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Article ; Online: Hypothyroidism and Type D Personality: Results From E-MPATHY, a Cross-sectional International Online Patient Survey.

Perros, Petros / Nagy, Endre Vezekenyi / Papini, Enrico / Abad-Madroñero, Juan / Lakwijk, Peter / Poots, Alan J / Mols, Floortje / Hegedüs, Laszlo

The Journal of clinical endocrinology and metabolism

2024

Abstract: Context: Between 10% and 15% of people with hypothyroidism experience persistent symptoms, despite achieving biochemical euthyroidism. The underlying causes are unclear. Type D personality (a vulnerability factor for general psychological distress) is ... ...

Abstract	Context: Between 10% and 15% of people with hypothyroidism experience persistent symptoms, despite achieving biochemical euthyroidism. The underlying causes are unclear. Type D personality (a vulnerability factor for general psychological distress) is associated with poor health status and symptom burden but has not been studied in people with hypothyroidism. Objective: To investigate type D personality in hypothyroidism and explore associations with other characteristics and patient-reported outcomes. Design: Multinational, cross-sectional survey. Setting: Online. Participants: Individuals with self-reported, treated hypothyroidism. Intervention: Questionnaire. Main outcome measures: Type D personality and associations with baseline characteristics, control of the symptoms of hypothyroidism by medication, satisfaction with care and treatment of hypothyroidism, impact of hypothyroidism on everyday living. Results: A total of 3915 responses were received, 3523 of which were valid. The prevalence of type D personality was 54.2%. Statistically significant associations were found between type D personality and several respondent characteristics (age, marital status, ethnicity, household income, comorbidities, type of treatment for hypothyroidism, most recent TSH level), anxiety, depression, somatization, poor control of the symptoms of hypothyroidism by medication, dissatisfaction with care and treatment of hypothyroidism, and a negative impact of hypothyroidism on everyday living). Discussion: Our study found a high prevalence of type D personality among people with hypothyroidism who responded to the survey. Type D personality may be an important determinant of dissatisfaction with treatment and care among people with hypothyroidism. Our findings require independent confirmation. Close collaboration between the disciplines of thyroidology and psychology is likely to be key in progressing our understanding in this area.
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgae140
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Article ; Online: Szerveződtek-e a „Rima ózdi rabszolgái”?

Péter Nagy

Metszetek, Vol 3, Iss

2023 Volume 2

Keywords	Social sciences (General) ; H1-99
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	University of Debrecen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Measuring efficiency and effectiveness of knowledge transfer in e-learning.

Nagy, Vitéz / Duma, László

Heliyon

2023 Volume 9, Issue 7, Page(s) e17502

Abstract: With e-learning rapidly gaining popularity, evaluating its effectiveness and efficiency has become ... crucial in any learning process, but e-learning lacks validated methods for this. Here we examine ways ... to evaluate that particularly in case of e-learning, conducting a literature review to assess available ...

Abstract	With e-learning rapidly gaining popularity, evaluating its effectiveness and efficiency has become a challenge in public education, the public sector, and the corporate sector. Measuring knowledge transfer is crucial in any learning process, but e-learning lacks validated methods for this. Here we examine ways to evaluate that particularly in case of e-learning, conducting a literature review to assess available measurement solutions, developing an evaluation method for knowledge transfer, and validating the method. Using logged data from e-courses, it is possible to assess the knowledge transfer in e-learning. We describe a novel method for classifying effectiveness and efficiency with measured values and measurement instruments. The new measurement method was aligned with a data set of an existing learning management system, and the effectiveness and efficiency of knowledge transfer was analysed using quantitative means, including descriptive statistics, regression modelling, and cluster analysis based on a specific e-learning course. This newly elaborated and validated knowledge transfer measurement technique could be a useful tool for anyone wanting to evaluate e-learning courses and can also serve as a baseline for academics to further develop or implement it on larger empirical datasets.
Language	English
Publishing date	2023-06-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e17502
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Article ; Online: CBD, a precursor of THC in e-cigarettes.

Czégény, Zsuzsanna / Nagy, Gréta / Babinszki, Bence / Bajtel, Ákos / Sebestyén, Zoltán / Kiss, Tivadar / Csupor-Löffler, Boglárka / Tóth, Barbara / Csupor, Dezső

Scientific reports

2021 Volume 11, Issue 1, Page(s) 8951

Abstract: ... operating temperature range of e-cigarettes (250-400 °C) and at 500 °C under both inert and oxidative ...

Abstract	The use of cannabidiol (CBD) in electronic cigarettes is widespread. Previously, it was reported that CBD is partly transformed to THC in case smoking as a cigarette, however, the pyrolysis of this compound has not been assessed extensively. The aim of our study was to investigate the effect of temperature on the composition of pyrolysis products of CBD. The experiments were performed in the typical operating temperature range of e-cigarettes (250-400 °C) and at 500 °C under both inert and oxidative conditions, and the pyrolysis products were identified and quantified by GC-MS. Depending on the temperature and atmosphere, 25-52% of CBD was transformed into other chemical substances: Δ
MeSH term(s)	Cannabidiol/chemistry ; Cannabinoids/analysis ; Cannabinoids/chemistry ; Dronabinol/analysis ; Dronabinol/chemistry ; Electronic Nicotine Delivery Systems ; Pyrolysis
Chemical Substances	Cannabinoids ; Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S) ; cannabichromene (K4497H250W)
Language	English
Publishing date	2021-04-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-88389-z
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Article ; Online: Measurement of e^{+}e^{-} Momentum and Angular Distributions from Linearly Polarized Photon Collisions.

Adam, J / Adamczyk, L / Adams, J R / Adkins, J K / Agakishiev, G / Aggarwal, M M / Ahammed, Z / Alekseev, I / Anderson, D M / Aparin, A / Aschenauer, E C / Ashraf, M U / Atetalla, F G / Attri, A / Averichev, G S / Bairathi, V / Barish, K / Behera, A / Bellwied, R /

Bhasin, A / Bielcik, J / Bielcikova, J / Bland, L C / Bordyuzhin, I G / Brandenburg, J D / Brandin, A V / Butterworth, J / Caines, H / Calderón de la Barca Sánchez, M / Cebra, D / Chakaberia, I / Chaloupka, P / Chan, B K / Chang, F-H / Chang, Z / Chankova-Bunzarova, N / Chatterjee, A / Chen, D / Chen, J H / Chen, X / Chen, Z / Cheng, J / Cherney, M / Chevalier, M / Choudhury, S / Christie, W / Crawford, H J / Csanád, M / Daugherity, M / Dedovich, T G / Deppner, I M / Derevschikov, A A / Didenko, L / Dong, X / Drachenberg, J L / Dunlop, J C / Edmonds, T / Elsey, N / Engelage, J / Eppley, G / Esha, R / Esumi, S / Evdokimov, O / Ewigleben, A / Eyser, O / Fatemi, R / Fazio, S / Federic, P / Fedorisin, J / Feng, C J / Feng, Y / Filip, P / Finch, E / Fisyak, Y / Francisco, A / Fulek, L / Gagliardi, C A / Galatyuk, T / Geurts, F / Gibson, A / Gopal, K / Grosnick, D / Hamad, A I / Hamed, A / Harris, J W / He, S / He, W / He, X / Heppelmann, S / Herrmann, N / Hoffman, E / Holub, L / Hong, Y / Horvat, S / Hu, Y / Huang, H Z / Huang, S L / Huang, T / Huang, X / Humanic, T J / Huo, P / Igo, G / Isenhower, D / Jacobs, W W / Jena, C / Jentsch, A / Ji, Y / Jia, J / Jiang, K / Jowzaee, S / Ju, X / Judd, E G / Kabana, S / Kabir, M L / Kagamaster, S / Kalinkin, D / Kang, K / Kapukchyan, D / Kauder, K / Ke, H W / Keane, D / Kechechyan, A / Kelsey, M / Khyzhniak, Y V / Kikoła, D P / Kim, C / Kimelman, B / Kincses, D / Kinghorn, T A / Kisel, I / Kiselev, A / Kisiel, A / Klein, S R / Kocan, M / Kochenda, L / Kosarzewski, L K / Kramarik, L / Kravtsov, P / Krueger, K / Kulathunga Mudiyanselage, N / Kumar, L / Kunnawalkam Elayavalli, R / Kwasizur, J H / Lacey, R / Lan, S / Landgraf, J M / Lauret, J / Lebedev, A / Lednicky, R / Lee, J H / Leung, Y H / Li, C / Li, W / Li, X / Li, Y / Liang, Y / Licenik, R / Lin, T / Lin, Y / Lisa, M A / Liu, F / Liu, H / Liu, P / Liu, T / Liu, X / Liu, Y / Liu, Z / Ljubicic, T / Llope, W J / Longacre, R S / Lukow, N S / Luo, S / Luo, X / Ma, G L / Ma, L / Ma, R / Ma, Y G / Magdy, N / Majka, R / Mallick, D / Margetis, S / Markert, C / Matis, H S / Mazer, J A / Minaev, N G / Mioduszewski, S / Mohanty, B / Mooney, I / Moravcova, Z / Morozov, D A / Nagy, M / Nam, J D / Nasim, Md / Nayak, K / Neff, D / Nelson, J M / Nemes, D B / Nie, M / Nigmatkulov, G / Niida, T / Nogach, L V / Nonaka, T / Odyniec, G / Ogawa, A / Oh, S / Okorokov, V A / Page, B S / Pak, R / Pandav, A / Panebratsev, Y / Pawlik, B / Pawlowska, D / Pei, H / Perkins, C / Pinsky, L / Pintér, R L / Pluta, J / Porter, J / Posik, M / Pruthi, N K / Przybycien, M / Putschke, J / Qiu, H / Quintero, A / Radhakrishnan, S K / Ramachandran, S / Ray, R L / Reed, R / Ritter, H G / Roberts, J B / Rogachevskiy, O V / Romero, J L / Ruan, L / Rusnak, J / Sahoo, N R / Sako, H / Salur, S / Sandweiss, J / Sato, S / Schmidke, W B / Schmitz, N / Schweid, B R / Seck, F / Seger, J / Sergeeva, M / Seto, R / Seyboth, P / Shah, N / Shahaliev, E / Shanmuganathan, P V / Shao, M / Shen, F / Shen, W Q / Shi, S S / Shou, Q Y / Sichtermann, E P / Sikora, R / Simko, M / Singh, J / Singha, S / Smirnov, N / Solyst, W / Sorensen, P / Spinka, H M / Srivastava, B / Stanislaus, T D S / Stefaniak, M / Stewart, D J / Strikhanov, M / Stringfellow, B / Suaide, A A P / Sumbera, M / Summa, B / Sun, X M / Sun, Y / Surrow, B / Svirida, D N / Szymanski, P / Tang, A H / Tang, Z / Taranenko, A / Tarnowsky, T / Thomas, J H / Timmins, A R / Tlusty, D / Tokarev, M / Tomkiel, C A / Trentalange, S / Tribble, R E / Tribedy, P / Tripathy, S K / Tsai, O D / Tu, Z / Ullrich, T / Underwood, D G / Upsal, I / Van Buren, G / Vanek, J / Vasiliev, A N / Vassiliev, I / Videbæk, F / Vokal, S / Voloshin, S A / Wang, F / Wang, G / Wang, J S / Wang, P / Wang, Y / Wang, Z / Webb, J C / Weidenkaff, P C / Wen, L / Westfall, G D / Wieman, H / Wissink, S W / Witt, R / Wu, Y / Xiao, Z G / Xie, G / Xie, W / Xu, H / Xu, N / Xu, Q H / Xu, Y F / Xu, Y / Xu, Z / Yang, C / Yang, Q / Yang, S / Yang, Y / Yang, Z / Ye, Z / Yi, L / Yip, K / Zbroszczyk, H / Zha, W / Zhang, D / Zhang, S / Zhang, X P / Zhang, Y / Zhang, Z J / Zhang, Z / Zhao, J / Zhong, C / Zhou, C / Zhu, X / Zhu, Z / Zurek, M / Zyzak, M

Physical review letters

2021 Volume 127, Issue 5, Page(s) 52302

Abstract: ... at the experimental limit of ≤0.2% of the observed yields. The differential cross section as a function of e^{+}e^ ...

Abstract	The Breit-Wheeler process which produces matter and antimatter from photon collisions is experimentally investigated through the observation of 6085 exclusive electron-positron pairs in ultraperipheral Au+Au collisions at sqrt[s_{NN}]=200 GeV. The measurements reveal a large fourth-order angular modulation of cos4Δϕ=(16.8±2.5)% and smooth invariant mass distribution absent of vector mesons (ϕ, ω, and ρ) at the experimental limit of ≤0.2% of the observed yields. The differential cross section as a function of e^{+}e^{-} pair transverse momentum P_{⊥} peaks at low value with sqrt[⟨P_{⊥}^{2}⟩]=38.1±0.9 MeV and displays a significant centrality dependence. These features are consistent with QED calculations for the collision of linearly polarized photons quantized from the extremely strong electromagnetic fields generated by the highly charged Au nuclei at ultrarelativistic speed. The experimental results have implications for vacuum birefringence and for mapping the magnetic field which is important for emergent QCD phenomena.
Language	English
Publishing date	2021-08-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.127.052302
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Article ; Online: Hypothyroidism and Somatization: Results from E-Mode Patient Self-Assessment of Thyroid Therapy, a Cross-Sectional, International Online Patient Survey.

Perros, Petros / Nagy, Endre Vezekenyi / Papini, Enrico / Van Der Feltz-Cornelis, Christina Maria / Weetman, Anthony Peter / Hay, Harriet Alexandra / Abad-Madroñero, Juan / Tallett, Amy Johanna / Bilas, Megan / Lakwijk, Peter / Poots, Alan J / Hegedüs, Laszlo

Thyroid : official journal of the American Thyroid Association

2023 Volume 33, Issue 8, Page(s) 927–939

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Female ; Cross-Sectional Studies ; Medically Unexplained Symptoms ; Self-Assessment ; Hypothyroidism/drug therapy ; Hypothyroidism/epidemiology ; Thyroxine/therapeutic use ; Triiodothyronine/therapeutic use
Chemical Substances	Thyroxine (Q51BO43MG4) ; Triiodothyronine (06LU7C9H1V)
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1086044-7
ISSN	1557-9077 ; 1050-7256
ISSN (online)	1557-9077
ISSN	1050-7256
DOI	10.1089/thy.2022.0641
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Article ; Online: Measuring efficiency and effectiveness of knowledge transfer in e-learning

Vitéz Nagy / László Duma

Heliyon, Vol 9, Iss 7, Pp e17502- (2023)

2023

Abstract	With e-learning rapidly gaining popularity, evaluating its effectiveness and efficiency has become a challenge in public education, the public sector, and the corporate sector. Measuring knowledge transfer is crucial in any learning process, but e-learning lacks validated methods for this. Here we examine ways to evaluate that particularly in case of e-learning, conducting a literature review to assess available measurement solutions, developing an evaluation method for knowledge transfer, and validating the method. Using logged data from e-courses, it is possible to assess the knowledge transfer in e-learning. We describe a novel method for classifying effectiveness and efficiency with measured values and measurement instruments. The new measurement method was aligned with a data set of an existing learning management system, and the effectiveness and efficiency of knowledge transfer was analysed using quantitative means, including descriptive statistics, regression modelling, and cluster analysis based on a specific e-learning course. This newly elaborated and validated knowledge transfer measurement technique could be a useful tool for anyone wanting to evaluate e-learning courses and can also serve as a baseline for academics to further develop or implement it on larger empirical datasets.
Keywords	E-learning efficiency ; E-learning effectiveness ; Knowledge transfer measurement ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	006
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: In-service teachers' TPACK development through an adaptive e-learning environment (ALE).

Elmaadaway, Mohamed Ali Nagy / Abouelenein, Yousri Attia Mohamed

Education and information technologies

2022 , Page(s) 1–26

Abstract: Due to the effects of the COVID-19 crisis on educational institutions, schools had to close and switch to online education. Training in-service teachers to incorporate and utilize technology as part of Internet-based instructions was a challenge and ... ...

Abstract	Due to the effects of the COVID-19 crisis on educational institutions, schools had to close and switch to online education. Training in-service teachers to incorporate and utilize technology as part of Internet-based instructions was a challenge and pressing necessity. TPACK is an essential framework for comprehending how teachers employ technology in teaching. Despite the significance of adaptive learning environments in recent years, research has not addressed how to use these environments to improve the TPACK of in-service teachers, particularly during crises. Consequently, our objective was to design an adaptive learning environment that provides in-service math, science, and English teachers with substantial and continuing support for each TPACK component. A total of 173 in-service teachers were divided into two groups: an experimental group of 83 who used adaptive learning and a control group of 90 who used Zoom techniques. TPACK questionnaires were administered before and after the experiment. The experimental group improved TPACK more than the control group. All teachers believed that adaptive learning training helped them to build technology-integrated lesson plans. This study provides ideas and practices for developing an adaptive learning environment for the in-service teachers' TPACK development. The challenges to adaptive learning environments have been highlighted, identifying the potential for future investigations.
Language	English
Publishing date	2022-12-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2001930-0
ISSN	1573-7608 ; 1360-2357
ISSN (online)	1573-7608
ISSN	1360-2357
DOI	10.1007/s10639-022-11477-8
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Article ; Online: Mit tudunk az e-cigaretta káros hatásairól?

Nagy, László Béla

Orvosi hetilap

2019 Volume 160, Issue 45, Page(s) 1767–1773

Abstract: ... an entirely new public health dilemma. The central issue in the debate is the disease risk imposed by e ... cigarettes. It is generally acknowledged that e-cigarettes are unlikely to be as harmful as conventional ... animal studies show that e-cigarettes can have multiple negative effects. Scientific evidence regarding ...

Title translation	What we know from the harmful effects of e-cigarettes?
Abstract	Electronic cigarettes are becoming increasingly popular with smokers worldwide. This has created an entirely new public health dilemma. The central issue in the debate is the disease risk imposed by e-cigarettes. It is generally acknowledged that e-cigarettes are unlikely to be as harmful as conventional cigarettes, but there are little data that quantify their relative harms. Experiments in cell cultures and animal studies show that e-cigarettes can have multiple negative effects. Scientific evidence regarding their human acute health effects is limited. The long term effects in humans are unknown, and there is no evidence that e-cigarettes are safer than tobacco in the long term. This review higlights the recent data regarding e-cigarettes toxicity impact on lung and cardiovascular system. Orv Hetil. 2019; 160(45): 1767-1773.
MeSH term(s)	Animals ; Electronic Nicotine Delivery Systems ; Humans ; Nicotine/administration & dosage ; Nicotine/adverse effects ; Public Health ; Smoking/adverse effects
Chemical Substances	Nicotine (6M3C89ZY6R)
Language	Hungarian
Publishing date	2019-11-03
Publishing country	Hungary
Document type	Journal Article ; Review
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/650.2019.31567
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Article: The role of selenium and vitamin E in a Transylvanian enzootic equine recurrent rhabdomyolysis syndrome.

Kósa, Csaba Attila / Nagy, Krisztina / Szenci, Ottó / Baska-Vincze, Boglárka / Andrásofszky, Emese / Szép, Róbert / Keresztesi, Ágnes / Mircean, Mircea / Taulescu, Marian / Kutasi, Orsolya

Acta veterinaria Hungarica

2021 Volume 69, Issue 3, Page(s) 256–265

Abstract: ... it is less than 2%. The objective of our study was to clarify the role of selenium and vitamin E ... for serum selenium, vitamin E, glutathione peroxidase (GSH-Px), muscle enzymes, lactate and electrolytes ... could be demonstrated (r = 0.777, P < 0.001). Serum vitamin E levels were low independently of the origin ...

Abstract	A severe form of recurrent exertional rhabdomyolysis occurs enzootically in a well-defined region of Transylvania, Harghita county. At the highest lying two settlements (more than 800 m above sea level), the prevalence of equine rhabdomyolysis is between 17 and 23%, while in the neighbouring villages in the valley it is less than 2%. The objective of our study was to clarify the role of selenium and vitamin E in the high prevalence of rhabdomyolysis in that region. Soil and hay samples were collected from each area to evaluate mineral content. Ten horses from the non-affected and 20 horses from the affected area were tested for serum selenium, vitamin E, glutathione peroxidase (GSH-Px), muscle enzymes, lactate and electrolytes. Hay samples collected from the affected area had lower selenium content. Horses in the affected regions had significantly lower serum selenium (P = 0.006) and GSH-Px levels than animals living in the non-affected regions. A good correlation between erythrocyte GSH-Px and serum selenium concentration could be demonstrated (r = 0.777, P < 0.001). Serum vitamin E levels were low independently of the origin of the horse. Based on our results, selenium deficiency possibly has a role in the Transylvanian enzootic equine recurrent rhabdomyolysis syndrome.
MeSH term(s)	Animals ; Glutathione Peroxidase/blood ; Horse Diseases/epidemiology ; Horses ; Rhabdomyolysis/epidemiology ; Rhabdomyolysis/veterinary ; Romania/epidemiology ; Selenium/blood ; Vitamin E/blood
Chemical Substances	Vitamin E (1406-18-4) ; Glutathione Peroxidase (EC 1.11.1.9) ; Selenium (H6241UJ22B)
Language	English
Publishing date	2021-09-07
Publishing country	Hungary
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605742-1
ISSN	1588-2705 ; 0236-6290 ; 0365-8198
ISSN (online)	1588-2705
ISSN	0236-6290 ; 0365-8198
DOI	10.1556/004.2021.00031
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