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Article: Observational study on healthcare workers protection in the angiographic suite during the SARS-CoV-2 pandemic: before and during vax era.

Cernigliaro, Massimiliano / Negroni, Davide / Sassone, Miriana / Paladini, Andrea / Carriero, Alessandro / Saba, Luca / Guzzardi, Giuseppe

Journal of public health research

2021 Volume 10, Issue 4

Abstract: Background: Since the first case of Coronavirus Disease 2019 (COVID-19) in Italy, all the hospital facilities had to reform their daily activities. Amidst them, the Interventional Radiology Department in the "Azienda Ospedaliera Universitaria" of Novara ...

Abstract	Background: Since the first case of Coronavirus Disease 2019 (COVID-19) in Italy, all the hospital facilities had to reform their daily activities. Amidst them, the Interventional Radiology Department in the "Azienda Ospedaliera Universitaria" of Novara (Italy) had to create a dedicated protocol for the patent's management during the pandemic. Design and methods: The time interval between February 2020 and March 2021 was divided into three different periods and we reported the evolution of our safety protocol, the changes in our daily activities and the rates of Sars-CoV-2 infection among the healthcare workers (HCW) of the Angiographic Suite. Personnel who had positive partners/family members or who had established close contacts of another nature outside the workplace were excluded from the study, in order to reduce any bias. Results: A total of 35 HCWs served in 355 patient procedures on Sars-CoV-2 positive patients from February 2020 to March 2021. During the year there was a reduction in the morbidity rate first from 7.9% to 1.4% and then currently reaching 0%. Conclusions: Dedicated routes, elevators, establishing Filter Areas and a clear demarcation between clean and contaminated areas, Dressing and undressing procedures, Cleaning procedures and the obligation to always wear a surgical mask during the working shift are essential to prevent in-hospital infection. The vaccines' arrival seems to further reduce the risk for healthcare workers, but it is still necessary to take docile precautions in view of the new mutations of the virus.
Language	English
Publishing date	2021-06-16
Publishing country	Italy
Document type	Journal Article
ISSN	2279-9028
ISSN	2279-9028
DOI	10.4081/jphr.2021.2265
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Article ; Online: Conversion factors for effective dose and organ doses with the air Kerma area product in hysterosalpingography.

D'Alessio, Andrea / Cannillo, Barbara / Guzzardi, Giuseppe / Cernigliaro, Massimiliano / Carriero, Alessandro / Brambilla, Marco

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

2020 Volume 81, Page(s) 40–46

Abstract: Histerosalpingography (HSG) remains the dominant diagnostic tool for investigation of infertility in women. Conversion factors used to estimate effective (E) and organ doses ( ... ...

Abstract	Histerosalpingography (HSG) remains the dominant diagnostic tool for investigation of infertility in women. Conversion factors used to estimate effective (E) and organ doses (H
MeSH term(s)	Female ; Fluoroscopy ; Humans ; Hysterosalpingography ; Monte Carlo Method ; Radiation Dosage ; Radiography
Language	English
Publishing date	2020-12-26
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1122650-x
ISSN	1724-191X ; 1120-1797
ISSN (online)	1724-191X
ISSN	1120-1797
DOI	10.1016/j.ejmp.2020.11.032
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Article: Intracranial Carotid Artery Aneurysm Treatment: First Reported Case of DERIVO

Guzzardi, Giuseppe / Del Sette, Bruno / Stanca, Carmelo / Paladini, Andrea / Galbiati, Andrea / Spinetta, Marco / Cernigliaro, Massimiliano / Leigheb, Massimiliano / Carriero, Alessandro

Brain sciences

2020 Volume 10, Issue 5

Abstract: Brain health may be threatened by aneurysm ruptures, and early recognition of these vascular malformations allows for neuroradiological intervention. Neurointerventional procedures are usually performed with femoral artery access. In patients with severe ...

Abstract	Brain health may be threatened by aneurysm ruptures, and early recognition of these vascular malformations allows for neuroradiological intervention. Neurointerventional procedures are usually performed with femoral artery access. In patients with severe anatomical complexity of the supra-aortic vessels, however, treatment by this approach could be hindered or impossible. Flow-diverter stent deployment is an effective and safe treatment for large, wide necked intracranial aneurysms, but it requires a complete and firm stability of the coaxial system to achieve a correct and precise deployment of the device. We present the first reported Italian case of a patient with an intracranial aneurysm which was treated with Flow-diverter stent (DERIVO®; AcandisGmbH & Co. KG; Pforzheim; Germany) by direct common carotid artery puncture due to severe tortuosity of supra-aortic trunks.
Language	English
Publishing date	2020-05-25
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci10050320
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Article: Innovation in Acute Ischemic Stroke Patients over 80 y/o-A Retrospective Monocentric Study on Mechanical Thrombectomy of Consecutive Patients: Is Age an Adequate Selection Criterion?

Cernigliaro, Massimiliano / Stanca, Carmelo / Galbiati, Andrea / Spinetta, Marco / Coda, Carolina / Negroni, Davide / Laganà, Domenico / Minici, Roberto / Airoldi, Chiara / Carriero, Alessandro / Guzzardi, Giuseppe

Journal of clinical medicine

2023 Volume 12, Issue 11

Abstract: Background: Although it is clear that stroke is a time-dependent and age-associated disease, we still need more evidence regarding the efficacy and outcomes in elderly patients who were excluded from the first trials of mechanical thrombectomy. The aim ... ...

Abstract	Background: Although it is clear that stroke is a time-dependent and age-associated disease, we still need more evidence regarding the efficacy and outcomes in elderly patients who were excluded from the first trials of mechanical thrombectomy. The aim of this study is to highlight patient characteristics, the timing of medical attention and therapy, successful recanalization, and functional outcomes in patients over 80 y/o who underwent mechanical thrombectomy at the Ospedale Maggiore della Carità di Novara (Hub) since endovascular stroke treatment was first started here. Methods: all 122 consecutive patients over 80 y/o at admission who underwent mechanical thrombectomy between 2017 and 2022 at our Hub center were retrospectively included in our database. A good functional outcome in these elderly patients was considered as the 90 days modified Rankin Scale (mRS) ≤ 3 and/or a decrease in functional status as ∆mRS ≤ 1 in order to interpret the results for patients with intact intellect and basal mRS > 3. Successful recanalization as a score of TICI ≥ 2b (Thrombolysis in Cerebral Infarction) was analyzed as a secondary outcome. Results: Good functional outcome (mRS ≤ 3 and/or ∆mRS ≤ 1) was observed in 45.90% (56/122). The rate of successful recanalization (TICI ≥ 2b) was 65.57% (80/122). Conclusion: Our data confirm that a good outcome in the elderly age group has a correlation with age; being younger, with a milder NIHSS (National Institutes of Health Stroke Scale) at the onset and with a lower pre-morbid mRS is statistically associated with a better outcome. However, age should not be a criterion to exclude older patients from mechanical thrombectomy. Decision-making should take into consideration the pre-morbid mRS and the severity of the stroke on the NIHSS scale, especially in the age group over 85 y/o.
Language	English
Publishing date	2023-05-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12113688
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Article ; Online: Observational study on healthcare workers protection in the angiographic suite during the SARS-CoV-2 pandemic

Massimiliano Cernigliaro / Davide Negroni / Miriana Sassone / Andrea Paladini / Alessandro Carriero / Luca Saba / Giuseppe Guzzardi

Journal of Public Health Research (2021)

before and during vax era

2021

Abstract	Background: Since the first case of Coronavirus Disease 2019 (COVID-19) in Italy, all the hospital facilities had to reform their daily activities. Amidst them, the Interventional Radiology Department in the “Azienda Ospedaliera Universitaria” of Novara (Italy) had to create a dedicated protocol for the patent’s management during the pandemic. Design and Methods: The time interval between February 2020 and March 2021 was divided into three different periods and we reported the evolution of our safety protocol, the changes in our daily activities and the rates of Sars-CoV-2 infection among the healthcare workers (HCW) of the Angiographic Suite. Personnel who had positive partners/family members or who had established close contacts of another nature outside the workplace were excluded from the study, in order to reduce any bias. Results: A total of 35 HCWs served in 355 patient procedures on Sars-CoV-2 positive patients from February 2020 to March 2021. During the year there was a reduction in the morbidity rate first from 7.9% to 1.4% and then currently reaching 0%. Conclusions: Dedicated routes, elevators, establishing Filter Areas and a clear demarcation between clean and contaminated areas, Dressing and undressing procedures, Cleaning procedures and the obligation to always wear a surgical mask during the working shift are essential to prevent in-hospital infection. The vaccines’ arrival seems to further reduce the risk for healthcare workers, but it is still necessary to take docile precautions in view of the new mutations of the virus.
Keywords	COVID-19 ; interventional radiology ; management protocol ; healthcare safety ; Public aspects of medicine ; RA1-1270
Subject code	900
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Innovation in Acute Ischemic Stroke Patients over 80 y/o—A Retrospective Monocentric Study on Mechanical Thrombectomy of Consecutive Patients

Massimiliano Cernigliaro / Carmelo Stanca / Andrea Galbiati / Marco Spinetta / Carolina Coda / Davide Negroni / Domenico Laganà / Roberto Minici / Chiara Airoldi / Alessandro Carriero / Giuseppe Guzzardi

Journal of Clinical Medicine, Vol 12, Iss 3688, p

Is Age an Adequate Selection Criterion?

2023 Volume 3688

Abstract	Background: Although it is clear that stroke is a time-dependent and age-associated disease, we still need more evidence regarding the efficacy and outcomes in elderly patients who were excluded from the first trials of mechanical thrombectomy. The aim of this study is to highlight patient characteristics, the timing of medical attention and therapy, successful recanalization, and functional outcomes in patients over 80 y/o who underwent mechanical thrombectomy at the Ospedale Maggiore della Carità di Novara (Hub) since endovascular stroke treatment was first started here. Methods: all 122 consecutive patients over 80 y/o at admission who underwent mechanical thrombectomy between 2017 and 2022 at our Hub center were retrospectively included in our database. A good functional outcome in these elderly patients was considered as the 90 days modified Rankin Scale (mRS) ≤ 3 and/or a decrease in functional status as ∆mRS ≤ 1 in order to interpret the results for patients with intact intellect and basal mRS > 3. Successful recanalization as a score of TICI ≥ 2b (Thrombolysis in Cerebral Infarction) was analyzed as a secondary outcome. Results: Good functional outcome (mRS ≤ 3 and/or ∆mRS ≤ 1) was observed in 45.90% (56/122). The rate of successful recanalization (TICI ≥ 2b) was 65.57% (80/122). Conclusion: Our data confirm that a good outcome in the elderly age group has a correlation with age; being younger, with a milder NIHSS (National Institutes of Health Stroke Scale) at the onset and with a lower pre-morbid mRS is statistically associated with a better outcome. However, age should not be a criterion to exclude older patients from mechanical thrombectomy. Decision-making should take into consideration the pre-morbid mRS and the severity of the stroke on the NIHSS scale, especially in the age group over 85 y/o.
Keywords	stroke ; elderly ; innovation ; brain ; mechanical thrombectomy ; direct aspiration ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Mechanical Thrombectomy by a Direct Aspiration First Pass Technique (ADAPT) in Ischemic Stroke: Results of Monocentric Study Based on Multimodal CT Patient Selection.

Guzzardi, Giuseppe / Del Sette, Bruno / Stanca, Carmelo / Galbiati, Andrea / Cernigliaro, Massimiliano / Carriero, Alessandro / Stecco, Alessandro

Stroke research and treatment

2018 Volume 2018, Page(s) 6192483

Abstract: Introduction: Mechanical thrombectomy with ADAP-technique of ischemic stroke has been reported as fast and effective. Aim of this study is to evaluate imaging criteria as possible predictors of stroke severity, therapeutic success, and outcome.: ... ...

Abstract	Introduction: Mechanical thrombectomy with ADAP-technique of ischemic stroke has been reported as fast and effective. Aim of this study is to evaluate imaging criteria as possible predictors of stroke severity, therapeutic success, and outcome. Materials and methods: Patients (30) presenting from October 2015 to April 2017 with Emergent Large Vessel Occlusion of the anterior circulation were treated with ADAP-technique. 22 received also IV tPA; 8 underwent endovascular treatment only. Every patient was evaluated with noncontrast CT, multiphase angiography-CT, and perfusion CT. Clinical and radiological characteristics were measured. Good clinical outcome was an improvement of 8 points on NIHSS at discharge or a modified Rankin Scale ≤2 at discharge and at 90 days. Results: Successful revascularization was obtained in 57% of patients, no procedural complications were witnessed, and only two hemorrhages were reported. Good outcome at discharge was obtained in 11 patients (37%) and predicted by NCCT ASPECT and TICI; outcome at 90 days was predicted by NCCT ASPECT, clot length, and premorbid mRS. Mortality was 23% at discharge and 30% at 90 days. Conclusion: ADAPT is an effective endovascular method of stroke treatment with fast procedural times. Multimodal CT evaluation is effective in assessing stroke severity, providing important prognostic information, which is able to select patients for the appropriate treatment.
Language	English
Publishing date	2018-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573724-7
ISSN	2042-0056 ; 2090-8105
ISSN (online)	2042-0056
ISSN	2090-8105
DOI	10.1155/2018/6192483
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Article: Progetto BIGEPI: dati ambientali e dati sanitari.

Maio, Sara / Gariazzo, Claudio / Stafoggia, Massimo / Ancona, Carla / Bisceglia, Lucia / Caranci, Nicola / Cernigliaro, Achille / Cesaroni, Giulia / Costa, Giuseppe / Marcon, Alessandro / Massari, Stefania / Nobile, Federica / Ranzi, Andrea / Renzi, Matteo / Scondotto, Salvatore / Zengarini, Nicolás / Verlato, Giuseppe / Viegi, Giovanni

Epidemiologia e prevenzione

2024 Volume 47, Issue 6, Page(s) 8–18

Abstract: Objectives: the BIGEPI project, co-funded by INAIL, has used big data to identify the health risks associated with short and long-term exposure to air pollution, extreme temperatures and occupational exposures.: Design: the project consists of 5 ... ...

Title translation	BIGEPI project: environmental and health data.
Abstract	Objectives: the BIGEPI project, co-funded by INAIL, has used big data to identify the health risks associated with short and long-term exposure to air pollution, extreme temperatures and occupational exposures. Design: the project consists of 5 specific work packages (WP) aimed at assessing: 1. the acute effects of environmental exposures over the national territory; 2. the acute effects of environmental exposures in contaminated areas, such as Sites of National Interest (SIN) and industrial sites; 3. the chronic effects of environmental exposures in 6 Italian longitudinal metropolitan studies; 4. the acute and chronic effects of environmental exposures in 7 epidemiological surveys on population samples; 5. the chronic effects of occupational exposures in the longitudinal metropolitan studies of Rome and Turin. Setting and participants: BIGEPI analyzed environmental and health data at different levels of detail: the whole Italian population (WP1); populations living in areas contaminated by pollutants of industrial origin (WP2); the entire longitudinal cohorts of the metropolitan areas of Bologna, Brindisi, Rome, Syracuse, Taranto and Turin (WP3 and WP5); population samples participating in the epidemiological surveys of Ancona, Palermo, Pavia, Pisa, Sassari, Turin and Verona (WP4). Main outcome measures: environmental exposure: PM10, PM2,5, NO2 and O3 concentrations and air temperature at 1 Km2 resolution at national level. Occupational exposures: employment history of subjects working in at least one of 25 sectors with similar occupational exposures to chemicals/carcinogens; self-reported exposure to dust/fumes/gas in the workplace. Health data: cause-specific mortality/hospitalisation; symptoms/diagnosis of respiratory/allergic diseases; respiratory function and bronchial inflammation. Results: BIGEPI analyzed data at the level of the entire Italian population, data on 2.8 million adults (>=30 yrs) in longitudinal metropolitan studies and on about 14,500 individuals (>=18 yrs) in epidemiological surveys on population samples. The population investigated in the longitudinal metropolitan studies had an average age of approximately 55 years and that of the epidemiological surveys was about 48 years; in both cases, 53% of the population was female. As regards environmental exposure, in the period 2013-2015, at national level average values for PM10, PM2.5, NO2 and summer O3 were: 21.1±13.6, 15.1±10.9, 14.7±9.1 and 80.3±17.3 µg/m3, for the temperature the average value was 13.9±7.2 °C. Data were analyzed for a total of 1,769,660 deaths from non-accidental causes as well as 74,392 incident cases of acute coronary event and 45,513 of stroke. Epidemiological investigations showed a high prevalence of symptoms/diagnoses of rhinitis (range: 14.2-40.5%), COPD (range: 4.7-19.3%) and asthma (range: 3.2-13.2%). The availability of these large datasets has made it possible to implement advanced statistical models for estimating the health effects of short- and long-term exposures to pollutants. The details are reported in the BIGEPI papers already published in other international journals and in those published in this volume of E&P. Conclusions: BIGEPI has confirmed the great potential of using big data in studies of the health effects of environmental and occupational factors, stimulating new directions of scientific research and confirming the need for preventive action on air quality and climate change for the health of the general population and the workers.
MeSH term(s)	Adult ; Humans ; Female ; Middle Aged ; Air Pollutants/adverse effects ; Air Pollutants/analysis ; Nitrogen Dioxide ; Italy/epidemiology ; Air Pollution ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Environmental Pollutants ; Respiratory Tract Diseases ; Particulate Matter/adverse effects ; Particulate Matter/analysis
Chemical Substances	Air Pollutants ; Nitrogen Dioxide (S7G510RUBH) ; Environmental Pollutants ; Particulate Matter
Language	Italian
Publishing date	2024-04-19
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	1038112-0
ISSN	1120-9763
ISSN	1120-9763
DOI	10.19191/EP23.6.S3.003
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Article ; Online: Time-Trends in Air Pollution Impact on Health in Italy, 1990-2019: An Analysis From the Global Burden of Disease Study 2019.

Conti, Sara / Fornari, Carla / Ferrara, Pietro / Antonazzo, Ippazio C / Madotto, Fabiana / Traini, Eugenio / Levi, Miriam / Cernigliaro, Achille / Armocida, Benedetta / Bragazzi, Nicola L / Cadum, Ennio / Carugno, Michele / Crotti, Giacomo / Deandrea, Silvia / Cortesi, Paolo A / Guido, Davide / Iavicoli, Ivo / Iavicoli, Sergio / La Vecchia, Carlo /

Lauriola, Paolo / Michelozzi, Paola / Scondotto, Salvatore / Stafoggia, Massimo / Violante, Francesco S / Abbafati, Cristiana / Albano, Luciana / Barone-Adesi, Francesco / Biondi, Antonio / Bosetti, Cristina / Buonsenso, Danilo / Carreras, Giulia / Castelpietra, Giulio / Catapano, Alberico / Cattaruzza, Maria S / Corso, Barbara / Damiani, Giovanni / Esposito, Francesco / Gallus, Silvano / Golinelli, Davide / Hay, Simon I / Isola, Gaetano / Ledda, Caterina / Mondello, Stefania / Pedersini, Paolo / Pensato, Umberto / Perico, Norberto / Remuzzi, Giuseppe / Sanmarchi, Francesco / Santoro, Rocco / Simonetti, Biagio / Unim, Brigid / Vacante, Marco / Veroux, Massimiliano / Villafañe, Jorge H / Monasta, Lorenzo / Mantovani, Lorenzo G

International journal of public health

2023 Volume 68, Page(s) 1605959

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Humans ; Global Burden of Disease ; Quality-Adjusted Life Years ; Air Pollution/adverse effects ; Particulate Matter/adverse effects ; Ozone/adverse effects ; Global Health ; Italy/epidemiology
Chemical Substances	Particulate Matter ; Ozone (66H7ZZK23N)
Language	English
Publishing date	2023-06-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2274130-6
ISSN	1661-8564 ; 1661-8556
ISSN (online)	1661-8564
ISSN	1661-8556
DOI	10.3389/ijph.2023.1605959
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Article ; Online: Perinephric myxoid pseudotumor of fat: A very rare entity that can mimic a renal cyst and retroperitoneal liposarcoma on imaging.

Chen, Frank / Desai, Madhura A / Cernigliaro, Joseph G / Edgar, Mark A / Alexander, Lauren F

Clinical imaging

2020 Volume 69, Page(s) 139–144

Abstract: ... a left perinephric mass whose appearance over time and on different imaging modalities variably suggested ... the solid nature of this mass, and ultimately, tissue sampling with histopathologic evaluation and molecular ...

Abstract	We present a case of perinephric myxoid pseudotumor of fat, a rare benign entity that often occurs in patients with non-neoplastic renal disease. In our case, an 80 year old man with end-stage renal disease was imaged over the course of 5 years during evaluation for renal transplantation. Imaging identified a left perinephric mass whose appearance over time and on different imaging modalities variably suggested a simple cyst, cystic neoplasm, and liposarcoma. Contrast enhanced examination was necessary to discern the solid nature of this mass, and ultimately, tissue sampling with histopathologic evaluation and molecular testing were required to make the diagnosis of myxoid pseudotumor of fat and exclude the imaging mimics.
MeSH term(s)	Aged, 80 and over ; Cysts ; Humans ; Kidney Diseases, Cystic ; Liposarcoma/diagnostic imaging ; Male ; Retroperitoneal Neoplasms
Language	English
Publishing date	2020-07-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1028123-x
ISSN	1873-4499 ; 0899-7071
ISSN (online)	1873-4499
ISSN	0899-7071
DOI	10.1016/j.clinimag.2020.06.041
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