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  1. Article ; Online: Patterns of cannabis use, perception of harm, and perceived impact of legislative change in an online sample of young adults from Lebanon: insight on recreational users versus dual motive users.

    Ghandour, Lilian / Slim, Andre / Abbas, Nada / El-Khoury, Joseph

    Harm reduction journal

    2024  Volume 21, Issue 1, Page(s) 41

    Abstract: Background: Lebanon remains as one of the major sources of cannabis worldwide. In 2020, its government passed a legislation enabling the cultivation of local medicinal cannabis. This first study following the legislative change examines the overlapping ... ...

    Abstract Background: Lebanon remains as one of the major sources of cannabis worldwide. In 2020, its government passed a legislation enabling the cultivation of local medicinal cannabis. This first study following the legislative change examines the overlapping use of cannabis for recreational/medicinal purposes and characteristics of the distinct cannabis user types.
    Methods: A total of 1230 young adults (18-24 years) filled an anonymous online survey in early 2020.
    Results: Young adults in the sample were distributed as follows: 33% 18-20 years; 60% males; 94% Lebanese; 75% students; and 89% living with family. The older young adults (21-24), males, those employed, living with non-family members, and who perceived themselves as being a little/lot richer than most were statistically significantly more present in the cannabis user subtypes (recreational only or recreational/medicinal) than non-cannabis users. When dual recreational/medicinal users are compared to recreational users only, the latter seemed to have a more conservative profile of behaviours, attitudes, and perceptions and acts of harm. The prevalence ratio comparing the prevalence of users supporting consuming cannabis "once or twice" in dual motive users vs. recreational users only was 1.13 for "once or twice", 1.25 for "occasionally", 1.64 for "regularly", and 2.4 for "daily". Any other illicit drug use was reported by 1% of the non-cannabis users, 36% of the recreational users only, and 58% of the recreational/medicinal users (p-value < 0.01). Similarly, any prescription drug use was reported by 3% of the non-cannabis users, 16% of the recreational users only, and 28% of both recreational/medicinal users (p-value < 0.01).
    Conclusion: The interface between recreational and medicinal cannabis use is complex. Dual motive users may warrant special attention as a subpopulation of cannabis users. This is relevant to contexts experiencing medicinal cannabis legislation changes, such as Lebanon, as policymakers and implementers should be sensitized to the emerging evidence for more data-informed policy changes.
    MeSH term(s) Male ; Humans ; Young Adult ; Female ; Cannabis ; Medical Marijuana ; Lebanon/epidemiology ; Hallucinogens ; Substance-Related Disorders ; Perception
    Chemical Substances Medical Marijuana ; Hallucinogens
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2146691-9
    ISSN 1477-7517 ; 1477-7517
    ISSN (online) 1477-7517
    ISSN 1477-7517
    DOI 10.1186/s12954-024-00958-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Risk assessment of mycotoxins in food.

    El Darra, Nada / Grimi, Nabil / Watson, Ian A / El Khoury, André

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1145998

    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1145998
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Inhibition of Aflatoxin B1 Synthesis in

    Al Khoury, Anthony / El Khoury, André / Rocher, Ophélie / Hindieh, Pamela / Puel, Olivier / Maroun, Richard G / Atoui, Ali / Bailly, Jean-Denis

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 23

    Abstract: Plant extracts may represent an ecofriendly alternative to chemical fungicides to limit aflatoxin B1 (AFB1) contamination of foods and feeds. Mate ( ...

    Abstract Plant extracts may represent an ecofriendly alternative to chemical fungicides to limit aflatoxin B1 (AFB1) contamination of foods and feeds. Mate (
    Language English
    Publishing date 2022-12-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27238550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A comparative review on methods of detection and quantification of mycotoxins in solid food and feed: a focus on cereals and nuts.

    Dib, Alaa Abou / Assaf, Jean Claude / Debs, Espérance / Khatib, Sami El / Louka, Nicolas / Khoury, André El

    Mycotoxin research

    2023  Volume 39, Issue 4, Page(s) 319–345

    Abstract: Many emerging factors and circumstances urge the need to develop and optimize the detection and quantification techniques of mycotoxins in solid food and feed. The diversity of mycotoxins, which have different properties and affinities, makes the ... ...

    Abstract Many emerging factors and circumstances urge the need to develop and optimize the detection and quantification techniques of mycotoxins in solid food and feed. The diversity of mycotoxins, which have different properties and affinities, makes the standardization of the analytical procedures and the adoption of a single protocol that covers the attributes of all mycotoxins a tedious or even an impossible mission. Several modifications and improvements have been undergone in order to optimize the performance of these methods including the extraction solvents, the extraction methods, the clean-up procedures, and the analytical techniques. The techniques range from the rapid screening methods, which lack sensitivity and specificity such as TLC, to a spectrum of more advanced protocols, namely, ELISA, HPLC, and GC-MS and LC-MS/MS. This review aims at assessing the current studies related to these analytical techniques of mycotoxins in solid food and feed. It discusses and evaluates, through a critical approach, various sample treatment techniques, and provides an in-depth examination of different mycotoxin detection methods. Furthermore, it includes a comparison of their actual accuracy and a thorough analysis of the observed benefits and drawbacks.
    MeSH term(s) Mycotoxins/analysis ; Chromatography, Liquid/methods ; Edible Grain/chemistry ; Nuts ; Tandem Mass Spectrometry/methods ; Food Contamination/analysis
    Chemical Substances Mycotoxins
    Language English
    Publishing date 2023-07-31
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 14500-2
    ISSN 1867-1632 ; 0178-7888
    ISSN (online) 1867-1632
    ISSN 0178-7888
    DOI 10.1007/s12550-023-00501-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Co-Occurrence of Aflatoxin B1 and Ochratoxin A in Lebanese Stored Wheat.

    Joubrane, Karine / Mnayer, Dima / El Khoury, AndrÉ / El Khoury, Anthony / Awad, Elie

    Journal of food protection

    2020  Volume 83, Issue 9, Page(s) 1547–1552

    MeSH term(s) Aflatoxin B1/analysis ; Food Contamination/analysis ; Lebanon ; Ochratoxins/analysis ; Triticum
    Chemical Substances Ochratoxins ; ochratoxin A (1779SX6LUY) ; Aflatoxin B1 (9N2N2Y55MH)
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 243284-5
    ISSN 1944-9097 ; 0362-028X
    ISSN (online) 1944-9097
    ISSN 0362-028X
    DOI 10.4315/JFP-20-110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Non-syndromic hypotrichosis: A report of two novel variants in the LSS gene.

    El Hakim, Joelle / Mehawej, Cybel / Chouery, Eliane / Megarbane, Andre / El-Feghaly, Jinia / El Khoury, Jinane

    Pediatric dermatology

    2023  Volume 40, Issue 5, Page(s) 960–961

    Abstract: To date, more than 15 genes have been linked to syndromic and non-syndromic hypotrichosis, among which the LSS gene encoding lanosterol synthase was recently linked to autosomal recessive isolated hypotrichosis. Here we report the case of a 6-year-old ... ...

    Abstract To date, more than 15 genes have been linked to syndromic and non-syndromic hypotrichosis, among which the LSS gene encoding lanosterol synthase was recently linked to autosomal recessive isolated hypotrichosis. Here we report the case of a 6-year-old girl born to non-consanguineous Iraqi parents and presenting with sparse lanugo hair since birth on the scalp, eyelashes, and eyebrows. Whole exome sequencing followed by Sanger sequencing allowed the detection of two novel compound heterozygous variants in LSS (p.Ile323Thr and p.Gly600Val). Reporting and investigating further cases with LSS variants might help establishing a better genotype-phenotype correlation.
    MeSH term(s) Child ; Female ; Humans ; Alopecia/genetics ; Eyebrows ; Hair ; Hypotrichosis/diagnosis ; Hypotrichosis/genetics ; Pedigree
    Chemical Substances lanosterol synthase (EC 5.4.99.7)
    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.15320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Public health risk associated with the co-occurrence of aflatoxin B

    Daou, Rouaa / Hoteit, Maha / Bookari, Khlood / Joubrane, Karine / Khabbaz, Lydia Rabbaa / Ismail, Ali / Maroun, Richard G / El Khoury, André

    Frontiers in public health

    2023  Volume 10, Page(s) 1072727

    Abstract: Background: Aflatoxin B: Objectives: In Lebanon, few studies address aflatoxin B: Methods: In this work, a total of 198 samples of spices, herbs, and nuts were collected from different sites. Aflatoxin B: Results: Aflatoxin B: Conclusion: ... ...

    Abstract Background: Aflatoxin B
    Objectives: In Lebanon, few studies address aflatoxin B
    Methods: In this work, a total of 198 samples of spices, herbs, and nuts were collected from different sites. Aflatoxin B
    Results: Aflatoxin B
    Conclusion: The consumption of spices, herbs, and nuts in Lebanon could lead to an increase in health risks associated with aflatoxin B
    MeSH term(s) Aflatoxin B1/analysis ; Aflatoxin B1/toxicity ; Nuts/chemistry ; Public Health ; Lebanon ; Food Contamination/analysis ; Mycotoxins/analysis ; Mycotoxins/toxicity
    Chemical Substances ochratoxin A (1779SX6LUY) ; Aflatoxin B1 (9N2N2Y55MH) ; Mycotoxins
    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.1072727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dietary Exposure and Risk Assessment of Mycotoxins in Thyme and Thyme-Based Products Marketed in Lebanon.

    Hassan, Hussein F / Koaik, Lara / Khoury, André El / Atoui, Ali / El Obeid, Tahra / Karam, Layal

    Toxins

    2022  Volume 14, Issue 5

    Abstract: This study aimed at evaluating the incidence of aflatoxin B1 (AFB1) and ochratoxin A (OTA) in thyme and thyme-based products, related dietary exposure, and cancer risk for regular and high consumption. A total of 160 samples were collected, and 32 ... ...

    Abstract This study aimed at evaluating the incidence of aflatoxin B1 (AFB1) and ochratoxin A (OTA) in thyme and thyme-based products, related dietary exposure, and cancer risk for regular and high consumption. A total of 160 samples were collected, and 32 composite samples were analyzed. AFB1 and OTA were respectively found in 84% (27/32) and 38% (12/32) of the samples. AFB1 exceeded the limits in 41% (13/32) and 25% (8/32) of the samples according to the Lebanese and European standards, respectively. OTA was unacceptable in only 6% (2/32) and 3% (1/32) of the samples according to the Lebanese and European standards, respectively. AFB1 and OTA daily exposure was shown to be 4.270 and 1.345 ng/kg bw/day, respectively. AFB1 was shown to be associated with 0.41 and 0.35 additional cancer cases per 100,000 persons per year for regular consumption, respectively; while for high consumption, an increase of 0.911 and 0.639 cancer cases per 100,000 person per year was noted, respectively. The margin of exposure (MOE) for OTA was >10,000 for the non-neoplastic effect and >200 for the neoplastic effect, representing no toxicological concerns for consumers.
    MeSH term(s) Aflatoxin B1/analysis ; Dietary Exposure/adverse effects ; Humans ; Lebanon/epidemiology ; Mycotoxins ; Neoplasms ; Risk Assessment ; Thymus Plant
    Chemical Substances Mycotoxins ; Aflatoxin B1 (9N2N2Y55MH)
    Language English
    Publishing date 2022-05-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins14050331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Staphylococcus epidermidis biofilm assembly and self-dispersion: bacteria and matrix dynamics.

    Jonblat, Suzanne / As-Sadi, Falah / Zibara, Kazem / Sabban, Marwan El / Dermesrobian, Vera / Khoury, André El / Kallassy, Mireille / Chokr, Ali

    International microbiology : the official journal of the Spanish Society for Microbiology

    2023  

    Abstract: Staphylococcus epidermidis, despite being a commensal of human skin and mucosa, is a major nosocomial pathogen implicated in device-associated infections. The dissemination of infection to other body sites is related to biofilm dispersal. This study ... ...

    Abstract Staphylococcus epidermidis, despite being a commensal of human skin and mucosa, is a major nosocomial pathogen implicated in device-associated infections. The dissemination of infection to other body sites is related to biofilm dispersal. This study focused on the dispersion stage of S. epidermidis CIP 444 biofilm, with the assessment of biofilm matrix composition in a time-dependent experiment (7 days extended) with 3 independent repetitions, using confocal laser scanning microcopy (CLSM) in association with ZEN 3.4 blue edition, COMSTAT, and ImageJ software. SYTO-9, propidium iodide (PI), DID'OIL, FITC, and calcofluor white M2R (CFW) were used to stain biofilm components. The results indicated that the biomass of dead cells increased from 15.18 ± 1.81 µm
    Language English
    Publishing date 2023-10-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1454951-7
    ISSN 1618-1905 ; 1139-6709
    ISSN (online) 1618-1905
    ISSN 1139-6709
    DOI 10.1007/s10123-023-00433-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Prevalence and Antibiotic Resistance of

    Hoteit, Maha / Yaghi, Joseph / El Khoury, Andre / Daou, Rouaa / Hindieh, Pamela / Assaf, Jean Claude / Al Dawi, Jana / El Khoury, Jennifer / Al Jawaldeh, Ayoub

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 12

    Abstract: The emergence, persistence, and spread of antibiotic-resistant microbes is a tremendous public health threat that is considered nowadays a critical One Health issue. In Lebanon, the consumption of raw bovine milk has been recently reported as a result of ...

    Abstract The emergence, persistence, and spread of antibiotic-resistant microbes is a tremendous public health threat that is considered nowadays a critical One Health issue. In Lebanon, the consumption of raw bovine milk has been recently reported as a result of the financial crisis. The objectives of the current study were (1) to evaluate raw bovine milk samples in a comprehensive manner for the types of antibiotics used and their residues, (2) to determine the presence of mesophilic bacteria, extended-spectrum β-lactamase (ESBL)-producing
    Language English
    Publishing date 2022-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11121815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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