LIVIVO - Search results -

Search results

Result 1 - 10 of total 69

Search options

Article ; Online: Circulating miRNAs and Preeclampsia: From Implantation to Epigenetics.

Giannubilo, Stefano Raffaele / Cecati, Monia / Marzioni, Daniela / Ciavattini, Andrea

International journal of molecular sciences

2024 Volume 25, Issue 3

Abstract: In this review, we comprehensively present the literature on circulating microRNAs (miRNAs) associated with preeclampsia, a pregnancy-specific disease considered the primary reason for maternal and fetal mortality and morbidity. miRNAs are single- ... ...

Abstract	In this review, we comprehensively present the literature on circulating microRNAs (miRNAs) associated with preeclampsia, a pregnancy-specific disease considered the primary reason for maternal and fetal mortality and morbidity. miRNAs are single-stranded non-coding RNAs, 20-24 nt long, which control mRNA expression. Changes in miRNA expression can induce a variation in the relative mRNA level and influence cellular homeostasis, and the strong presence of miRNAs in all body fluids has made them useful biomarkers of several diseases. Preeclampsia is a multifactorial disease, but the etiopathogenesis remains unclear. The functions of trophoblasts, including differentiation, proliferation, migration, invasion and apoptosis, are essential for a successful pregnancy. During the early stages of placental development, trophoblasts are strictly regulated by several molecular pathways; however, an imbalance in these molecular pathways can lead to severe placental lesions and pregnancy complications. We then discuss the role of miRNAs in trophoblast invasion and in the pathogenesis, diagnosis and prediction of preeclampsia. We also discuss the potential role of miRNAs from an epigenetic perspective with possible future therapeutic implications.
MeSH term(s)	Pregnancy ; Humans ; Female ; Placenta/metabolism ; Circulating MicroRNA/metabolism ; Pre-Eclampsia/metabolism ; Trophoblasts/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Epigenesis, Genetic ; RNA, Messenger/genetics
Chemical Substances	Circulating MicroRNA ; MicroRNAs ; RNA, Messenger
Language	English
Publishing date	2024-01-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25031418
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: HELLP Syndrome and Differential Diagnosis with Other Thrombotic Microangiopathies in Pregnancy.

Giannubilo, Stefano Raffaele / Marzioni, Daniela / Tossetta, Giovanni / Ciavattini, Andrea

Diagnostics (Basel, Switzerland)

2024 Volume 14, Issue 4

Abstract: Thrombotic microangiopathies (TMAs) comprise a distinct group of diseases with different manifestations that can occur in both pediatric and adult patients. They can be hereditary or acquired, with subtle onset or a rapidly progressive course, and they ... ...

Abstract	Thrombotic microangiopathies (TMAs) comprise a distinct group of diseases with different manifestations that can occur in both pediatric and adult patients. They can be hereditary or acquired, with subtle onset or a rapidly progressive course, and they are particularly known for their morbidity and mortality. Pregnancy is a high-risk time for the development of several types of thrombotic microangiopathies. The three major syndromes are hemolysis, elevated liver function tests, and low platelets (HELLP); hemolytic uremic syndrome (HUS); and thrombotic thrombocytopenic purpura (TTP). Because of their rarity, clinical information and therapeutic results related to these conditions are often obtained from case reports, small series, registries, and reviews. The collection of individual observations, the evolution of diagnostic laboratories that have identified autoimmune and/or genetic abnormalities using von Willebrand factor post-secretion processing or genetic-functional alterations in the regulation of alternative complement pathways in some of these TMAs, and, most importantly, the introduction of advanced treatments, have enabled the preservation of affected organs and improved survival rates. Although TMAs may show different etiopathogenesis routes, they all show the presence of pathological lesions, which are characterized by endothelial damage and the formation of thrombi rich in platelets at the microvascular level, as a common denominator, and thrombotic damage to microcirculation pathways induces "mechanical" (microangiopathic) hemolytic anemia, the consumption of platelets, and ischemic organ damage. In this review, we highlight the current knowledge about the diagnosis and management of these complications during pregnancy.
Language	English
Publishing date	2024-02-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics14040352
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Inguinoscrotal Hernia, a Possible Cause of Rapidly Developing Fetal Scrotal Mass: Case Report and Literature Update.

Montironi, Ramona / Giannubilo, Stefano Raffaele / Cappanera, Irene / Battistoni, Giovanna Irene / Mancinelli, Romina / Ciavattini, Andrea

Healthcare (Basel, Switzerland)

2024 Volume 12, Issue 5

Abstract: Inguinoscrotal hernia is a common pediatric disease but a rare condition in the fetus. We present a case, from our institution, of fetal inguinoscrotal hernia with possible rapid development. In addition to our case, we present a literature update on ... ...

Abstract	Inguinoscrotal hernia is a common pediatric disease but a rare condition in the fetus. We present a case, from our institution, of fetal inguinoscrotal hernia with possible rapid development. In addition to our case, we present a literature update on fetal inguinoscrotal hernia in order to enhance the ability to recognize it from the other scrotal masses on ultrasound. Antenatal management, differential diagnosis and postnatal management are also discussed.
Language	English
Publishing date	2024-03-02
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare12050583
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: The "Bad Father": Paternal Role in Biology of Pregnancy and in Birth Outcome.

Giannubilo, Stefano Raffaele / Marzioni, Daniela / Tossetta, Giovanni / Montironi, Ramona / Meccariello, Maria Liberata / Ciavattini, Andrea

Biology

2024 Volume 13, Issue 3

Abstract: Pregnancy is generally studied as a biological interaction between a mother and a fetus; however, the father, with his characteristics, lifestyle, genetics, and living environment, is by no means unrelated to the outcome of pregnancy. The half of the ... ...

Abstract	Pregnancy is generally studied as a biological interaction between a mother and a fetus; however, the father, with his characteristics, lifestyle, genetics, and living environment, is by no means unrelated to the outcome of pregnancy. The half of the fetal genetic heritage of paternal derivation can be decisive in cases of inherited chromosomal disorders, and can be the result of de novo genetic alterations. In addition to the strictly pathological aspects, paternal genetics may transmit thrombophilic traits that affect the implantation and vascular construction of the feto-placental unit, lead to placenta-mediated diseases such as pre-eclampsia and fetal growth retardation, and contribute to the multifactorial genesis of preterm delivery. Biological aspects of immunological tolerance to paternal antigens also appear to be crucial for these pathologies. Finally, this review describes the biological findings by which the environment, exposure to pathogens, lifestyle, and nutritional style of the father affect fetal pathophysiological and epigenetic definition.
Language	English
Publishing date	2024-03-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology13030165
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The Role of NQO1 in Ovarian Cancer.

Tossetta, Giovanni / Fantone, Sonia / Goteri, Gaia / Giannubilo, Stefano Raffaele / Ciavattini, Andrea / Marzioni, Daniela

International journal of molecular sciences

2023 Volume 24, Issue 9

Abstract: Ovarian cancer is one of the most dangerous gynecologic malignancies showing a high fatality rate because of late diagnosis and relapse occurrence due to chemoresistance onset. Several researchers reported that oxidative stress plays a key role in ... ...

Abstract	Ovarian cancer is one of the most dangerous gynecologic malignancies showing a high fatality rate because of late diagnosis and relapse occurrence due to chemoresistance onset. Several researchers reported that oxidative stress plays a key role in ovarian cancer occurrence, growth and development. The NAD(P)H:quinone oxidoreductase 1 (NQO1) is an antioxidant enzyme that, using NADH or NADPH as substrates to reduce quinones to hydroquinones, avoids the formation of the highly reactive semiquinones, then protecting cells against oxidative stress. In this review, we report evidence from the literature describing the effect of NQO1 on ovarian cancer onset and progression.
MeSH term(s)	Female ; Humans ; NAD(P)H Dehydrogenase (Quinone)/genetics ; Neoplasm Recurrence, Local ; Antioxidants ; NADH, NADPH Oxidoreductases ; Quinones ; Ovarian Neoplasms
Chemical Substances	NAD(P)H Dehydrogenase (Quinone) (EC 1.6.5.2) ; Antioxidants ; NADH, NADPH Oxidoreductases (EC 1.6.-) ; Quinones ; NQO1 protein, human (EC 1.6.5.2)
Language	English
Publishing date	2023-04-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24097839
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: The Multifaced Actions of Curcumin in Pregnancy Outcome.

Tossetta, Giovanni / Fantone, Sonia / Giannubilo, Stefano Raffaele / Marzioni, Daniela

Antioxidants (Basel, Switzerland)

2021 Volume 10, Issue 1

Abstract: Curcumin, also known as diferuloylmethane, is the main polyphenolic substance present in the rhizomes ... ...

Abstract	Curcumin, also known as diferuloylmethane, is the main polyphenolic substance present in the rhizomes of
Language	English
Publishing date	2021-01-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10010126
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: HTRA1 in Placental Cell Models: A Possible Role in Preeclampsia.

Tossetta, Giovanni / Fantone, Sonia / Giannubilo, Stefano Raffaele / Ciavattini, Andrea / Senzacqua, Martina / Frontini, Andrea / Marzioni, Daniela

Current issues in molecular biology

2023 Volume 45, Issue 5, Page(s) 3815–3828

Abstract: The HtrA serine peptidase 1 (HTRA1) is a multidomain secretory protein with serine-protease activity involved in the regulation of many cellular processes in both physiological and pathological conditions. HTRA1 is normally expressed in the human ... ...

Abstract	The HtrA serine peptidase 1 (HTRA1) is a multidomain secretory protein with serine-protease activity involved in the regulation of many cellular processes in both physiological and pathological conditions. HTRA1 is normally expressed in the human placenta, and its expression is higher in the first trimester compared to the third trimester, suggesting an important role of this serine protease in the early phases of human placenta development. The aim of this study was to evaluate the functional role of HTRA1 in in vitro models of human placenta in order to define the role of this serine protease in preeclampsia (PE). BeWo and HTR8/SVneo cells expressing HTRA1 were used as syncytiotrophoblast and cytotrophoblast models, respectively. Oxidative stress was induced by treating BeWo and HTR8/SVneo cells with H
Language	English
Publishing date	2023-05-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb45050246
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5122: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Maternal hemodynamics and computerized cardiotocography during labor with epidural analgesia.

Giannubilo, Stefano Raffaele / Amici, Mirco / Pizzi, Simone / Simonini, Alessandro / Ciavattini, Andrea

Archives of gynecology and obstetrics

2022 Volume 307, Issue 6, Page(s) 1789–1794

Abstract: Purpose: To analyze the mechanisms involved in the fetal heart rate (FHR) abnormalities after the epidural analgesia in labor.: Methods: A prospective unblinded single-center observational study on 55 term singleton pregnant women with spontaneous ... ...

Abstract	Purpose: To analyze the mechanisms involved in the fetal heart rate (FHR) abnormalities after the epidural analgesia in labor. Methods: A prospective unblinded single-center observational study on 55 term singleton pregnant women with spontaneous labor. All women recruited underwent serial bedside measurements of the main hemodynamic parameters using a non-invasive ultrasound system (USCOM-1A). Total vascular resistances (TVR), heart rate (HR), stroke volume (SV), cardiac output (CO) and arterial blood pressure were measured before epidural administration (T0), after 5 min 5 (T1) from epidural bolus and at the end of the first stage of labor (T2). FHR was continuously recorded through computerized cardiotocography before and after the procedure. Results: The starting CO was significantly higher in a subgroup of women with low TVR than in women with high-TVR group. After the bolus of epidural analgesia in the low-TVR group there was a significant reduction in CO and then increased again at the end of the first stage, in the high-TVR group the CO increased insignificantly after the anesthesia bolus, while it increased significantly in the remaining part of the first stage of labor. On the other hand, CO was inversely correlated with the number of decelerations detected on cCTG in the 1 hour after the epidural bolus while the short-term variation was significantly lower in the group with high-TVR. Conclusion: Maternal hemodynamic status at the onset of labor can make a difference in fetal response to the administration of epidural analgesia.
MeSH term(s)	Pregnancy ; Female ; Humans ; Analgesia, Epidural/methods ; Cardiotocography/methods ; Prospective Studies ; Labor, Obstetric ; Hemodynamics ; Heart Rate, Fetal ; Analgesia, Obstetrical/methods
Language	English
Publishing date	2022-06-15
Publishing country	Germany
Document type	Observational Study ; Journal Article
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-022-06658-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Um I Zs.55: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Modulation of NRF2/KEAP1 Signaling in Preeclampsia.

Tossetta, Giovanni / Fantone, Sonia / Piani, Federica / Crescimanno, Caterina / Ciavattini, Andrea / Giannubilo, Stefano Raffaele / Marzioni, Daniela

Cells

2023 Volume 12, Issue 11

Abstract: Placentation is a key and tightly regulated process that ensures the normal development of the placenta and fetal growth. Preeclampsia (PE) is a hypertensive pregnancy-related disorder involving about 5-8% of all pregnancies and clinically characterized ... ...

Abstract	Placentation is a key and tightly regulated process that ensures the normal development of the placenta and fetal growth. Preeclampsia (PE) is a hypertensive pregnancy-related disorder involving about 5-8% of all pregnancies and clinically characterized by de novo maternal hypertension and proteinuria. In addition, PE pregnancies are also characterized by increased oxidative stress and inflammation. The NRF2/KEAP1 signaling pathway plays an important role in protecting cells against oxidative damage due to increased reactive oxygen species (ROS) levels. ROS activate NRF2, allowing its binding to the antioxidant response element (ARE) region present in the promoter of several antioxidant genes such as heme oxygenase, catalase, glutathione peroxidase and superoxide dismutase that neutralize ROS, protecting cells against oxidative stress damages. In this review, we analyze the current literature regarding the role of the NRF2/KEAP1 pathway in preeclamptic pregnancies, discussing the main cellular modulators of this pathway. Moreover, we also discuss the main natural and synthetic compounds that can regulate this pathway in in vivo and in vitro models.
MeSH term(s)	Humans ; Pregnancy ; Female ; Reactive Oxygen Species/metabolism ; NF-E2-Related Factor 2/metabolism ; Kelch-Like ECH-Associated Protein 1/metabolism ; Pre-Eclampsia ; Signal Transduction/physiology
Chemical Substances	Reactive Oxygen Species ; NF-E2-Related Factor 2 ; Kelch-Like ECH-Associated Protein 1 ; KEAP1 protein, human
Language	English
Publishing date	2023-06-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12111545
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Antenatal Diagnosis and Management of Fetal Intestinal Volvulus: Case Series and Literature Review.

Montironi, Ramona / Tosto, Valentina / Quintili, Dayana / Crescenzi, Daniele / Battistoni, Giovanna Irene / Cobellis, Giovanni / Giannubilo, Stefano Raffaele / Ciavattini, Andrea

Journal of clinical medicine

2023 Volume 12, Issue 14

Abstract: Fetal intestinal volvulus is a rare condition that can lead to hemorrhage, bowel necrosis, and urgent surgical treatment after birth. Thus, prompt diagnosis and treatment are essential to avoiding fetal or neonatal demise. Prenatal ultrasound is a ... ...

Abstract	Fetal intestinal volvulus is a rare condition that can lead to hemorrhage, bowel necrosis, and urgent surgical treatment after birth. Thus, prompt diagnosis and treatment are essential to avoiding fetal or neonatal demise. Prenatal ultrasound is a keystone tool in the diagnostic course. However, sonographic findings tend to be non-specific, with limited understanding of the pathophysiology behind their atypical presentation. With a literature review and a case series, we aim to optimize the antenatal diagnosis and management of this rare but life-threatening condition. Six cases from our institution were retrospectively analyzed over 12 years. A literature review was conducted until December 2022. A total of 300 articles matched the keyword "Fetal volvulus", and 52 studies were eligible for the review. Our 6 cases are added to the 107 cases reported in the literature of fetal intestinal volvulus with antenatal ultrasound assessment and without associated gastroschisis or omphalocele. Several prenatal symptoms and ultrasound markers, even if not specific, were more frequently reported. Different experiences of management were described regarding follow-up, the timing of delivery, the mode of delivery, and surgery outcomes. This paper highlights the importance of suspecting and assessing fetal volvulus at routine ultrasound scans, describing the most frequent antenatal presentations and management in order to improve fetal and neonatal outcomes.
Language	English
Publishing date	2023-07-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12144790
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito