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  1. Article ; Online: Animal Experimental Models in Bone Metabolic Disease.

    Usategui-Martín, Ricardo / Pérez-Castrillón, José Luis

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: Bone is a highly specialized and dynamic tissue with several crucial functions, including support, movement support, protection of vital organs, and mineral storage [ ... ]. ...

    Abstract Bone is a highly specialized and dynamic tissue with several crucial functions, including support, movement support, protection of vital organs, and mineral storage [...].
    MeSH term(s) Animals ; Bone Diseases, Metabolic/metabolism ; Bone and Bones/metabolism ; Models, Animal
    Language English
    Publishing date 2023-05-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Animal Experimental Models in Bone Metabolic Disease

    Ricardo Usategui-Martín / José Luis Pérez-Castrillón

    International Journal of Molecular Sciences, Vol 24, Iss 9534, p

    2023  Volume 9534

    Abstract: Bone is a highly specialized and dynamic tissue with several crucial functions, including support, movement support, protection of vital organs, and mineral storage [.] ...

    Abstract Bone is a highly specialized and dynamic tissue with several crucial functions, including support, movement support, protection of vital organs, and mineral storage [.]
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  3. Article ; Online: MEFV gene mutation (c.229G>T) as a cause of fever of unknown origin.

    Miramontes-González, Jose Pablo / Cristea, Andreea Catalina / Martín, Miriam Gabella / González Fernández, María / Pérez-Castrillón, José Luis

    European journal of internal medicine

    2024  

    Language English
    Publishing date 2024-02-05
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2024.01.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Treatment of Vitamin D Deficiency with Calcifediol: Efficacy and Safety Profile and Predictability of Efficacy.

    Pérez-Castrillon, Jose-Luis / Usategui-Martín, Ricardo / Pludowski, Pawel

    Nutrients

    2022  Volume 14, Issue 9

    Abstract: Calcifediol (25-OH-vitamin D3) is the prohormone of the vitamin D endocrine system. It is used to prevent and treat vitamin D deficiency. Calcifediol, as well as cholecalciferol (vitamin D3), is efficient and safe in the general population, although ... ...

    Abstract Calcifediol (25-OH-vitamin D3) is the prohormone of the vitamin D endocrine system. It is used to prevent and treat vitamin D deficiency. Calcifediol, as well as cholecalciferol (vitamin D3), is efficient and safe in the general population, although calcifediol has certain advantages over cholecalciferol, such as its rapid onset of action and greater potency. This review analyzed studies comparing the efficacy and safety of both calcifediol and cholecalciferol drugs in the short and long term (>6 months). Calcifediol was found to be more efficacious, with no increase in toxicity. We also assessed the predictability of both molecules. A 25OHD increase depends on the dose and frequency of calcifediol administration. In contrast, after cholecalciferol administration, 25OHD increase depends on more factors than dose and frequency of administration, also phenotypic aspects (such as obesity and malabsorption), and genotypic factors impacts in this increase.
    MeSH term(s) Calcifediol ; Cholecalciferol/adverse effects ; Dietary Supplements/adverse effects ; Humans ; Vitamin D/therapeutic use ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/drug therapy ; Vitamins
    Chemical Substances Vitamins ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; Calcifediol (P6YZ13C99Q)
    Language English
    Publishing date 2022-05-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14091943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Missense Variant in

    Usategui-Martín, Ricardo / Galindo-Cabello, Nadia / Pastor-Idoate, Salvador / Fernández-Gómez, José María / Del Real, Álvaro / Ferreño, Diego / Lapresa, Rebeca / Martín-Rodriguez, Francisco / Riancho, José A / Almeida, Ángeles / Pérez-Castrillón, José Luis

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: Metabolic bone diseases cover a broad spectrum of disorders that share alterations in bone metabolism that lead to a defective skeleton, which is associated with increasing morbidity, disability, and mortality. There is a close connection between the ... ...

    Abstract Metabolic bone diseases cover a broad spectrum of disorders that share alterations in bone metabolism that lead to a defective skeleton, which is associated with increasing morbidity, disability, and mortality. There is a close connection between the etiology of metabolic bone diseases and genetic factors, with
    MeSH term(s) Animals ; Mice ; Biomarkers ; Bone and Bones ; Bone Diseases, Metabolic ; Case-Control Studies ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide ; Tumor Suppressor Protein p53/genetics ; Humans
    Chemical Substances Biomarkers ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Genistein supplementation has no effects on vitamin D levels in healthy Spanish postmenopausal women.

    Pérez-Alonso, María / Calero-Paniagua, Ismael / Usategui-Martin, Ricardo / Briongos, Laisa-Socorro / Ruiz-Mambrilla, Marta / Olmos, José-Manuel / González-Sagrado, Manuel / De Luis, Daniel / Dueñas-Laita, Antonio / Pérez-Castrillón, José-Luis

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition

    2023  

    Language English
    Publishing date 2023-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 120692-8
    ISSN 0300-9831
    ISSN 0300-9831
    DOI 10.1024/0300-9831/a000781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.210: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Vitamin D Receptor (

    Usategui-Martín, Ricardo / De Luis-Román, Daniel-Antonio / Fernández-Gómez, José María / Ruiz-Mambrilla, Marta / Pérez-Castrillón, José-Luis

    Nutrients

    2022  Volume 14, Issue 2

    Abstract: The vitamin D receptor (VDR), a member of the nuclear receptor superfamily of transcriptional regulators, is crucial to calcitriol signalling. VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D ... ...

    Abstract The vitamin D receptor (VDR), a member of the nuclear receptor superfamily of transcriptional regulators, is crucial to calcitriol signalling. VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the
    MeSH term(s) Adolescent ; Adult ; Aged ; Alleles ; Child ; Dietary Supplements ; Female ; Genetic Association Studies ; Genotype ; Humans ; Male ; Middle Aged ; Polymorphism, Genetic ; Receptors, Calcitriol/genetics ; Vitamin D/administration & dosage ; Young Adult
    Chemical Substances Receptors, Calcitriol ; VDR protein, human ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2022-01-15
    Publishing country Switzerland
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14020360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Molecular Mechanisms Involved in Hypoxia-Induced Alterations in Bone Remodeling.

    Usategui-Martín, Ricardo / Rigual, Ricardo / Ruiz-Mambrilla, Marta / Fernández-Gómez, José-María / Dueñas, Antonio / Pérez-Castrillón, José Luis

    International journal of molecular sciences

    2022  Volume 23, Issue 6

    Abstract: Bone is crucial for the support of muscles and the protection of vital organs, and as a reservoir of calcium and phosphorus. Bone is one of the most metabolically active tissues and is continuously renewed to adapt to the changes required for healthy ... ...

    Abstract Bone is crucial for the support of muscles and the protection of vital organs, and as a reservoir of calcium and phosphorus. Bone is one of the most metabolically active tissues and is continuously renewed to adapt to the changes required for healthy functioning. To maintain normal cellular and physiological bone functions sufficient oxygen is required, as evidence has shown that hypoxia may influence bone health. In this scenario, this review aimed to analyze the molecular mechanisms involved in hypoxia-induced bone remodeling alterations and their possible clinical consequences. Hypoxia has been associated with reduced bone formation and reduced osteoblast matrix mineralization due to the hypoxia environment inhibiting osteoblast differentiation. A hypoxic environment is involved with increased osteoclastogenesis and increased bone resorptive capacity of the osteoclasts. Clinical studies, although with contradictory results, have shown that hypoxia can modify bone remodeling.
    MeSH term(s) Bone Remodeling ; Cell Differentiation ; Humans ; Hypoxia ; Osteoblasts ; Osteoclasts/physiology ; Osteogenesis/physiology
    Language English
    Publishing date 2022-03-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23063233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Molecular Mechanisms Involved in Hypoxia-Induced Alterations in Bone Remodeling

    Ricardo Usategui-Martín / Ricardo Rigual / Marta Ruiz-Mambrilla / José-María Fernández-Gómez / Antonio Dueñas / José Luis Pérez-Castrillón

    International Journal of Molecular Sciences, Vol 23, Iss 3233, p

    2022  Volume 3233

    Abstract: Bone is crucial for the support of muscles and the protection of vital organs, and as a reservoir of calcium and phosphorus. Bone is one of the most metabolically active tissues and is continuously renewed to adapt to the changes required for healthy ... ...

    Abstract Bone is crucial for the support of muscles and the protection of vital organs, and as a reservoir of calcium and phosphorus. Bone is one of the most metabolically active tissues and is continuously renewed to adapt to the changes required for healthy functioning. To maintain normal cellular and physiological bone functions sufficient oxygen is required, as evidence has shown that hypoxia may influence bone health. In this scenario, this review aimed to analyze the molecular mechanisms involved in hypoxia-induced bone remodeling alterations and their possible clinical consequences. Hypoxia has been associated with reduced bone formation and reduced osteoblast matrix mineralization due to the hypoxia environment inhibiting osteoblast differentiation. A hypoxic environment is involved with increased osteoclastogenesis and increased bone resorptive capacity of the osteoclasts. Clinical studies, although with contradictory results, have shown that hypoxia can modify bone remodeling.
    Keywords hypoxia ; bone remodeling ; HIF ; osteoclast ; osteoblast ; oxygen ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 616
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Analysis of Bone Histomorphometry in Rat and Guinea Pig Animal Models Subject to Hypoxia.

    Usategui-Martín, Ricardo / Del Real, Álvaro / Sainz-Aja, José A / Prieto-Lloret, Jesús / Olea, Elena / Rocher, Asunción / Rigual, Ricardo J / Riancho, José A / Pérez-Castrillón, José Luis

    International journal of molecular sciences

    2022  Volume 23, Issue 21

    Abstract: Hypoxia may be associated with alterations in bone remodeling, but the published results are contradictory. The aim of this study was to characterize the bone morphometry changes subject to hypoxia for a better understanding of the bone response to ... ...

    Abstract Hypoxia may be associated with alterations in bone remodeling, but the published results are contradictory. The aim of this study was to characterize the bone morphometry changes subject to hypoxia for a better understanding of the bone response to hypoxia and its possible clinical consequences on the bone metabolism. This study analyzed the bone morphometry parameters by micro-computed tomography (μCT) in rat and guinea pig normobaric hypoxia models. Adult male and female Wistar rats were exposed to chronic hypoxia for 7 and 15 days. Additionally, adult male guinea pigs were exposed to chronic hypoxia for 15 days. The results showed that rats exposed to chronic constant and intermittent hypoxic conditions had a worse trabecular and cortical bone health than control rats (under a normoxic condition). Rats under chronic constant hypoxia were associated with a more deteriorated cortical tibia thickness, trabecular femur and tibia bone volume over the total volume (BV/TV), tibia trabecular number (Tb.N), and trabecular femur and tibia bone mineral density (BMD). In the case of chronic intermittent hypoxia, rats subjected to intermittent hypoxia had a lower cortical femur tissue mineral density (TMD), lower trabecular tibia BV/TV, and lower trabecular thickness (Tb.Th) of the tibia and lower tibia Tb.N. The results also showed that obese rats under a hypoxic condition had worse values for the femur and tibia BV/TV, tibia trabecular separation (Tb.Sp), femur and tibia Tb.N, and BMD for the femur and tibia than normoweight rats under a hypoxic condition. In conclusion, hypoxia and obesity may modify bone remodeling, and thus bone microarchitecture, and they might lead to reductions in the bone strength and therefore increase the risk of fragility fracture.
    MeSH term(s) Rats ; Guinea Pigs ; Male ; Female ; Animals ; Bone Density/physiology ; X-Ray Microtomography ; Rats, Sprague-Dawley ; Rats, Wistar ; Tibia/diagnostic imaging ; Tibia/physiology ; Obesity ; Models, Animal ; Hypoxia
    Language English
    Publishing date 2022-10-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232112742
    Database MEDical Literature Analysis and Retrieval System OnLINE

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