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  1. Article ; Online: Should We Really Still Be Using Creatinine in the Critical Care Setting?

    Chen, Teresa K / Shlipak, Michael G

    Clinical journal of the American Society of Nephrology : CJASN

    2023  Volume 18, Issue 8, Page(s) 988–990

    MeSH term(s) Humans ; Creatinine ; Critical Care ; Intensive Care Units ; Critical Illness
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.0000000000000225
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    Zs.A 6584: Show issues Location:
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  2. Article ; Online: Cystatin C should be routinely available for estimating kidney function.

    Lees, Jennifer S / Fabian, June / Shlipak, Michael G

    Current opinion in nephrology and hypertension

    2024  Volume 33, Issue 3, Page(s) 337–343

    Abstract: Purpose of review: In this report, we summarize why the availability of cystatin C is important across a variety of clinical scenarios, the recent literature on when, why and in whom cystatin C testing should be considered, and how nephrologists can ... ...

    Abstract Purpose of review: In this report, we summarize why the availability of cystatin C is important across a variety of clinical scenarios, the recent literature on when, why and in whom cystatin C testing should be considered, and how nephrologists can take practical steps to incorporate cystatin C testing into their practice.
    Recent findings: Large intra-individual discrepancies between estimated glomerular filtration rate by creatinine (eGFRcr) and estimated glomerular filtration rate by creatinine eGFRcys (known as eGFRdiff) are observed in at least 1 in 4 people. These differences are seen more commonly among more vulnerable individuals: older adults, females, non-White individuals and those living with multiple medical conditions. A large eGFRdiff, where eGFRcys is lower than eGFRcr, is associated with a plethora of adverse outcomes, including medication-associated adverse events, acute kidney injury, cardiovascular disease, kidney failure and all-cause mortality. Among studies that have measured GFR, eGFRcr-cys usually provides the most accurate estimation of kidney function compared to mGFR, including among participants with large discrepancies between eGFRcr and eGFRcys.
    Summary: Cystatin C improves sensitivity and specificity of chronic kidney disease diagnosis, improves detection of harmful acute and chronic changes in kidney function, improves precision of treatment eligibility and safety, and may reduce healthcare inequalities. Better education, curiosity, and motivation among nephrologists could substantially improve the availability and utilization of cystatin C.
    MeSH term(s) Female ; Humans ; Aged ; Cystatin C ; Creatinine ; Renal Insufficiency, Chronic/diagnosis ; Glomerular Filtration Rate ; Kidney
    Chemical Substances Cystatin C ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000980
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  3. Article ; Online: Age-adapted eGFR thresholds underestimate the risks beyond kidney failure associated with CKD in older populations.

    Lees, Jennifer S / Shlipak, Michael G

    Journal of the American Geriatrics Society

    2022  Volume 70, Issue 12, Page(s) 3660–3664

    MeSH term(s) Humans ; Aged ; Glomerular Filtration Rate ; Renal Insufficiency ; Renal Insufficiency, Chronic/complications ; Kidney Failure, Chronic/complications
    Language English
    Publishing date 2022-09-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18046
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  4. Article ; Online: The Promise of Tubule Biomarkers in Kidney Disease: A Review.

    Ix, Joachim H / Shlipak, Michael G

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2021  Volume 78, Issue 5, Page(s) 719–727

    Abstract: For over 70 years, serum creatinine has remained the primary index for detection and monitoring of kidney disease. Tubulointerstitial damage and fibrosis are highly prognostic for subsequent kidney failure in biopsy studies, yet this pathology is ... ...

    Abstract For over 70 years, serum creatinine has remained the primary index for detection and monitoring of kidney disease. Tubulointerstitial damage and fibrosis are highly prognostic for subsequent kidney failure in biopsy studies, yet this pathology is invisible to the clinician in the absence of a biopsy. Recent discovery of biomarkers that reflect distinct aspects of kidney tubule disease have led to investigations of whether these markers can provide additional information on risk of chronic kidney disease (CKD) progression and associated adverse clinical end points, above and beyond estimated glomerular filtration rate and albuminuria. These biomarkers can be loosely grouped into those that mark tubule cell injury (eg, kidney injury molecule 1, monocyte chemoattractant protein 1) and those that mark tubule cell dysfunction (eg, α
    MeSH term(s) Albuminuria ; Biomarkers ; Glomerular Filtration Rate ; Humans ; Kidney Tubules ; Renal Insufficiency, Chronic/diagnosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-05-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2021.03.026
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  5. Article ; Online: Serum Cystatin C for Estimation of GFR.

    Shlipak, Michael G / Inker, Lesley A / Coresh, Josef

    JAMA

    2022  Volume 328, Issue 9, Page(s) 883–884

    MeSH term(s) Biomarkers/blood ; Creatinine ; Cystatin C/blood ; Glomerular Filtration Rate
    Chemical Substances Biomarkers ; Cystatin C ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2022-08-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.12407
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  6. Article ; Online: Cystatin C is ready for clinical use.

    Ebert, Natalie / Shlipak, Michael G

    Current opinion in nephrology and hypertension

    2020  Volume 29, Issue 6, Page(s) 591–598

    Abstract: Purpose of review: The goal of this update is to raise awareness of clinical scenarios where cystatin C has clear and immediate benefits as an alternative glomerular filtration rate (GFR) biomarker to supplement creatinine. An additional goal is to ... ...

    Abstract Purpose of review: The goal of this update is to raise awareness of clinical scenarios where cystatin C has clear and immediate benefits as an alternative glomerular filtration rate (GFR) biomarker to supplement creatinine. An additional goal is to focus the estimated GFR (eGFR) controversy onto medication prescribing for agents with narrow therapeutic windows where better GFR estimation will lead to improved medical care.
    Recent findings: Equations that include cystatin C predict GFR more accurately than serum creatinine in children, adults, and older adults with larger effects among persons who are acutely ill. Numerous studies have evaluated medication dosing based on either GFR estimate; vancomycin was the most frequently studied drug and its target level and elimination were better predicted by cystatin C. Overall, approaches to medication dosing and monitoring that include cystatin C concentrations have been shown to result in a better achievement of drug trough levels. Furthermore, cystatin C offers the opportunity to avoid the race coefficient that is required for any current creatinine-based eGFR equation, which has been appropriately criticized for introducing unnecessary imprecision, assumptions and values on GFR estimation.
    Summary: Hospital laboratories must make cystatin C available for clinical care to improve the safety and efficacy of medications that have narrow therapeutic windows.
    MeSH term(s) Aged ; Biomarkers/blood ; Child ; Creatinine/blood ; Cystatin C/blood ; Glomerular Filtration Rate ; Humans ; Male ; Middle Aged ; Renal Insufficiency, Chronic/blood
    Chemical Substances Biomarkers ; Cystatin C ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2020-08-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000638
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  7. Article ; Online: The authors reply.

    Tummalapalli, Sri Lekha / Shlipak, Michael G / Cheung, Michael / Zoungas, Sophia

    Kidney international

    2021  Volume 99, Issue 5, Page(s) 1241

    MeSH term(s) Humans ; Kidney ; Renal Insufficiency, Chronic ; Risk Assessment
    Language English
    Publishing date 2021-04-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.02.009
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    Zs.A 797: Show issues Location:
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  8. Article ; Online: Hyperfiltration: Much Ado about Nothing?

    Tummalapalli, Sri Lekha / Shlipak, Michael G

    Clinical journal of the American Society of Nephrology : CJASN

    2019  Volume 14, Issue 6, Page(s) 789–791

    MeSH term(s) Diabetes Mellitus, Type 1 ; Humans ; Kidney ; Kidney Diseases ; Kidney Glomerulus
    Language English
    Publishing date 2019-05-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.05330419
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  9. Article ; Online: Modifiable kidney disease risk factors among nondiabetic adults with obesity from the Multi-Ethnic Study of Atherosclerosis.

    Harhay, Meera N / Kim, Yuna / Moore, Kari / Harhay, Michael O / Katz, Ronit / Shlipak, Michael G / Mattix-Kramer, Holly J

    Obesity (Silver Spring, Md.)

    2023  Volume 31, Issue 12, Page(s) 3056–3065

    Abstract: Objective: It is unknown whether weight change or physical fitness is associated with chronic kidney disease (CKD) risk among nondiabetic adults with obesity.: Methods: This was a prospective, longitudinal cohort study of adults with obesity without ... ...

    Abstract Objective: It is unknown whether weight change or physical fitness is associated with chronic kidney disease (CKD) risk among nondiabetic adults with obesity.
    Methods: This was a prospective, longitudinal cohort study of adults with obesity without baseline CKD or diabetes enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA). Linear mixed-effects and multistate models were adjusted for demographics, time-varying covariates including blood pressure, and comorbidities these were used to examine associations of weight change and slow walking pace (<2 miles/h) with (i) rate of annual estimated glomerular filtration rate (eGFR) decline and (ii) incident CKD, defined as eGFR
    Results: Among 1208 included MESA participants (median BMI 33.0 kg/m
    Conclusions: Slow walking pace and weight gain were associated with CKD risk among adults with obesity who did not have diabetes at baseline.
    MeSH term(s) Humans ; Adult ; Longitudinal Studies ; Prospective Studies ; Obesity/complications ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/epidemiology ; Glomerular Filtration Rate ; Hypertension/epidemiology ; Hypertension/complications ; Risk Factors ; Diabetes Mellitus ; Weight Gain ; Atherosclerosis/epidemiology ; Disease Progression
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.23883
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    Zs.MG 87: Show issues

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  10. Article ; Online: Chronic kidney disease detection, staging and treatment in cardiovascular disease prevention.

    Lamprea-Montealegre, Julio Alejandro / Shlipak, Michael G / Estrella, Michelle M

    Heart (British Cardiac Society)

    2021  Volume 107, Issue 16, Page(s) 1282–1288

    Abstract: Globally, nearly 10% of the population has chronic kidney disease (CKD), defined as a glomerular filtration rate less than 60 mL/min/1.73 ... ...

    Abstract Globally, nearly 10% of the population has chronic kidney disease (CKD), defined as a glomerular filtration rate less than 60 mL/min/1.73 m
    MeSH term(s) Albuminuria/diagnosis ; Albuminuria/etiology ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Early Diagnosis ; Glomerular Filtration Rate ; Heart Disease Risk Factors ; Humans ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/physiopathology ; Renal Insufficiency, Chronic/therapy ; Risk Assessment/methods ; Severity of Illness Index
    Language English
    Publishing date 2021-02-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2020-318004
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