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Article ; Online: How I treat biliary tract cancer.

Lamarca, A / Edeline, J / Goyal, L

ESMO open

2022 Volume 7, Issue 1, Page(s) 100378

Abstract: Management of biliary tract cancers (BTCs) is rapidly evolving. Curative management relies on surgical resection followed by adjuvant capecitabine for cholangiocarcinoma and gallbladder cancers. Unfortunately relapse rate remains high, and better ... ...

Abstract	Management of biliary tract cancers (BTCs) is rapidly evolving. Curative management relies on surgical resection followed by adjuvant capecitabine for cholangiocarcinoma and gallbladder cancers. Unfortunately relapse rate remains high, and better adjuvant strategies are urgently required. A majority of patients are diagnosed with advanced disease, when chemotherapy with cisplatin and gemcitabine followed by second-line 5-FU and oxaliplatin /irinotecan is the cornerstone of treatment for most patients in the absence of targetable alterations. Targeted therapies, including therapies for tumours with fibroblast growth factor receptor-2 (FGFR-2) fusions, isocitrate dehydrogenase-1 (IDH-1) mutations, B-Raf proto-oncogene serine/threonine kinase (BRAF) V600E mutations, neurotrophic tyrosine receptor kinase (NTRK) fusions, Human epidermal growth factor-2 (HER-2) amplifications, and/or microsatellite instability are rapidly changing the treatment paradigm for many patients with advanced BTC, especially for patients with intrahepatic cholangiocarcinoma. Because of this, molecular profiling should be considered early on patients pathway to allow adequate planning of therapy. Ongoing research is likely to clarify the role of immunotherapy, liver-directed therapy, and liver transplant for BTCs in the future.
MeSH term(s)	Bile Duct Neoplasms/diagnosis ; Bile Duct Neoplasms/genetics ; Bile Duct Neoplasms/therapy ; Bile Ducts, Intrahepatic/metabolism ; Bile Ducts, Intrahepatic/pathology ; Biliary Tract Neoplasms/diagnosis ; Biliary Tract Neoplasms/genetics ; Biliary Tract Neoplasms/therapy ; Cholangiocarcinoma/diagnosis ; Cholangiocarcinoma/genetics ; Cholangiocarcinoma/therapy ; Humans ; Neoplasm Recurrence, Local
Language	English
Publishing date	2022-01-13
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	2059-7029
ISSN (online)	2059-7029
DOI	10.1016/j.esmoop.2021.100378
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Article: Developing new ceramide analogs against non-small cell lung cancer (NSCLC).

Dai, Lu / Goyal, Navneet / Liu, Jiawang / Foroozesh, Maryam / Qin, Zhiqiang

American journal of cancer research

2024 Volume 14, Issue 1, Page(s) 86–96

Abstract: Non-small cell lung cancer (NSCLC) constitutes the predominant form of lung cancer and stands as the leading cause of cancer-related mortality in the United States. Conventional chemotherapy and radiotherapy yield suboptimal responses in a significant ... ...

Abstract	Non-small cell lung cancer (NSCLC) constitutes the predominant form of lung cancer and stands as the leading cause of cancer-related mortality in the United States. Conventional chemotherapy and radiotherapy yield suboptimal responses in a significant portion of lung cancer patients, resulting in a discouraging 5-year survival rate of approximately 15%. Despite advancements in targeted therapy and immunotherapy, many NSCLC patients exhibit either negligible or partial responses, emphasizing the pressing necessity for the discovery of innovative anti-cancer agents. Our previous study demonstrated that ABC294640, an inhibitor of one of the key enzymes in sphingolipid metabolism, sphingosine kinase 2 (SphK2), displayed anti-NSCLC activities
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2589522-9
ISSN	2156-6976
ISSN	2156-6976
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Article ; Online: The relationship between dietary patterns and ophthalmic disease.

Mulpuri, Lakshman / Sridhar, Jayanth / Goyal, Himani / Tonk, Rahul

Current opinion in ophthalmology

2023 Volume 34, Issue 3, Page(s) 189–194

Abstract: Purpose of review: There is a rising interest in the impact of diet on the pathogenesis of common ophthalmic conditions. The purpose of this review is to summarize the potential preventive and therapeutic power of dietary interventions described in ... ...

Abstract	Purpose of review: There is a rising interest in the impact of diet on the pathogenesis of common ophthalmic conditions. The purpose of this review is to summarize the potential preventive and therapeutic power of dietary interventions described in recent basic science and epidemiological literature. Recent findings: Basic science investigations have elucidated a variety of mechanisms by which diet may impact ophthalmic disease, particularly through its action on chronic oxidative stress, inflammation and macular pigmentation. Epidemiologic investigations have shown the real-world influence of diet on the incidence and progression of a number of ophthalmic diseases, particularly cataract, age-related macular degeneration (AMD) and diabetic retinopathy. A large observational cohort study found a 20% reduction in the incidence of cataract among vegetarians compared with nonvegetarians. Two recent systematic reviews found that higher adherence to Mediterranean dietary patterns was associated with a decreased risk of progression of AMD to later stages. Finally, large meta-analyses found that patients following plant-based and Mediterranean diets had significant reductions of mean haemoglobin A1c scores and incidence of diabetic retinopathy as compared with controls. Summary: There is a significant and growing body of evidence that Mediterranean diet and plant-based diets - those that maximize fruits, vegetables, legumes, whole grains and nuts; and that minimize animal products and processed foods - help prevent vision loss from cataract, AMD and diabetic retinopathy. These diets may hold benefits for other ophthalmic conditions, as well. Nevertheless, there is a need for further randomized, controlled and longitudinal studies in this area.
MeSH term(s)	Animals ; Humans ; Diabetic Retinopathy/epidemiology ; Diabetic Retinopathy/etiology ; Diabetic Retinopathy/prevention & control ; Diet, Mediterranean ; Macular Degeneration/epidemiology ; Macular Degeneration/etiology ; Macular Degeneration/prevention & control ; Cataract/epidemiology ; Cataract/etiology ; Cataract/prevention & control ; Observational Studies as Topic
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1049383-9
ISSN	1531-7021 ; 1040-8738
ISSN (online)	1531-7021
ISSN	1040-8738
DOI	10.1097/ICU.0000000000000943
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Zs.A 3047: Show issues

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Article ; Online: How flying bees land

Goyal, P. / van Leeuwen, J.L. / Muijres, F.T.

Annual Report 2022 JMBC - Research Highlight

2023

Keywords	Life Science
Language	English
Publisher	JM Burgerscentrum
Publishing country	nl
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Economic Hardships in Managing COVID-19 Patients in the Intensive Care Unit: A Retrospective Observational Study at a Tertiary Care Hospital in North India.

Vig, S L / Goyal, Pooja / Saini, Shipra / Singh, Mitasha / Prasad, Jagdish / Parashar, Lokesh

Cureus

2024 Volume 16, Issue 2, Page(s) e54588

Abstract: Background: The information on healthcare expenditure is crucial to know the impact of the pandemic on public health budgets, thereby correctly managing the ongoing crisis and preparing for subsequent waves.: Objective: To estimate the length of stay ...

Abstract	Background: The information on healthcare expenditure is crucial to know the impact of the pandemic on public health budgets, thereby correctly managing the ongoing crisis and preparing for subsequent waves. Objective: To estimate the length of stay and cost incurred on COVID-19 patients who died in the ICU. Methods: It is a record-based descriptive study conducted on 76 deceased COVID-19 patients admitted to the ICU of a dedicated COVID-19 hospital (DCH) between April and October 2020. Central Government Health Services (CGHS) package rate list, Delhi-NCR, was used as a reference for the cost of the ICU bed, ventilator, investigations, and procedures. Results: The median duration of stay in the hospital was 12 days, and in the ICU, it was eight days. The median total cost of managing the patient was 91,235.6 INR; of this, the median total cost for ICU stay per patient was 6,904 INR. The major proportion of total expenses was contributed by personal protective equipment (PPE) kits, an average of 11,091.33 INR per month. The median cost of stay in the ICU, on the ventilator, in the ward, and mean cost of investigations were higher among those with associated co-morbidities. Conclusion: Most elderly male with co-morbidities lost their battle after ventilator support in the ICU. Patients with co-morbidities and severe disease not only have a long duration of hospitalization and poor survival rate but also fetch an economic burden close to one lakh on the institute.
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.54588
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Article ; Online: Real-world treatment patterns and clinical outcomes in patients treated with eribulin after prior phosphoinositide 3-Kinase inhibitor treatment for metastatic breast cancer.

Goyal, Ravi K / Zhang, Jingchuan / Davis, Keith L / Sluga-O'Callaghan, Martina / Kaufman, Peter A

Breast cancer research and treatment

2024 Volume 205, Issue 1, Page(s) 201–210

Abstract: Purpose: In 2010, the US Food and Drug Administration approved eribulin for the treatment of metastatic breast cancer (MBC). Since then, the treatment landscape has evolved with many new therapy classes, a more recent one being the small molecule ... ...

Abstract	Purpose: In 2010, the US Food and Drug Administration approved eribulin for the treatment of metastatic breast cancer (MBC). Since then, the treatment landscape has evolved with many new therapy classes, a more recent one being the small molecule inhibitors of phosphoinositide 3 kinase (PI3K). We sought to characterize the treatment patterns and clinical outcomes of patients with MBC who received eribulin following prior treatment with a PI3K inhibitor. Methods: A retrospective cohort study based on medical record review included MBC patients who initiated eribulin between March 2019 and September 2020 following prior treatment with a PI3K inhibitor was conducted. Patient demographics, treatment characteristics, and clinical outcomes were analyzed descriptively. Real-world progression-free survival (rwPFS) and overall survival (OS) were estimated from the initiation of eribulin therapy using Kaplan-Meier analyses. Results: 82 eligible patients were included. Patients' median age at eribulin initiation was 62 years; 86.5% had hormone receptor-positive, human epidermal growth factor receptor 2-negative tumors. Eribulin was most often administered in the second or third line (82.9%) in the metastatic setting. Best overall response on eribulin was reported as complete or partial response in 72% of the patients. The median rwPFS was 18.9 months (95% confidence interval [CI], 12.4-not estimable); median OS was not reached. The estimated rwPFS and OS rates at 12 months were 63.3% (95% CI, 50.5-73.7) and 82.6% (95% CI, 72.4-89.3), respectively. Conclusion: Our real-world study suggests that eribulin may be a potential treatment option for MBC patients who fail a prior PI3K inhibitor.
MeSH term(s)	Humans ; Furans/therapeutic use ; Ketones/therapeutic use ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Breast Neoplasms/mortality ; Middle Aged ; Aged ; Retrospective Studies ; Phosphoinositide-3 Kinase Inhibitors/therapeutic use ; Adult ; Neoplasm Metastasis ; Treatment Outcome ; Aged, 80 and over ; Polyether Polyketides
Chemical Substances	eribulin (LR24G6354G) ; Furans ; Ketones ; Phosphoinositide-3 Kinase Inhibitors ; Polyether Polyketides
Language	English
Publishing date	2024-02-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-023-07080-1
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Zs.A 1655: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Characteristics of natural and planted sandalwood-supporting soils in Seoni district, Madhya Pradesh

Choudhari, P L / Prasad, J / Singh, S J / Gurav, P / Goyal, K

2024

Abstract: Two sandalwood-supporting pedons, one planted (P1) and other natural growing, were characterized in Seoni district of Madhya Pradesh. The solum depth of both the pedon was 30 cm underlain by weathered basalt beyond 50 cm. Pedon was dark reddish brown ... ...

Abstract	Two sandalwood-supporting pedons, one planted (P1) and other natural growing, were characterized in Seoni district of Madhya Pradesh. The solum depth of both the pedon was 30 cm underlain by weathered basalt beyond 50 cm. Pedon was dark reddish brown while P2 was characterized by dark reddish brown to dusky red. P2 had sandy clay texture (A1 horizon) and other horizons of both the pedons was associated with clay texture. These soils had more than 35 cmol(p+)kg-1 CEC and dominance of smectite (>20%) followed by vermiculite. There was more than 20 per cent feldspar in Bw horizon of P1 while underlying horizon of P2 had 25 per cent quartz. The nearly neutral soils had more than 1.0 per cent organic carbon barring A2 horizon of P2. These calcareous soils were dominated by exchangeable Ca++ followed by Mg++, Na+, K+ on exchange complex and grouped as Typic Haplustepts and Typic Ustorthents at subgroup level.
Keywords	Soil ; Soil Science
Language	English
Publishing date	2024-03-02
Publisher	Soil Conservation Society of India
Publishing country	in
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pediatric Primary Care Diagnoses Among Children with Intrauterine Opioid Exposure.

Beldick, Stephanie R / Rohde, Jessica F / Short, Vanessa L / Abatemarco, Diane J / Goyal, Neera K

Journal of health care for the poor and underserved

2023 Volume 34, Issue 1, Page(s) 161–179

Abstract: Background and objectives: Characterizing common concerns for children with intrauterine opioid exposure (IOE) can inform tailored primary care.: Methods: Retrospective analysis of primary care data of children with IOE from birth to age two years ... ...

Abstract	Background and objectives: Characterizing common concerns for children with intrauterine opioid exposure (IOE) can inform tailored primary care. Methods: Retrospective analysis of primary care data of children with IOE from birth to age two years within one multi-state pediatric health system. Well child care (WCC) and problem-based visit diagnoses were categorized, and descriptive statistics were tabulated. Results: Three hundred and eighty-five (385) children with IOE had 3,622 primary care visits, of which 51.4% were WCC and 48.6% were problem-based. Most frequent visit diagnoses were upper respiratory complaints (14.8% of visits), feeding difficulties (12.2%), and perinatal viral exposure (9.8%). Although visit type (WCC vs. problem-based) varied across diagnostic category, frequent utilization of both visit types were documented for several diagnoses in infancy (e.g., fussiness/colic, feeding difficulties). Conclusions: Well child care visits for children with IOE are key opportunities for anticipatory guidance with an emphasis on problems that may contribute to acute health care utilization, particularly in early infancy.
MeSH term(s)	Female ; Pregnancy ; Child ; Humans ; Child, Preschool ; Analgesics, Opioid ; Child Health Services ; Retrospective Studies ; Child Health ; Primary Health Care
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2023-07-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1142637-8
ISSN	1548-6869 ; 1049-2089
ISSN (online)	1548-6869
ISSN	1049-2089
DOI	10.1353/hpu.2023.0011
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Zs.A 3605: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 493: Show issues

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Article ; Online: Concordance of Adolescent Gender, Race, and Ethnicity: Self-report Versus Medical Record Data.

Cruz, Andrea T / Palmer, Chella A / Augustine, Erin M / Casper, T Charles / Dowshen, Nadia / Elsholz, Cara L / Mollen, Cynthia J / Pickett, Michelle L / Schmidt, Sarah K / Stukus, Kristin S / Goyal, Monika K / Reed, Jennifer L

Pediatrics

2024 Volume 153, Issue 2

MeSH term(s)	Humans ; Adolescent ; Ethnicity ; Self Report ; Medical Records ; Racial Groups
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	207677-9
ISSN	1098-4275 ; 0031-4005
ISSN (online)	1098-4275
ISSN	0031-4005
DOI	10.1542/peds.2023-063161
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Um IV Zs.131: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 357: Show issues

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Article ; Online: Sleep disturbance among breast cancer survivors and controls from midlife to early older adulthood: Pink SWAN.

Goyal, Neha / Levine, Beverly J / Crawford, Sybil L / Avis, Nancy E

Journal of cancer survivorship : research and practice

2022 Volume 18, Issue 2, Page(s) 489–498

Abstract: Purpose: To compare sleep disturbance from 5 years pre- to 5 years post-diagnosis between breast cancer survivors (BCS) and women without cancer over the same period and to identify BCS subgroups exhibiting different sleep trajectories.: Methods: ... ...

Abstract	Purpose: To compare sleep disturbance from 5 years pre- to 5 years post-diagnosis between breast cancer survivors (BCS) and women without cancer over the same period and to identify BCS subgroups exhibiting different sleep trajectories. Methods: Analyses included data from 152 BCS and 2163 controls from 20 years of follow-up in the longitudinal Study of Women's Health Across the Nation (SWAN), a multi-racial/ethnic cohort study. SWAN participants were assessed approximately annually from 1995 to 2015 using a standardized protocol. Pink SWAN focused on women who reported no cancer at SWAN enrollment and developed incident breast cancer after enrollment or did not develop breast cancer. Nonparametric locally weighted scatterplot smoothing plots and linear mixed models were used to compare the prevalence of the most frequently reported sleep problem, frequently waking several times a night (a sleep maintenance problem) during the previous 2 weeks, between BCS and controls in the 5 years pre- to 5 years post-diagnosis. We characterized heterogeneity among BCS on this sleep problem using group-based trajectories and examined pre-diagnosis variables as predictors of group membership. Results: No differences were found between BCS and controls in prevalence of frequent nighttime awakenings either before or after diagnosis. Among BCS, three trajectory groups were identified. Thirty-seven percent of BCS had consistently low prevalence of waking several times per night, 30% had high prevalence, and 33% had increasing prevalence which started 2 years pre-diagnosis. Prevalence of pre-diagnosis vasomotor symptoms, anxiety, depressive symptoms, and smoking differed among these groups. Conclusion: Among mid-aged women diagnosed with breast cancer, this diagnosis did not trigger/amplify a sleep maintenance problem. The majority of BCS had similar levels of this sleep problem from pre- to post-diagnosis. Implications for cancer survivors: Although sleep maintenance problems were not amplified by a cancer diagnosis, a subset of BCS may have sleep issues that should be monitored and treated, as indicated.
MeSH term(s)	Female ; Humans ; Aged ; Middle Aged ; Breast Neoplasms/epidemiology ; Cancer Survivors ; Cohort Studies ; Longitudinal Studies ; Sleep ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/etiology
Language	English
Publishing date	2022-08-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388888-X
ISSN	1932-2267 ; 1932-2259
ISSN (online)	1932-2267
ISSN	1932-2259
DOI	10.1007/s11764-022-01247-3
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