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  1. Book ; Conference proceedings: Ada: du composant à l'application ; Conférence

    Rosen, Jean-Pierre

    (Conference Internationale Francophone Ada-France / ULB ; 1988)

    1988  

    Institution Université Libre de Bruxelles
    Event/congress Conférence Ada France (1988.12.13-14, Brüssel)
    Author's details Jean-Pierre Rosen [Hrsg.]. Université Libre de Bruxelles
    Series title Conference Internationale Francophone Ada-France / ULB ; 1988
    Size 154 S
    Publisher afcet
    Publishing place Bruxelles
    Document type Book ; Conference proceedings
    ISBN 2903677530 ; 9782903677534
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  2. Book ; Conference proceedings: Actes des Journées ADA

    Rosen, J. P / Vignes, S

    (BIGRE et GLOBULE ; 1986,49)

    1986  

    Institution ENST
    Group Ada, AFCET-Informatique
    Event/congress Journées ADA (1986.06.17-18, Paris)
    Author's details J. P. Rosen; S. Vignes [Hrsg.]. Group Ada, AFCET-Informatique; ENST
    Series title BIGRE et GLOBULE ; 1986,49
    Size IV,217 S
    Publishing place Rennes
    Document type Book ; Conference proceedings
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Article: Surgical Treatment for Rectocele by Posterior Colporrhaphy Compared to Stapled Transanal Rectal Resection.

    Gluck, Ohad / Matani, Doraid / Rosen, Ada / Barber, Elad / Weiner, Eran / Ginath, Shimon

    Journal of clinical medicine

    2023  Volume 12, Issue 2

    Abstract: Background: Rectocele is defined as a defect in the rectovaginal septum, causing symptoms like obstructed defecation syndrome (ODS), vaginal bulging, etc. Once the rectocele is larger than 3 cm and/or symptomatic, surgery should be considered. The ... ...

    Abstract Background: Rectocele is defined as a defect in the rectovaginal septum, causing symptoms like obstructed defecation syndrome (ODS), vaginal bulging, etc. Once the rectocele is larger than 3 cm and/or symptomatic, surgery should be considered. The surgical approach can be either transvaginal, transanal or transperineal. Two of the most common procedures in treating rectocele are posterior colporrhaphy (PC) and stapled trans anal rectal resection (STARR). The purpose of this study was to compare surgical outcomes of both procedures. Methods: This is a retrospective cohort study. Included were patients of the age of 18−85 years that underwent either STARR (n = 49 patients) or PC (n = 24 patients) procedures after a full clinical (defecography and physical exam before and after the surgery) and physiologic (a detailed questionnaire before and after the surgery) surveys. Symptoms of ODS before and after surgery were evaluated by questioners. Results: Preoperatively, the patients in the STARR group had significantly higher rates of ODS: straining (90.9% vs. 65.2%), incomplete evacuation (100% vs. 69.6%), hard stool (57.8% vs. 43.5%), sense of obstruction (76.1% vs. 56.5%), and use of digitation (64.4% vs. 47.8%), or laxatives (70% vs. 47.8%), p < 0.001. Anatomically, the mean rectocele size was smaller for the STARR group, compared to the PC group (3.8 ± 1.4 vs. 5.3 ± 2.2 cm, respectively, p < 0.001). Postoperatively, in the STARR group, higher rates of patients complained about straining (36.4% vs. 21.7%, p < 0.001) and use of digitation (64.4% vs. 26.1%, p < 0.001), whereas lower rates of patients complained about incomplete evacuation (41.2% vs. 56.5%, p = 0.05) and sense of obstruction (17.6%, vs. 34.8%, p = 0.03), compared to the PC group. Among patients who underwent the STARR procedure, a decrease in rates of all symptoms was noted (straining 54.5%, incomplete evacuation 58.8%, hard stool 29.2%, sense of obstruction 58.5%, use of digitation 0.1%, and use of laxatives 31.5%). Both procedures are effective in reducing rectocele size (STARR- 1.9 ± 1 cm, PC- 3.1 ± 1). Conclusions: Both STARR and PC are effective in treating rectocele. It seems that the STARR procedure is superior to the PC procedure in treating symptoms of ODS.
    Language English
    Publishing date 2023-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12020678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Obstructed defecation syndrome: diagnosis and therapeutic options, with special focus on the STARR procedure.

    Rosen, Ada

    The Israel Medical Association journal : IMAJ

    2010  Volume 12, Issue 2, Page(s) 104–106

    MeSH term(s) Constipation/etiology ; Constipation/surgery ; Digestive System Surgical Procedures/methods ; Female ; Humans ; Rectal Diseases/surgery ; Rectocele/surgery ; Rectum/surgery ; Syndrome ; Ulcer/surgery
    Language English
    Publishing date 2010-02
    Publishing country Israel
    Document type Editorial
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ten-year Follow-up Study of Grenz Ray Treatment for Lentigo Maligna and Early Lentigo Maligna Melanoma.

    Drakensjö, Iara R T / Rosen, Einar / Frohm Nilsson, Margareta / Girnita, Ada

    Acta dermato-venereologica

    2020  Volume 100, Issue 17, Page(s) adv00282

    Abstract: Radiotherapy is often used to treat lentigo maligna. However, the long-term efficacy and safety of radiotherapy approaches have not been thoroughly evaluated. We aimed to evaluate the long-term efficacy and safety of ultrasoft X-ray/Grenz ray treatment ... ...

    Abstract Radiotherapy is often used to treat lentigo maligna. However, the long-term efficacy and safety of radiotherapy approaches have not been thoroughly evaluated. We aimed to evaluate the long-term efficacy and safety of ultrasoft X-ray/Grenz ray treatment in those patients. A total of 161 lesions from 159 patients received treatment with Grenz ray between 2005 and 2007. Follow-up of recurrence was performed 10 years after the final treatment. In the study setting, the cure rates were 97% for primary therapy with Grenz ray alone and 100% when Grenz ray was combined with partial or radical excision. The treatment is well tolerated, simple to perform, and has an excellent cosmetic outcome, with 94% of patients pleased with the results. Grenz ray is painless, effective, and safe for use when surgery is not feasible. Thus, Grenz ray can be considered as a standard treatment option for lentigo maligna.
    MeSH term(s) Follow-Up Studies ; Humans ; Hutchinson's Melanotic Freckle/radiotherapy ; Hutchinson's Melanotic Freckle/surgery ; Melanoma ; Neoplasm Recurrence, Local ; Skin Neoplasms/radiotherapy ; X-Rays
    Language English
    Publishing date 2020-10-06
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-3631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Computed Tomography-Guided Placement of Sacral Electrodes.

    Rosen, Ada / Elias, Sorin / Ganer Herman, Hadas / Condrea, Alexander / Ginath, Shimon

    The Israel Medical Association journal : IMAJ

    2021  Volume 23, Issue 12, Page(s) 773–776

    Abstract: Background: The current approach to performing sacral neuromodulation consists of a two-stage procedure, the first of which includes insertion of the sacral electrode under fluoroscopic visualization of the S3 foramen. Alternatively, in certain ... ...

    Abstract Background: The current approach to performing sacral neuromodulation consists of a two-stage procedure, the first of which includes insertion of the sacral electrode under fluoroscopic visualization of the S3 foramen. Alternatively, in certain situations computed tomography (CT)-guided insertion can be used.
    Objectives: To evaluate the use of CT in cases of reinsertion of the electrode due to infection, dislocation, or rupture.
    Methods: Medical records of patients who underwent neuromodulation device reinsertion between 2005 and 2016 for fecal incontinence were reviewed. Study outcomes included procedure course, successful placement, and long-term treatment success.
    Results: During the study period, we inserted a neuromodulation device in 67 patients. A CT-guided insertion of a sacral electrode was performed in 10 patients. In nine patients, the insertion and the final location of the electrode were successful. In one patient, the electrode migrated upward due to a malformation of the S3 foramen on both sides and had to be placed in S4. In a mean follow-up of 68.4 ± 30.0 months following the re-insertion, there was a significant reduction in the number of incontinence episodes per day (P < 0.001) and the number of pads used per day (P = 0.002).
    Conclusions: CT-guided insertion of a sacral electrode is a safe and promising option, especially in recurrent and or selected cases.
    MeSH term(s) Adolescent ; Aged ; Electric Stimulation Therapy/methods ; Electrodes, Implanted ; Fecal Incontinence/therapy ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Sacrum/diagnostic imaging ; Sacrum/innervation ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2021-12-26
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Leflunomide Confers Rapid Recovery from COVID-19 and is Coupled with Temporal Immunologic Changes.

    Dona, Ada Alice / Sanchez, James F / Palmer, Joycelynne M / Synold, Timothy W / Chiuppesi, Flavia / Thomas, Sandra / Caserta, Enrico / Singer, Mahmoud / Tandoh, Theophilus / Chowdhury, Arnab / Krishnan, Amrita / Rosenzweig, Michael / Diamond, Don J / Rosen, Steven / Pichiorri, Flavia / Dadwal, Sanjeet

    Journal of immunological sciences

    2023  Volume 7, Issue 1, Page(s) 9–27

    Abstract: Background: Vaccines for SARS-CoV-2 have been considerably effective in reducing rates of infection and severe COVID-19. However, many patients, especially those who are immunocompromised due to cancer or other factors, as well as individuals who are ... ...

    Abstract Background: Vaccines for SARS-CoV-2 have been considerably effective in reducing rates of infection and severe COVID-19. However, many patients, especially those who are immunocompromised due to cancer or other factors, as well as individuals who are unable to receive vaccines or are in resource-poor countries, will continue to be at risk for COVID-19. We describe clinical, therapeutic, and immunologic correlatives in two patients with cancer and severe COVID-19 who were treated with leflunomide after failing to respond to standard-of-care comprising remdesivir and dexamethasone. Both patients had breast cancer and were on therapy for the malignancy.
    Methods: The protocol is designed with the primary objective to assess the safety and tolerability of leflunomide in treating severe COVID-19 in patients with cancer. Leflunomide dosing consisted of a loading dose of 100 mg daily for the first three days, followed by daily dosing, at the assigned dose level (Dose Level 1: 40 mg, Dose Level -1, 20 mg; Dose Level 2, 60 mg), for an additional 11 days. At defined intervals, serial monitoring of blood samples for toxicity, pharmacokinetics, and immunologic correlative studies were performed, as well as nasopharyngeal swabs for PCR analysis of SARS-CoV-2.
    Results: Preclinically, leflunomide impaired viral RNA replication, and clinically, it led to a rapid improvement in the two patients discussed herein. Both patients completely recovered, with minimal toxicities; all adverse events experienced were considered unrelated to leflunomide. Single-cell mass-cytometry analysis showed that leflunomide increased levels of CD8+ cytotoxic and terminal effector T cells and decreased naïve and memory B cells.
    Conclusions: With ongoing COVID-19 transmission and occurrence of breakthrough infections in vaccinated individuals, including patients with cancer, therapeutic agents that target both the virus and host inflammatory response would be helpful despite the availability of currently approved anti-viral agents. Furthermore, from an access to care perspective, especially in resource-limited areas, an inexpensive, readily available, effective drug with existing safety data in humans is relevant in the real-world setting.
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article
    DOI 10.29245/2578-3009/2023/1.1241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Immunologic and Protective Properties of Subunit- vs. Whole Toxoid-Derived Anti-Botulinum Equine Antitoxin.

    Ben David, Alon / Barnea, Ada / Torgeman, Amram / Diamant, Eran / Dor, Eyal / Schwartz, Arieh / Rosen, Osnat / Caspi, Noa / Saraf, Miki / Lerer, Elad / Adar, Yaakov / Lupo, Edith / Toister, Einat / Zichel, Ran

    Vaccines

    2022  Volume 10, Issue 9

    Abstract: Botulism is a paralytic disease caused by botulinum neurotoxins (BoNTs). Equine antitoxin is currently the standard therapy for botulism in human. The preparation of equine antitoxin relies on the immunization of horses with botulinum toxoid, which ... ...

    Abstract Botulism is a paralytic disease caused by botulinum neurotoxins (BoNTs). Equine antitoxin is currently the standard therapy for botulism in human. The preparation of equine antitoxin relies on the immunization of horses with botulinum toxoid, which suffers from low yield and safety limitations. The Hc fragment of BoNTs was suggested to be a potent antibotulinum subunit vaccine. The current study presents a comparative evaluation of equine-based toxoid-derived antitoxin (TDA) and subunit-derived antitoxin (SDA). The potency of recombinant Hc/A, Hc/B, and Hc/E in mice was similar to that of toxoids of the corresponding serotypes. A single boost with Hc/E administered to a toxoid E-hyperimmune horse increased the neutralizing antibody concentration (NAC) from 250 to 850 IU/mL. Immunization of naïve horses with the recombinant subunits induced a NAC comparable to that of horses immunized with the toxoid. SDA and TDA bound common epitopes on BoNTs, as demonstrated by an in vitro competition binding assay. In vivo, SDA and TDA showed similar efficacy when administered to guinea pigs postexposure to a lethal dose of botulinum toxins. Collectively, the results of the current study suggest that recombinant BoNT subunits may replace botulinum toxoids as efficient and safe antigens for the preparation of pharmaceutical anti-botulinum equine antitoxins.
    Language English
    Publishing date 2022-09-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10091522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Contour Transtar in true rectal prolapse.

    Rosen, Ada / Condrea, Alexander / Shimonov, Mordechai / Ginath, Shimon

    The Israel Medical Association journal : IMAJ

    2015  Volume 17, Issue 4, Page(s) 219–222

    Abstract: Background: A new device, the CCS-30 Contour Transtar, was recently launched for the treatment of obstructed defecation syndrome (ODS).: Objectives: To evaluate the efficacy of the Contour Transtar in resection of true rectal prolapse in relation to ... ...

    Abstract Background: A new device, the CCS-30 Contour Transtar, was recently launched for the treatment of obstructed defecation syndrome (ODS).
    Objectives: To evaluate the efficacy of the Contour Transtar in resection of true rectal prolapse in relation to age and concomitant urogynecologic procedures.
    Methods: During a 50 (median) month period 15 women with rectal prolapse of ≥ 5 cm and complaints of obstructed defecation underwent perineal resection of rectal prolapse with the Contour Transtar.
    Results: In 3 of the 15 patients (20%) rectal prolapse recurred. Amelioration of ODS symptoms and improved continence were noted in 82% and 75%, respectively, following surgery.
    Conclusions: The Contour Transtar procedure for full-thickness rectal prolapse is a safe and promising procedure and is likely suitable for elderly poor risk patients.
    MeSH term(s) Aged ; Aged, 80 and over ; Colectomy/adverse effects ; Colectomy/instrumentation ; Colectomy/methods ; Comparative Effectiveness Research ; Constipation/etiology ; Female ; Humans ; Middle Aged ; Recovery of Function ; Rectal Prolapse/complications ; Rectal Prolapse/surgery ; Recurrence ; Surgical Instruments ; Treatment Outcome
    Language English
    Publishing date 2015-04
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A Novel Rabbit Spirometry Model of Type E Botulism and Its Use for the Evaluation of Postsymptom Antitoxin Efficacy.

    Diamant, Eran / Pass, Avi / Rosen, Osnat / Ben David, Alon / Torgeman, Amram / Barnea, Ada / Tal, Arnon / Rosner, Amir / Zichel, Ran

    Antimicrobial agents and chemotherapy

    2018  Volume 62, Issue 4

    Abstract: Botulinum neurotoxins (BoNTs), the most poisonous substances known in nature, pose significant concern to health authorities. The only approved therapeutic for botulism is antitoxin. While administered to patients only after symptom onset, antitoxin ... ...

    Abstract Botulinum neurotoxins (BoNTs), the most poisonous substances known in nature, pose significant concern to health authorities. The only approved therapeutic for botulism is antitoxin. While administered to patients only after symptom onset, antitoxin efficacy is evaluated in animals mostly in relation to time postintoxication regardless of symptoms. This is most likely due to the difficulty in measuring early symptoms of botulism in animals. In this study, a rabbit spirometry model was developed to quantify early respiratory symptoms of type E botulism that were further used as a trigger for treatment. Impaired respiration, in the form of a reduced minute volume, was detected as early as 18.1 ± 2.9 h after intramuscular exposure to 2 rabbit 50% lethal doses (LD
    MeSH term(s) Animals ; Antitoxins/therapeutic use ; Botulism/drug therapy ; Rabbits ; Serogroup ; Spirometry/methods
    Chemical Substances Antitoxins
    Language English
    Publishing date 2018-03-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.02379-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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