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  1. Article ; Online: Management of Allergic Diseases During COVID-19 Outbreak.

    Izquierdo-Domínguez, Adriana / Rojas-Lechuga, María Jesús / Alobid, Isam

    Current allergy and asthma reports

    2021  Volume 21, Issue 2, Page(s) 8

    Abstract: Purpose of review: The coronavirus disease 2019 (COVID-19) has challenged healthcare system capacities and safety for health care workers, reshaping doctor-patient interaction favoring e-Health or telemedicine. The pandemic situation may make difficult ... ...

    Abstract Purpose of review: The coronavirus disease 2019 (COVID-19) has challenged healthcare system capacities and safety for health care workers, reshaping doctor-patient interaction favoring e-Health or telemedicine. The pandemic situation may make difficult to prioritize patients with allergies diseases (AD), face-to-face evaluation, and moreover concern about the possible COVID-19 diagnosis, since COVID-19 shared many symptoms in common with AD. Being COVID-19 a novel disease, everyone is susceptible; there are some advances on vaccine and specific treatment. We evaluate existing literature on allergic diseases (AD): allergic rhinitis, asthma, food allergy, drug allergy, and skin allergy, and potential underlying mechanisms for any interrelationship between AD and COVID-19.
    Recent findings: There is inconclusive and controversial evidence of the association between AD and the risk of adverse clinical outcomes of COVID-19. AD patients should minimize hospital and face-to-face visits, and those who have used biologics and allergen immunotherapy should continue the treatment. It is essential to wear personal protective equipment for the protection of health care workers. Social distancing, rational use of facemasks, eye protection, and hand disinfection for health care workers and patients deserve further attention and promotion. Teleconsultation during COVID-19 times for AD patients is very encouraging and telemedicine platform can provide a reliable service in patient care.
    MeSH term(s) Asthma/immunology ; Asthma/therapy ; Biological Products ; COVID-19/prevention & control ; Dermatitis, Allergic Contact/immunology ; Dermatitis, Allergic Contact/therapy ; Dermatitis, Atopic/immunology ; Dermatitis, Atopic/therapy ; Desensitization, Immunologic ; Disease Management ; Disease Outbreaks ; Drug Hypersensitivity/immunology ; Drug Hypersensitivity/therapy ; Food Hypersensitivity/immunology ; Food Hypersensitivity/therapy ; Health Personnel ; Humans ; Infection Control/methods ; Pandemics/prevention & control ; Personal Protective Equipment ; Physical Distancing ; Rhinitis, Allergic/immunology ; Rhinitis, Allergic/therapy ; SARS-CoV-2 ; Telemedicine
    Chemical Substances Biological Products
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-021-00989-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5548: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Impact of Asthma Inhalers on Global Climate: A Systematic Review of Their Carbon Footprint and Clinical Outcomes in Spain.

    Montoro, J / Antolín-Amérigo, D / Izquierdo-Domínguez, A / Zapata, J J / González, G / Valero, A

    Journal of investigational allergology & clinical immunology

    2023  Volume 33, Issue 4, Page(s) 250–262

    Abstract: Background: Pressurized metered-dose inhalers (pMDIs) exert an environmental impact resulting from CO2 emissions. Therapeutic alternatives with less environmental impact are widely used. Nevertheless, the choice of device and appropriate therapy should ... ...

    Abstract Background: Pressurized metered-dose inhalers (pMDIs) exert an environmental impact resulting from CO2 emissions. Therapeutic alternatives with less environmental impact are widely used. Nevertheless, the choice of device and appropriate therapy should meet the clinical needs and the characteristics of the patient.
    Objective: The primary objective was to estimate the impact of pMDIs prescribed for any indication on annual CO2 emissions in Spain.The secondary objective was to evaluate the potential impact of switching pMDIs to dry-powder inhalers (DPIs) in patients with asthma.
    Methods: A systematic review of the evidence published during 2010-2021 was carried out. Average annual CO2 emissions of DPIs and pMDIs were calculated in 2 scenarios: the current situation and a hypothetical situation involving a switch from all pMDIs to DPIs. The impact of the switch on clinical outcomes was also evaluated.
    Results: The total value of CO2-eq/year due to DPIs and pMDIs accounted for 0.0056% and 0.0909%, respectively, of total emissions in Spain. In the event of switching pMDIs to DPIs, except those used for rescue medication, the percentages were 0.0076% and 0.0579%. The evaluation of efficacy, handling, satisfaction, safety, and use of health care resources was not conclusive.
    Conclusions: Current CO2 emissions by pMDIs account for a small percentage of the total CO2 footprint in Spain. Nevertheless, there is a need for research into new and more sustainable devices. Suitability and patient clinical criteria such as age and inspiratory flow should be prioritized when prescribing an inhaler.
    MeSH term(s) Humans ; Carbon Footprint ; Spain/epidemiology ; Carbon Dioxide/therapeutic use ; Asthma/drug therapy ; Dry Powder Inhalers ; Administration, Inhalation
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2023-01-04
    Publishing country Spain
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1128657-x
    ISSN 1018-9068
    ISSN 1018-9068
    DOI 10.18176/jiaci.0887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3487: Show issues Location:
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  3. Article: COVID-19 as a Turning Point in the Need for Specialized Smell Units.

    Izquierdo-Domínguez, A / Calvo-Henríquez, C / Ceballos, J C / Rodriguez-Iglesias, M / Mullol, J / Alobid, I

    Journal of investigational allergology & clinical immunology

    2023  Volume 33, Issue 5, Page(s) 400–402

    Language English
    Publishing date 2023-01-17
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1128657-x
    ISSN 1018-9068
    ISSN 1018-9068
    DOI 10.18176/jiaci.0891
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3487: Show issues Location:
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  4. Article: Impact of climate change-related environmental factors on the allergens production and the epidemiology and severity of allergic pathologies.

    Montoro, J / Antolín-Amérigo, D / Artés, M / Izquierdo-Domínguez, A / Zapata, J J / Mur, P / Carrillo, T / Antépara, I / Feo, F / Moral, A / Valero, A

    Journal of investigational allergology & clinical immunology

    2024  

    Abstract: Background: Allergic disease affects up to 40% of the global adult population, a proportion that is increasing with environmental changes related to global warming.: Methods: We undertook a systematic review of the literature to identify and evaluate ...

    Abstract Background: Allergic disease affects up to 40% of the global adult population, a proportion that is increasing with environmental changes related to global warming.
    Methods: We undertook a systematic review of the literature to identify and evaluate the current evidence of the impact of climate change-related environmental factors on the allergen production and the epidemiology and severity of allergic pathologies. PECO criteria were established and guided the literature searches of the PubMed and Cochrane databases (Jan 1, 2016 to Dec 31, 2021). Study outcomes were categorized and grouped to facilitate data synthesis. Outcomes were classified as significant (statistical significance <0.05), non-significant (p>0.05) or undetermined (p value not reported). Study quality was assessed using MMAT analysis.
    Results: Of 195 studies, 40 were considered relevant and 9 of them provided data to be included in the data quantitative synthesis. Environmental factors, including the presence of pollutants, temperature, and drought, influenced the type, volume, and timing of exposure to local aeroallergens. The most relevant environmental factor was the presence of environmental pollutants, of which tropospheric ozone was the most frequently associated to changes in allergen production, prevalence, and severity of allergic disease. Also, several publications demonstrated the impact of environmental factors on the healthcare burden.
    Conclusions: Climate-change related environmental factors increased allergic disease in terms of prevalence, severity, and healthcare burden due to alterations in allergen exposure (volume and type) with the presence of pollutants such as ozone being the most commonly reported driver of such increase.
    Language English
    Publishing date 2024-01-11
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 1128657-x
    ISSN 1018-9068
    ISSN 1018-9068
    DOI 10.18176/jiaci.0988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3487: Show issues Location:
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  5. Article ; Online: Olfactory dysfunction during COVID-19 pandemic.

    Izquierdo-Domínguez, Adriana / Rojas-Lechuga, María Jesús / Mullol, Joaquim / Alobid, Isam

    Medicina clinica (English ed.)

    2020  Volume 155, Issue 9, Page(s) 403–408

    Keywords covid19
    Language English
    Publishing date 2020-10-09
    Publishing country Spain
    Document type Journal Article
    ISSN 2387-0206
    ISSN (online) 2387-0206
    DOI 10.1016/j.medcle.2020.06.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pérdida del sentido del olfato durante la pandemia COVID-19.

    Izquierdo-Domínguez, Adriana / Rojas-Lechuga, María Jesús / Mullol, Joaquim / Alobid, Isam

    Medicina clinica

    2020  Volume 155, Issue 9, Page(s) 403–408

    Title translation Olfactory dysfunction during COVID-19 pandemic.
    MeSH term(s) Asia/epidemiology ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Europe/epidemiology ; Humans ; Models, Neurological ; Neurologic Examination ; North America/epidemiology ; Olfaction Disorders/drug therapy ; Olfaction Disorders/epidemiology ; Olfaction Disorders/etiology ; Olfaction Disorders/physiopathology ; Olfactory Pathways/diagnostic imaging ; Olfactory Receptor Neurons/physiology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Smell/physiology
    Keywords covid19
    Language Spanish
    Publishing date 2020-06-12
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2020.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The 8-Odorant Barcelona Olfactory Test (BOT-8): Validation of a New Test in the Spanish Population During the COVID-19 Pandemic.

    Rojas-Lechuga, M J / Ceballos, J C / Valls-Mateus, M / Mackers, P / Izquierdo-Domínguez, A / López-Chacón, M / Langdon, C / Mariño-Sánchez, F / Valero, J / Mullol, J / Alobid, I

    Journal of investigational allergology & clinical immunology

    2022  Volume 32, Issue 4, Page(s) 291–298

    Abstract: Background and objective: Most smell tests are difficult to implement in daily clinical practice owing to their long duration. The aim of the present study was to develop and validate a short, easy-to-perform, and reusable smell test to be implemented ... ...

    Abstract Background and objective: Most smell tests are difficult to implement in daily clinical practice owing to their long duration. The aim of the present study was to develop and validate a short, easy-to-perform, and reusable smell test to be implemented during the COVID-19 pandemic.
    Methods: The study population comprised 120 healthy adults and 195 patients with self-reported olfactory dysfunction (OD). The 8-Odorant Barcelona Olfactory Test (BOT-8) was used for detection, memory/recognition, and forced-choice identification. In addition, a rose threshold test was performed, and a visual analog scale was applied. The Smell Diskettes Olfaction Test (SDOT) was used for correlation in healthy volunteers, and the University of Pennsylvania Smell Identification Test (UPSIT) was used for patients with OD to establish cut-offs for anosmia and hyposmia. In order to take account of the COVID-19 pandemic, disposable cotton swabs with odorants were compared with the original test.
    Results: In healthy persons, the mean (SD) BOT-8 score was 100% for detection, 94.5% (1.07) for memory/recognition, and 89.6% (0.86) for identification. In patients with OD, the equivalent values were 86% (32.8), 73.2% (37.9), and 77.1% (34.2), respectively. BOT-8 demonstrated good test-retest reliability, with agreement of 96.7% and a quadratic k of 0.84 (P<.001). A strong correlation was observed between BOT-8 and SDOT (r=0.67, P<.001) and UPSIT (r=0.86, P<.001). Agreement was excellent for disposable cotton swabs, with a k of 0.79 compared with the original test. The cut-off point for anosmia was ≤3 (area under the curve, 0.83; sensitivity, 0.673; specificity, 0.993).
    Conclusion: BOT-8 offers an efficient and fast method for assessment of smell threshold, detection, memory, and identification in daily clinical practice. Disposable cotton swabs with odorants proved to be useful and safe during the COVID-19 pandemic.
    MeSH term(s) Adult ; Anosmia ; COVID-19/epidemiology ; Humans ; Odorants ; Olfaction Disorders/diagnosis ; Olfaction Disorders/epidemiology ; Pandemics ; Reproducibility of Results ; Smell
    Language English
    Publishing date 2022-05-09
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1128657-x
    ISSN 1018-9068
    ISSN 1018-9068
    DOI 10.18176/jiaci.0824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3487: Show issues Location:
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  8. Article ; Online: The Loss of Smell and Taste in the COVID-19 Outbreak: a Tale of Many Countries.

    Mullol, Joaquim / Alobid, Isam / Mariño-Sánchez, Franklin / Izquierdo-Domínguez, Adriana / Marin, Concepció / Klimek, Ludger / Wang, De-Yun / Liu, Zheng

    Current allergy and asthma reports

    2020  Volume 20, Issue 10, Page(s) 61

    Abstract: Purpose of review: Olfactory dysfunction in upper airway viral infections (common cold, acute rhinosinusitis) is common (> 60%). During the COVID-19 outbreak, frequency of sensory disorders (smell and/or taste) in affected patients has shown a high ... ...

    Abstract Purpose of review: Olfactory dysfunction in upper airway viral infections (common cold, acute rhinosinusitis) is common (> 60%). During the COVID-19 outbreak, frequency of sensory disorders (smell and/or taste) in affected patients has shown a high variability from 5 to 98%, depending on the methodology, country, and study.
    Recent findings: A sudden, severe, isolated loss of smell and/or taste, in the absence of other upper airway inflammatory diseases (allergic rhinitis, chronic rhinosinusitis, nasal polyposis), should alert individuals and physicians on being potentially affected by COVID-19. The evaluation of smell/taste disorders with a visual analogue scale or an individual olfactory or gustatory test, at the hospital or by telemedicine, to prevent contamination might facilitate an early detection of infected patients and reduce the transmission of SARS-CoV-2. During the COVID-19 outbreak, patients with sudden loss of smell should initiate social distancing and home isolation measures and be tested for SARS-CoV-2 diagnostic test when available. Olfactory training is recommended when smell does not come back after 1 month but can be started earlier.
    MeSH term(s) Acute Disease ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/physiopathology ; Coronavirus Infections/prevention & control ; Humans ; Olfaction Disorders/virology ; Pandemics/prevention & control ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Sinusitis ; Taste Disorders/virology
    Keywords covid19
    Language English
    Publishing date 2020-08-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-020-00961-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pérdida del sentido del olfato durante la pandemia COVID-19

    Izquierdo-Domínguez, Adriana / Rojas-Lechuga, María Jesús / Mullol, Joaquim / Alobid, Isam

    Med Clin (Barc)

    Keywords covid19
    Publisher Elsevier; PMC; WHO
    Document type Article ; Online
    Note WHO #Covidence: #597198
    DOI 10.1016/j.medcli.2020.06.006
    Database COVID19

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  10. Article: Pérdida del sentido del olfato durante la pandemia COVID-19./ Pérdida del sentido del olfato durante la pandemia COVID-19./ Olfactory dysfunction during COVID-19 pandemic

    Izquierdo-Domínguez, Adriana / Rojas-Lechuga, María Jesús / Mullol, Joaquim / Alobid, Isam

    Med. clin (Ed. impr.)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #619655
    Database COVID19

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