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Book ; Thesis: Über die retrokorneale Membran als Komplikation nach perforierender Keratoplastik

Cachovan, Georg

1994

Author's details	vorgelegt von Georg Cachovan
Language	German
Size	43 Bl. : graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Hamburg, Univ., Diss., 1995
HBZ-ID	HT007078688
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Freehand vs. depth-gauge rotary instruments for veneer preparation: A controlled randomized simulator study.

Ahlers, M Oliver / Cachovan, Georg / Jakstat, Holger A / Edelhoff, Daniel / Roehl, Jakob C / Platzer, Ursula

Journal of prosthodontic research

2023

Abstract: Purpose: To investigate whether depth-gauge burs in veneer preparations influence preparation depth in a randomized, controlled, single-blinded trial and whether inexperienced operators can perform adequate veneer preparations.: Methods: Participants ...

Abstract	Purpose: To investigate whether depth-gauge burs in veneer preparations influence preparation depth in a randomized, controlled, single-blinded trial and whether inexperienced operators can perform adequate veneer preparations. Methods: Participants were 20 undergraduate dental students with no prior veneer preparation experience. The instruments used were the "Laminate Veneer System" (LVS), "Keramik-Veneers. de" (KVD), and a "Freehand" group (FH) for reference. All participants prepared three educational acrylic resin maxillae and three mandibular central incisors mounted in typodonts in patient simulators. The objectives were to achieve a preparation depth of 0.6 mm (tooth 11) and 0.4 mm (tooth 31). The sequences of the instruments used and prepared teeth were randomized. The measurements were performed using a laser triangulation coordinate-measuring machine. The data were stratified according to tooth location. Results: The preparation depths of both depth-gauge-instrument-groups LVS and KVD achieved the objectives significantly better than did the instruments from the "Freehand" group (P < 0.001). The differences between the depth gauge groups were insignificant, although the maximum preparation depths were smaller in the KVD group. Regarding the prepared teeth, the preparation depths in the mandibular incisors were lower, and the differences were smaller. Conclusions: The use of special depth-gauge burs for initial veneer preparation leads to significantly lower preparation depths than "Freehand" preparations. The tapered instruments resulted in a lower incidence of extreme preparation depths. The inexperienced operators performed veneer preparation remarkably well.
Language	English
Publishing date	2023-10-17
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2470657-7
ISSN	2212-4632 ; 1883-1958
ISSN (online)	2212-4632
ISSN	1883-1958
DOI	10.2186/jpr.JPR_D_22_00317
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; Thesis: Dreidimensionale digitale Analyse der internen und marginalen Passung gefräster Lithiumdisilikat-Teilkronen in vitro

Wenzl, Christina [Verfasser] / Güntsch, Arndt [Gutachter] / Schmidt, Monika Gutachter] / [Cachovan, Georg [Gutachter]

2017

Author's details	Christina Susanne Wenzl ; Gutachter: Arndt Güntsch, Monika Schmidt, Georg Cachovan
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Friedrich-Schiller-Universität Jena
Publishing place	Jena
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Detection of significant bacteriuria by use of the iQ200 automated urine microscope.

Stürenburg, Enno / Kramer, Jan / Schön, Gerhard / Cachovan, Georg / Sobottka, Ingo

Journal of clinical microbiology

2014 Volume 52, Issue 8, Page(s) 2855–2860

Abstract: In the microbiology laboratory, there is an augmented need for rapid screening methods for the detection of bacteria in urine samples, since about two-thirds of these samples will not yield any bacteria or will yield insignificant growth when cultured. ... ...

Abstract	In the microbiology laboratory, there is an augmented need for rapid screening methods for the detection of bacteria in urine samples, since about two-thirds of these samples will not yield any bacteria or will yield insignificant growth when cultured. Thus, a reliable screening method can free up laboratory resources and can speed up the reporting of a negative urine result. In this study, we have evaluated the detection of leukocytes, bacteria, and a new sediment indicator, the "all small particles" (ASP), by an automated instrument, the iQ200 urine analyzer, to detect negative urine samples that can be excluded from culture. A coupled automated strip reader (iChem Velocity), enabling the detection of nitrite and leukocyte esterase, was tested in parallel. In total, 963 urine samples were processed through both conventional urine culture and the iQ200/iChem Velocity workstation. Using the data, a multivariate regression model was established, and the predicted specificity and the possible reduction in urine cultures were calculated for the indicators and their respective combinations (leukocytes plus bacteria plus ASP and leukocyte esterase plus nitrite). Among all options, diagnostic performance was best using the whole microscopic content of the sample (leukocytes plus bacteria plus ASP). By using a cutoff value of ≥ 10(4) CFU/ml for defining a positive culture, a given sensitivity of 95% resulted in a specificity of 61% and a reduction in urine cultures of 35%. By considering the indicators alone, specificity and the culture savings were both much less satisfactory. The regression model was also used to determine possible cutoff values for running the instrument as part of daily routine. By using a graphical representation of all combinations possible, we derived cutoff values for leukocyte, bacterial, and ASP count, which should enable the iQ200 microscope to screen out approximately one-third of the urine samples, significantly reducing the workload in the microbiology laboratory.
MeSH term(s)	Automation, Laboratory/methods ; Bacteria/cytology ; Bacteriuria/diagnosis ; Carboxylic Ester Hydrolases/analysis ; Humans ; Mass Screening/methods ; Microscopy/methods ; Nitrites/analysis ; Sensitivity and Specificity ; Urine/chemistry ; Urine/microbiology
Chemical Substances	Nitrites ; leukocyte esterase (EC 3.1.-) ; Carboxylic Ester Hydrolases (EC 3.1.1.-)
Language	English
Publishing date	2014-05-28
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.00112-14
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Zs.A 1188: Show issues

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Article ; Online: In vitro activity of photoactivated disinfection using a diode laser in infected root canals.

Schiffner, Ulrich / Cachovan, Georg / Bastian, Jochen / Sculean, Anton / Eick, Sigrun

Acta odontologica Scandinavica

2014 Volume 72, Issue 8, Page(s) 673–680

Abstract: Objective: To investigate the lethal activity of photoactivated disinfection (PAD) on Enterococcus faecalis (ATCC 29212) and mixed populations of aerobic or anaerobic bacteria in infected root canals using a diode laser after the application of a ... ...

Abstract	Objective: To investigate the lethal activity of photoactivated disinfection (PAD) on Enterococcus faecalis (ATCC 29212) and mixed populations of aerobic or anaerobic bacteria in infected root canals using a diode laser after the application of a photosensitizer (PS). Materials and methods: First, the bactericidal activity of a low power diode laser (200 mW) against E. faecalis ATCC 29212 pre-treated with a PS (toluidine blue) for 2 min were examined after different irradiation times (30 s, 60 s and 90 s). The bactericidal activity in the presence of human serum or human serum albumin (HSA) was also examined. Second, root canals were infected with E. faecalis or with mixed aerobic or anaerobic microbial populations for 3 days and then irrigated with 1.5% sodium hypochlorite and exposed to PAD for 60 s. Results: Photosensitization followed by laser irradiation for 60 s was sufficient to kill E. faecalis. Bacteria suspended in human serum (25% v/v) were totally eradicated after 30 s of irradiation. The addition of HSA (25 mg/ml or 50 mg/ml) to bacterial suspensions increased the antimicrobial efficacy of PAD after an irradiation time of 30 s, but no longer. The bactericidal effect of sodium hypochlorite was only enhanced by PAD during the early stages of treatment. PAD did not enhance the activity of sodium hypochlorite against a mixture of anaerobic bacteria. Conclusions: The bactericidal activity of PAD appears to be enhanced by serum proteins in vitro, but is limited to bacteria present within the root canal.
MeSH term(s)	Actinobacteria/drug effects ; Actinomyces/drug effects ; Bacteremia/drug therapy ; Bacterial Load/drug effects ; Bifidobacterium/drug effects ; Blood Bactericidal Activity ; Dental Pulp Cavity/drug effects ; Dental Pulp Cavity/microbiology ; Disinfection/methods ; Enterococcus faecalis/drug effects ; Humans ; Lasers, Semiconductor/therapeutic use ; Low-Level Light Therapy/instrumentation ; Materials Testing ; Peptostreptococcus/drug effects ; Photochemotherapy/methods ; Photosensitizing Agents/therapeutic use ; Root Canal Irrigants/therapeutic use ; Serum Albumin/pharmacology ; Shewanella/drug effects ; Sodium Hypochlorite/therapeutic use ; Time Factors ; Tolonium Chloride/therapeutic use
Chemical Substances	Photosensitizing Agents ; Root Canal Irrigants ; Serum Albumin ; Tolonium Chloride (15XUH0X66N) ; Sodium Hypochlorite (DY38VHM5OD)
Language	English
Publishing date	2014-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	210362-x
ISSN	1502-3850 ; 0001-6357
ISSN (online)	1502-3850
ISSN	0001-6357
DOI	10.3109/00016357.2014.898087
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Article ; Online: Antibacterial activity of moxifloxacin on bacteria associated with periodontitis within a biofilm.

Tsaousoglou, Phoebus / Nietzsche, Sandor / Cachovan, Georg / Sculean, Anton / Eick, Sigrun

Journal of medical microbiology

2013 Volume 63, Issue Pt 2, Page(s) 284–292

Abstract: The activity of moxifloxacin was compared with ofloxacin and doxycycline against bacteria associated with periodontitis within a biofilm (single strain and mixed population) in vitro. MICs and minimal bactericidal concentrations (MBCs) of moxifloxacin, ... ...

Abstract	The activity of moxifloxacin was compared with ofloxacin and doxycycline against bacteria associated with periodontitis within a biofilm (single strain and mixed population) in vitro. MICs and minimal bactericidal concentrations (MBCs) of moxifloxacin, ofloxacin and doxycyline were determined against single strains and mixed populations in a planktonic state. Single-species biofilms of two Porphyromonas gingivalis and two Aggregatibacter actinomycetemcomitans strains and a multispecies biofilm consisting of 12 species were formed for 3 days. The minimal biofilm eradication concentrations (MBECs) were determined after exposing the biofilms to the antibacterials (0.002-512 µg ml(-1)) for 18 h, addition of nutrient broth for 3 days and subsequent subcultivation. Photographs were taken using confocal laser-scanning microscopy and scanning electron microscopy. The MICs and MBCs did not differ between ofloxacin and moxifloxacin against A. actinomycetemcomitans, whilst moxifloxacin was more active than the other tested antibacterials against anaerobes and the mixed population. The single-species biofilms were eradicated by moderate concentrations of the antibacterials, and the lowest MBECs were always found for moxifloxacin (2-8 µg ml(-1)). MBECs against the multispecies biofilms were 128, >512 and >512 µg ml(-1) for moxifloxacin, ofloxacin and doxycycline, respectively. In summary, moxifloxacin in a topical formulation may have potential as an adjunct to mechanical removal of the biofilms.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Aza Compounds/pharmacology ; Bacteria/drug effects ; Bacteria/isolation & purification ; Bacterial Physiological Phenomena ; Biofilms/drug effects ; Biofilms/growth & development ; Doxycycline/pharmacology ; Fluoroquinolones ; Humans ; Microbial Sensitivity Tests ; Microbial Viability/drug effects ; Moxifloxacin ; Ofloxacin/pharmacology ; Periodontitis/microbiology ; Quinolines/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Aza Compounds ; Fluoroquinolones ; Quinolines ; Ofloxacin (A4P49JAZ9H) ; Doxycycline (N12000U13O) ; Moxifloxacin (U188XYD42P)
Language	English
Publishing date	2013-11-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218356-0
ISSN	1473-5644 ; 0022-2615
ISSN (online)	1473-5644
ISSN	0022-2615
DOI	10.1099/jmm.0.065441-0
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Zs.A 634: Show issues

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Book ; Thesis: Über die retrokorneale Membran als Komplikation nach perforierender Keratoplastik

Cachovan, Georg

1995

Author's details	vorgelegt von Georg Cachovan
Language	German
Size	43 Bl, graph. Darst
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., FB Medizin, Diss.--Hamburg, 1995
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Odontogenic infections: an 8-year epidemiologic analysis in a dental emergency outpatient care unit.

Cachovan, Georg / Phark, Jin-Ho / Schön, Gerhard / Pohlenz, Philipp / Platzer, Ursula

Acta odontologica Scandinavica

2013 Volume 71, Issue 3-4, Page(s) 518–524

Abstract: Objectives: The purpose of this investigation was to analyze epidemiological patterns, clinical features and the management of odontogenic infections in patients undergoing treatment in a dental emergency outpatient care unit.: Study design: A ... ...

Abstract	Objectives: The purpose of this investigation was to analyze epidemiological patterns, clinical features and the management of odontogenic infections in patients undergoing treatment in a dental emergency outpatient care unit. Study design: A retrospective analysis of 58 161 case records of patients presenting to an emergency outpatient unit in Hamburg, Germany between 2000-2007 was performed. From this pool, patients with odontogenic infections were identified using an ICD-10 code, analyzing age, gender, medical co-morbidities, duration of pain, ratio of infiltrates/abscesses, affected teeth, management of infection and administered antibiotics. Results: Of the 58 161 patients, 5357 (9.2%) were identified as having odontogenic infections, with 2689 (50.2%) inflammatory infiltrates and 2668 (49.8%) abscesses. Mean age was 34.8 ± 16.8 years. As the primary site of odontogenic infection, the most significantly affected teeth were the maxillary and mandibular first molars. Patients in age-group 20-29 years (25.1%) utilized the emergency care unit more frequently than other age groups. Clindamycin was the most frequently administered antibiotic. Conclusions: Early recognition, diagnosis and management of odontogenic infections are requisite for avoiding or minimizing the development of potential complications. Strategies and evidence-based protocols should be developed within the dental ambulatory care sector, advancing interdisciplinary cooperation between general dentists and oral or maxillofacial surgeons.
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Dental Health Services/organization & administration ; Emergency Service, Hospital/organization & administration ; Focal Infection, Dental/epidemiology ; Focal Infection, Dental/therapy ; Germany/epidemiology ; Humans ; Infant ; Infant, Newborn ; Middle Aged ; Young Adult
Language	English
Publishing date	2013-05
Publishing country	England
Document type	Journal Article
ZDB-ID	210362-x
ISSN	1502-3850 ; 0001-6357
ISSN (online)	1502-3850
ISSN	0001-6357
DOI	10.3109/00016357.2012.696694
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Article ; Online: Effect of CNC-milling on the marginal and internal fit of dental ceramics: a pilot study.

Schaefer, Oliver / Kuepper, Harald / Thompson, Geoffrey A / Cachovan, Georg / Hefti, Arthur F / Guentsch, Arndt

Dental materials : official publication of the Academy of Dental Materials

2013 Volume 29, Issue 8, Page(s) 851–858

Abstract: Objectives: Machined restorations have been investigated for their preciseness before, while detailed information on the milling-step itself are lacking. Therefore, the aim of this laboratory study was to quantify the effect of a novel milling-procedure ...

Abstract	Objectives: Machined restorations have been investigated for their preciseness before, while detailed information on the milling-step itself are lacking. Therefore, the aim of this laboratory study was to quantify the effect of a novel milling-procedure on the marginal and internal fit of ceramic restorations. Methods: An acrylic model of a lower left first molar was prepared to receive a ceramic partial crown and was duplicated by one step dual viscosity impressions. Gypsum casts were formed and laser-scanned to realize virtual datasets, before restorations were designed, exported (PRE) and machined from lithium disilicate blanks. Crowns were digitized by a structure-light-scanner to obtain post-milling-data (POST). PRE and POST were virtually superimposed on the reference tooth and subjected to computer-aided-inspection. Visual fit-discrepancies were displayed with colors, while root mean square deviations (RMSD) and degrees of similarity (DS) were computed and analysed by t-tests for paired samples (n=5, α=0.05). Results: The milling procedure resulted in a small increase of the marginal and internal fit discrepancies (RMSD mean: 3μm and 6μm, respectively). RMSD differences were not statistically significant (p=0.495 and p=0.160 for marginal and internal fit, respectively). These results were supported by the DS data. Significance: The products of digital dental workflows are prone to imprecisions. However, the present findings suggest that differences between computer-aided designed and actually milled restorations are small, especially when compared to typical fit discrepancies observed clinically. Imprecisions introduced by digital design or production processes are small.
MeSH term(s)	Calcium Sulfate/chemistry ; Ceramics/chemistry ; Computer-Aided Design ; Crowns/standards ; Dental Impression Technique ; Dental Marginal Adaptation ; Dental Materials/chemistry ; Dental Models ; Dental Porcelain/chemistry ; Humans ; Image Processing, Computer-Assisted/methods ; Imaging, Three-Dimensional/methods ; Molar/anatomy & histology ; Pilot Projects ; Surface Properties ; Tooth Preparation, Prosthodontic/methods ; User-Computer Interface
Chemical Substances	Dental Materials ; lithia disilicate ; Dental Porcelain (12001-21-7) ; Glass ceramics (85422-94-2) ; Calcium Sulfate (WAT0DDB505)
Language	English
Publishing date	2013-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605995-8
ISSN	1879-0097 ; 0109-5641
ISSN (online)	1879-0097
ISSN	0109-5641
DOI	10.1016/j.dental.2013.04.018
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Zs.A 2039: Show issues

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Article ; Online: Comparative antibacterial efficacies of hydrodynamic and ultrasonic irrigation systems in vitro.

Cachovan, Georg / Schiffner, Ulrich / Altenhof, Saskia / Guentsch, Arndt / Pfister, Wolfgang / Eick, Sigrun

Journal of endodontics

2013 Volume 39, Issue 9, Page(s) 1171–1175

Abstract: Introduction: To ensure root canal treatment success, endodontic microbiota should be efficiently reduced. The in vitro bactericidal effects of a hydrodynamic system and a passive ultrasonic irrigation system were compared.: Methods: Single-rooted ... ...

Abstract	Introduction: To ensure root canal treatment success, endodontic microbiota should be efficiently reduced. The in vitro bactericidal effects of a hydrodynamic system and a passive ultrasonic irrigation system were compared. Methods: Single-rooted extracted teeth (n = 250) were contaminated with suspensions of Enterococcus faecalis ATCC 29212, mixed aerobic cultures, or mixed anaerobic cultures. First, the antibacterial effects of the hydrodynamic system (RinsEndo), a passive ultrasonic irrigation system (Piezo smart), and manual rinsing with 0.9% NaCl (the control) were compared. Colony-forming units were counted. Second, the 2 systems were used with 1.5% sodium hypochlorite (NaOCl) alone or NaOCl + 0.2% chlorhexidine (CHX). The colony-forming units in the treated and untreated roots were determined during a period of 5 days. Results: Both irrigation systems reduced bacterial numbers more effectively than manual rinsing (P < .001). With NaCl, ultrasonic activated irrigation reduced bacterial counts significantly better than hydrodynamic irrigation (P = .042). The NaOCl + CHX combination was more effective than NaOCl alone for both systems (P < .001), but hydrodynamic irrigation was more effective with NaOCl + CHX than the passive ultrasonic irrigation system. Conclusions: Both irrigation systems, when combined with NaOCl + CHX, removed bacteria from root canals.
MeSH term(s)	Actinomyces/drug effects ; Anti-Bacterial Agents/administration & dosage ; Bacterial Load/drug effects ; Bifidobacterium/drug effects ; Chlorhexidine/administration & dosage ; Coculture Techniques ; Dental Pulp Cavity/drug effects ; Dental Pulp Cavity/microbiology ; Disinfection/instrumentation ; Disinfection/methods ; Drug Combinations ; Enterococcus faecalis/drug effects ; Eubacterium/drug effects ; Humans ; Hydrodynamics ; Materials Testing ; Peptostreptococcus/drug effects ; Root Canal Irrigants/administration & dosage ; Root Canal Preparation/instrumentation ; Sodium Hypochlorite/administration & dosage ; Therapeutic Irrigation/instrumentation ; Therapeutic Irrigation/methods ; Ultrasonics/instrumentation ; Ultrasonics/methods
Chemical Substances	Anti-Bacterial Agents ; Drug Combinations ; Root Canal Irrigants ; Sodium Hypochlorite (DY38VHM5OD) ; Chlorhexidine (R4KO0DY52L)
Language	English
Publishing date	2013-09
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	752412-2
ISSN	1878-3554 ; 0099-2399
ISSN (online)	1878-3554
ISSN	0099-2399
DOI	10.1016/j.joen.2013.06.008
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