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  1. Article ; Online: Potentially Misleading Details Regarding the Association of Primary Tumor Volume With Survival in Patients With T3 Glottic Cancer.

    D'Ascanio, Luca / Latini, Gino / di Stadio, Arianna

    JAMA otolaryngology-- head & neck surgery

    2023  Volume 149, Issue 6, Page(s) 560

    MeSH term(s) Humans ; Laryngeal Neoplasms/pathology ; Tumor Burden ; Carcinoma, Squamous Cell/pathology ; Retrospective Studies ; Glottis/pathology ; Neoplasm Staging ; Laryngectomy
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2023.0690
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  2. Article ; Online: Visual-Olfactory Training and Patient Preference in Treatment of COVID-19 Olfactory Loss-How Salient Stimuli Might Support Recovery of Smell.

    Di Stadio, Arianna / D'Ascanio, Luca / Brenner, Michael J

    JAMA otolaryngology-- head & neck surgery

    2023  Volume 149, Issue 7, Page(s) 650

    MeSH term(s) Humans ; Smell ; COVID-19 ; Olfactory Training ; Patient Preference ; Anosmia ; Olfaction Disorders/therapy ; Blindness
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2023.1134
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  3. Article ; Online: Persistent COVID-19 parosmia and olfactory loss post olfactory training: randomized clinical trial comparing central and peripheral-acting therapeutics.

    Cantone, Elena / D'Ascanio, Luca / De Luca, Pietro / Roccamatisi, Dalila / La La Mantia, Ignazio / Brenner, Michael J / Di Stadio, Arianna

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2024  

    Abstract: Purpose: Although COVID-19 anosmia is often transient, patients with persistent olfactory dysfunction (pOD) can experience refractory parosmia and diminished smell. This study evaluated four putative therapies for parosmia in patients with chronic COVID- ...

    Abstract Purpose: Although COVID-19 anosmia is often transient, patients with persistent olfactory dysfunction (pOD) can experience refractory parosmia and diminished smell. This study evaluated four putative therapies for parosmia in patients with chronic COVID-19 olfactory impairment.
    Methods: After screening nasal endoscopy, 85 patients (49 female, 58%) with pOD and treatment-refractory parosmia were randomized to: (1) ultramicronized palmitoylethanolamide and luteolin + olfactory training (OT) (umPEALUT group, n = 17), (2) alpha-lipoic acid + OT (ALA group, n = 21), (3) umPEALUT + ALA + OT (combination group, n = 28), or 4) olfactory training (OT) alone (control group, n = 23). Olfactory function was assessed at baseline (T
    Results: The umPEALUT group had the largest improvement in TDI scores (21.8 ± 9.4 to 29.7 ± 7.5) followed by the combination group (19.6 ± 6.29 to 27.5 ± 2.7), both p < 0.01. The control and ALA groups had no significant change. Patients in the combination and umPEALUT groups had significantly improved TDI scores compared to ALA and control groups (p < 0.001). Rates of parosmia resolution after 6 months were reported at 96% for combination, 65% for control, 53% for umPEALUT and 29% for ALA (p < 0.001). All treatment regimens were well-tolerated.
    Conclusions: umPEALUT and OT, with or without ALA, was associated with improvement in TDI scores and parosmia, whereas OT alone or OT with ALA were associated with little benefit.
    Language English
    Publishing date 2024-03-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-024-08548-6
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  4. Article ; Online: Modified Valente Technique for Cauliflower Ear: Outcomes in Children at Two-Year Follow-Up : New Surgical Technique for Cauliflower Ear.

    D'Ascanio, Luca / Gostoli, Eleonora / Ricci, Giampietro / De Luca, Pietro / Latini, Gino / Brenner, Michael J / Di Stadio, Arianna

    Aesthetic plastic surgery

    2024  

    Abstract: Background: Cauliflower ear deformity, a common sequela of auricular trauma, presents an esthetic and reconstructive challenge. Existing surgical techniques have limitations, including complexity, donor site morbidity, and variable long-term outcomes.!## ...

    Abstract Background: Cauliflower ear deformity, a common sequela of auricular trauma, presents an esthetic and reconstructive challenge. Existing surgical techniques have limitations, including complexity, donor site morbidity, and variable long-term outcomes.
    Materials and methods: In this case series, we present a novel and minimally invasive surgical approach for the correction of cauliflower ear deformity that adapts the Valente otoplasty technique; it combines cartilage debulking with helical rim release and Mustardé mattress stitches to restore ear contour and reduce the risk of recurrence. The procedural steps include bielliptic post-auricular skin and soft tissue incision, release of the cartilaginous spring, removal of excess fibrocartilaginous tissue, cartilage reshaping with suture to restore contour, and tissue redistribution to promote adherence of skin to the cartilage framework.
    Results: Outcomes were evaluated in 7 patients (9 ears) with cauliflower ear deformity, assessing surgical duration, complications, patient satisfaction, and esthetic outcomes at two years after surgery. The mean surgical duration per patient was 52 ± 17 minutes, including 2 bilateral procedures. Follow-up at 24 months showed favorable esthetic outcome in all patients with sustained improvements in auricular contour and symmetry with neither loss of the shape nor recurrence of deformity. Patients reported high satisfaction and improved quality of life, with mean Glasgow Children Benefit Questionnaire scores of 99.3 ± 6.3.
    Conclusions: This technique thus demonstrated lasting correction of cauliflower ear with favorable cosmetic outcomes, low risk of complications, and high patient satisfaction. Further investigations and longer-term follow-up are warranted to validate the technique's durability and expand its application to older and more diverse patient populations.
    Level of evidence iv: This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the Table of contents or the online Instructions to Authors www.springer.com/00266 .
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 532791-x
    ISSN 1432-5241 ; 0364-216X
    ISSN (online) 1432-5241
    ISSN 0364-216X
    DOI 10.1007/s00266-024-03914-5
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  5. Article ; Online: Survival Outcomes for Patients With T3N0M0 Squamous Cell Carcinoma of the Glottic Larynx.

    D'Ascanio, Luca / Piazza, Fabio

    JAMA otolaryngology-- head & neck surgery

    2018  Volume 144, Issue 6, Page(s) 542–543

    MeSH term(s) Carcinoma, Squamous Cell ; Glottis ; Humans ; Laryngeal Neoplasms
    Language English
    Publishing date 2018-03-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2018.0077
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  6. Article ; Online: Suturing Technique for the Correction of the Obtuse Nasolabial Angle.

    D'Ascanio, Luca / Piazza, Fabio

    JAMA facial plastic surgery

    2017  Volume 20, Issue 1, Page(s) 85–86

    MeSH term(s) Nose/surgery ; Rhinoplasty ; Suture Techniques ; Sutures
    Language English
    Publishing date 2017-12-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2702062-9
    ISSN 2168-6092 ; 2168-6076
    ISSN (online) 2168-6092
    ISSN 2168-6076
    DOI 10.1001/jamafacial.2017.1987
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  7. Article ; Online: More on Implantation of an Artificial Larynx after Total Laryngectomy.

    D'Ascanio, Luca / Piazza, Fabio

    The New England journal of medicine

    2017  Volume 376, Issue 14, Page(s) e29

    MeSH term(s) Humans ; Laryngeal Neoplasms/surgery ; Laryngectomy ; Larynx ; Larynx, Artificial
    Language English
    Publishing date 2017--06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1701193
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  8. Article ; Online: Daytime Sleepiness and Surgical Skill.

    Ori, Michele / D'Ascanio, Luca / Ricci, Giampietro

    JAMA facial plastic surgery

    2019  Volume 21, Issue 4, Page(s) 343–344

    MeSH term(s) Nose ; Rhinoplasty
    Language English
    Publishing date 2019-04-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2702062-9
    ISSN 2168-6092 ; 2168-6076
    ISSN (online) 2168-6092
    ISSN 2168-6076
    DOI 10.1001/jamafacial.2018.2040
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  9. Article ; Online: Clarification of a Suspension Technique for Unstable Nasal Bones.

    Ori, Michele / Ricci, Giampietro / D'Ascanio, Luca

    JAMA facial plastic surgery

    2019  Volume 21, Issue 6, Page(s) 573–574

    MeSH term(s) Nasal Bone/surgery ; Rhinoplasty
    Language English
    Publishing date 2019-11-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2702062-9
    ISSN 2168-6092 ; 2168-6076
    ISSN (online) 2168-6092
    ISSN 2168-6076
    DOI 10.1001/jamafacial.2019.1110
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  10. Article ; Online: Covid-19 negatively impacted on small oncology surgery but none on major procedures: Regional experience.

    D'Ascanio, Luca / Latini, Gino / Pandolfini, Manlio / Imperatori, Luca / Di Stadio, Arianna

    Oral oncology

    2021  Volume 124, Page(s) 105439

    Abstract: Aim: To understand the impact of COVID pandemic on the activity and patients' care of the Head and Neck regional Unit, temporary moved in a COVID-free hospital.: Methods: We retrospectively analyzed the yearly activity of the "Head & Neck Cancer Unit" ...

    Abstract Aim: To understand the impact of COVID pandemic on the activity and patients' care of the Head and Neck regional Unit, temporary moved in a COVID-free hospital.
    Methods: We retrospectively analyzed the yearly activity of the "Head & Neck Cancer Unit" at the Azienda Ospedali Riuniti Marche Nord (Italy) during 2020 (COVID-19 pandemic) and we compared it with the one performed in 2019. Statistical analyses were performed using Chi-square.
    Results: No significant differences were observed comparing the total number of patients treated for H&N squamous cell carcinoma (SCC) in 2019 with the ones in 2020. Moreover, no differences were identified in term of cancer stage at the moment of the surgery between 2019 and 2020. On the contrary, a significant reduction in the number of surgical procedures carried out for thyroid (p < 0.05) and skin (p < 0.001) malignancies was identified.
    Conclusions: Despite Covid-19 limitations, our institution was able to preserve the number of major oncologic procedures without negative impact on patients' care. We believe that the creation of specific COVID-free hospital can be the key preserve quality of care in epidemic emergency.
    MeSH term(s) COVID-19/epidemiology ; Head and Neck Neoplasms/surgery ; Hospital Units ; Humans ; Italy/epidemiology ; Pandemics ; Retrospective Studies ; Surgical Oncology
    Language English
    Publishing date 2021-07-14
    Publishing country England
    Document type Letter
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2021.105439
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