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Article ; Online: K

Fujii, Naoto / McGarr, Gregory W / McNeely, Brendan D / Ichinose, Masashi / Nishiyasu, Takeshi / Kenny, Glen P

2019 Volume 866, Page(s) 172828

Abstract: The venoarteriolar reflex is a local mechanism that induces vasoconstriction during venous congestion in various tissues, including skin. This response is thought to play a critical role in minimizing capillary damage or edema resulting from ... ...

Abstract	The venoarteriolar reflex is a local mechanism that induces vasoconstriction during venous congestion in various tissues, including skin. This response is thought to play a critical role in minimizing capillary damage or edema resulting from overperfusion, though factors that modulate this response remain largely unknown. Here, we hypothesized that nitric oxide synthase (NOS), cyclooxygenase (COX), and Ca
MeSH term(s)	Adult ; Arterioles/physiology ; Humans ; KATP Channels/metabolism ; Male ; Nitric Oxide Synthase/metabolism ; Potassium Channels, Calcium-Activated/metabolism ; Potassium Channels, Voltage-Gated/metabolism ; Prostaglandin-Endoperoxide Synthases/metabolism ; Regional Blood Flow ; Skin/blood supply ; Skin/metabolism ; Veins/physiology
Chemical Substances	KATP Channels ; Potassium Channels, Calcium-Activated ; Potassium Channels, Voltage-Gated ; Nitric Oxide Synthase (EC 1.14.13.39) ; Prostaglandin-Endoperoxide Synthases (EC 1.14.99.1)
Language	English
Publishing date	2019-11-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2019.172828
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Article ; Online: The roles of K

Louie, Jeffrey C / Fujii, Naoto / Meade, Robert D / McNeely, Brendan D / Kenny, Glen P

American journal of physiology. Regulatory, integrative and comparative physiology

2017 Volume 312, Issue 5, Page(s) R821–R827

Abstract: We recently showed the varying roles of ... ...

Abstract	We recently showed the varying roles of Ca
MeSH term(s)	Blood Flow Velocity/physiology ; Exercise/physiology ; Heat-Shock Response/physiology ; Humans ; KATP Channels/metabolism ; Male ; Potassium Channels/metabolism ; Potassium Channels, Calcium-Activated/metabolism ; Potassium Channels, Voltage-Gated/metabolism ; Regional Blood Flow/physiology ; Skin/blood supply ; Skin Physiological Phenomena ; Sweating/physiology ; Vasodilation/physiology ; Young Adult
Chemical Substances	KATP Channels ; Potassium Channels ; Potassium Channels, Calcium-Activated ; Potassium Channels, Voltage-Gated
Language	English
Publishing date	2017-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603839-6
ISSN	1522-1490 ; 0363-6119
ISSN (online)	1522-1490
ISSN	0363-6119
DOI	10.1152/ajpregu.00507.2016
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Article ; Online: Slow inactivation in Shaker K channels is delayed by intracellular tetraethylammonium.

González-Pérez, Vivian / Neely, Alan / Tapia, Christian / González-Gutiérrez, Giovanni / Contreras, Gustavo / Orio, Patricio / Lagos, Verónica / Rojas, Guillermo / Estévez, Tania / Stack, Katherine / Naranjo, David

The Journal of general physiology

2008 Volume 132, Issue 6, Page(s) 633–650

Abstract: After removal of the fast N-type inactivation gate, voltage-sensitive Shaker (Shaker IR) K channels ... a constriction of the external mouth of the channel pore that prevents K(+) ion conduction. This constriction is ... IR K channels is poorly dependent on external TEA but severely delayed by internal TEA. Based ...

Abstract	After removal of the fast N-type inactivation gate, voltage-sensitive Shaker (Shaker IR) K channels are still able to inactivate, albeit slowly, upon sustained depolarization. The classical mechanism proposed for the slow inactivation observed in cell-free membrane patches--the so called C inactivation--is a constriction of the external mouth of the channel pore that prevents K(+) ion conduction. This constriction is antagonized by the external application of the pore blocker tetraethylammonium (TEA). In contrast to C inactivation, here we show that, when recorded in whole Xenopus oocytes, slow inactivation kinetics in Shaker IR K channels is poorly dependent on external TEA but severely delayed by internal TEA. Based on the antagonism with internally or externally added TEA, we used a two-pulse protocol to show that half of the channels inactivate by way of a gate sensitive to internal TEA. Such gate had a recovery time course in the tens of milliseconds range when the interpulse voltage was -90 mV, whereas C-inactivated channels took several seconds to recover. Internal TEA also reduced gating charge conversion associated to slow inactivation, suggesting that the closing of the internal TEA-sensitive inactivation gate could be associated with a significant amount of charge exchange of this type. We interpreted our data assuming that binding of internal TEA antagonized with U-type inactivation (Klemic, K.G., G.E. Kirsch, and S.W. Jones. 2001. Biophys. J. 81:814-826). Our results are consistent with a direct steric interference of internal TEA with an internally located slow inactivation gate as a "foot in the door" mechanism, implying a significant functional overlap between the gate of the internal TEA-sensitive slow inactivation and the primary activation gate. But, because U-type inactivation is reduced by channel opening, trapping the channel in the open conformation by TEA would also yield to an allosteric delay of slow inactivation. These results provide a framework to explain why constitutively C-inactivated channels exhibit gating charge conversion, and why mutations at the internal exit of the pore, such as those associated to episodic ataxia type I in hKv1.1, cause severe changes in inactivation kinetics.
MeSH term(s)	Allosteric Site/drug effects ; Allosteric Site/physiology ; Animals ; Cytoplasm/metabolism ; Electrophysiology ; Energy Transfer/physiology ; Female ; Ion Channel Gating/drug effects ; Ion Channel Gating/physiology ; Kv1.4 Potassium Channel/drug effects ; Kv1.4 Potassium Channel/genetics ; Kv1.4 Potassium Channel/metabolism ; Membrane Potentials ; Mice ; Oocytes ; Potassium/metabolism ; Potassium Channel Blockers/metabolism ; Potassium Channel Blockers/pharmacology ; Protein Interaction Domains and Motifs/drug effects ; Protein Interaction Domains and Motifs/genetics ; Structure-Activity Relationship ; Tetraethylammonium/metabolism ; Tetraethylammonium/pharmacology ; Thermodynamics ; Xenopus laevis
Chemical Substances	Kv1.4 Potassium Channel ; Potassium Channel Blockers ; Tetraethylammonium (66-40-0) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2008-11-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3118-5
ISSN	1540-7748 ; 0022-1295
ISSN (online)	1540-7748
ISSN	0022-1295
DOI	10.1085/jgp.200810057
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Article ; Online: Mechanisms of nicotine-induced cutaneous vasodilation and sweating in young adults: roles for K

Fujii, Naoto / Louie, Jeffrey C / McNeely, Brendan D / Amano, Tatsuro / Nishiyasu, Takeshi / Kenny, Glen P

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

2017 Volume 42, Issue 5, Page(s) 470–478

Abstract: We evaluated the influence of K ...

Abstract	We evaluated the influence of K
Language	English
Publishing date	2017-05
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2236708-1
ISSN	1715-5320 ; 1715-5312
ISSN (online)	1715-5320
ISSN	1715-5312
DOI	10.1139/apnm-2016-0615
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Article ; Online: Prostacyclin does not affect sweating but induces skin vasodilatation to a greater extent in older versus younger women: roles of NO and K

Fujii, Naoto / McNeely, Brendan D / Nishiyasu, Takeshi / Kenny, Glen P

Experimental physiology

2017 Volume 102, Issue 5, Page(s) 578–586

Abstract: ... and calcium-activated potassium (K ...

Abstract	New findings: What is the central question of this study? It remains unknown whether ageing modulates prostacyclin-induced cutaneous vasodilatation in women. What is the main finding and its importance? Prostacyclin induced cutaneous vasodilatation, albeit the magnitude of increase at lower concentrations of prostacyclin was greater in older relative to young women. This response was associated with greater contributions of nitric oxide synthase and calcium-activated potassium channels. Our results suggest that administration of prostacyclin might be an effective therapy to reverse microvascular hypoperfusion, especially in older women. We previously reported that prostacyclin induces cutaneous vasodilatation but not sweating in younger and older men. Furthermore, we demonstrated that nitric oxide synthase and calcium-activated potassium (K
Language	English
Publishing date	2017-05-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1016295-1
ISSN	1469-445X ; 0958-0670
ISSN (online)	1469-445X
ISSN	0958-0670
DOI	10.1113/EP086297
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Article: Influence of base dynamics on the conformational properties of DNA: Observation of static conformational states in rigid duplexes at 77 K.

Neely, Robert K / Jones, Anita C

Journal of the American Chemical Society

2006 Volume 128, Issue 50, Page(s) 15952–15953

Abstract: Time-resolved fluorescence of 2-aminopurine-labeled DNA duplexes at 77 K reveals the relationship ... temperature is not populated in the frozen duplex at 77 K; this geometry is accessed by thermal motion ...

Abstract	Time-resolved fluorescence of 2-aminopurine-labeled DNA duplexes at 77 K reveals the relationship between base dynamics and the conformational heterogeneity that results in the well-known multiexponential fluorescence decay at room temperature. The conformation that exhibits rapid interbase charge transfer at room temperature is not populated in the frozen duplex at 77 K; this geometry is accessed by thermal motion of the bases, it is not a minimum energy structure of the duplex. Three photophysically distinct conformational states persist in the frozen duplex; these are minimum energy structures and do not interconvert at room temperature on the time scale of the 2-aminopurine excited-state lifetime.
MeSH term(s)	Base Sequence ; DNA/chemistry ; Molecular Sequence Data ; Nucleic Acid Conformation ; Spectrometry, Fluorescence ; Temperature
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2006-12-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/ja064390m
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Article ; Online: K+ channel mechanisms underlying cholinergic cutaneous vasodilation and sweating in young humans: roles of KCa, KATP, and KV channels?

Fujii, Naoto / Louie, Jeffrey C / McNeely, Brendan D / Zhang, Sarah Yan / Tran, My-An / Kenny, Glen P

American journal of physiology. Regulatory, integrative and comparative physiology

2016 Volume 311, Issue 3, Page(s) R600–6

Abstract: ... vasodilation and sweating. K(+) channels are thought to play a role in regulating cholinergic cutaneous ... vasodilation and sweating, though which K(+) channels are involved in their regulation remains unclear ... We evaluated the hypotheses that 1) Ca(2+)-activated K(+) (KCa), ATP-sensitive K(+) (KATP), and voltage-gated K ...

Abstract	Acetylcholine released from cholinergic nerves is involved in heat loss responses of cutaneous vasodilation and sweating. K(+) channels are thought to play a role in regulating cholinergic cutaneous vasodilation and sweating, though which K(+) channels are involved in their regulation remains unclear. We evaluated the hypotheses that 1) Ca(2+)-activated K(+) (KCa), ATP-sensitive K(+) (KATP), and voltage-gated K(+) (KV) channels all contribute to cholinergic cutaneous vasodilation; and 2) KV channels, but not KCa and KATP channels, contribute to cholinergic sweating. In 13 young adults (24 ± 5 years), cutaneous vascular conductance (CVC) and sweat rate were evaluated at intradermal microdialysis sites that were continuously perfused with: 1) lactated Ringer (Control), 2) 50 mM tetraethylammonium (KCa channel blocker), 3) 5 mM glybenclamide (KATP channel blocker), and 4) 10 mM 4-aminopyridine (KV channel blocker). At all sites, cholinergic cutaneous vasodilation and sweating were induced by coadministration of methacholine (0.0125, 0.25, 5, 100, and 2,000 mM, each for 25 min). The methacholine-induced increase in CVC was lower with the KCa channel blocker relative to Control at 0.0125 (1 ± 1 vs. 9 ± 6%max) and 5 (2 ± 5 vs. 17 ± 14%max) mM methacholine, whereas it was lower in the presence of KATP (69 ± 7%max) and KV (57 ± 14%max) channel blocker compared with Control (79 ± 6%max) at 100 mM methacholine. Furthermore, methacholine-induced sweating was lower at the KV channel blocker site (0.42 ± 0.17 mg·min(-1)·cm(-2)) compared with Control (0.58 ± 0.15 mg·min(-1)·cm(-2)) at 2,000 mM methacholine. In conclusion, we show that KCa, KATP, and KV channels play a role in cholinergic cutaneous vasodilation, whereas only KV channels contribute to cholinergic sweating in normothermic resting humans.
MeSH term(s)	Acetylcholine/metabolism ; Humans ; Ion Channel Gating/physiology ; KATP Channels/metabolism ; Male ; Potassium Channels, Calcium-Activated/metabolism ; Potassium Channels, Voltage-Gated/metabolism ; Skin/blood supply ; Sweating/physiology ; Vasodilation/physiology ; Young Adult
Chemical Substances	KATP Channels ; Potassium Channels, Calcium-Activated ; Potassium Channels, Voltage-Gated ; Acetylcholine (N9YNS0M02X)
Language	English
Publishing date	2016-07-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603839-6
ISSN	1522-1490 ; 0363-6119
ISSN (online)	1522-1490
ISSN	0363-6119
DOI	10.1152/ajpregu.00249.2016
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Article: Fast-electron transport and heating of solid targets in high-intensity laser interactions measured by K alpha fluorescence.

Martinolli, E / Koenig, M / Baton, S D / Santos, J J / Amiranoff, F / Batani, D / Perelli-Cippo, E / Scianitti, F / Gremillet, L / Mélizzi, R / Decoster, A / Rousseaux, C / Hall, T A / Key, M H / Snavely, R / MacKinnon, A J / Freeman, R R / King, J A / Stephens, R /

Neely, D / Clarke, R J

Physical review. E, Statistical, nonlinear, and soft matter physics

2006 Volume 73, Issue 4 Pt 2, Page(s) 46402

Abstract: ... intensity laser-matter interaction. X-ray K alpha emission spectroscopy with absolute photon counting served ... shifted K alpha emission. Data show a 200 microm fast-electron range in solid Al. The relative intensities ... of spectrally shifted Al K alpha lines imply a mean temperature of a few tens of eV up to a 100 microm depth ...

Abstract	We present experimental results on fast-electron energy deposition into solid targets in ultrahigh intensity laser-matter interaction. X-ray K alpha emission spectroscopy with absolute photon counting served to diagnose fast-electron propagation in multilayered targets. Target heating was measured from ionization-shifted K alpha emission. Data show a 200 microm fast-electron range in solid Al. The relative intensities of spectrally shifted Al K alpha lines imply a mean temperature of a few tens of eV up to a 100 microm depth. Experimental results suggest refluxing of the electron beam at target rear side. They were compared with the predictions of both a collisional Monte Carlo and a collisional-electromagnetic, particle-fluid transport code. The validity of the code modeling of heating in such highly transient conditions is discussed.
Language	English
Publishing date	2006-04
Publishing country	United States
Document type	Journal Article
ISSN	1539-3755
ISSN	1539-3755
DOI	10.1103/PhysRevE.73.046402
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Article: Impact of Fluoroquinolone Susceptibility Suppression on Discharge Prescribing for Acute Uncomplicated Cystitis.

Hayden, Dillon A / White, Bryan P / Neely, Stephen / Bennett, Kiya K

Open forum infectious diseases

2023 Volume 10, Issue 10, Page(s) ofad459

Abstract: Background: Fluoroquinolones (FQs) are associated with adverse effects and increasing resistance. However, uncomplicated cystitis remains a frequent reason for FQ use. Selective reporting involves withholding susceptibilities for select antimicrobial ... ...

Abstract	Background: Fluoroquinolones (FQs) are associated with adverse effects and increasing resistance. However, uncomplicated cystitis remains a frequent reason for FQ use. Selective reporting involves withholding susceptibilities for select antimicrobial agents on microbiology reports, in hopes of dissuading use by providers. The purpose of this study was to investigate the impact of FQ susceptibility suppression on discharge prescribing for hospitalized patients with uncomplicated cystitis. Methods: This retrospective quasi-experimental analysis was conducted among adult patients at a 350-bed academic medical center. Its aim was to compare the incidence of FQ prescribing for cystitis at hospital discharge, one year before and after implementation (1 March 2017-31 March 2019) of a policy to suppress FQ urinary susceptibility results for pansusceptible Results: There was a relative risk reduction of 39% in discharge FQ prescribing when adjusted for discharge team (adjusted risk ratio, 0.61; 95% CI, .40-.93). Almost all FQ use was inappropriate, largely due to organisms' susceptibility to a guideline-preferred agent (n = 61). In multivariate analysis, odds ratios of discharge FQ prescribing were 0.22 (95% CI, .12-.39) for insured patients, 0.43 (95% CI, .21-.86) for patients with antibiotic allergy, and 57.8 (95% CI, 13.7-244) for those receiving inpatient FQ. Discharge from a medicine team was protective against discharge FQ prescribing. Conclusions: With multidisciplinary inpatient medicine services and avoidance of inpatient FQ use, suppression of FQ susceptibilities on pansusceptible urine isolates for
Language	English
Publishing date	2023-09-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofad459
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Article ; Online: Asymmetric Synthesis of Nidulalin A and Nidulaxanthone A: Selective Carbonyl Desaturation Using an Oxoammonium Salt.

Ji, Kaijie / Johnson, Richard P / McNeely, James / Al Faruk, Md / Porco, John A

Journal of the American Chemical Society

2024 Volume 146, Issue 7, Page(s) 4892–4902

Abstract: Nidulaxanthone A is a dimeric, dihydroxanthone natural product that was isolated in 2020 ... ...

Abstract	Nidulaxanthone A is a dimeric, dihydroxanthone natural product that was isolated in 2020 from
MeSH term(s)	Ketones ; Xanthines ; Sodium Chloride ; Dimerization
Chemical Substances	nidulalin A ; Ketones ; Xanthines ; Sodium Chloride (451W47IQ8X)
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c13864
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