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Article ; Online: Keeping an eye on the many symptoms of COVID-19.

Ozates, Serdar / Bostanci Ceran, Basak

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2021 Volume 259, Issue 9, Page(s) 2865–2866

MeSH term(s)	COVID-19/diagnosis ; COVID-19/physiopathology ; Humans
Language	English
Publishing date	2021-02-24
Publishing country	Germany
Document type	Letter
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-021-05125-z
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Article ; Online: Ocular manifestations of coronavirus disease 2019.

Bostanci Ceran, Basak / Ozates, Serdar

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2020 Volume 258, Issue 9, Page(s) 1959–1963

Abstract: Purpose: Coronavirus disease 2019 (COVID-19) is an ongoing global public health problem, and most of the COVID-19 research is focused mainly on the respiratory system because of life-threatening results. However, manifestations in other organs should ... ...

Abstract	Purpose: Coronavirus disease 2019 (COVID-19) is an ongoing global public health problem, and most of the COVID-19 research is focused mainly on the respiratory system because of life-threatening results. However, manifestations in other organs should not be ignored since they can also be a mode of transmission. We sought to describe the ocular manifestations of COVID-19 and investigate the association between ocular involvement and clinical presentation and laboratory outcomes. Methods: This cross-sectional study was conducted between March 1, 2020, and April 30, 2020. Ninety-three sequentially hospitalized and clinically confirmed COVID-19 patients were included in the study. The systemic and ocular symptoms, clinical findings, and laboratory outcomes were recorded. Results: Of the 93 COVID-19 patients, 54 (58.1%) were male, and 39 (41.9%) were female. Mean age of the patients was 39.4 ± 21.9 (min 7, max 88) years. Twenty patients (n 21.5%) had at least one ocular abnormality. Most common findings included hyperemia (n = 20), epiphora (n = 9), increased secretion (n = 6), chemosis (n = 3), follicular conjunctivitis (n = 2), and episcleritis (n = 2). The most common symptom was photophobia (n 15). Patients with ocular involvement were more likely to have higher neutrophil counts (p = 0.001), and increased CRP (p < 0.001), PCT (p = 0.001), and ESR levels (p < 0.001). Mean lymphocyte count was statistically lower in patients with ocular manifestations (p = 0.001). Mean age and number of patients with fever over 37.3 °C in the ocular involvement group was found to be higher (p < 0.001, p = 0.006, respectively). Conclusion: Older age, high fever, increased neutrophil/lymphocyte ratio, and high levels of acute phase reactants seemed to be risk factors for ocular involvement.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Betacoronavirus ; COVID-19 ; Child ; Conjunctivitis, Viral/diagnosis ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Cross-Sectional Studies ; Eye Infections, Viral/diagnosis ; Female ; Humans ; Hyperemia/diagnosis ; Lacrimal Apparatus Diseases/diagnosis ; Lymphocyte Count ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Real-Time Polymerase Chain Reaction ; SARS-CoV-2 ; Scleritis/diagnosis ; Turkey/epidemiology ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-06-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-020-04777-7
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Article ; Online: Comment on: Safety of phakic intraocular collamer lens implantation in 95 highly myopic special-needs children.

Ceran, Basak Bostanci / Yusuf, Imran H / Karim, Rushmia / Tassignon, Marie-José

Journal of cataract and refractive surgery

2021 Volume 47, Issue 12, Page(s) 1605–1606

MeSH term(s)	Child ; Humans ; Myopia/surgery ; Phakic Intraocular Lenses
Language	English
Publishing date	2021-10-20
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	632744-8
ISSN	1873-4502 ; 0886-3350
ISSN (online)	1873-4502
ISSN	0886-3350
DOI	10.1097/j.jcrs.0000000000000852
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Article ; Online: Changes in Limbal Optical Coherence Tomography Angiography Outcomes in Patients With Overnight Contact Lens Wear.

Bostanci Ceran, Basak / Ozates, Serdar / Arifoglu, Hasan Basri / Tasindi, Emrullah

Eye & contact lens

2021 Volume 47, Issue 10, Page(s) 552–554

Abstract: Objectives: To evaluate the perilimbal vasculature of patients who wear contact lenses (CLs) overnight with optical coherence tomography angiography (OCTA) and compare the results with healthy population.: Methods: Forty-two patients were included in ...

Abstract	Objectives: To evaluate the perilimbal vasculature of patients who wear contact lenses (CLs) overnight with optical coherence tomography angiography (OCTA) and compare the results with healthy population. Methods: Forty-two patients were included in this observational study. The OCTA imaging was performed in the temporal quadrant of the perilimbal region using a swept-source optical coherence tomography system (Triton DRI-OCT; Topcon Corporation, Tokyo, Japan). The assessments were made in two depths: starting from the conjunctival epithelium to 200 μm scleral depth and the scleral depth between 200 and 1,000 μm. The vessel density, vessel length density, vessel diameter index, and fractal dimension were the main outcomes and compared between overnight CL users and healthy population. Results: Twenty-two patients who have been using CLs overnight for at least 3 months and 20 healthy individuals were included in the study. The vessel density at the superficial layer was significantly higher in the CL group compared with the control group (P<0.001). Vessel diameter index, vessel length density, and fractal dimension at the superficial layer did not differ between the groups (P>0.05 for all). There was no difference in the vessel density, vessel diameter index, vessel length density, and fractal dimension in the deep layer between the groups (P>0.05 for all). Conclusions: Patients who use CL overnight exhibit increased vessel density in the superficial layers of the perilimbal region, which may suggest new vessel formation in the conjunctiva. Anterior segment OCTA may be useful to evaluate the initial changes in limbal vasculature in CL users.
MeSH term(s)	Conjunctiva/diagnostic imaging ; Contact Lenses ; Fluorescein Angiography ; Humans ; Sclera ; Tomography, Optical Coherence
Language	English
Publishing date	2021-09-20
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	2103049-2
ISSN	1542-233X ; 1542-2321
ISSN (online)	1542-233X
ISSN	1542-2321
DOI	10.1097/ICL.0000000000000819
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Article ; Online: Airborne pathogen projection during ophthalmic examination.

Bostanci Ceran, Basak / Karakoç, Alp / Taciroğlu, Ertuğrul

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2020 Volume 258, Issue 10, Page(s) 2275–2282

Abstract: Purpose: Microscale droplets act as coronaviruses (CoV) carriers in the air when released from an infected person and may infect others during close contact such as ophthalmic examination. The main objective of the present work is to demonstrate how CoV ...

Abstract	Purpose: Microscale droplets act as coronaviruses (CoV) carriers in the air when released from an infected person and may infect others during close contact such as ophthalmic examination. The main objective of the present work is to demonstrate how CoV deposited droplets are projected during biomicroscopy and to discuss what kind of precautions should be taken in ophthalmic practice. Methods: A coupled fluid-structure system comprising smoothed particle hydrodynamics and the finite element method has been built to assess the projection of droplets spreading from an infected person. Different conditions based on the maximum exit flow velocity from the infector's mouth during the ophthalmic examination were modeled. Results: During exhalation, for which the exit flow is ~ 1000 mm/s, the average horizontal distance of the flow front was ~ 200 mm while individual particles can reach up to ~ 500 mm. In case of coughing or sneezing (corresponding to an exit flow of ~ 12,000 mm/s), the average horizontal distance of the flow front was ~ 1300 mm. Conclusion: During the ophthalmic examination, the proximity to the patient's nose and mouth was observed to be less than the horizontal distance of flow front particles. Even though mounted breath shields are used, particles flew beyond the shield and contaminate the ophthalmologist. Compared with the current protective breath shields, the use of a larger shield with a minimum radius of 18 cm is needed to decrease viral transmission.
MeSH term(s)	Aerosols ; Air Microbiology ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Eye Diseases/diagnosis ; Humans ; Infection Control/methods ; Inhalation Exposure/prevention & control ; Pandemics/prevention & control ; Particle Size ; Particulate Matter ; Physical Examination ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; Rheology/methods ; SARS-CoV-2 ; Slit Lamp ; Slit Lamp Microscopy
Chemical Substances	Aerosols ; Particulate Matter
Keywords	covid19
Language	English
Publishing date	2020-06-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-020-04815-4
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Article: Ocular manifestations of coronavirus disease 2019

Bostanci Ceran, Basak / Ozates, Serdar

Graefes Arch Clin Exp Ophthalmol

Abstract: PURPOSE: Coronavirus disease 2019 (COVID-19) is an ongoing global public health problem, and most of the COVID-19 research is focused mainly on the respiratory system because of life-threatening results. However, manifestations in other organs should not ...

Abstract	PURPOSE: Coronavirus disease 2019 (COVID-19) is an ongoing global public health problem, and most of the COVID-19 research is focused mainly on the respiratory system because of life-threatening results. However, manifestations in other organs should not be ignored since they can also be a mode of transmission. We sought to describe the ocular manifestations of COVID-19 and investigate the association between ocular involvement and clinical presentation and laboratory outcomes. METHODS: This cross-sectional study was conducted between March 1, 2020, and April 30, 2020. Ninety-three sequentially hospitalized and clinically confirmed COVID-19 patients were included in the study. The systemic and ocular symptoms, clinical findings, and laboratory outcomes were recorded. RESULTS: Of the 93 COVID-19 patients, 54 (58.1%) were male, and 39 (41.9%) were female. Mean age of the patients was 39.4 ± 21.9 (min 7, max 88) years. Twenty patients (n 21.5%) had at least one ocular abnormality. Most common findings included hyperemia (n = 20), epiphora (n = 9), increased secretion (n = 6), chemosis (n = 3), follicular conjunctivitis (n = 2), and episcleritis (n = 2). The most common symptom was photophobia (n 15). Patients with ocular involvement were more likely to have higher neutrophil counts (p = 0.001), and increased CRP (p < 0.001), PCT (p = 0.001), and ESR levels (p < 0.001). Mean lymphocyte count was statistically lower in patients with ocular manifestations (p = 0.001). Mean age and number of patients with fever over 37.3 °C in the ocular involvement group was found to be higher (p < 0.001, p = 0.006, respectively). CONCLUSION: Older age, high fever, increased neutrophil/lymphocyte ratio, and high levels of acute phase reactants seemed to be risk factors for ocular involvement.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #531144
Database	COVID19

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Article: Airborne pathogen projection during ophthalmic examination

Bostanci Ceran, Basak / Karakoç, Alp / Taciroglu, Ertugrul

Graefes Arch Clin Exp Ophthalmol

Abstract: PURPOSE: Microscale droplets act as coronaviruses (CoV) carriers in the air when released from an infected person and may infect others during close contact such as ophthalmic examination. The main objective of the present work is to demonstrate how CoV ... ...

Abstract	PURPOSE: Microscale droplets act as coronaviruses (CoV) carriers in the air when released from an infected person and may infect others during close contact such as ophthalmic examination. The main objective of the present work is to demonstrate how CoV deposited droplets are projected during biomicroscopy and to discuss what kind of precautions should be taken in ophthalmic practice. METHODS: A coupled fluid-structure system comprising smoothed particle hydrodynamics and the finite element method has been built to assess the projection of droplets spreading from an infected person. Different conditions based on the maximum exit flow velocity from the infector's mouth during the ophthalmic examination were modeled. RESULTS: During exhalation, for which the exit flow is ~ 1000 mm/s, the average horizontal distance of the flow front was ~ 200 mm while individual particles can reach up to ~ 500 mm. In case of coughing or sneezing (corresponding to an exit flow of ~ 12,000 mm/s), the average horizontal distance of the flow front was ~ 1300 mm. CONCLUSION: During the ophthalmic examination, the proximity to the patient's nose and mouth was observed to be less than the horizontal distance of flow front particles. Even though mounted breath shields are used, particles flew beyond the shield and contaminate the ophthalmologist. Compared with the current protective breath shields, the use of a larger shield with a minimum radius of 18 cm is needed to decrease viral transmission.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #614119
Database	COVID19

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Article ; Online: Atypical case of ocular hemosiderosis: leopard cataract.

Masket, Samuel / Ceran, Basak Bostanci

Journal of cataract and refractive surgery

2011 Volume 37, Issue 10, Page(s) 1902–1904

Abstract: Unlabelled: We present an interventional case report of an 83-year-old woman who developed ocular hemosiderosis secondary to massive retinal and intravitreal bleeding associated with a choroidal neovascular membrane as a result of age-related macular ... ...

Abstract	Unlabelled: We present an interventional case report of an 83-year-old woman who developed ocular hemosiderosis secondary to massive retinal and intravitreal bleeding associated with a choroidal neovascular membrane as a result of age-related macular degeneration. Anterior segment manifestations included low-grade inflammation, posterior synechiae, reversible hyperchromic heterochromia, and a mature cataract with "leopard spots." The longstanding vitreous hemorrhage was thought to be the etiology of these findings. At the request of the vitreoretinal surgeon, cataract surgery was performed to provide visualization of the posterior segment. However, the patient's visual potential was limited by her underlying retinal pathology. Financial disclosure: Neither author has a financial or proprietary interest in any material or method mentioned. Additional disclosure is found in the footnotes.
MeSH term(s)	Aged, 80 and over ; Cataract/diagnosis ; Cataract/etiology ; Combined Modality Therapy ; Female ; Glucocorticoids/therapeutic use ; Hemosiderosis/diagnosis ; Hemosiderosis/etiology ; Humans ; Lens Capsule, Crystalline/pathology ; Phacoemulsification ; Photochemotherapy ; Retinal Detachment/etiology ; Retinal Detachment/surgery ; Retinal Hemorrhage/complications ; Triamcinolone Acetonide/therapeutic use ; Vitreous Hemorrhage/complications ; Wet Macular Degeneration/complications ; Wet Macular Degeneration/diagnosis ; Wet Macular Degeneration/drug therapy
Chemical Substances	Glucocorticoids ; Triamcinolone Acetonide (F446C597KA)
Language	English
Publishing date	2011-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	632744-8
ISSN	1873-4502 ; 0886-3350
ISSN (online)	1873-4502
ISSN	0886-3350
DOI	10.1016/j.jcrs.2011.07.024
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Article ; Online: Retinal pigment epithelium tear formation following intravitreal ranibizumab injection in choroidal neovascularization secondary to choroidal osteoma.

Erol, Muhammet K / Coban, Deniz Turgut / Ceran, Basak Bostanci / Bulut, Mehmet

Cutaneous and ocular toxicology

2014 Volume 33, Issue 3, Page(s) 259–263

Abstract: Choroidal osteoma is an extremely rare osseous tumor of the choroid where choroidal neovascularization (CNV) is the major cause of visual loss. We report the case of a 28-year-old female with CNV secondary to choroidal osteoma, who developed RPE tear ... ...

Abstract	Choroidal osteoma is an extremely rare osseous tumor of the choroid where choroidal neovascularization (CNV) is the major cause of visual loss. We report the case of a 28-year-old female with CNV secondary to choroidal osteoma, who developed RPE tear after intravitreal ranibizumab treatment.
MeSH term(s)	Adult ; Angiogenesis Inhibitors/administration & dosage ; Angiogenesis Inhibitors/adverse effects ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/adverse effects ; Choristoma/complications ; Choristoma/drug therapy ; Choristoma/pathology ; Choroid Neoplasms/complications ; Choroid Neoplasms/drug therapy ; Choroid Neoplasms/pathology ; Choroidal Neovascularization/drug therapy ; Choroidal Neovascularization/pathology ; Female ; Humans ; Intravitreal Injections/adverse effects ; Osteoma/complications ; Osteoma/drug therapy ; Osteoma/pathology ; Ranibizumab ; Retinal Perforations/etiology ; Retinal Pigment Epithelium/pathology
Chemical Substances	Angiogenesis Inhibitors ; Antibodies, Monoclonal, Humanized ; Ranibizumab (ZL1R02VT79)
Language	English
Publishing date	2014-09
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	605635-0
ISSN	1556-9535 ; 1556-9527 ; 0731-3829
ISSN (online)	1556-9535
ISSN	1556-9527 ; 0731-3829
DOI	10.3109/15569527.2013.844702
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Article ; Online: Comparison of tear osmolarity and ocular comfort between daily disposable contact lenses: hilafilcon B hydrogel versus narafilcon A silicone hydrogel.

Sarac, Ozge / Gurdal, Canan / Bostancı-Ceran, Basak / Can, Izzet

International ophthalmology

2012 Volume 32, Issue 3, Page(s) 229–233

Abstract: The aim of this study was to evaluate tear osmolarity and ocular comfort with two different types of hydrogel daily disposable lenses. The right eyes of 15 first-time contact lens users were included in this prospective study. All eyes wore hilafilcon B ... ...

Abstract	The aim of this study was to evaluate tear osmolarity and ocular comfort with two different types of hydrogel daily disposable lenses. The right eyes of 15 first-time contact lens users were included in this prospective study. All eyes wore hilafilcon B silicone hydrogel contact lenses for 8 h (group 1). After 1 week without contact lenses, all eyes wore narafilcon A silicone hydrogel contact lenses for 8 h (group 2). Tear osmolarity measurement was performed before and after 4 and 8 h of each contact lens wear. Ocular comfort was assessed after 4 and 8 h of each contact lens wear. In group 1, the mean baseline, 4- and 8-h tear osmolarity values were 293 ± 10.57, 303.00 ± 10.5 mOsm/L (p = 0.023), and 295.0 ± 1.4 mOsm/L (p > 0.05), respectively. In group 2, the mean baseline, 4- and 8-h tear osmolarity values were 294 ± 13.65, 300.9 ± 11.3 mOsm/L (p = 0.007), and 298.80 ± 7.2 mOsm/L (p > 0.05), respectively. In group 1, the mean comfort score was 7.20 ± 0.45 and 8.60 ± 0.45 at 4 and 8 h, respectively (p = 0.038). In group 2, the mean comfort score significantly decreased from 9.80 ± 0.45 to 7.80 ± 0.84 at 4 h (p = 0.039). Both hydrogel and silicone hydrogel daily disposable contact lenses elevated tear osmolarity during 8 h of contact lens wear. The increase in tear osmolarity with both contact lenses was below the cut-off value for dry eye and was not associated with ocular comfort.
MeSH term(s)	Adult ; Contact Lenses, Hydrophilic ; Disposable Equipment ; Female ; Humans ; Hydrogel, Polyethylene Glycol Dimethacrylate ; Male ; Middle Aged ; Osmolar Concentration ; Patient Satisfaction ; Prospective Studies ; Silicone Elastomers ; Tears/chemistry ; Young Adult
Chemical Substances	Silicone Elastomers ; Hydrogel, Polyethylene Glycol Dimethacrylate (25852-47-5)
Language	English
Publishing date	2012-04-07
Publishing country	Netherlands
Document type	Comparative Study ; Evaluation Study ; Journal Article
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-012-9556-y
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