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Article ; Online: A Diagnostic CopyCat: Culture-Negative Infective Endocarditis of a Bioprosthetic Valve Presenting as ANCA Vasculitis.

Hamilton, David E / Cinti, Sandro K / Lapedis, Cathryn J / Eagle, Kim A

2023

Language	English
Publishing date	2023-11-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.123.067136
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Ui IV Zs.60: Show issues

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Article ; Online: Effects of procalcitonin on antimicrobial treatment decisions in patients with coronavirus disease 2019 (COVID-19).

Conlon, Anna S C / Chopra, Zoey / Cahalan, Shannon / Cinti, Sandro / Rao, Krishna

Infection control and hospital epidemiology

2022 Volume 44, Issue 8, Page(s) 1314–1320

Abstract: Objective: To describe the natural course of procalcitonin (PCT) in patients with coronavirus disease 2019 (COVID-19) and the correlation between PCT and antimicrobial prescribing to provide insight into best practices for PCT data utilization in ... ...

Abstract	Objective: To describe the natural course of procalcitonin (PCT) in patients with coronavirus disease 2019 (COVID-19) and the correlation between PCT and antimicrobial prescribing to provide insight into best practices for PCT data utilization in antimicrobial stewardship in this population. Design: Single-center, retrospective, observational study. Setting: Michigan Medicine. Patients: Inpatients aged ≥18 years hospitalized March 1, 2020, through October 31, 2021, who were positive for severe acute respiratory coronavirus virus 2 (SARS-CoV-2), with ≥1 PCT measurement. Exclusion criteria included antibiotics for nonpulmonary bacterial infection on admission, treatment with azithromycin only for chronic obstructive pulmonary disease (COPD) exacerbation, and pre-existing diagnosis of cystic fibrosis with positive respiratory cultures. Methods: A structured query was used to extract data. For patients started on antibiotics, bacterial pneumonia (bPNA) was determined through chart review. Multivariable models were used to assess associations of PCT level and bPNA with antimicrobial use. Results: Of 793 patients, 224 (28.2%) were initiated on antibiotics: 33 (14.7%) had proven or probable bPNA, 125 (55.8%) had possible bPNA, and 66 (29.5%) had no bPNA. Patients had a mean of 4.1 (SD, ±5.2) PCT measurements if receiving antibiotics versus a mean of 2.0 (SD, ±2.6) if not. Initial PCT level was highest for those with proven/probable bPNA and was associated with antibiotic initiation (odds ratio 95% confidence interval [CI], 1.17-1.30). Initial PCT (rate ratio [RR] 95% CI, 1.01-1.08), change in PCT over time (RR 95% CI, 1.01-1.05), and bPNA group (RR 95% CI, 1.23-1.84) were associated with antibiotic duration. Conclusions: PCT trends are associated with the decision to initiate antibiotics and duration of treatment, independent of bPNA status and comorbidities. Prospective studies are needed to determine whether PCT level can be used to safely make decisions regarding antibiotic treatment for COVID-19.
MeSH term(s)	Humans ; Adolescent ; Adult ; Procalcitonin ; Retrospective Studies ; COVID-19 ; SARS-CoV-2 ; Anti-Bacterial Agents/therapeutic use ; Pneumonia, Bacterial/drug therapy ; Biomarkers
Chemical Substances	Procalcitonin ; Anti-Bacterial Agents ; Biomarkers
Language	English
Publishing date	2022-11-04
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2022.262
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Zs.A 1714: Show issues

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Article: Medical marijuana in HIV-positive patients: what do we know?

Cinti, Sandro

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)

2009 Volume 8, Issue 6, Page(s) 342–346

Abstract: On November 4, 2008, our state passed the Michigan Medical Marijuana Act (MMMA), which allows the medical use of marijuana for certain conditions and/or constellation of symptoms. This article will (1) review the current evidence that medical marijuana ... ...

Abstract	On November 4, 2008, our state passed the Michigan Medical Marijuana Act (MMMA), which allows the medical use of marijuana for certain conditions and/or constellation of symptoms. This article will (1) review the current evidence that medical marijuana is useful for certain chronic conditions, particularly pain and wasting syndromes experienced by HIV-positive people; (2) discuss the adverse effects of marijuana; (3) summarize the new Michigan law and the challenges it poses for physicians, and (4) review the experience in California where medical marijuana has been legal since 1996.
MeSH term(s)	California ; Cannabis/adverse effects ; Cannabis/drug effects ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Wasting Syndrome/drug therapy ; Humans ; Legislation, Drug ; Marijuana Smoking/adverse effects ; Mental Disorders/chemically induced ; Michigan ; Pain/drug therapy ; Pain/etiology ; Phytotherapy/adverse effects
Language	English
Publishing date	2009-11
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1545-1097
ISSN	1545-1097
DOI	10.1177/1545109709351167
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ordering Stains That Aren't Indicated.

Magers, Martin J / Cinti, Sandro K

AMA journal of ethics

2016 Volume 18, Issue 8, Page(s) 793–799

Abstract: The pathologist rarely interacts with patients face-to-face, but he or she nonetheless maintains a crucial relationship with the patient (i.e., the patient-pathologist relationship). A more tangible relationship, the pathologist-clinician relationship, ... ...

Abstract	The pathologist rarely interacts with patients face-to-face, but he or she nonetheless maintains a crucial relationship with the patient (i.e., the patient-pathologist relationship). A more tangible relationship, the pathologist-clinician relationship, is typically augmented by the patient-pathologist relationship, but at times the two distinct relationships are at odds, creating ethical dilemmas for the pathologist. This case study and discussion highlight some of these potential ethical questions and underscore the need for pathologists and clinicians to have cooperative, collaborative, and professional relationships. Pathologists should feel empowered to guide the clinician's use of appropriate clinical testing to ensure proper management of the patient and responsible use of health care resources.
MeSH term(s)	Biopsy/economics ; Biopsy/methods ; Coloring Agents/economics ; Cooperative Behavior ; Cost Control ; Ethics, Medical ; Health Care Costs ; Health Resources ; Humans ; Interprofessional Relations ; Pathologists/ethics ; Pathology, Clinical/ethics ; Pathology, Clinical/methods ; Physician-Patient Relations
Chemical Substances	Coloring Agents
Language	English
Publishing date	2016-08-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	2376-6980
ISSN (online)	2376-6980
DOI	10.1001/journalofethics.2016.18.8.ecas5-1608
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Article ; Online: Ocular cytomegalovirus infection: a challenging diagnosis.

Cinti, Sandro

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

2008 Volume 28, Issue 2, Page(s) 91–92

MeSH term(s)	Antigens, Viral/analysis ; Antigens, Viral/blood ; Antigens, Viral/cerebrospinal fluid ; Antiviral Agents/therapeutic use ; Biopsy ; Cytomegalovirus Retinitis/diagnosis ; Cytomegalovirus Retinitis/immunology ; Cytomegalovirus Retinitis/therapy ; Decision Support Techniques ; Diagnosis, Differential ; Ganciclovir/therapeutic use ; Humans ; Immunocompromised Host/immunology ; Optic Nerve/pathology ; Optic Nerve/physiopathology ; Optic Nerve/virology ; Optic Neuritis/diagnosis ; Optic Neuritis/immunology ; Optic Neuritis/therapy ; Predictive Value of Tests ; RNA, Viral/analysis ; RNA, Viral/blood
Chemical Substances	Antigens, Viral ; Antiviral Agents ; RNA, Viral ; Ganciclovir (P9G3CKZ4P5)
Language	English
Publishing date	2008-06
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	1189901-3
ISSN	1536-5166 ; 1070-8022
ISSN (online)	1536-5166
ISSN	1070-8022
DOI	10.1097/WNO.0b013e31817728da
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Zs.A 1670: Show issues

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Article ; Online: Human Disease due to Mycobacterium bovis Linked to Free-Ranging Deer in Michigan.

Sunstrum, James / Power, Laura E / Fligiel, Helene M / Lauter, Carl / Kawam, Rayanah / Dado, Christopher / Weatherhead, Matthew / Denbesten, Karen / Bott, Jonathan / Cinti, Sandro / Maxwell, Daniel / Signs, Kimberly / Stobierski, Mary Grace / Cosgrove, Melinda / Moriarty, Megan / Vanderklok, Michael / Meyerson, Joshua / Thacker, Tyler / Robbe-Austerman, Suelee

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2024 Volume 78, Issue 3, Page(s) 637–645

Abstract: Background: A unique enzootic focus of Mycobacterium bovis in free-ranging deer was identified in northern lower Michigan in 1994, with subsequent evidence of transmission to local cattle herds. Between 2002 and 2017, 3 Michigan deer hunters with M. ... ...

Abstract	Background: A unique enzootic focus of Mycobacterium bovis in free-ranging deer was identified in northern lower Michigan in 1994, with subsequent evidence of transmission to local cattle herds. Between 2002 and 2017, 3 Michigan deer hunters with M. bovis disease were previously reported. We present 4 additional human cases linked to the zoonotic focus in deer, utilizing genomic epidemiology to confirm close molecular associations among human, deer and cattle M. bovis isolates. Methods: Identification of human tuberculosis (TB) cases with cultures of M. bovis was provided from the Michigan Department of Health and Human Services (MDHHS) tuberculosis database. Clinical review and interviews focused on risk factors for contact with wildlife and cattle. Whole genome sequences of human isolates were compared with a veterinary library of M. bovis strains to identify those linked to the enzootic focus. Results: Three confirmed and 1 probable human case with M. bovis disease were identified between 2019 and 2022, including cutaneous disease, 2 severe pulmonary disease cases, and human-to-human transmission. The 3 human isolates had 0-3 single-nucleotide polymorphisms (SNPs) with M. bovis strains circulating in wild deer and domestic cattle in Michigan. Conclusions: Spillover of enzootic M. bovis from deer to humans and cattle continues to occur in Michigan. Future studies should examine the routes of transmission and degree of risk to humans through expanded epidemiological surveys. A One Health approach linking human, veterinary and environmental health should address screening for TB infection, public education, and mitigation of transmission.
MeSH term(s)	Animals ; Humans ; Cattle ; Mycobacterium bovis/genetics ; Michigan/epidemiology ; Deer/microbiology ; Tuberculosis/epidemiology ; Tuberculosis/veterinary ; Tuberculosis/prevention & control ; Animals, Wild
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciae009
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 480: Show issues

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Article ; Online: Comorbid status in patients with osteomyelitis is associated with long-term incidence of extremity amputation.

Schmidt, Brian M / Keeney-Bonthrone, Toby P / Hawes, Armani M / Karmakar, Monika / Frydrych, Lynn M / Cinti, Sandro K / Pop-Busui, Rodica / Delano, Matthew J

BMJ open diabetes research & care

2023 Volume 11, Issue 6

Abstract: Introduction: Osteomyelitis is associated with significant morbidity, including amputation. There are limited data on long-term amputation rates following an osteomyelitis diagnosis. We sought to determine the incidence of amputation in patients with ... ...

Abstract	Introduction: Osteomyelitis is associated with significant morbidity, including amputation. There are limited data on long-term amputation rates following an osteomyelitis diagnosis. We sought to determine the incidence of amputation in patients with osteomyelitis over 2 years. Research design and methods: Observational cohort study of 1186 inpatients with osteomyelitis between 2004 and 2015 and stratified by osteomyelitis location status to evaluate the impact on amputation, mortality rates, readmission data, and inpatient days. Results: Persons with diabetes had 3.65 times greater probability of lower extremity amputation (p<0.001), readmission (p<0.001), and longer inpatient stay (p<0.001) and had higher 2-year mortality (relative risk (RR) 1.23, p=0.0027), adjusting for risk factors. Male gender (RR 1.57, p<0.001), black race (RR 1.41, p<0.05), former smoking status (RR 1.38, p<0.01), myocardial infarction (RR 1.72, p<0.001), congestive heart failure (RR 1.56, p<0.001), peripheral vascular disease (RR 2.25, p<0.001) and renal disease (RR 1.756, p<0.001) were independently associated with amputation. Male gender (RR 1.39, p<0.01), black race (RR 1.27, p<0.05), diabetes (RR 2.77, p<0.001) and peripheral vascular disease (RR 1.59, p<0.001) had increased risk of lower, not upper, extremity amputation. Conclusions: Patients with osteomyelitis have higher rates of amputation and hospitalization. Clinicians must incorporate demographic and comorbid risk factors to protect against amputation.
MeSH term(s)	Humans ; Male ; Amputation, Surgical ; Diabetic Foot/diagnosis ; Extremities/surgery ; Incidence ; Osteomyelitis/complications ; Osteomyelitis/epidemiology ; Osteomyelitis/surgery ; Peripheral Vascular Diseases/complications ; Female
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2732918-5
ISSN	2052-4897 ; 2052-4897
ISSN (online)	2052-4897
ISSN	2052-4897
DOI	10.1136/bmjdrc-2023-003611
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Article: Medical Versus Interventional Treatment of Intra-Abdominal Abscess in Patients With Crohn Disease.

Graham, Emily / Rao, Krishna / Cinti, Sandro

Infectious diseases

2017 Volume 10, Page(s) 1179916117701736

Abstract: Background: Few studies exist to guide the treatment approach to intra-abdominal abscesses in Crohn disease, which can include antimicrobials alone or in conjunction with percutaneous drainage or surgery. The primary aim of this study is to review ... ...

Abstract	Background: Few studies exist to guide the treatment approach to intra-abdominal abscesses in Crohn disease, which can include antimicrobials alone or in conjunction with percutaneous drainage or surgery. The primary aim of this study is to review outcomes from different treatment approaches to intra-abdominal abscess in Crohn disease. Methods: Medical records were reviewed for patients admitted to the University of Michigan health care system with Crohn disease and intra-abdominal abscess over a 4-year period. Outcomes were compared among medical and interventional approaches. The χ Results: Of the 33 patients included, 13 were in the medical group and 20 were in the interventional group. Abscess recurrence/nonresolution occurred in 31% of patients in the medical group and 25% of patients in the interventional group ( Conclusions: In this study, there was no significant difference in outcome between medical and interventional therapy for intra-abdominal abscess in Crohn disease.
Language	English
Publishing date	2017-04-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2551443-X
ISSN	1178-6337
ISSN	1178-6337
DOI	10.1177/1179916117701736
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Article: Clostridioides difficile

Ulrich, Robert J / Bott, Jonathan / Imlay, Hannah / Lopez, Kerri / Cinti, Sandro / Rao, Krishna

Open forum infectious diseases

2019 Volume 6, Issue 11, Page(s) ofz409

Abstract: Objective: Clostridioides difficile: Methods: We retrospectively analyzed all total colectomy patients over a 20-year period at our institution. : Results: C. difficile: Conclusions: C. ... ...

Abstract	Objective: Clostridioides difficile Methods: We retrospectively analyzed all total colectomy patients over a 20-year period at our institution. Results: C. difficile Conclusions: C. difficile
Language	English
Publishing date	2019-10-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofz409
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Article: Pandemic influenza: are we ready?

Cinti, Sandro

Disaster management & response : DMR : an official publication of the Emergency Nurses Association

2004 Volume 3, Issue 3, Page(s) 61–67

Abstract: An influenza pandemic is inevitable, and the H5N1 avian influenza outbreak in Southeast Asia has heightened concern that a disaster is imminent. Pandemic preparations are beginning around the world, and it is important for first responders, particularly ... ...

Abstract	An influenza pandemic is inevitable, and the H5N1 avian influenza outbreak in Southeast Asia has heightened concern that a disaster is imminent. Pandemic preparations are beginning around the world, and it is important for first responders, particularly disaster management personnel, to understand the difference between pandemic and epidemic influenza preparedness. This article will focus on distinguishing between an influenza epidemic and an influenza pandemic and, in light of these distinctions, how to manage the next pandemic with limited resources, particularly the absence of vaccine.
MeSH term(s)	Adolescent ; Adult ; Aged ; Antigenic Variation ; Antiviral Agents/economics ; Antiviral Agents/therapeutic use ; Child ; Child, Preschool ; Communicable Diseases, Emerging/prevention & control ; Disaster Planning/economics ; Disaster Planning/methods ; Disease Outbreaks/prevention & control ; Disease Transmission, Infectious/prevention & control ; Female ; Global Health ; History, 20th Century ; Humans ; Infant ; Infant, Newborn ; Infection Control/economics ; Infection Control/methods ; Influenza A virus/genetics ; Influenza Vaccines/economics ; Influenza Vaccines/supply & distribution ; Influenza, Human/epidemiology ; Influenza, Human/history ; Influenza, Human/transmission ; Male ; Middle Aged ; Population Surveillance/methods ; Pregnancy
Chemical Substances	Antiviral Agents ; Influenza Vaccines
Keywords	covid19
Language	English
Publishing date	2004-11-24
Publishing country	United States
Document type	Historical Article ; Journal Article ; Review
ZDB-ID	2098440-6
ISSN	1540-2487
ISSN	1540-2487
DOI	10.1016/j.dmr.2005.05.002
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