LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 227

Search options

  1. Book: Neuropsychopharmacology: A tribute to Joseph T. Coyle

    Coyle, Joseph T. / Schwarcz, Robert

    (Advances in pharmacology ; volume 76)

    2016  

    Author's details edited by Robert Schwarcz
    Series title Advances in pharmacology ; volume 76
    Collection
    Language English
    Size XX, 400 Seiten, Illustrationen
    Edition First edition
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT019029097
    ISBN 978-0-12-809745-8 ; 0-12-809745-0
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uf I Zs 171 -76- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book ; Conference proceedings: Early glial dysfunction in epilepsy

    Schwarcz, Robert

    [based on an investigators workshop at the 2006 meeting of the American Epilepsy Society ...]

    (Epilepsia ; 49, Suppl. 2)

    2008  

    Institution American Epilepsy Society
    Author's details guest ed. Robert Schwarcz
    Series title Epilepsia ; 49, Suppl. 2
    Collection
    Language English
    Size 62 S. : Ill., graph. Darst.
    Publisher Blackwell
    Publishing place Malden, MA
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT015446677
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 517 -49,Suppl.2- not available for loan Zeitschriften-Lesesaal

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: The Probiotic

    Schwarcz, Robert / Foo, Ann / Sathyasaikumar, Korrapati V / Notarangelo, Francesca M

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: The gut-brain axis is increasingly understood to play a role in neuropsychiatric disorders. The probiotic ... ...

    Abstract The gut-brain axis is increasingly understood to play a role in neuropsychiatric disorders. The probiotic bacterium
    MeSH term(s) Animals ; Kynurenine ; Limosilactobacillus reuteri ; Kynurenic Acid ; Amino Acids ; Probiotics ; Mammals
    Chemical Substances Kynurenine (343-65-7) ; Kynurenic Acid (H030S2S85J) ; Amino Acids
    Language English
    Publishing date 2024-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073679
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: A single prenatal lipopolysaccharide injection has acute, but not long-lasting, effects on cerebral kynurenine pathway metabolism in mice.

    Notarangelo, Francesca M / Schwarcz, Robert

    The European journal of neuroscience

    2021  Volume 54, Issue 6, Page(s) 5968–5981

    Abstract: In rodents, a single injection of lipopolysaccharide (LPS) during gestation causes chemical and functional abnormalities in the offspring. These effects may involve changes in the kynurenine pathway (KP) of tryptophan degradation and may provide insights ...

    Abstract In rodents, a single injection of lipopolysaccharide (LPS) during gestation causes chemical and functional abnormalities in the offspring. These effects may involve changes in the kynurenine pathway (KP) of tryptophan degradation and may provide insights into the pathophysiology of psychiatric diseases. Using CD1 mice, we examined acute and long-term effects of prenatal LPS treatment on the levels of kynurenine and its neuroactive downstream products kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK) and quinolinic acid. To this end, LPS (100 μg/kg, i.p.) was administered on gestational day 15, and KP metabolites were measured 4 and 24 h later or in adulthood. After 4 h, kynurenine, KYNA and 3-HK levels were elevated in the fetal brain, 3-HK and KYNA levels were increased in the maternal plasma, and kynurenine was increased in the maternal brain, whereas no changes were seen in the placenta. These effects were less prominent after 24 h, and prenatal LPS did not affect the basal levels of KP metabolites in the forebrain of adult animals. In addition, a second LPS injection (1 mg/kg) in adulthood in the offspring of prenatally saline- and LPS-treated mice caused a similar elevation in 3-HK levels in both groups after 24 h, but the effect was significantly more pronounced in male mice. Thus, acute immune activation during pregnancy has only short-lasting effects on KP metabolism and does not cause cerebral KP metabolites to be disproportionally affected by a second immune challenge in adulthood. However, prenatal KYNA elevations still contribute to functional abnormalities in the offspring.
    MeSH term(s) Animals ; Female ; Kynurenic Acid ; Kynurenine ; Lipopolysaccharides ; Male ; Mice ; Placenta ; Pregnancy ; Quinolinic Acid
    Chemical Substances Lipopolysaccharides ; Kynurenine (343-65-7) ; Quinolinic Acid (F6F0HK1URN) ; Kynurenic Acid (H030S2S85J)
    Language English
    Publishing date 2021-08-17
    Publishing country France
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.15416
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2548: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: The Discovery and Characterization of Targeted Perikaryal-Specific Brain Lesions With Excitotoxins.

    Coyle, Joseph T / Schwarcz, Robert

    Frontiers in neuroscience

    2020  Volume 14, Page(s) 927

    Abstract: The neurotoxic action of glutamic acid was first described by Lucas and Newhouse, who demonstrated neural degeneration in the inner layers of the neonatal mouse retina after systemic treatment with L-glutamate. Olney extended these findings by showing ... ...

    Abstract The neurotoxic action of glutamic acid was first described by Lucas and Newhouse, who demonstrated neural degeneration in the inner layers of the neonatal mouse retina after systemic treatment with L-glutamate. Olney extended these findings by showing that neuronal degeneration affected other brain structures including neurons within the arcuate nucleus of the hypothalamus and the area postrema, that the lesion spared axons passing through these areas, and that the neurotoxic potency of glutamate analogs correlated with their excitatory potency, resulting in the designation "excitotoxins." As this method affected only a small number of brain regions, it was not suitable for targeted brain lesions. The Coyle laboratory showed that direct injection of the potent glutamate receptor agonist, kainic acid, into the rat striatum caused a rapid degeneration of intrinsic neurons while sparing axons of passage or termination including the unmyelinated dopaminergic terminals. Kainic acid also exhibited this perikaryal-specific and axon-sparing profile when injected into the cerebellum, hippocampus and eye. However, neuronal vulnerability was highly variable, with hippocampal CA3, pyriform cortex and amygdala neurons exhibiting great sensitivity due to kainate's high convulsive activity. In a comparison study, ibotenic acid, a potent glutamatergic agonist isolated from the
    Language English
    Publishing date 2020-09-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2020.00927
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book: Kynurenine and serotonin pathways

    Schwarcz, Robert

    progress in tryptophan research ; [held May 9 - 12, 1989, in Baltimore, Maryland]

    (Proceedings of the International Study Group for Tryptophan Research ; 6 ; Advances in experimental medicine and biology ; 294)

    1991  

    Author's details ed. by Robert Schwarcz
    Series title Proceedings of the International Study Group for Tryptophan Research ; 6
    Advances in experimental medicine and biology ; 294
    Proceedings
    Collection Proceedings
    Keywords Kynurenine / congresses ; Serotonin / congresses ; Kynurenin ; Serotonin ; Tryptophanstoffwechsel
    Subject Tryptophan ; Enteroamin ; Hydroxytryptamin ; Thrombocytin ; Aminoethylindolol ; CAS 50-67-9
    Language English
    Size XVII, 715 S. : Ill., graph. Darst.
    Publisher Plenum Pr
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003933912
    ISBN 0-306-43929-8 ; 978-0-306-43929-2
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -294- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Alterations in rat prefrontal cortex kynurenic acid levels are involved in the enduring cognitive dysfunctions induced by tetrahydrocannabinol exposure during the adolescence.

    Beggiato, Sarah / Ieraci, Alessandro / Zuccarini, Mariachiara / Di Iorio, Patrizia / Schwarcz, Robert / Ferraro, Luca

    Frontiers in psychiatry

    2022  Volume 13, Page(s) 996406

    Abstract: Introduction: Cannabis abuse during adolescence is a risk factor for cognitive impairments in psychiatric disorders later in life. To date, the possible causal relationship between cannabinoids, kynurenic acid (KYNA; i.e., a neuroactive metabolite of ... ...

    Abstract Introduction: Cannabis abuse during adolescence is a risk factor for cognitive impairments in psychiatric disorders later in life. To date, the possible causal relationship between cannabinoids, kynurenic acid (KYNA; i.e., a neuroactive metabolite of tryptophan degradation) and cognition has not been investigated in adolescence. Early exposure to delta 9-tetrahydrocannabinol (THC; i.e., the main psychotropic component of cannabis) causes enduring cognitive deficits, which critically involve impaired glutamatergic function in the prefrontal cortex (PFC). In addition, prenatal cannabis exposure results in enduring increases in PFC KYNA levels. Based on these findings, the effects of chronic THC exposure in rats, during another critical period of neurodevelopment particularly sensitive to perturbation by exogenous stimuli, such as adolescence, have been investigated.
    Methods: Male Wistar rats were chronically treated with vehicle or ascending intraperitoneal (i.p.) doses of THC starting on postnatal day (PND) 35 until PND 45. In adulthood (PND 75), cognitive assessment (Y-maze) and extracellular KYNA/glutamate levels were measured in the PFC by
    Results: Compared to vehicle-treated controls, extracellular basal KYNA levels were higher in the PFC of adult rats chronically exposed to THC in adolescence (
    Discussion: We propose that the observed alterations in PFC KYNA signaling might be involved in the cognitive dysfunction induced by the exposure to THC during the adolescence. In the translational realm, these experiments raise the prospect of prevention of KYNA neosynthesis as a possible novel approach to counteract some of the detrimental long-term effects of adolescence cannabis use.
    Language English
    Publishing date 2022-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.996406
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Deletion of quinolinate phosphoribosyltransferase gene accelerates frailty phenotypes and neuromuscular decline with aging in a sex-specific pattern.

    Chung, Tae / Bopp, Taylor / Ward, Chris / Notarangelo, Francesca M / Schwarcz, Robert / Westbrook, Reyhan / Xue, Qian-Li / Walston, Jeremy / Hoke, Ahmet

    Aging cell

    2023  Volume 22, Issue 7, Page(s) e13849

    Abstract: Decline in neuromuscular function with aging is known to be a major determinant of disability and all-cause mortality in late life. Despite the importance of the problem, the neurobiology of age-associated muscle weakness is poorly understood. In a ... ...

    Abstract Decline in neuromuscular function with aging is known to be a major determinant of disability and all-cause mortality in late life. Despite the importance of the problem, the neurobiology of age-associated muscle weakness is poorly understood. In a previous report, we performed untargeted metabolomics on frail older adults and discovered prominent alteration in the kynurenine pathway, the major route of dietary tryptophan degradation that produces neurotoxic intermediate metabolites. We also showed that neurotoxic kynurenine pathway metabolites are correlated with increased frailty score. For the present study, we sought to further examine the neurobiology of these neurotoxic intermediates by utilizing a mouse model that has a deletion of the quinolinate phosphoribosyltransferase (QPRT) gene, a rate-limiting step of the kynurenine pathway. QPRT
    MeSH term(s) Male ; Female ; Mice ; Animals ; Kynurenine/metabolism ; Frailty/genetics ; Phenotype ; Aging ; Muscle Weakness
    Chemical Substances Kynurenine (343-65-7) ; nicotinate-nucleotide diphosphorylase (carboxylating) (EC 2.4.2.19)
    Language English
    Publishing date 2023-04-20
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.13849
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6581: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book ; Conference proceedings: Excitatory amino acids and epilepsy

    Schwarcz, Robert

    [proceedings of the 1st International Symposium on Excitatory Amino Acids and Epilepsy, held September 2 - 5, 1985, at Château de Fillerval, France>

    (Advances in experimental medicine and biology ; 203)

    1986  

    Event/congress International Symposium on Excitatory Amino Acids and Epilepsy (1, 1985, Fillerval)
    Author's details ed. by Robert Schwarcz
    Series title Advances in experimental medicine and biology ; 203
    Collection
    Keywords Amino Acids / pharmacology / congresses ; Epilepsy / etiology / congresses ; Epilepsie ; Aminosäuren
    Subject Aminosäuren ; Aminocarbonsäuren ; Aminosäure ; Fallsucht
    Size XI, 735 S. : Ill., graph. Darst.
    Publisher Plenum Pr
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT002872216
    ISBN 0-306-42402-9 ; 978-0-306-42402-1
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1987 A 148 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Preface.

    Schwarcz, Robert / Enna, S J

    Advances in pharmacology (San Diego, Calif.)

    2016  Volume 76, Page(s) xvii–xx

    Language English
    Publishing date 2016
    Publishing country United States
    Document type Editorial
    ISSN 1557-8925
    ISSN (online) 1557-8925
    DOI 10.1016/S1054-3589(16)30042-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top