed genes (DEGs) that were further processed using different databases through the STRING-DB portal, to reveal deregulated protein-protein interaction networks. We found that genes implicated in RNA metabolism, processing and formation of the ribosomal subunits and protein translation and metabolism are upregulated in AA-exposed colon tissue; these genes were also overexpressed in human colon adenocarcinoma samples and were negatively correlated with patient overall survival (OS), based on publicly available datasets. Further investigation of the potential role of these genes during the early stages of colon carcinogenesis may shed light into the underlying mechanisms induced by dietary AA exposure.
    Language English
    Publishing date 2023-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11100856
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  7. Article ; Online: Knowledge and Attitudes of Hospice and Palliative Care Professionals toward Diversity and Religious Literacy in Cyprus: A Cross-Sectional Study.

    Pentaris, Panagiotis / Christodoulou, Panayiota

    Journal of palliative medicine

    2020  Volume 24, Issue 2, Page(s) 233–239

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Attitude of Health Personnel ; Cross-Sectional Studies ; Cyprus ; Hospice Care ; Hospices ; Humans ; Literacy ; Palliative Care ; Surveys and Questionnaires
    Language English
    Publishing date 2020-08-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1427361-5
    ISSN 1557-7740 ; 1096-6218
    ISSN (online) 1557-7740
    ISSN 1096-6218
    DOI 10.1089/jpm.2020.0011
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5440: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Short-Term L-Citrulline Supplementation Does Not Affect Inspiratory Muscle Oxygenation and Respiratory Performance in Older Adults.

    Theodorou, Anastasios A / Chatzinikolaou, Panagiotis N / Margaritelis, Nikos V / Christodoulou, Filippos / Tsatalas, Themistoklis / Paschalis, Vassilis

    Nutrients

    2023  Volume 15, Issue 8

    Abstract: In sports nutrition, nitric oxide ( ... ...

    Abstract In sports nutrition, nitric oxide (NO
    MeSH term(s) Aged ; Humans ; Male ; Citrulline/pharmacology ; Dietary Supplements ; Oxyhemoglobins ; Respiratory Muscles ; Cross-Over Studies
    Chemical Substances Citrulline (29VT07BGDA) ; Oxyhemoglobins
    Language English
    Publishing date 2023-04-18
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15081951
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  9. Article: Amygdalin as a chemoprotective agent in co-treatment with cisplatin.

    Christodoulou, Panayiota / Boutsikos, Panagiotis / Neophytou, Christiana M / Kyriakou, Theodora-Christina / Christodoulou, Maria-Ioanna / Papageorgis, Panagiotis / Stephanou, Anastasis / Patrikios, Ioannis

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 1013692

    Abstract: Amygdalin is a naturally occurring glycoside used in traditional Chinese medicine and is known to have anti-cancer properties. Even though the anti-cancer properties of amygdalin are well known, its effect on normal cells has not been thoroughly ... ...

    Abstract Amygdalin is a naturally occurring glycoside used in traditional Chinese medicine and is known to have anti-cancer properties. Even though the anti-cancer properties of amygdalin are well known, its effect on normal cells has not been thoroughly investigated. The aim of the present study was to investigate a possible chemo-protective role of amygdalin against the cytotoxic effects of chemotherapy for normal human cells. Specifically, it was tested in combination with a strong chemotherapeutic drug cisplatin. Human non-tumorigenic MCF12F epithelial cell line, human fibroblasts cells, human breast cancer MCF7 and MDA-MB-231 cells were treated with cisplatin in a dose- and time-depended manner in the absence or presence of amygdalin. When MCF12F cells and fibroblasts underwent pre-treatment with amygdalin followed by cisplatin treatment (24 h amygdalin + 24 h cisplatin), the cell viability was increased (22%,
    Language English
    Publishing date 2022-09-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.1013692
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  10. Article ; Online: Altered SERCA Expression in Breast Cancer.

    Christodoulou, Panayiota / Yiallouris, Andreas / Michail, Artemis / Christodoulou, Maria-Ioanna / Politis, Panagiotis K / Patrikios, Ioannis

    Medicina (Kaunas, Lithuania)

    2021  Volume 57, Issue 10

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Breast Neoplasms/genetics ; Calcium ; Female ; Homeostasis ; Humans ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism
    Chemical Substances Sarcoplasmic Reticulum Calcium-Transporting ATPases (EC 3.6.3.8) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-10-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57101074
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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