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Book ; Conference proceedings: International Symposium on Cell Signaling

Carreau, Serge

October 28 - 31, 2010, Florianópolis, Brazil

(Life sciences ; 89,15/16 = Special issue)

2011

Event/congress	International Symposium on Cell Signaling (2010, Florianópolis)
Author's details	ed.: Serge Carreau
Series title	Life sciences ; 89,15/16 = Special issue
Collection
Language	English
Size	S. 505 - 594 : Ill., graph. Darst.
Publisher	Elsevier
Publishing place	Amsterdam u.a.
Publishing country	Netherlands
Document type	Book ; Conference proceedings
HBZ-ID	HT017014101
Database	Catalogue ZB MED Medicine, Health

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Uc I Zs 368 -89-	verfügbar in Königswinter	Königswinter

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Book ; Conference proceedings: 2nd Polish-French Symposium Endocrinology of Reproduction

Carreau, Serge

23rd - 25th April 2009, Kraków

(Folia histochemica et cytobiologica ; 47,5)

2009

Event/congress	Polish-French Symposium Endocrinology of Reproduction (2, 2009, Krakau)
Author's details	ed. Serge Carreau
Series title	Folia histochemica et cytobiologica ; 47,5
Collection
Language	English
Size	S154 S. : Ill., graph. Darst.
Publishing place	S.l.
Publishing country	Poland
Document type	Book ; Conference proceedings
HBZ-ID	HT017727558
Database	Catalogue ZB MED Medicine, Health

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Zs B 6 -47-	verfügbar in Königswinter	Königswinter

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Article ; Online: An Addison disease revealed with a serious hyponatremia.

Maguet, Hadrien / Carreau, Agnès / Hautefeuille, Serge / Bonnin, Pierre / Beaune, Gaspard

Annales de biologie clinique

2017 Volume 75, Issue 1, Page(s) 87–91

Abstract: We present the case of an Addison's disease revealed by a serious hyponatremia. The serum concentration of ACTH and 21-hydroxylase antibodies were increased and lead to the diagnosis. The cortisol blood level was lowered but required to take into account ...

Title translation	Une maladie d’Addison révélée par une hyponatrémie sévère.
Abstract	We present the case of an Addison's disease revealed by a serious hyponatremia. The serum concentration of ACTH and 21-hydroxylase antibodies were increased and lead to the diagnosis. The cortisol blood level was lowered but required to take into account the stress induced by the hospitalisation of the patient. Addison's disease is characterized by the destruction of the adrenal cortex. Autoimmune adrenalitis is the main cause of adrenal insufficiency. Treatment involves normalisation of sodium concentration and corticosteroids replacement. With a good patient compliance, the survival rate of Addisonian patient is similar to that of the normal population. Management of patient requires vigilance because of the occurrence of others autoimmunes diseases during patient life.
MeSH term(s)	Addison Disease/blood ; Addison Disease/complications ; Addison Disease/diagnosis ; Adrenocorticotropic Hormone/analysis ; Adrenocorticotropic Hormone/blood ; Autoantibodies/blood ; Coma/blood ; Coma/diagnosis ; Coma/etiology ; Diagnosis, Differential ; Humans ; Hydrocortisone/analysis ; Hydrocortisone/blood ; Hyponatremia/blood ; Hyponatremia/complications ; Hyponatremia/diagnosis ; Male ; Middle Aged ; Severity of Illness Index ; Steroid 21-Hydroxylase/immunology
Chemical Substances	Autoantibodies ; Adrenocorticotropic Hormone (9002-60-2) ; Steroid 21-Hydroxylase (EC 1.14.14.16) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2017-02-01
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	2023584-7
ISSN	1950-6112 ; 0003-3898
ISSN (online)	1950-6112
ISSN	0003-3898
DOI	10.1684/abc.2016.1212
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Estrogens--male hormones?

Carreau, Serge

Folia histochemica et cytobiologica

2003 Volume 41, Issue 3, Page(s) 107–111

Abstract: The cytochrome P450 aromatase is the terminal enzyme responsible for the irreversible transformation of androgens into estrogens; it is present in the endoplasmic reticulum membrane of cells and rather ubiquitous in its localization. The aromatase gene ... ...

Abstract	The cytochrome P450 aromatase is the terminal enzyme responsible for the irreversible transformation of androgens into estrogens; it is present in the endoplasmic reticulum membrane of cells and rather ubiquitous in its localization. The aromatase gene is unique in humans and its expression is regulated in a cell-specific manner via the alternative use of various promoters located in the first exon I of the CYP19 gene. The aromatase gene expression and its translation into a fully active protein have been shown in most of the testicular cells including germ cells as well as in the epithelial cells of the epididymis in mammals. Together with the widespread distribution of estrogen receptors (ERalpha and ERbeta) in the genital tract of the male, a physiological role for estrogens in the regulation of mammalian reproductive functions including the regulation of gonadotropin feedback, is now well recognized. Moreover, in men the aromatase deficiency is associated with severe bone maturation problems, alterations of lipid and sugar metabolism and sterility; but conversely an excess of estrogens is responsible for the impairment of spermatogenesis. In addition, estrogens play an important role in the control of osteoporosis and of atherosclerosis, especially in elderly men. Consequently, estradiol seems to be a critical factor not only for normal reproduction (at least for maturation and survival of germ cells) but also for various physiological processes and thus, estrogens should be now considered as "male hormones".
MeSH term(s)	Androgens/metabolism ; Animals ; Aromatase/genetics ; Aromatase/metabolism ; Estrogens/metabolism ; Humans ; Male ; Testis/cytology ; Testis/metabolism
Chemical Substances	Androgens ; Estrogens ; Aromatase (EC 1.14.14.1)
Language	English
Publishing date	2003
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	605761-5
ISSN	1897-5631 ; 0239-8508 ; 0015-5586
ISSN (online)	1897-5631
ISSN	0239-8508 ; 0015-5586
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The testicular aromatase: from gene to physiological role.

Carreau, Serge

Reproductive biology

2002 Volume 2, Issue 1, Page(s) 5–12

Abstract: The aromatase is the terminal enzyme responsible for estrogen biosynthesis. It is present in the endoplasmic reticulum membrane of steroidogenic cells. The aromatase gene is unique and its expression is regulated in a tissue and more precisely, in a cell- ...

Abstract	The aromatase is the terminal enzyme responsible for estrogen biosynthesis. It is present in the endoplasmic reticulum membrane of steroidogenic cells. The aromatase gene is unique and its expression is regulated in a tissue and more precisely, in a cell-specific manner via the alternative use of various promoters located in the first exon I. Physiological role of estrogens in the regulation of mammalian testicular functions is indicated by: 1/the aromatase gene expression and its transduction in a fully active protein in somatic cells as well in germ cells of testes, 2/ the widespread distribution of estrogen receptors (ERalpha and ERbeta) in the genital tract of the male. Our recent data showing that human ejaculated spermatozoa expressed specific transcripts for P450arom support and expand the observations reported in germ cells of other mammalian species. Therefore, female hormones (or the ratio androgens/estrogens) do play a role, either directly on germ cells or via testicular somatic cells, in the maintenance of male gonadal functions. Several steps, including spermatid production, the sperm maturation and/or survival provide opportunity for estrogen action.
MeSH term(s)	Animals ; Aromatase/genetics ; Aromatase/physiology ; Estrogens/biosynthesis ; Gene Expression ; Humans ; Leydig Cells/enzymology ; Male ; Sertoli Cells/enzymology ; Spermatogenesis ; Spermatozoa/enzymology ; Testis/enzymology ; Testis/physiology
Chemical Substances	Estrogens ; Aromatase (EC 1.14.14.1)
Language	English
Publishing date	2002-03
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	2189316-0
ISSN	1642-431X
ISSN	1642-431X
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Article ; Online: Oestrogens and spermatogenesis.

Carreau, Serge / Hess, Rex A

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

2010 Volume 365, Issue 1546, Page(s) 1517–1535

Abstract: The role of oestrogens in male reproductive tract physiology has for a long time been a subject of debate. The testis produces significant amounts of oestrogenic hormones, via aromatase, and oestrogen receptors (ERs)alpha (ESR1) and ERbeta (ESR2) are ... ...

Abstract	The role of oestrogens in male reproductive tract physiology has for a long time been a subject of debate. The testis produces significant amounts of oestrogenic hormones, via aromatase, and oestrogen receptors (ERs)alpha (ESR1) and ERbeta (ESR2) are selectively expressed in cells of the testis as well as the epididymal epithelium, depending upon species. This review summarizes the current knowledge concerning the presence and activity of aromatase and ERs in testis and sperm and the potential roles that oestrogens may have in mammalian spermatogenesis. Data show that physiology of the male gonad is in part under the control of a balance of androgens and oestrogens, with aromatase serving as a modulator.
MeSH term(s)	Animals ; Estrogens/physiology ; Humans ; Male ; Spermatogenesis/physiology ; Spermatozoa/enzymology ; Spermatozoa/physiology ; Testis/physiology
Chemical Substances	Estrogens
Language	English
Publishing date	2010-04-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	208382-6
ISSN	1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
ISSN (online)	1471-2970
ISSN	0080-4622 ; 0264-3839 ; 0962-8436
DOI	10.1098/rstb.2009.0235
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Article: Estrogens in male germ cells.

Carreau, Serge / Bouraima-Lelong, Helene / Delalande, Christelle

Spermatogenesis

2012 Volume 1, Issue 2, Page(s) 90–94

Abstract: The biosynthesis of steroids and the production of spermatozoa are two major functions of the mammalian testis which are tightly controlled by gonadotropins and numerous locally produced factors. Among these are the estrogens that are produced within the ...

Abstract	The biosynthesis of steroids and the production of spermatozoa are two major functions of the mammalian testis which are tightly controlled by gonadotropins and numerous locally produced factors. Among these are the estrogens that are produced within the seminiferous epithelium via the irreversible transformation of androgens (C19) into estrogens (C18) by aromatase. We have recently reported that male germ cells are the new source of estrogens in the testis. For instance, estrogen receptors (ER) are found mainly in spermatids that give rise to spermatozoa. Moreover, it is noteworthy that GPR 30 (a transmembrane ER) induces rapid responses after estradiol binding, which, in turn, modulates cyclins and proapoptotic factors (e.g., BAX) to affect germ cell cycle progression and apoptosis. In summary, at least in the animal species that were studied thus far, germ cells are the major source and the target of estrogens, affecting normal male gonadal development and spermatogenesis, in particular spermiogenesis. These findings have also shed new light on the possible adverse effects of endocrine disruptors having estrogenic activities that can cause abnormal development of the male genital tract.
Language	English
Publishing date	2012-01-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2629571-4
ISSN	2156-5562 ; 2156-5554
ISSN (online)	2156-5562
ISSN	2156-5554
DOI	10.4161/spmg.1.2.16766
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Article ; Online: Role of estrogens in spermatogenesis.

Carreau, Serge / Bouraima-Lelong, Helene / Delalande, Christelle

Frontiers in bioscience (Elite edition)

2012 Volume 4, Issue 1, Page(s) 1–11

Abstract: Aromatase converts irreversibly androgens into estrogens and is present in the endoplasmic reticulum of various cells of mammalian testes ... at least in rodents, all testicular cells except peritubular cells express aromatase. In testis, high affinity ... ...

Abstract	Aromatase converts irreversibly androgens into estrogens and is present in the endoplasmic reticulum of various cells of mammalian testes at least in rodents, all testicular cells except peritubular cells express aromatase. In testis, high affinity estrogen receptors, ERalpha and/or ERbeta, together with a membrane rapid effect recently described, mediate the effects of estrogens. From the experimental models, in vitro studies and data collected in patients, it is now demonstrated that estrogens play an important role in the testis of vertebrates. At least it is supported by the widespread distribution of estrogen receptors in the testicular cells and the simultaneous presence of a biologically active aromatase in all germ cells (especially in meiotic and post-meiotic stages). Thus the role of estrogens (intracrine, autocrine and / or paracrine) in spermatogenesis (proliferation, apoptosis, survival and maturation) and more generally, in male reproduction is now evidenced, and much more complex than previously predicted.
MeSH term(s)	Animals ; Aromatase/metabolism ; Estrogens/physiology ; Humans ; Male ; Receptors, Estrogen/physiology ; Spermatogenesis/physiology ; Testis/enzymology ; Testis/physiology
Chemical Substances	Estrogens ; Receptors, Estrogen ; Aromatase (EC 1.14.14.1)
Language	English
Publishing date	2012-01-01
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2565080-4
ISSN	1945-0508 ; 1945-0494
ISSN (online)	1945-0508
ISSN	1945-0494
DOI	10.2741/e356
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Article ; Online: Bariatric Surgery Rapidly Decreases Cardiac Dietary Fatty Acid Partitioning and Hepatic Insulin Resistance Through Increased Intra-abdominal Adipose Tissue Storage and Reduced Spillover in Type 2 Diabetes.

Carreau, Anne-Marie / Noll, Christophe / Blondin, Denis P / Frisch, Frédérique / Nadeau, Mélanie / Pelletier, Mélissa / Phoenix, Serge / Cunnane, Stephen C / Guérin, Brigitte / Turcotte, Eric E / Lebel, Stéfane / Biertho, Laurent / Tchernof, André / Carpentier, André C

Diabetes

2020 Volume 69, Issue 4, Page(s) 567–577

Abstract: Reduced storage of dietary fatty acids (DFAs) in abdominal adipose tissues with enhanced cardiac partitioning has been shown in subjects with type 2 diabetes (T2D) and prediabetes. We measured DFA metabolism and organ partitioning using positron emission ...

Abstract	Reduced storage of dietary fatty acids (DFAs) in abdominal adipose tissues with enhanced cardiac partitioning has been shown in subjects with type 2 diabetes (T2D) and prediabetes. We measured DFA metabolism and organ partitioning using positron emission tomography with oral and intravenous long-chain fatty acid and glucose tracers during a standard liquid meal in 12 obese subjects with T2D before and 8-12 days after bariatric surgery (sleeve gastrectomy or sleeve gastrectomy and biliopancreatic diversion with duodenal switch). Bariatric surgery reduced cardiac DFA uptake from a median (standard uptake value [SUV]) 1.75 (interquartile range 1.39-2.57) before to 1.09 (1.04-1.53) after surgery (
MeSH term(s)	Adult ; Bariatric Surgery ; Blood Glucose/metabolism ; Body Composition/physiology ; Diabetes Mellitus, Type 2/diagnostic imaging ; Diabetes Mellitus, Type 2/metabolism ; Fatty Acids/metabolism ; Female ; Humans ; Insulin Resistance/physiology ; Intra-Abdominal Fat/diagnostic imaging ; Intra-Abdominal Fat/metabolism ; Liver/diagnostic imaging ; Liver/metabolism ; Male ; Middle Aged ; Myocardium/metabolism ; Obesity/diagnostic imaging ; Obesity/metabolism ; Obesity/surgery ; Tomography, X-Ray Computed ; Treatment Outcome
Chemical Substances	Blood Glucose ; Fatty Acids
Language	English
Publishing date	2020-01-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db19-0773
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Article: Transcripts of aromatase and estrogen receptors and significance of other RNAs in human spermatozoa.

Carreau, Serge / Isabelle, Galeraud-Denis

Archives of andrology

2008 Volume 53, Issue 5, Page(s) 249–255

Abstract: The existence of a complex population of mRNAs in human sperm is well documented but their role is not completely elucidated. Evidence for a latent transcriptional capacity and/or a potential translation de novo in mature spermatozoa from fertile men has ...

Abstract	The existence of a complex population of mRNAs in human sperm is well documented but their role is not completely elucidated. Evidence for a latent transcriptional capacity and/or a potential translation de novo in mature spermatozoa from fertile men has been provided and is helpful in understanding the final steps of sperm maturation (capacitation and/or the acrosome reaction). Spermatogenesis is controlled by gonadotrophins and testosterone, their effects are modulated by locally-produced factors that include estrogens derived from the irreversible transformation of androgens by aromatase. The data demonstrating an additional source of estrogens in rat germ cells along with several studies showing a decreased sperm motility in men deficient in aromatase has led to the further explanation of the expression of aromatase in ejaculated spermatozoa from fertile men. A significant decrease in the amount of aromatase transcripts in the immotile sperm fraction was recorded. In addition, the levels of transcripts encoding for proteins involved in either nuclear condensation protamines 1 and 2 (Prm1 and Prm2) or in capacitation endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide sythase (nNOS) and c-myc were compared in low and high motile sperm prepared from the same sample. No significant change in the ratio of c-myc/Prm2 between the two populations of spermatozoa was observed. Conversely the amount of Prm1 mRNA was significantly higher in the low motile fraction than in the high motile fraction; in most of the high motile sperm samples analyzed, eNOS and nNOS transcripts were undetectable, whereas they were observed in low motile sperm. Moreover, a partial or complete disappearance of c-myc transcripts was observed after capacitation. Analysis of the mRNA profile in human ejaculated sperm could be helpful either as a diagnostic tool to evaluate the male gamete quality and/or as a prognostic value for fertilization and embryo development.
MeSH term(s)	Aromatase/genetics ; Humans ; Male ; RNA, Messenger/genetics ; Receptors, Estrogen/genetics ; Spermatozoa/enzymology ; Spermatozoa/metabolism
Chemical Substances	RNA, Messenger ; Receptors, Estrogen ; Aromatase (EC 1.14.14.1)
Language	English
Publishing date	2008-02-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	430351-9
ISSN	0148-5016
ISSN	0148-5016
DOI	10.1080/01485010701569908
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