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Article: PI3K/Akt/mTOR Signaling Pathway in Blood Malignancies-New Therapeutic Possibilities.

Wiese, Wojciech / Barczuk, Julia / Racinska, Olga / Siwecka, Natalia / Rozpedek-Kaminska, Wioletta / Slupianek, Artur / Sierpinski, Radoslaw / Majsterek, Ireneusz

Cancers

2023 Volume 15, Issue 21

Abstract: Blood malignancies remain a therapeutic challenge despite the development of numerous treatment strategies. The phosphatidylinositol-3 kinase (PI3K)/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway plays a central role in ... ...

Abstract	Blood malignancies remain a therapeutic challenge despite the development of numerous treatment strategies. The phosphatidylinositol-3 kinase (PI3K)/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway plays a central role in regulating many cellular functions, including cell cycle, proliferation, quiescence, and longevity. Therefore, dysregulation of this pathway is a characteristic feature of carcinogenesis. Increased activation of PI3K/Akt/mTOR signaling enhances proliferation, growth, and resistance to chemo- and immunotherapy in cancer cells. Overactivation of the pathway has been found in various types of cancer, including acute and chronic leukemia. Inhibitors of the PI3K/Akt/mTOR pathway have been used in leukemia treatment since 2014, and some of them have improved treatment outcomes in clinical trials. Recently, new inhibitors of PI3K/Akt/mTOR signaling have been developed and tested both in preclinical and clinical models. In this review, we outline the role of the PI3K/Akt/mTOR signaling pathway in blood malignancies' cells and gather information on the inhibitors of this pathway that might provide a novel therapeutic opportunity against leukemia.
Language	English
Publishing date	2023-11-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15215297
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Article ; Online: The Prevalence of Tobacco, Heated Tobacco, and E-Cigarette Use in Poland: A 2022 Web-Based Cross-Sectional Survey.

Jankowski, Mateusz / Ostrowska, Aurelia / Sierpiński, Radosław / Skowron, Adam / Sytnik-Czetwertyński, Janusz / Giermaziak, Wojciech / Gujski, Mariusz / Wierzba, Waldemar / Pinkas, Jarosław

International journal of environmental research and public health

2022 Volume 19, Issue 8

Abstract: Monitoring tobacco use on a regular schedule is a basic tool of tobacco control policy. This study aimed (1) to assess the current prevalence and patterns of tobacco and e-cigarette use, as well as (2) to identify socioeconomic factors associated with ... ...

Abstract	Monitoring tobacco use on a regular schedule is a basic tool of tobacco control policy. This study aimed (1) to assess the current prevalence and patterns of tobacco and e-cigarette use, as well as (2) to identify socioeconomic factors associated with smoking behavior among adults in Poland. This cross-sectional study was carried out in March 2022 on a nationwide, representative sample of 1090 adults in Poland. The computer-assisted web interview (CAWI) technique was used. Daily tobacco smoking was declared by 28.8% of respondents (27.1% of females and 30.8% of males;
MeSH term(s)	Adult ; Child ; Cross-Sectional Studies ; Electronic Nicotine Delivery Systems ; Female ; Humans ; Internet ; Male ; Poland/epidemiology ; Prevalence ; Nicotiana ; Tobacco Products ; Tobacco Smoking/epidemiology ; Vaping/epidemiology
Language	English
Publishing date	2022-04-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19084904
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Article ; Online: First-year follow-up costs of myocardial infarction management in Poland from the payer's perspective.

Skowrońska, Anna / Sinnadurai, Siamala / Teisseyre, Paweł / Gryka, Patrycja / Doryńska, Agnieszka / Dzierwa, Magdalena / Gąsior, Mariusz / Grabowski, Marcin / Kamiński, Karol / Kasprzak, Jarosław D / Kubica, Jacek / Lesiak, Maciej / Szafran, Bartosz / Wójcik, Mariusz / Pinkas, Jarosław / Sierpiński, Radosław / Gellert, Ryszard / Jankowski, Piotr

Kardiologia polska

2024 Volume 82, Issue 2, Page(s) 183–191

Abstract: Background: Myocardial infarction (MI) remains a major burden for healthcare systems. Therefore, we intended to analyze the determinants of cost management of patients hospitalized for MI in Poland.: Methods: Data on patients hospitalized and ... ...

Abstract	Background: Myocardial infarction (MI) remains a major burden for healthcare systems. Therefore, we intended to analyze the determinants of cost management of patients hospitalized for MI in Poland. Methods: Data on patients hospitalized and discharged with the diagnosis of acute MI were derived from the public payer claims database. Adult patients, reported between October 1, 2017 and December 31, 2019, were included. Costs of hospitalization for acute MI and cumulative one-year follow-up were analyzed. Results: The median (IQR) of the total direct cost was €3804.7 (2674.1-5712.7) per patient and 29% (€1113.6 [380.5-2490.4]) of these were costs related to the use of post-hospitalization healthcare resources. The median cost of cardiovascular disease management was €3624.7 (2582.1-5258.5), and 26% of this sum were follow-up costs. The analysis of the total cost for individual years showed a slight increase in median costs in subsequent years: €3450.7 (2407.8-5205.2) in 2017, €3753.8 (2642.6-5681.9) in 2018, and €3944.9 (2794.8-5844.4) in 2019. Male sex, heart failure, atrial fibrillation, diabetes, kidney disease, chronic obstructive pulmonary disease, and history of stroke in addition to hospitalization in a department other than cardiology or internal disease were independently related to the cost of MI patient management. Conclusions: The high cost of management of MI patients was independently related to sex, heart failure, atrial fibrillation, diabetes, kidney disease, chronic obstructive pulmonary disease, and history of stroke as well as hospitalization in other than cardiology or internal disease department.
MeSH term(s)	Adult ; Humans ; Male ; Follow-Up Studies ; Poland ; Atrial Fibrillation ; Myocardial Infarction/therapy ; Heart Failure ; Stroke/therapy ; Diabetes Mellitus ; Kidney Diseases ; Pulmonary Disease, Chronic Obstructive ; Cost-Benefit Analysis
Language	English
Publishing date	2024-02-13
Publishing country	Poland
Document type	Journal Article
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.33963/v.phj.99006
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Article ; Online: Diagnostic role of chest computed tomography in coronavirus disease 2019.

Jędrusik, Piotr / Gaciong, Zbigniew / Sklinda, Katarzyna / Sierpiński, Radosław / Walecki, Jerzy / Gujski, Mariusz

Polish archives of internal medicine

2020 Volume 130, Issue 6, Page(s) 520–528

Abstract: Coronavirus disease 2019 (COVID‑19) is an infectious disease caused by a novel strain of coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), that appeared in China in December 2019 and spread globally, evolving into the currently ... ...

Abstract	Coronavirus disease 2019 (COVID‑19) is an infectious disease caused by a novel strain of coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), that appeared in China in December 2019 and spread globally, evolving into the currently observed pandemic. The laboratory diagnosis of SARS‑CoV‑2 infection is currently based on real‑time reverse transcriptase-polymerase chain reaction (RT‑PCR) testing, and imaging cannot replace genetic testing in patients with suspected COVID‑19. However, with predominant respiratory manifestations of COVID‑19, particularly in more severe cases, chest imaging using computed tomography (CT) plays a major role in detecting viral lung infection, evaluating the nature and extent of pulmonary lesions, and monitoring the disease activity. The role of chest CT as a diagnostic tool may be increased when the laboratory testing capacities using RT‑PCR prove inaccurate or insufficient during a major outbreak of the disease. In these settings, a rapid presumptive diagnosis of COVID‑19 potentially offered by CT might be an advantage, in addition to obvious benefits of delineating the nature and extent of pulmonary lesions. In the present paper, we reviewed the diagnostic role of chest CT in patients with COVID‑19.
MeSH term(s)	Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/pathology ; Humans ; Lung/diagnostic imaging ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/pathology ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; Tomography, X-Ray Computed
Keywords	covid19
Language	English
Publishing date	2020-05-09
Publishing country	Poland
Document type	Journal Article
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.15348
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Article ; Online: Occupational risks for SARS-CoV-2 infection: the Polish experience.

Sierpiński, Radosław / Pinkas, Jaroslaw / Jankowski, Mateusz / Juszczyk, Grzegorz / Topór-Mądry, Roman / Szumowski, Łukasz

International journal of occupational medicine and environmental health

2020 Volume 33, Issue 6, Page(s) 781–789

Abstract: Objectives: The disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), termed COVID-19, is asymptomatic or mild in most cases. These patients do not need treatment in hospital and can be isolated at home. To date, most ... ...

Abstract	Objectives: The disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), termed COVID-19, is asymptomatic or mild in most cases. These patients do not need treatment in hospital and can be isolated at home. To date, most studies have been conducted among inpatients with severe COVID-19. In this study, the authors surveyed patients with mild COVID-19 who remained in home isolation, and analyzed the sources and occupational risk factors for SARS-CoV-2 infections. Material and methods: This cross-sectional study was carried out on April 17-18, 2020, among patients infected with SARS-CoV-2 who remained in home isolation in Poland. Data were acquired through a structured interview that included questions about the isolation course, symptoms, comorbidities, infection source, household characteristics, occupation, and workplace. Data were presented with descriptive statistics. Results: Of the 4878 patients in home isolation, the authors were able to contact 3313. Of them, 1191 patients declined their invitation, and 2122 agreed to take part. The median age of the patients included in the study was 50 years; 59% were female. Most patients (92%) had not been abroad before the infection. More than half (55%) knew how they became infected; of them, 75% became infected at work. Of all patients, 70% were occupationally active. Nearly half of the occupationally active patients (48%) worked in healthcare, 3% worked in public administration or defense, 3% worked in transportation, and 2% worked in education. Sixty-five percent of the occupationally active patients worked in companies with >100 employees. Conclusions: Most of the patients with COVID-19 in home isolation in Poland were occupationally active, wherein the majority of people who were aware of the source of SARS-CoV-2 infection worked in healthcare. As most of the infected patients worked in companies with >100 employees, which is not a Polish employment pattern, the authors expect that smaller companies may have a lower risk of SARS-CoV-2 infections. Int J Occup Med Environ Health. 2020;33(6):781-9.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Cross-Sectional Studies ; Disease Transmission, Infectious/statistics & numerical data ; Female ; Humans ; Male ; Occupational Exposure/adverse effects ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Poland/epidemiology ; Retrospective Studies ; Risk Assessment/methods ; Risk Factors ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-07-22
Publishing country	Poland
Document type	Journal Article ; Multicenter Study
ZDB-ID	1199049-1
ISSN	1896-494X ; 0867-8383 ; 1232-1087
ISSN (online)	1896-494X
ISSN	0867-8383 ; 1232-1087
DOI	10.13075/ijomeh.1896.01663
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Article ; Online: The Prevalence of Tobacco, Heated Tobacco, and E-Cigarette Use in Poland

Mateusz Jankowski / Aurelia Ostrowska / Radosław Sierpiński / Adam Skowron / Janusz Sytnik-Czetwertyński / Wojciech Giermaziak / Mariusz Gujski / Waldemar Wierzba / Jarosław Pinkas

International Journal of Environmental Research and Public Health, Vol 19, Iss 4904, p

A 2022 Web-Based Cross-Sectional Survey

2022 Volume 4904

Abstract	Monitoring tobacco use on a regular schedule is a basic tool of tobacco control policy. This study aimed (1) to assess the current prevalence and patterns of tobacco and e-cigarette use, as well as (2) to identify socioeconomic factors associated with smoking behavior among adults in Poland. This cross-sectional study was carried out in March 2022 on a nationwide, representative sample of 1090 adults in Poland. The computer-assisted web interview (CAWI) technique was used. Daily tobacco smoking was declared by 28.8% of respondents (27.1% of females and 30.8% of males; p = 0.2) and 4.2% were occasional smokers (4.2% of females and 4.3% of males; p = 0.8). Most of the current smokers (62.1%) smoked regular cigarettes and 25.2% smoked hand-rolled cigarettes. The prevalence of daily e-cigarette use was 4.8% (4.0% among females and 5.6% among males; p = 0.2). Daily heated tobacco use was declared by 4.0% of respondents (5.1% of females and 2.9% of males; p = 0.07). Age, having children, and educational level were significantly associated with current daily tobacco smoking. This study revealed a high prevalence of tobacco and e-cigarette use among adults in Poland. The presented data underscore the importance of further improvements in adopting a comprehensive tobacco control strategy in Poland.
Keywords	tobacco ; smoking ; cigarettes ; e-cigarettes ; heated tobacco ; prevalence ; Medicine ; R
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: The Potential Benefits of the Influenza Vaccination on COVID-19 Mortality Rate—A Retrospective Analysis of Patients in Poland

Kinga Izabela Stańczak-Mrozek / Adam Sobczak / Leszek Lipiński / Elżbieta Sienkiewicz / Dorota Makarewicz / Roman Topór-Mądry / Jarosław Pinkas / Radosław Adam Sierpiński

Vaccines, Vol 10, Iss 5, p

2022 Volume 5

Abstract: In this study, we used publicly available data from the Centrum e-Zdrowia (CeZ) Polish Databank proposing a possible correlation between influenza vaccination and mortality due to COVID-19. We limited our search to the patients with positive COVID‑19 ... ...

Abstract	In this study, we used publicly available data from the Centrum e-Zdrowia (CeZ) Polish Databank proposing a possible correlation between influenza vaccination and mortality due to COVID-19. We limited our search to the patients with positive COVID‑19 laboratory tests from 1 January 2020 to 31 March 2021 and who filled a prescription for any influenza vaccine during the 2019–2020 influenza season. In total, we included 116,277 patients and used a generalized linear model to analyze the data. We found out that patients aged 60+ who received an influenza vaccination have a lower probability of death caused by COVID-19 in comparison to unvaccinated, and the magnitude of this difference grows with age. For people below 60 years old, we did not observe an influence of the vaccination. Our results suggest a potential protective effect of the influenza vaccine on COVID-19 mortality of the elderly. Administration of the influenza vaccine before the influenza season would reduce the burden of increased influenza incidence, the risk of influenza and COVID‑19 coinfection and render the essential medical resources accessible to cope with another wave of COVID-19. To our knowledge, this is the first study showing a correlation between influenza vaccination and the COVID-19 mortality rate in Poland.
Keywords	COVID-19 ; influenza vaccine ; prevention ; cross-protection ; Medicine ; R
Subject code	310
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: The Potential Benefits of the Influenza Vaccination on COVID-19 Mortality Rate-A Retrospective Analysis of Patients in Poland.

Stańczak-Mrozek, Kinga Izabela / Sobczak, Adam / Lipiński, Leszek / Sienkiewicz, Elżbieta / Makarewicz, Dorota / Topór-Mądry, Roman / Pinkas, Jarosław / Sierpiński, Radosław Adam

Vaccines

2021 Volume 10, Issue 1

Abstract: In this study,we used publicly available data from the Centrum e-Zdrowia (CeZ) Polish Databank proposing a possible correlation between influenza vaccination and mortality due to COVID-19. We limited our search to the patients with positive COVID‑19 ... ...

Abstract	In this study,we used publicly available data from the Centrum e-Zdrowia (CeZ) Polish Databank proposing a possible correlation between influenza vaccination and mortality due to COVID-19. We limited our search to the patients with positive COVID‑19 laboratory tests from 1 January 2020 to 31 March 2021 and who filled a prescription for any influenza vaccine during the 2019-2020 influenza season. In total, we included 116,277 patients and used a generalized linear model to analyze the data.We found out that patients aged 60+ who received an influenza vaccination have a lower probability of death caused by COVID-19 in comparison to unvaccinated, and the magnitude of this difference grows with age. For people below 60 years old, we did not observe an influence of the vaccination. Our results suggest a potential protective effect of the influenza vaccine on COVID-19 mortality of the elderly. Administration of the influenza vaccine before the influenza season would reduce the burden of increased influenza incidence, the risk of influenza and COVID‑19 coinfection and render the essential medical resources accessible to cope with another wave of COVID-19. To our knowledge, this is the first study showing a correlation between influenza vaccination and the COVID-19 mortality rate in Poland.
Language	English
Publishing date	2021-12-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10010005
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Article ; Online: Occupational risks for SARS-CoV-2 infection

Radosław Sierpiński / Jaroslaw Pinkas / Mateusz Jankowski / Grzegorz Juszczyk / Roman Topór-Mądry / Łukasz Szumowski

International Journal of Occupational Medicine and Environmental Health, Vol 33, Iss 6, Pp 781-

the Polish experience

2020 Volume 789

Abstract: Objectives The disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), termed COVID-19, is asymptomatic or mild in most cases. These patients do not need treatment in hospital and can be isolated at home. To date, most studies ...

Abstract	Objectives The disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), termed COVID-19, is asymptomatic or mild in most cases. These patients do not need treatment in hospital and can be isolated at home. To date, most studies have been conducted among inpatients with severe COVID-19. In this study, the authors surveyed patients with mild COVID-19 who remained in home isolation, and analyzed the sources and occupational risk factors for SARS-CoV-2 infections. Material and Methods This cross-sectional study was carried out on April 17–18, 2020, among patients infected with SARS-CoV-2 who remained in home isolation in Poland. Data were acquired through a structured interview that included questions about the isolation course, symptoms, comorbidities, infection source, household characteristics, occupation, and workplace. Data were presented with descriptive statistics. Results Of the 4878 patients in home isolation, the authors were able to contact 3313. Of them, 1191 patients declined their invitation, and 2122 agreed to take part. The median age of the patients included in the study was 50 years; 59% were female. Most patients (92%) had not been abroad before the infection. More than half (55%) knew how they became infected; of them, 75% became infected at work. Of all patients, 70% were occupationally active. Nearly half of the occupationally active patients (48%) worked in healthcare, 3% worked in public administration or defense, 3% worked in transportation, and 2% worked in education. Sixty-five percent of the occupationally active patients worked in companies with >100 employees. Conclusions Most of the patients with COVID-19 in home isolation in Poland were occupationally active, wherein the majority of people who were aware of the source of SARS-CoV-2 infection worked in healthcare. As most of the infected patients worked in companies with >100 employees, which is not a Polish employment pattern, the authors expect that smaller companies may have a lower risk of ...
Keywords	occupational exposure ; public health ; quarantine ; coronavirus infection ; patient isolation ; cross-sectional survey ; Medicine ; R
Subject code	610
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Nofer Institute of Occupational Medicine
Document type	Article ; Online
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Article ; Online: Sex differences in the frequency of gastrointestinal symptoms and olfactory or taste disorders in 1942 nonhospitalized patients with coronavirus disease 2019 (COVID-19).

Sierpiński, Radosław / Pinkas, Jarosław / Jankowski, Mateusz / Zgliczyński, Wojciech S / Wierzba, Waldemar / Gujski, Mariusz / Szumowski, Łukasz

Polish archives of internal medicine

2020 Volume 130, Issue 6, Page(s) 501–505

Abstract: Introduction: The coronavirus disease 2019 (COVID 19) is a communicable disease caused by a novel coronavirus.: Objectives: This study aimed to assess self‑reported frequency of gastrointestinal symptoms and olfactory or taste disorders in ... ...

Abstract	Introduction: The coronavirus disease 2019 (COVID 19) is a communicable disease caused by a novel coronavirus. Objectives: This study aimed to assess self‑reported frequency of gastrointestinal symptoms and olfactory or taste disorders in nonhospitalized patients with COVID‑19 in Poland. Patients and methods: This cross‑sectional survey was conducted between April 17 and 18, 2020, in 4516 nonhospitalized patients with COVID‑19 in Poland. The questionnaire included 8 questions related to the health status, symptoms of COVID‑19, comorbidities, and smoking status. Results: Completed questionnaires were obtained from 1942 patients with COVID‑19 with a response rate of 43%. The median age of the respondents was 50 years; 60.2% were women. Among nonhospitalized patients with COVID‑19, 21.3% had hypertension, 4.5% had diabetes, and 3.1% had a chronic respiratory disease. Regular tobacco use was declared by 11.2% of patients with COVID‑19. At least one gastrointestinal symptom was reported by 53.6% of patients. Almost half of patients (47%) with COVID‑19 reported lack of appetite and 24.2% reported diarrhea. Among 1942 interviewed patients, 54.2% reported at least 1 olfactory or taste disorder and 42.5% reported both alterations. Self‑reported olfactory and taste disorders were 49.2% and 47.5%, respectively. Self‑reported frequency of gastrointestinal symptoms and olfactory or taste disorders during COVID‑19 was significantly higher (P <0.001) in women than men. Conclusions: This study demonstrated that olfactory and taste disorders are frequent symptoms in patients with mild‑to‑moderate COVID‑19. Moreover, our study indicated sex differences in the frequency of gastrointestinal symptoms and olfactory or taste disorders among nonhospitalized patients with COVID‑19.
MeSH term(s)	Adult ; Betacoronavirus ; COVID-19 ; Comorbidity ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Cross-Sectional Studies ; Digestive System/virology ; Female ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/epidemiology ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Poland ; SARS-CoV-2 ; Surveys and Questionnaires ; Taste Disorders/diagnosis ; Taste Disorders/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-06-03
Publishing country	Poland
Document type	Journal Article
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.15414
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