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  1. Article ; Online: 圖書館事業與交流／The Relationship of Leadership Development and Learning Organization Dimensions／Connie K. Haley, Yuhfen Diana Wu

    Connie K. Haley, Yuhfen Diana Wu Connie K. Haley, Yuhfen Diana Wu

    Tushuguanxue yu Zixun Kexue, Vol 37, Iss

    2011  Volume 2

    Abstract: This research examined the relationship among learning organization dimensions, leadership development, employee development, and their interactions with two demographic variables (gender and ethnicity) in the context of libraries. The researchers ... ...

    Abstract This research examined the relationship among learning organization dimensions, leadership development, employee development, and their interactions with two demographic variables (gender and ethnicity) in the context of libraries. The researchers conducted a multivariate analysis of the variance to assess the differences by leadership training groups (low training hours vs. high training hours), or by gender; and by workplace training groups (low vs. high), or by ethnicity (white vs. all others) on a linear combination of the seven dimensions of the learning organization. A conclusive summary is provided along with contributive discussion. Implications and contributions to librarians are discussed in addition to future research recommendations. Also included are conclusive final thoughts accompanied by the limitations of this research. 本研究旨在探討美國圖書館界學習型組織，領導智能與員工發展之間的關系，以及它們與兩項人口變量（性別、種族）的相互作用。作者採用線性組合研究了學習型組織的七個範疇，並且使用多變量變異數分析方法來評估領導智能培訓組的差異（培訓時數多寡對比），在職培訓組的差異（培訓時數多寡對比），及種族的差異（白人或其他族裔對比）。除了討論未來研究方向的建議，作者並提供人力資源發展工作者和圖書館員一些啟示。研究最後提出作者的想法及本研究的侷限性。 頁次：146-165
    Keywords Bibliography. Library science. Information resources ; Z
    Language English
    Publishing date 2011-10-01T00:00:00Z
    Publisher National Taiwan Normal University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: New Glaucoma Medications.

    Wu, Connie Mao

    International ophthalmology clinics

    2023  Volume 63, Issue 4, Page(s) 13–21

    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207382-1
    ISSN 1536-9617 ; 0020-8167
    ISSN (online) 1536-9617
    ISSN 0020-8167
    DOI 10.1097/IIO.0000000000000482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Selective Laser Trabeculoplasty.

    Wu, Connie Mao / Chang, Ta Chen

    International ophthalmology clinics

    2023  Volume 63, Issue 4, Page(s) 23–32

    MeSH term(s) Humans ; Trabeculectomy ; Laser Therapy ; Lasers
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 207382-1
    ISSN 1536-9617 ; 0020-8167
    ISSN (online) 1536-9617
    ISSN 0020-8167
    DOI 10.1097/IIO.0000000000000483
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  4. Article: Data Quality Control for Electronic Pathology Reporting.

    Wu, Qianru / Ganz, Connie / Li, Lifeng

    Journal of registry management

    2023  Volume 49, Issue 3, Page(s) 95–96

    MeSH term(s) Humans ; Electronic Health Records ; Pathology, Clinical ; Research Report ; Electronics
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article
    ISSN 1945-6123
    ISSN 1945-6123
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  5. Article: Response to "Polyradiculitis Complicating SARS-CoV-2 Vaccinations is Not Infrequent".

    Lanman, Tyler / Wu, Connie / Cheung, Helen / Goyal, Neelam / Greene, Maxwell

    The Neurohospitalist

    2022  Volume 13, Issue 2, Page(s) 210–211

    Language English
    Publishing date 2022-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2629083-2
    ISSN 1941-8752 ; 1941-8744
    ISSN (online) 1941-8752
    ISSN 1941-8744
    DOI 10.1177/19418744221138634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Subwavelength Bessel beam arrays with high uniformity based on a metasurface.

    Wu, Chenyang / Huang, Xuanlun / Yipeng, Ji / Wang, Jiaxing / Chang-Hasnain, Connie J

    Applied optics

    2024  Volume 63, Issue 9, Page(s) 2234–2240

    Abstract: Bessel beam arrays are highly attractive due to non-diffraction properties, parallel processing, and large capacity capabilities. However, conventional approaches of generating Bessel beams, such as spatial light modulators, axicons, and diffraction ... ...

    Abstract Bessel beam arrays are highly attractive due to non-diffraction properties, parallel processing, and large capacity capabilities. However, conventional approaches of generating Bessel beams, such as spatial light modulators, axicons, and diffraction optical elements, suffer from various limitations of system complexity and bulkiness, low uniformity, and limited numerical aperture (NA). The limited NA imposes constraints on achieving minimal full width at half maximum (FWHM) of the Bessel beam, ultimately compromising the resolution of the beam. In this study, we demonstrate a method for generating Bessel beam arrays with regular and random patterns via an ultra-compact metasurface. This approach integrates the phase profile of an optimized beam splitter with a meta-axicon. The Bessel beam arrays exhibit subwavelength dimensions of FWHM (590 nm, ∼0.9
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.519840
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  7. Article ; Online: Designing inhaled small molecule drugs for severe respiratory diseases: an overview of the challenges and opportunities.

    Rinderknecht, Cornelia H / Ning, Miaoran / Wu, Connie / Wilson, Mark S / Gampe, Christian

    Expert opinion on drug discovery

    2024  Volume 19, Issue 4, Page(s) 493–506

    Abstract: Introduction: Inhaled drugs offer advantages for the treatment of respiratory diseases over oral drugs by delivering the drug directly to the lung, thus improving the therapeutic index. There is an unmet medical need for novel therapies for lung ... ...

    Abstract Introduction: Inhaled drugs offer advantages for the treatment of respiratory diseases over oral drugs by delivering the drug directly to the lung, thus improving the therapeutic index. There is an unmet medical need for novel therapies for lung diseases, exacerbated by a multitude of challenges for the design of inhaled small molecule drugs.
    Areas covered: The authors review the challenges and opportunities for the design of inhaled drugs for respiratory diseases with a focus on new target discovery, medicinal chemistry, and pharmacokinetic, pharmacodynamic, and toxicological evaluation of drug candidates.
    Expert opinion: Inhaled drug discovery is facing multiple unique challenges. Novel biological targets are scarce, as is the guidance for medicinal chemistry teams to design compounds with inhalation-compatible features. It is exceedingly difficult to establish a PK/PD relationship given the complexity of pulmonary PK and the impact of physical properties of the drug substance on PK. PK, PD and toxicology studies are technically challenging and require large amounts of drug substance. Despite the current challenges, the authors foresee that the design of inhaled drugs will be facilitated in the future by our increasing understanding of pathobiology, emerging medicinal chemistry guidelines, advances in drug formulation, PBPK models, and
    MeSH term(s) Humans ; Respiratory Tract Diseases/drug therapy ; Administration, Inhalation ; Lung Diseases/drug therapy ; Drug Discovery
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2259618-5
    ISSN 1746-045X ; 1746-0441
    ISSN (online) 1746-045X
    ISSN 1746-0441
    DOI 10.1080/17460441.2024.2319049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Bone Marrow Biopsies: Is CT, Fluoroscopy, or no Imaging Guidance the Most Cost-Effective Strategy?

    Gyftopoulos, Soterios / Cardoso, Madalena Da Silva / Wu, Jim S / Subhas, Naveen / Chang, Connie Y

    Academic radiology

    2024  

    Abstract: Rationale and objectives: To determine the most cost-effective strategy for pelvic bone marrow biopsies.: Materials and methods: A decision analytic model from the health care system perspective for patients with high clinical concern for multiple ... ...

    Abstract Rationale and objectives: To determine the most cost-effective strategy for pelvic bone marrow biopsies.
    Materials and methods: A decision analytic model from the health care system perspective for patients with high clinical concern for multiple myeloma (MM) was used to evaluate the incremental cost-effectiveness of three bone marrow core biopsy techniques: computed tomography (CT) guided, and fluoroscopy guided, no-imaging (landmark-based). Model input data on utilities, costs, and probabilities were obtained from comprehensive literature review and expert opinion. Costs were estimated in 2023 U.S. dollars. Primary effectiveness outcome was quality adjusted life years (QALY). Willingness to pay threshold was $100,000 per QALY gained.
    Results: No-imaging based biopsy was the most cost-effective strategy as it had the highest net monetary benefit ($4218) and lowest overall cost ($92.17). Fluoroscopy guided was excluded secondary to extended dominance. CT guided biopsies were less preferred as it had an incremental cost-effectiveness ratio ($334,043) greater than the willingness to pay threshold. Probabilistic sensitivity analysis found non-imaging based biopsy to be the most cost-effective in 100% of simulations and at all willingness to pay thresholds up to $200,000.
    Conclusion: No-imaging based biopsy appears to be the most cost-effective strategy for bone marrow core biopsy in patients suspected of MM.
    Clinical relevance: No imaging guidance is the preferred strategy, although image-guidance may be required for challenging anatomy. CT image interpretation may be helpful for planning biopsies. Establishing a non-imaging guided biopsy service with greater patient anxiety and pain support may be warranted.
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2024.01.019
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    Zs.A 4594: Show issues Location:
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  9. Article ; Online: Doxycycline for central centrifugal cicatricial alopecia: A single center retrospective analysis.

    Obi, Ashley / McKinley, Jayvon / Oladunjoye, Esther / Williams, Akilah / Li, Vivian / Wu, Jianni / Yang, Connie / Darwin, Evan / Gulati, Nicholas / Haskin, Alessandra / Correa da Rosa, Joel / Svidzinski, Cula

    Journal of the American Academy of Dermatology

    2024  

    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2024.01.086
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    Zs.A 1540: Show issues Location:
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  10. Article ; Online: High-Throughput, High-Multiplex Digital Protein Detection with Attomolar Sensitivity.

    Wu, Connie / Dougan, Tyler J / Walt, David R

    ACS nano

    2022  Volume 16, Issue 1, Page(s) 1025–1035

    Abstract: A major challenge in many clinical diagnostic applications is the measurement of low-abundance proteins and other biomolecules in biological fluids. Digital technologies such as the digital enzyme-linked immunosorbent assay (ELISA) have enabled 1000-fold ...

    Abstract A major challenge in many clinical diagnostic applications is the measurement of low-abundance proteins and other biomolecules in biological fluids. Digital technologies such as the digital enzyme-linked immunosorbent assay (ELISA) have enabled 1000-fold increases in sensitivity over conventional protein detection methods. However, current digital ELISA technologies still possess insufficient sensitivities for many rare protein biomarkers and require specialized instrumentation or time-consuming workflows that have limited their widespread implementation. To address these challenges, we have developed a more sensitive and streamlined digital ELISA platform, Molecular On-bead Signal Amplification for Individual Counting (MOSAIC), which attains low attomolar limits of detection, with an order of magnitude enhancement in sensitivity over these other methods. MOSAIC uses a rapid, automatable flow cytometric readout that vastly increases throughput and is easily integrated into existing laboratory infrastructure. As MOSAIC provides high sampling efficiencies for rare target molecules, assay bead number can readily be tuned to enhance signal-to-background with high measurement precision. Furthermore, the solution-based signal readout of MOSAIC expands the number of analytes that can simultaneously be measured for higher-order multiplexing with femtomolar sensitivities or below, compared with microwell- or droplet-based digital methods. As a proof of principle, we apply MOSAIC toward improving the detectability of low-abundance cytokines in saliva and ultrasensitive multiplexed measurements of eight protein analytes in plasma and saliva. The attomolar sensitivity, high throughput, and broad multiplexing abilities of MOSAIC provide highly accessible and versatile ultrasensitive capabilities that can potentially accelerate protein biomarker discovery and diagnostic testing for diverse disease applications.
    MeSH term(s) Enzyme-Linked Immunosorbent Assay/methods ; Biomarkers ; Cytokines
    Chemical Substances Biomarkers ; Cytokines
    Language English
    Publishing date 2022-01-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.1c08675
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