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  1. Article ; Online: Conflicts of Interest Among Infectious Diseases Clinical Practice Guideline Authors and the Pharmaceutical Industry.

    Ahiskali, Aileen S / Drekonja, Dimitri M / Alpern, Jonathan D

    JAMA network open

    2023  Volume 6, Issue 4, Page(s) e238592

    MeSH term(s) Humans ; Conflict of Interest ; Medicine ; Drug Industry
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.8592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Blastomycosis-Some Progress but Still Much to Learn.

    Pullen, Matthew F / Alpern, Jonathan D / Bahr, Nathan C

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 8

    Abstract: Blastomycosis, caused ... ...

    Abstract Blastomycosis, caused by
    Language English
    Publishing date 2022-08-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8080824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Factors Associated With Adherence to First-line Antiviral Therapy Among Commercially Insured Patients With Chronic Hepatitis B.

    Alpern, Jonathan D / Joo, Heesoo / Bahr, Nathan C / Leventhal, Thomas M

    Open forum infectious diseases

    2023  Volume 10, Issue 3, Page(s) ofad118

    Abstract: Background: Nonadherence to antiviral therapy can lead to poor clinical outcomes among patients with chronic hepatitis B (CHB). We used a claims database to evaluate risk factors for nonadherence to antiviral therapy among commercially insured patients ... ...

    Abstract Background: Nonadherence to antiviral therapy can lead to poor clinical outcomes among patients with chronic hepatitis B (CHB). We used a claims database to evaluate risk factors for nonadherence to antiviral therapy among commercially insured patients with CHB in the United States.
    Methods: We obtained data for commercially insured adult patients with CHB prescribed entecavir or tenofovir disoproxil fumarate (TDF) in 2019. Primary outcomes were adherence to entecavir and adherence to TDF. Enrollees with a proportion of days covered (PDC) ≥80% were considered adherent. We presented adjusted odds ratios (AORs) from multivariate logistic regressions.
    Results: Eighty-three percent (n = 640) of entecavir patients were adherent, and 81% (n = 687) of TDF patients were adherent. Ninety-day supply (vs 30-day supply; AOR, 2.21;
    Conclusions: Ninety-day and mixed-duration supplies of entecavir and TDF were associated with higher fill rates as compared with 30-day supplies among commercially insured patients with CHB.
    Language English
    Publishing date 2023-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cutaneous Leishmaniasis.

    Knapp, Alexia P / Alpern, Jonathan D

    The New England journal of medicine

    2020  Volume 382, Issue 2, Page(s) e2

    MeSH term(s) Hand/parasitology ; Hand/pathology ; Humans ; Leishmania/isolation & purification ; Leishmaniasis, Cutaneous/complications ; Leishmaniasis, Cutaneous/pathology ; Male ; Skin Ulcer/parasitology ; Skin Ulcer/pathology ; Young Adult
    Language English
    Publishing date 2020-01-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMicm1908092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Food and Drug Administration Approval of Artesunate for Severe Malaria: Enough to Achieve Best Practice?

    Thomas, Christine M / Stauffer, William M / Alpern, Jonathan D

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 76, Issue 3, Page(s) e864–e866

    Abstract: Intravenous artesunate has been the global standard of care for severe malaria for over 2 decades. Yet, until recently, artesunate has only been available to patients through an expanded-access protocol from the Centers for Disease Control and Prevention. ...

    Abstract Intravenous artesunate has been the global standard of care for severe malaria for over 2 decades. Yet, until recently, artesunate has only been available to patients through an expanded-access protocol from the Centers for Disease Control and Prevention. In May 2020, the Food and Drug Administration approved artesunate, allowing US hospitals to stock the drug and ensuring prompt treatment for this life-threatening infection. However, because of artesunate's high cost and the infrequency of severe malaria in the United States, hospitals may be reluctant to stock the drug. As US health systems weigh the decision to stock artesunate, we propose a hospital tier framework to inform this decision and support clinicians caring for patients who present with severe malaria.
    MeSH term(s) Humans ; United States ; Artesunate/therapeutic use ; Antimalarials/therapeutic use ; United States Food and Drug Administration ; Artemisinins/therapeutic use ; Malaria/drug therapy
    Chemical Substances Artesunate (60W3249T9M) ; Antimalarials ; Artemisinins
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Off-Label Therapies for COVID-19-Are We All In This Together?

    Alpern, Jonathan D / Gertner, Elie

    Clinical pharmacology and therapeutics

    2020  Volume 108, Issue 2, Page(s) 182–184

    MeSH term(s) COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Drug Industry ; Drug Prescriptions ; Drug Utilization ; Hospitals ; Humans ; Hydroxychloroquine/therapeutic use ; Off-Label Use ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; United States ; United States Food and Drug Administration
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Keywords covid19
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.1862
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  7. Article ; Online: Antiparasitic Drugs in the United States-Two Roads to High Prices.

    Shahriar, Arman A / Alpern, Jonathan D

    Frontiers in sociology

    2020  Volume 5, Page(s) 540478

    Abstract: High prescription drug prices contribute significantly to healthcare spending in the United States and compromise patients' access to quality medical care. A number of factors allow drug manufacturers to set much higher prices in the US than in other ... ...

    Abstract High prescription drug prices contribute significantly to healthcare spending in the United States and compromise patients' access to quality medical care. A number of factors allow drug manufacturers to set much higher prices in the US than in other comparable high-income nations. Price-control depends primarily on the entry and persistence of generic products following the expiration of the market exclusivity period granted to the manufacturer of the brand name drug. Unfortunately, barriers to generic entry are common, allowing off-patent drugs like albendazole to remain relatively expensive despite having been marketed in the US for decades. By contrast, miltefosine became FDA approved more recently and has maintained a high price tag by way of a novel incentive program-the neglected tropical disease (NTD) priority review voucher (PRV) program. The voucher has a high market value and can be sold or transferred well before the drug for which it was awarded becomes available on the market. While both drugs are used to treat parasitic infections that are uncommon in the US, they differ by market and regulatory conditions-each telling an interesting pricing story.
    Language English
    Publishing date 2020-10-22
    Document type Journal Article
    ISSN 2297-7775
    ISSN (online) 2297-7775
    DOI 10.3389/fsoc.2020.540478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Costs of malaria treatment in the United States.

    Park, Joohyun / Joo, Heesoo / Maskery, Brian A / Alpern, Jonathan D / Weinberg, Michelle / Stauffer, William M

    Journal of travel medicine

    2023  Volume 30, Issue 3

    Abstract: We estimated inpatient and outpatient payments for malaria treatment in the USA. The mean cost per hospitalized patient was significantly higher than for non-hospitalized patients (e.g. $27 642 vs $1177 among patients with private insurance). Patients ... ...

    Abstract We estimated inpatient and outpatient payments for malaria treatment in the USA. The mean cost per hospitalized patient was significantly higher than for non-hospitalized patients (e.g. $27 642 vs $1177 among patients with private insurance). Patients with severe malaria payed two to four times more than those hospitalized with uncomplicated malaria.
    MeSH term(s) Humans ; United States/epidemiology ; Malaria/drug therapy ; Malaria/epidemiology ; Hospitalization ; Health Care Costs
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taad013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Drug-dispensing limits within Medicaid during the COVID-19 pandemic.

    Alpern, Jonathan D / Chomilo, Nathan / DeSilva, Malini

    Journal of managed care & specialty pharmacy

    2021  Volume 27, Issue 10, Page(s) 1489–1493

    Abstract: ... ...

    Abstract SUMMARY
    MeSH term(s) COVID-19/epidemiology ; Chronic Disease ; Humans ; Insurance, Health, Reimbursement/economics ; Insurance, Health, Reimbursement/standards ; Medicaid/economics ; Medicaid/standards ; Pandemics ; Physical Distancing ; Policy ; SARS-CoV-2 ; United States/epidemiology
    Language English
    Publishing date 2021-10-12
    Publishing country United States
    Document type Journal Article
    ISSN 2376-1032
    ISSN (online) 2376-1032
    DOI 10.18553/jmcp.2021.27.10.1489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Erosion of Public Trust and SARS-CoV-2 Vaccines- More Action Is Needed.

    Nahum, Ari / Drekonja, Dimitri M / Alpern, Jonathan D

    Open forum infectious diseases

    2021  Volume 8, Issue 2, Page(s) ofaa657

    Abstract: As states and health systems prepare to deliver severe acute respiratory syndrome coronavirus 2 vaccines to the American public, a confluence of factors has the potential to interfere with these efforts: misinformation about coronavirus disease 2019, ... ...

    Abstract As states and health systems prepare to deliver severe acute respiratory syndrome coronavirus 2 vaccines to the American public, a confluence of factors has the potential to interfere with these efforts: misinformation about coronavirus disease 2019, vaccine hesitancy, and the erosion of the American public's trust in the vaccine regulatory process due to recent and ongoing events. Broad action is needed to address these issues, including improved and consistent communication by the Food and Drug Administration, restoration of the Centers for Disease Control as an independent and science-driven institution, and more aggressive policies to counteract misinformation, particularly on social media platforms.
    Language English
    Publishing date 2021-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofaa657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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