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  1. Article ; Online: Olfactory Dysfunction in COVID-19: Diagnosis and Management.

    Whitcroft, Katherine Lisa / Hummel, Thomas

    JAMA

    2020  Volume 323, Issue 24, Page(s) 2512–2514

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Humans ; Olfaction Disorders/diagnosis ; Olfaction Disorders/etiology ; Olfaction Disorders/therapy ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.8391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Olfactory Dysfunction in COVID-19 ; Diagnosis and Management

    Whitcroft, Katherine Lisa / Hummel, Thomas

    JAMA

    2020  Volume 323, Issue 24, Page(s) 2512

    Keywords General Medicine ; covid19
    Language English
    Publisher American Medical Association (AMA)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.8391
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.88: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article: Olfaction: Sensitive indicator of inflammatory burden in chronic rhinosinusitis.

    Yan, Xiaoguang / Whitcroft, Katherine Lisa / Hummel, Thomas

    Laryngoscope investigative otolaryngology

    2020  Volume 5, Issue 6, Page(s) 992–1002

    Abstract: Background and objective: Olfactory dysfunction has a high prevalence in chronic rhinosinusitis (CRS) patients and significantly affects quality of life. CRS is recognized as a complex disorder encompassing heterogeneous inflammatory processes in the ... ...

    Abstract Background and objective: Olfactory dysfunction has a high prevalence in chronic rhinosinusitis (CRS) patients and significantly affects quality of life. CRS is recognized as a complex disorder encompassing heterogeneous inflammatory processes in the nose and paranasal sinuses. Olfactory dysfunction in CRS patients is associated with the level of inflammatory mediators and the efficiency of inflammatory control. Learning about the association between CRS-related inflammation and olfactory function will provide clues to the pathogenesis of CRS.
    Structure: The first section of this review describes the assessment of olfactory function using various measures, from ratings to MR based imaging. Then, we discuss the conductive and inflammatory mechanisms related to olfactory dysfunction in CRS: olfaction is associated with certain inflammatory patterns and is potentially a marker of CRS subtype. Finally, we review anti-inflammatory therapies including conservative and surgical approaches, and their effectiveness in olfactory dysfunction in CRS.
    Conclusion: Assessment of olfactory function should be considered in the clinical evaluation of CRS patients, not only for detecting and quantifying patients' symptom, but also because it appears to be useful to objectively assess the efficacy of CRS treatment over time. In addition, olfaction can be expected to expand the library of CRS phenotypes and endotypes and, hence, pave the way for more precise, tailored treatment options.
    Language English
    Publishing date 2020-10-28
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2378-8038
    ISSN 2378-8038
    DOI 10.1002/lio2.485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sestamibi scintigraphy for parathyroid localisation: a reminder of the dangers of false positives.

    Whitcroft, Katherine Lisa / Sharma, Anup

    BMJ case reports

    2014  Volume 2014

    Abstract: Surgical parathyroidectomy is the only curative treatment for primary hyperparathyroidism. As minimally invasive parathyroidectomy increases in popularity, so does reliance on preoperative parathyroid localisation techniques. One such technique is ... ...

    Abstract Surgical parathyroidectomy is the only curative treatment for primary hyperparathyroidism. As minimally invasive parathyroidectomy increases in popularity, so does reliance on preoperative parathyroid localisation techniques. One such technique is sestamibi scintigraphy. We report a case of false-positive sestamibi scintigraphy caused by follicular variant of papillary thyroid carcinoma. Subsequent completion thyroidectomy was not possible due to widespread postoperative fibrosis. This case, therefore, highlights the potential dangers of false-positive results due to thyroid carcinoma and encourages surgeons to consider this possibility when faced with intrathyroidal or otherwise ambiguous parathyroid localisation results.
    MeSH term(s) Adenoma/complications ; Adenoma/diagnostic imaging ; Adenoma/surgery ; Aged ; Carcinoma/complications ; Carcinoma/diagnostic imaging ; Carcinoma/surgery ; Carcinoma, Papillary ; Diagnostic Errors ; False Positive Reactions ; Female ; Humans ; Hyperparathyroidism, Primary/diagnostic imaging ; Hyperparathyroidism, Primary/etiology ; Hyperparathyroidism, Primary/surgery ; Parathyroid Glands/diagnostic imaging ; Parathyroid Neoplasms/complications ; Parathyroid Neoplasms/diagnostic imaging ; Parathyroid Neoplasms/surgery ; Parathyroidectomy ; Radionuclide Imaging ; Radiopharmaceuticals ; Technetium Tc 99m Sestamibi ; Thyroid Cancer, Papillary ; Thyroid Neoplasms/complications ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/surgery ; Thyroidectomy
    Chemical Substances Radiopharmaceuticals ; Technetium Tc 99m Sestamibi (971Z4W1S09)
    Language English
    Publishing date 2014-03-11
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2013-203225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Investigating the nasal cycle using unilateral peak nasal inspiratory flow and acoustic rhinometry minimal cross-sectional area measurements.

    Tan, Martin Fan Min / Whitcroft, Katherine Lisa / Mehta, Nishchay / Schilder, Anne / Leung, Terence S / Andrews, Peter J

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

    2019  Volume 44, Issue 4, Page(s) 518–524

    Abstract: Objective: To plot the nasal cycle using unilateral peak nasal inspiratory flow (UPNIF) and unilateral minimal cross-sectional area (UMCA) readings demonstrating a linear relationship in normal nasal function. Additionally, to determine how this changes ...

    Abstract Objective: To plot the nasal cycle using unilateral peak nasal inspiratory flow (UPNIF) and unilateral minimal cross-sectional area (UMCA) readings demonstrating a linear relationship in normal nasal function. Additionally, to determine how this changes in abnormal nasal function.
    Design: A cross-sectional study measuring UPNIF and UMCA in controls demonstrating normal nasal function and in patients with nasal obstruction.
    Setting: Royal National Throat Nose and Ear Hospital, London.
    Participants: A total of 39 participants, 26 controls and 13 patients, were recruited. Controls exhibited normal nasal function with SNOT-22 <5. Patients nasal obstruction symptoms secondary to inflammation or structural abnormality with SNOT-22 >9.
    Main outcome measures and results: Airflow rates and resistance values were derived from UPNIF and UMCA measurements respectively based on Poiseuille's laws. Ratios between right and left UPNIF and UMCA values were taken to adjust for confounding factors. The relationship of 1/Resistance Ratio and Airflow Rate Ratio demonstrated a linear of direct proportionality of strong correlation and statistical significance (correlation coefficient = 0.76, P « 0.01). This suggests that data points from controls with a normal nasal cycle lie closely along the regressed line, whilst those lying significantly away were shown to belong to patients with nasal dysfunction. Olfactory dysfunction appears to be a sensitive discriminator in predicting this.
    Conclusion: This study demonstrates the directly proportional relationship of 1/Resistance Ratio and Airflow Rate Ratio in normal nasal function. Furthermore, nasal pathology can be predicted if data points lie significantly outside these normal limits. Further studies are needed to validate exact normal and abnormal thresholds.
    MeSH term(s) Adult ; Airway Resistance/physiology ; Cross-Sectional Studies ; Female ; Humans ; Inspiratory Capacity/physiology ; London ; Male ; Nasal Obstruction/physiopathology ; Reference Values ; Rhinometry, Acoustic
    Keywords covid19
    Language English
    Publishing date 2019-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2205891-6
    ISSN 1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
    ISSN (online) 1749-4486
    ISSN 1749-4478 ; 0307-7772 ; 1365-2273
    DOI 10.1111/coa.13313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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